LT3630729T - Pirimidino junginys - Google Patents

Pirimidino junginys

Info

Publication number
LT3630729T
LT3630729T LTEPPCT/JP2018/020997T LT18732930T LT3630729T LT 3630729 T LT3630729 T LT 3630729T LT 18732930 T LT18732930 T LT 18732930T LT 3630729 T LT3630729 T LT 3630729T
Authority
LT
Lithuania
Prior art keywords
pyrimidine compound
pyrimidine
compound
Prior art date
Application number
LTEPPCT/JP2018/020997T
Other languages
English (en)
Inventor
Tomoichi Shinohara
Shin Iwata
Kenta Arai
Nobuaki Ito
Masaki Suzuki
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of LT3630729T publication Critical patent/LT3630729T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTEPPCT/JP2018/020997T 2017-05-31 2018-05-31 Pirimidino junginys LT3630729T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2017/020322 WO2018220762A1 (ja) 2017-05-31 2017-05-31 ピリミジン化合物
PCT/JP2018/020997 WO2018221667A1 (en) 2017-05-31 2018-05-31 Pyrimidine compound

Publications (1)

Publication Number Publication Date
LT3630729T true LT3630729T (lt) 2022-01-10

Family

ID=62685028

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/JP2018/020997T LT3630729T (lt) 2017-05-31 2018-05-31 Pirimidino junginys

Country Status (23)

Country Link
US (4) US10800758B2 (lt)
EP (1) EP3630729B1 (lt)
JP (1) JP6739653B2 (lt)
KR (3) KR102688531B1 (lt)
CN (1) CN110603248B (lt)
AU (1) AU2018277949B2 (lt)
CY (1) CY1125073T1 (lt)
DK (1) DK3630729T3 (lt)
EA (1) EA038907B1 (lt)
ES (1) ES2901452T3 (lt)
HR (1) HRP20211913T1 (lt)
HU (1) HUE056942T2 (lt)
IL (1) IL270579B2 (lt)
LT (1) LT3630729T (lt)
MX (1) MX391338B (lt)
MY (1) MY199251A (lt)
PH (1) PH12019502639A1 (lt)
PL (1) PL3630729T3 (lt)
PT (1) PT3630729T (lt)
SA (1) SA519410563B1 (lt)
SI (1) SI3630729T1 (lt)
TW (3) TWI860022B (lt)
WO (2) WO2018220762A1 (lt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ775496A (en) * 2018-11-30 2026-01-30 Otsuka Pharma Co Ltd Heterocyclic compounds for the treatment of epilepsy
JP6870064B2 (ja) * 2018-11-30 2021-05-12 大塚製薬株式会社 ピリミジン化合物の医薬用途
JP7804407B2 (ja) * 2020-05-29 2026-01-22 大塚製薬株式会社 複素環化合物の医薬用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009559A2 (en) * 2002-07-18 2004-01-29 Queen's University At Kingston Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents
PL2509961T3 (pl) * 2009-12-11 2016-09-30 Pochodne imidazolidynodionu
CN102811620B (zh) * 2010-01-25 2015-03-25 Chdi基金会股份有限公司 一些犬尿氨酸-3-单加氧酶抑制剂、药物组合物及其使用方法
ES2560304T3 (es) * 2010-12-06 2016-02-18 Autifony Therapeutics Limited Derivados de hidantoína útiles como inhibidores de Kv3
EP2718285B1 (en) 2011-06-07 2016-03-16 Autifony Therapeutics Limited Hydantoin derivatives as kv3 inhibitors
JP2014521651A (ja) 2011-07-28 2014-08-28 シーエイチディーアイ ファウンデーション,インコーポレーテッド 特定のキヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法
CN103974944B (zh) 2011-12-06 2016-11-02 奥蒂福尼疗法有限公司 用作kv3抑制剂的乙内酰脲衍生物
GB201521751D0 (en) * 2015-12-10 2016-01-27 Autifony Therapeutics Ltd Novel uses

Also Published As

Publication number Publication date
AU2018277949A1 (en) 2019-12-12
SI3630729T1 (sl) 2022-01-31
MX2019014384A (es) 2020-01-23
NZ759385A (en) 2024-11-29
IL270579A (lt) 2019-12-31
TW201902890A (zh) 2019-01-16
PL3630729T3 (pl) 2022-01-24
WO2018221667A1 (en) 2018-12-06
EA201992831A1 (ru) 2020-03-30
HRP20211913T1 (hr) 2022-03-04
HUE056942T2 (hu) 2022-03-28
CA3064176A1 (en) 2018-12-06
TWI860022B (zh) 2024-10-21
JP6739653B2 (ja) 2020-08-12
KR20250065436A (ko) 2025-05-12
TW202346283A (zh) 2023-12-01
EP3630729B1 (en) 2021-11-03
US10800758B2 (en) 2020-10-13
KR20240116588A (ko) 2024-07-29
KR20200011962A (ko) 2020-02-04
PH12019502639A1 (en) 2020-06-08
ES2901452T3 (es) 2022-03-22
KR102688531B1 (ko) 2024-07-26
IL270579B1 (en) 2023-04-01
WO2018220762A1 (ja) 2018-12-06
AU2018277949B2 (en) 2021-11-18
CN110603248A (zh) 2019-12-20
IL270579B2 (en) 2023-08-01
EP3630729A1 (en) 2020-04-08
US20250361224A1 (en) 2025-11-27
SA519410563B1 (ar) 2022-07-25
MY199251A (en) 2023-10-23
CN110603248B (zh) 2023-07-04
US20200017476A1 (en) 2020-01-16
DK3630729T3 (da) 2021-12-13
BR112019023988A2 (pt) 2020-06-30
US20230138411A1 (en) 2023-05-04
TWI808974B (zh) 2023-07-21
US20200399245A1 (en) 2020-12-24
JP2020503334A (ja) 2020-01-30
CY1125073T1 (el) 2023-03-24
PT3630729T (pt) 2021-12-16
MX391338B (es) 2025-03-21
TW202502754A (zh) 2025-01-16
EA038907B1 (ru) 2021-11-08

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