LT3849970T - Kristalinis (r)-5-karbamoilpiridin-3-il-2-metil-4-(3-(trifluormetoksi)benzil) piperazin-1-karboksilatas, jo kompozicijos ir panaudojimo būdai - Google Patents

Kristalinis (r)-5-karbamoilpiridin-3-il-2-metil-4-(3-(trifluormetoksi)benzil) piperazin-1-karboksilatas, jo kompozicijos ir panaudojimo būdai

Info

Publication number: LT3849970T
Authority: LT; Lithuania
Prior art keywords: carbamoylpyridin; trifluoromethoxy; piperazine; carboxylate; benzyl
Prior art date: 2018-09-13

Application number

LTEPPCT/US2019/050771T

Other languages

English (en)

Lithuanian (lt)

Inventor

Lianfeng Huang

Nancy TSOU

Nicole White

Jun Xu

Qun Zhang

Original Assignee

Celgene Corporation

Lundbeck La Jolla Research Center, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-09-13

Filing date

2019-09-12

Publication date

2024-10-10

2019-09-12 Application filed by Celgene Corporation, Lundbeck La Jolla Research Center, Inc. filed Critical Celgene Corporation

2024-10-10 Publication of LT3849970T publication Critical patent/LT3849970T/lt

Links

XXDVCULQMDDOAX-CYBMUJFWSA-N (5-carbamoylpyridin-3-yl) (2R)-2-methyl-4-[[3-(trifluoromethoxy)phenyl]methyl]piperazine-1-carboxylate Chemical compound O(C(F)(F)F)C1=CC=CC(CN2C[C@H](N(CC2)C(=O)OC2=CC(C(=O)N)=CN=C2)C)=C1 XXDVCULQMDDOAX-CYBMUJFWSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

LTEPPCT/US2019/050771T 2018-09-13 2019-09-12 Kristalinis (r)-5-karbamoilpiridin-3-il-2-metil-4-(3-(trifluormetoksi)benzil) piperazin-1-karboksilatas, jo kompozicijos ir panaudojimo būdai LT3849970T (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201862731014P	2018-09-13	2018-09-13
PCT/US2019/050771 WO2020056105A1 (en)	2018-09-13	2019-09-12	Crystalline (r)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl) piperazine-1-carboxylate, compositions and methods of use thereof

Publications (1)

Publication Number	Publication Date
LT3849970T true LT3849970T (lt)	2024-10-10

Family

ID=68069873

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEPPCT/US2019/050771T LT3849970T (lt)	2018-09-13	2019-09-12	Kristalinis (r)-5-karbamoilpiridin-3-il-2-metil-4-(3-(trifluormetoksi)benzil) piperazin-1-karboksilatas, jo kompozicijos ir panaudojimo būdai

Country Status (28)

Country	Link
US (4)	US11053199B2 (pl)
EP (2)	EP3849970B1 (pl)
JP (1)	JP7405840B2 (pl)
KR (1)	KR102844245B1 (pl)
CN (3)	CN118561814A (pl)
AU (1)	AU2019337623B2 (pl)
BR (1)	BR112021004340A2 (pl)
CA (1)	CA3112200A1 (pl)
CL (1)	CL2021000596A1 (pl)
CO (1)	CO2021003295A2 (pl)
DK (1)	DK3849970T3 (pl)
EA (1)	EA202190511A1 (pl)
ES (1)	ES2993173T3 (pl)
FI (1)	FI3849970T3 (pl)
HR (1)	HRP20241294T1 (pl)
HU (1)	HUE068147T2 (pl)
IL (1)	IL281276B2 (pl)
LT (1)	LT3849970T (pl)
MA (1)	MA53607B1 (pl)
MX (1)	MX2021002923A (pl)
MY (2)	MY210363A (pl)
PL (1)	PL3849970T3 (pl)
PT (1)	PT3849970T (pl)
RS (1)	RS65967B1 (pl)
SG (1)	SG11202102143RA (pl)
SI (1)	SI3849970T1 (pl)
SM (1)	SMT202400369T1 (pl)
WO (1)	WO2020056105A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN118561814A (zh) *	2018-09-13	2024-08-30	细胞基因公司	结晶(r)-2-甲基-4-(3-(三氟甲氧基)苄基)哌嗪-1-甲酸5-氨基甲酰基吡啶-3-基酯、其组合物及使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2007010076A (es)	2005-02-17	2007-10-16	Astellas Pharma Inc	Derivado de heterociclico-1-carboxilato que contiene nitrogeno no aromatico de piridilo.
WO2015116774A1 (en) *	2014-01-29	2015-08-06	Synta Pharmaceuticals Corp.	Targeted therapeutics
CN110709084A (zh) *	2017-03-13	2020-01-17	阿比德治疗公司	双重magl和faah抑制剂
CN118561814A (zh)	2018-09-13	2024-08-30	细胞基因公司	结晶(r)-2-甲基-4-(3-(三氟甲氧基)苄基)哌嗪-1-甲酸5-氨基甲酰基吡啶-3-基酯、其组合物及使用方法

2019
- 2019-09-12 CN CN202410683425.0A patent/CN118561814A/zh active Pending
- 2019-09-12 SM SM20240369T patent/SMT202400369T1/it unknown
- 2019-09-12 RS RS20241039A patent/RS65967B1/sr unknown
- 2019-09-12 CA CA3112200A patent/CA3112200A1/en active Pending
- 2019-09-12 FI FIEP19778721.1T patent/FI3849970T3/fi active
- 2019-09-12 SI SI201930824T patent/SI3849970T1/sl unknown
- 2019-09-12 PL PL19778721.1T patent/PL3849970T3/pl unknown
- 2019-09-12 AU AU2019337623A patent/AU2019337623B2/en active Active
- 2019-09-12 EP EP19778721.1A patent/EP3849970B1/en active Active
- 2019-09-12 KR KR1020217010747A patent/KR102844245B1/ko active Active
- 2019-09-12 SG SG11202102143RA patent/SG11202102143RA/en unknown
- 2019-09-12 HU HUE19778721A patent/HUE068147T2/hu unknown
- 2019-09-12 EP EP24185102.1A patent/EP4434583B1/en active Active
- 2019-09-12 MY MYPI2024007477A patent/MY210363A/en unknown
- 2019-09-12 LT LTEPPCT/US2019/050771T patent/LT3849970T/lt unknown
- 2019-09-12 HR HRP20241294TT patent/HRP20241294T1/hr unknown
- 2019-09-12 CN CN201980060119.9A patent/CN113227069B/zh active Active
- 2019-09-12 JP JP2021514123A patent/JP7405840B2/ja active Active
- 2019-09-12 ES ES19778721T patent/ES2993173T3/es active Active
- 2019-09-12 PT PT197787211T patent/PT3849970T/pt unknown
- 2019-09-12 CN CN202410683444.3A patent/CN118530218A/zh active Pending
- 2019-09-12 MA MA53607A patent/MA53607B1/fr unknown
- 2019-09-12 IL IL281276A patent/IL281276B2/en unknown
- 2019-09-12 DK DK19778721.1T patent/DK3849970T3/da active
- 2019-09-12 BR BR112021004340-3A patent/BR112021004340A2/pt unknown
- 2019-09-12 MX MX2021002923A patent/MX2021002923A/es unknown
- 2019-09-12 WO PCT/US2019/050771 patent/WO2020056105A1/en not_active Ceased
- 2019-09-12 MY MYPI2021001295A patent/MY208901A/en unknown
- 2019-09-12 EA EA202190511A patent/EA202190511A1/ru unknown
- 2019-09-12 US US16/569,578 patent/US11053199B2/en active Active
2021
- 2021-03-10 CL CL2021000596A patent/CL2021000596A1/es unknown
- 2021-03-12 CO CONC2021/0003295A patent/CO2021003295A2/es unknown
- 2021-06-03 US US17/338,182 patent/US11680046B2/en active Active
2023
- 2023-05-05 US US18/143,765 patent/US12410133B2/en active Active
2025
- 2025-08-06 US US19/292,473 patent/US20260062384A1/en active Pending

Also Published As

Publication number	Publication date
KR102844245B1 (ko)	2025-08-11
CL2021000596A1 (es)	2021-07-30
DK3849970T3 (da)	2024-09-30
HRP20241294T1 (hr)	2024-12-06
JP7405840B2 (ja)	2023-12-26
EP3849970A1 (en)	2021-07-21
US20230382861A1 (en)	2023-11-30
MA53607B1 (fr)	2025-05-30
EP3849970B1 (en)	2024-07-03
PL3849970T3 (pl)	2025-01-07
US11680046B2 (en)	2023-06-20
IL281276A (en)	2021-04-29
SG11202102143RA (en)	2021-04-29
US20200095201A1 (en)	2020-03-26
EP4434583A3 (en)	2024-11-20
AU2019337623B2 (en)	2024-12-05
CN118530218A (zh)	2024-08-23
CN113227069A (zh)	2021-08-06
SMT202400369T1 (it)	2024-11-15
SI3849970T1 (sl)	2024-11-29
PT3849970T (pt)	2024-09-25
US11053199B2 (en)	2021-07-06
MY210363A (en)	2025-09-13
RS65967B1 (sr)	2024-10-31
AU2019337623A1 (en)	2021-05-13
US20260062384A1 (en)	2026-03-05
MX2021002923A (es)	2021-09-08
IL281276B1 (en)	2024-09-01
IL281276B2 (en)	2025-01-01
MY208901A (en)	2025-06-09
CN118561814A (zh)	2024-08-30
EA202190511A1 (ru)	2021-07-05
CO2021003295A2 (es)	2021-07-30
FI3849970T3 (fi)	2024-09-20
EP4434583B1 (en)	2026-04-01
CA3112200A1 (en)	2020-03-19
US12410133B2 (en)	2025-09-09
WO2020056105A9 (en)	2020-05-28
US20210363105A1 (en)	2021-11-25
CN113227069B (zh)	2024-11-05
JP2022500441A (ja)	2022-01-04
BR112021004340A2 (pt)	2021-05-25
WO2020056105A1 (en)	2020-03-19
ES2993173T3 (en)	2024-12-23
MA53607A (fr)	2021-12-22
EP4434583A2 (en)	2024-09-25
HUE068147T2 (hu)	2024-12-28
KR20210057789A (ko)	2021-05-21

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