LT3994134T - (s)-3-hidroksi-1-(1h-indol-5-il)-2-okso-pirolidin-3-karboksirūgšties 3,5- difluorbenzilamido gamybos būdas - Google Patents
(s)-3-hidroksi-1-(1h-indol-5-il)-2-okso-pirolidin-3-karboksirūgšties 3,5- difluorbenzilamido gamybos būdasInfo
- Publication number
- LT3994134T LT3994134T LTEPPCT/EP2020/068317T LTEP2020068317T LT3994134T LT 3994134 T LT3994134 T LT 3994134T LT EP2020068317 T LTEP2020068317 T LT EP2020068317T LT 3994134 T LT3994134 T LT 3994134T
- Authority
- LT
- Lithuania
- Prior art keywords
- difluorobenzylamide
- indol
- pyrrolidine
- oxo
- hydroxy
- Prior art date
Links
- WVGGJQVCOTYFPV-FQEVSTJZSA-N (3s)-n-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1h-indol-5-yl)-2-oxopyrrolidine-3-carboxamide Chemical compound O=C([C@@]1(C(N(CC1)C=1C=C2C=CNC2=CC=1)=O)O)NCC1=CC(F)=CC(F)=C1 WVGGJQVCOTYFPV-FQEVSTJZSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/547—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame spiro-condensed or forming part of bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19184056 | 2019-07-03 | ||
| PCT/EP2020/068317 WO2021001328A1 (en) | 2019-07-03 | 2020-06-30 | Process for manufacturing (s)-3-hydroxy-1-(1h-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3994134T true LT3994134T (lt) | 2024-05-10 |
Family
ID=67145670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/EP2020/068317T LT3994134T (lt) | 2019-07-03 | 2020-06-30 | (s)-3-hidroksi-1-(1h-indol-5-il)-2-okso-pirolidin-3-karboksirūgšties 3,5- difluorbenzilamido gamybos būdas |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US12378225B2 (lt) |
| EP (1) | EP3994134B9 (lt) |
| JP (1) | JP7579322B2 (lt) |
| KR (1) | KR20220028030A (lt) |
| CN (2) | CN114026069B (lt) |
| AU (1) | AU2020299711B2 (lt) |
| BR (1) | BR112021026624A2 (lt) |
| CA (1) | CA3145579A1 (lt) |
| DK (1) | DK3994134T3 (lt) |
| ES (1) | ES2984363T3 (lt) |
| FI (1) | FI3994134T3 (lt) |
| HR (1) | HRP20240534T1 (lt) |
| HU (1) | HUE066832T2 (lt) |
| IL (1) | IL289479B2 (lt) |
| LT (1) | LT3994134T (lt) |
| MX (1) | MX2021016001A (lt) |
| NZ (1) | NZ783049A (lt) |
| PL (1) | PL3994134T3 (lt) |
| PT (1) | PT3994134T (lt) |
| RS (1) | RS65436B1 (lt) |
| SI (1) | SI3994134T1 (lt) |
| TW (1) | TWI870425B (lt) |
| WO (1) | WO2021001328A1 (lt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230170693A (ko) * | 2021-03-28 | 2023-12-19 | 캔웰 바이오테크 리미티드 | Metap-2 억제제, 약제학적 조성물 및 이의 치료 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010048374A1 (de) | 2010-10-13 | 2012-04-19 | Merck Patent Gmbh | Pyrrolidinone als MetAP-2 Inhibitoren |
| DE102012006884A1 (de) | 2012-04-04 | 2013-10-10 | Merck Patent Gmbh | Cyclische Amide als MetAP-2 Inhibitoren |
| CN103087072B (zh) * | 2013-02-05 | 2014-02-26 | 复旦大学 | 一种（+）-三环羟内酯制备方法 |
| SMT201800270T1 (it) | 2013-12-13 | 2018-07-17 | Daiichi Sankyo Co Ltd | 5-idrossi-4-(trifluorometil)pirazolpiridina-derivato |
| SG11201700832YA (en) | 2014-08-04 | 2017-03-30 | Merck Patent Gmbh | Pyrrolidinone derivatives as metap-2 inhibitors |
| ES2923002T3 (es) * | 2015-02-11 | 2022-09-22 | Theravance Biopharma R&D Ip Llc | Acido (2S,4R)-5-(5'-cloro-2'-fluorobifenil-4-il)-4-(etoxioxailamino)-2-hidroximetil-2-metilpentanoico como inhibidor de la neprilisina |
| RU2715241C2 (ru) | 2015-02-19 | 2020-02-26 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота |
-
2020
- 2020-06-30 HU HUE20734955A patent/HUE066832T2/hu unknown
- 2020-06-30 IL IL289479A patent/IL289479B2/en unknown
- 2020-06-30 CA CA3145579A patent/CA3145579A1/en active Pending
- 2020-06-30 PL PL20734955.6T patent/PL3994134T3/pl unknown
- 2020-06-30 LT LTEPPCT/EP2020/068317T patent/LT3994134T/lt unknown
- 2020-06-30 JP JP2022500028A patent/JP7579322B2/ja active Active
- 2020-06-30 AU AU2020299711A patent/AU2020299711B2/en active Active
- 2020-06-30 DK DK20734955.6T patent/DK3994134T3/da active
- 2020-06-30 CN CN202080048299.1A patent/CN114026069B/zh active Active
- 2020-06-30 EP EP20734955.6A patent/EP3994134B9/en active Active
- 2020-06-30 NZ NZ783049A patent/NZ783049A/en unknown
- 2020-06-30 BR BR112021026624A patent/BR112021026624A2/pt unknown
- 2020-06-30 FI FIEP20734955.6T patent/FI3994134T3/fi active
- 2020-06-30 WO PCT/EP2020/068317 patent/WO2021001328A1/en not_active Ceased
- 2020-06-30 RS RS20240462A patent/RS65436B1/sr unknown
- 2020-06-30 ES ES20734955T patent/ES2984363T3/es active Active
- 2020-06-30 KR KR1020227003063A patent/KR20220028030A/ko not_active Ceased
- 2020-06-30 HR HRP20240534TT patent/HRP20240534T1/hr unknown
- 2020-06-30 PT PT207349556T patent/PT3994134T/pt unknown
- 2020-06-30 CN CN202411312435.XA patent/CN119192144A/zh active Pending
- 2020-06-30 US US17/597,102 patent/US12378225B2/en active Active
- 2020-06-30 MX MX2021016001A patent/MX2021016001A/es unknown
- 2020-06-30 SI SI202030413T patent/SI3994134T1/sl unknown
- 2020-07-02 TW TW109122384A patent/TWI870425B/zh active
-
2025
- 2025-04-15 US US19/179,374 patent/US20250304557A1/en active Pending
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