LT4053128T - 5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui - Google Patents

5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui

Info

Publication number
LT4053128T
LT4053128T LTEP22152688.2T LT22152688T LT4053128T LT 4053128 T LT4053128 T LT 4053128T LT 22152688 T LT22152688 T LT 22152688T LT 4053128 T LT4053128 T LT 4053128T
Authority
LT
Lithuania
Prior art keywords
pyrazolo
difluorophenyl
pyrazol
pyrrolidin
treating cancer
Prior art date
Application number
LTEP22152688.2T
Other languages
English (en)
Inventor
Kollol Pal
Stephane Ciblat
Vincent Albert
Nicolas BRUNEAU-LATOUR
Jonathan BOUDREAULT
Original Assignee
Biohaven Therapeutics Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohaven Therapeutics Ltd. filed Critical Biohaven Therapeutics Ltd.
Publication of LT4053128T publication Critical patent/LT4053128T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTEP22152688.2T 2017-12-15 2018-12-12 5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui LT4053128T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762599490P 2017-12-15 2017-12-15

Publications (1)

Publication Number Publication Date
LT4053128T true LT4053128T (lt) 2024-11-25

Family

ID=65139120

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEPPCT/US2018/065187T LT3724191T (lt) 2017-12-15 2018-12-12 5-(2-(2,5-difluorofenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazol[1,5-a]pirimidino dariniai ir susiję junginiai kaip trk kinazės inhibitoriai, skirti vėžiui gydyti
LTEP22152688.2T LT4053128T (lt) 2017-12-15 2018-12-12 5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2018/065187T LT3724191T (lt) 2017-12-15 2018-12-12 5-(2-(2,5-difluorofenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazol[1,5-a]pirimidino dariniai ir susiję junginiai kaip trk kinazės inhibitoriai, skirti vėžiui gydyti

Country Status (26)

Country Link
US (4) US11230546B2 (lt)
EP (2) EP3724191B9 (lt)
JP (1) JP7321183B2 (lt)
KR (1) KR102738182B1 (lt)
CN (1) CN111819179B (lt)
AU (1) AU2018383571B2 (lt)
CA (1) CA3084814A1 (lt)
DK (2) DK4053128T3 (lt)
EA (1) EA202091475A1 (lt)
ES (2) ES2992993T3 (lt)
FI (1) FI4053128T3 (lt)
HR (2) HRP20241426T1 (lt)
HU (2) HUE069285T2 (lt)
IL (1) IL275059B2 (lt)
LT (2) LT3724191T (lt)
MX (1) MX2020006293A (lt)
PL (2) PL4053128T3 (lt)
PT (2) PT4053128T (lt)
RS (1) RS66124B1 (lt)
SA (1) SA520412192B1 (lt)
SG (1) SG11202005237SA (lt)
SI (2) SI3724191T1 (lt)
SM (1) SMT202400435T1 (lt)
TW (1) TWI848925B (lt)
WO (1) WO2019118584A1 (lt)
ZA (2) ZA202003483B (lt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202091475A1 (ru) 2017-12-15 2020-09-09 Пирамид Байосайенсиз, Инк. ПРОИЗВОДНЫЕ 5-(2-(2,5-ДИФТОРФЕНИЛ)ПИРРОЛИДИН-1-ИЛ)-3-(1H-ПИРАЗОЛ-1-ИЛ)ПИРАЗОЛО[1,5-а]ПИРИМИДИНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Trk КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ РАКА
GB201813791D0 (en) * 2018-08-23 2018-10-10 Benevolental Bio Ltd Organic compounds
CN111718350B (zh) * 2019-03-19 2021-04-13 华中师范大学 吡唑取代的吡唑并嘧啶化合物和药物组合物及其应用
JP7209415B2 (ja) * 2019-03-19 2023-01-20 セントラル チャイナ ノーマル ユニバーシティ ピラゾロピリミジン化合物、医薬組成物、及びその使用
CN111848626B (zh) * 2019-04-30 2021-11-30 江苏柯菲平医药股份有限公司 Trk激酶抑制剂及其用途
CN112979654B (zh) * 2019-12-16 2024-03-19 赛诺哈勃药业（成都）有限公司 杂芳基稠环化合物、其制备方法及应用
JP7767301B2 (ja) * 2020-04-15 2025-11-11 ピラミッド バイオサイエンシズ インコーポレイテッド チロシン受容体キナーゼ阻害剤を調製する方法
CN114437077B (zh) * 2020-11-04 2024-01-30 浙江同源康医药股份有限公司 用作激酶抑制剂的化合物及其应用
CN114437075B (zh) * 2020-11-03 2026-01-30 上海瑶琪生物科技有限公司 用作ntrk激酶抑制剂的化合物及其应用
KR102541026B1 (ko) * 2020-11-11 2023-06-12 주식회사 한독 Trk 억제제 화합물의 제조 방법
WO2022132936A1 (en) * 2020-12-15 2022-06-23 Children's Hospital Medical Center Multi-cyclic irak and flt3 inhibiting compounds and uses thereof
JP2025532532A (ja) * 2022-09-07 2025-10-01 蘇州朗睿生物医薬有限公司 大環状イミダゾ［１，２－ｂ］ピリダジン誘導体並びにその調製方法及び用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
WO2009140128A2 (en) * 2008-05-13 2009-11-19 Irm Llc Compounds and compositions as kinase inhibitors
AR074052A1 (es) * 2008-10-22 2010-12-22 Array Biopharma Inc Compuestos pirazolo{1,5-a}pirimidina sustituida como inhibidores de trk cinasa
CN102271515B (zh) 2008-10-31 2014-07-02 健泰科生物技术公司 吡唑并嘧啶jak抑制剂化合物和方法
US8591943B2 (en) * 2009-04-09 2013-11-26 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
WO2011029027A1 (en) 2009-09-03 2011-03-10 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
WO2012125668A1 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
EP2834243B1 (en) * 2012-03-09 2018-04-25 Lexicon Pharmaceuticals, Inc. PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
US20140288043A1 (en) * 2013-03-19 2014-09-25 Genentech, Inc. Pyrazolopyridine compounds
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
FR3029769A1 (fr) * 2014-12-10 2016-06-17 Tornier Sa Kit pour une prothese d'epaule
CA2971024C (en) * 2014-12-15 2023-09-26 Handok Inc. Fused ring heteroaryl compounds and their use as trk inhibitors
AR103297A1 (es) 2014-12-30 2017-05-03 Forma Therapeutics Inc Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina
JP6475084B2 (ja) 2015-05-21 2019-02-27 臼井国際産業株式会社 トルクセンサ用シャフトの製造設備およびその製造方法
DE102016219374B4 (de) 2016-10-06 2018-06-14 Siemens Aktiengesellschaft Langzeitstabile und stoffschlüssige Strompfadverbindung für Nieder-, Mittelspannungs- und/oder Hochspannungsanlagen bzw. –Schaltgeräte mittels Nanomaterialien
EA202091475A1 (ru) 2017-12-15 2020-09-09 Пирамид Байосайенсиз, Инк. ПРОИЗВОДНЫЕ 5-(2-(2,5-ДИФТОРФЕНИЛ)ПИРРОЛИДИН-1-ИЛ)-3-(1H-ПИРАЗОЛ-1-ИЛ)ПИРАЗОЛО[1,5-а]ПИРИМИДИНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Trk КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ РАКА
CN112398593B (zh) 2019-08-13 2024-08-16 上海朗帛通信技术有限公司 一种被用于无线通信的节点中的方法和装置
JP7767301B2 (ja) 2020-04-15 2025-11-11 ピラミッド バイオサイエンシズ インコーポレイテッド チロシン受容体キナーゼ阻害剤を調製する方法

Also Published As

Publication number Publication date
IL275059B1 (en) 2023-07-01
KR20200099557A (ko) 2020-08-24
RS66124B1 (sr) 2024-11-29
PT4053128T (pt) 2024-10-15
TWI848925B (zh) 2024-07-21
FI4053128T3 (fi) 2024-10-25
EP3724191B9 (en) 2022-05-18
LT3724191T (lt) 2022-04-25
US20230124248A1 (en) 2023-04-20
US20210094956A1 (en) 2021-04-01
US20240246976A1 (en) 2024-07-25
HUE059313T2 (hu) 2022-11-28
EP4053128B8 (en) 2024-10-02
HRP20220464T1 (hr) 2022-05-27
US11739096B2 (en) 2023-08-29
AU2018383571A1 (en) 2020-06-18
ES2908773T3 (es) 2022-05-03
US12486276B2 (en) 2025-12-02
BR112020011775A2 (pt) 2020-11-17
EP4053128A1 (en) 2022-09-07
PL3724191T3 (pl) 2022-04-25
CN111819179B (zh) 2023-09-01
TW201936194A (zh) 2019-09-16
PT3724191T (pt) 2022-03-07
SG11202005237SA (en) 2020-07-29
MX2020006293A (es) 2020-12-03
ZA202205900B (en) 2023-11-29
ES2992993T3 (en) 2024-12-20
DK3724191T3 (da) 2022-03-14
IL275059A (en) 2020-07-30
IL275059B2 (en) 2023-11-01
HRP20241426T1 (hr) 2024-12-20
US20220235055A1 (en) 2022-07-28
SA520412192B1 (ar) 2022-08-11
US11230546B2 (en) 2022-01-25
HUE069285T2 (hu) 2025-02-28
CA3084814A1 (en) 2019-06-20
SMT202400435T1 (it) 2025-01-14
EP3724191A1 (en) 2020-10-21
PL4053128T3 (pl) 2025-01-27
DK4053128T3 (da) 2024-10-21
EP4053128B1 (en) 2024-08-21
ZA202003483B (en) 2023-01-25
EP3724191B1 (en) 2022-01-26
WO2019118584A1 (en) 2019-06-20
JP2021506954A (ja) 2021-02-22
SI4053128T1 (sl) 2025-03-31
CN111819179A (zh) 2020-10-23
SI3724191T1 (sl) 2022-06-30
EA202091475A1 (ru) 2020-09-09
KR102738182B1 (ko) 2024-12-03
AU2018383571B2 (en) 2023-09-21
JP7321183B2 (ja) 2023-08-04

Similar Documents

Publication Publication Date Title
ZA202003483B (en) 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer
IL277576A (en) Mutated pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
PH12018500792A1 (en) Benzolactam compounds as protein kinase inhibitors
IL265918B (en) Converted pyrazolo[1,5–a]pyridine compounds as ret kinase inhibitors
PT3833670T (pt) Derivados de 6-(4-amino-3-metil-2-oxa-8-azaspiro[4.5]decan-8-il)-3-(2,3-diclorofenil)-2-metilpirimidin-4(3h)-ona e compostos similares como inibidores de ptpn11 (shp2) para o tratamento do cancro
HUE052454T2 (hu) CDK4 inhibitorok 2-((5-(1-(3-(metilszulfonil)propil)piperidin-4-il)piridin-2-il)amino)-pirido[2,3-D]pirimidin-7(8H)-on származékok és rokonvegyületek tumorok kezelésére
PT3458456T (pt) Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida
NZ598086A (en) Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
IL288529A (en) History of imidazo[2,1-c]pyrimidine as prc2 inhibitors for cancer therapy
PH12019500478A1 (en) 8-(azetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridinyl compounds, compositions and methods of use thereof
HK40029595A (en) 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer
PL3621966T3 (pl) Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK