LTC2152290I2 - Anti-il-5 antikūnų skyrimo būdai - Google Patents
Anti-il-5 antikūnų skyrimo būdaiInfo
- Publication number
- LTC2152290I2 LTC2152290I2 LTPA2016005C LTPA2016005C LTC2152290I2 LT C2152290 I2 LTC2152290 I2 LT C2152290I2 LT PA2016005 C LTPA2016005 C LT PA2016005C LT PA2016005 C LTPA2016005 C LT PA2016005C LT C2152290 I2 LTC2152290 I2 LT C2152290I2
- Authority
- LT
- Lithuania
- Prior art keywords
- antibodies
- methods
- administering anti
- administering
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91483307P | 2007-04-30 | 2007-04-30 | |
| US99071507P | 2007-11-28 | 2007-11-28 | |
| PCT/US2008/062015 WO2008134721A1 (en) | 2007-04-30 | 2008-04-30 | Methods for administering anti-il-5 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTPA2016005I1 LTPA2016005I1 (lt) | 2018-11-12 |
| LTC2152290I2 true LTC2152290I2 (lt) | 2018-12-27 |
Family
ID=39926128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTPA2016005C LTC2152290I2 (lt) | 2007-04-30 | 2016-03-03 | Anti-il-5 antikūnų skyrimo būdai |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20100086554A1 (lt) |
| EP (4) | EP2152290B1 (lt) |
| JP (6) | JP2010526088A (lt) |
| CY (1) | CY1115456T1 (lt) |
| DK (1) | DK2152290T3 (lt) |
| ES (1) | ES2492943T3 (lt) |
| HR (1) | HRP20140789T1 (lt) |
| LT (1) | LTC2152290I2 (lt) |
| PL (1) | PL2152290T3 (lt) |
| PT (1) | PT2152290E (lt) |
| SI (1) | SI2152290T1 (lt) |
| WO (2) | WO2008134724A2 (lt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2152290B1 (en) * | 2007-04-30 | 2014-06-04 | GlaxoSmithKline LLC | Methods for administering anti-il-5 antibodies |
| EP2274009B1 (en) | 2008-03-28 | 2013-11-13 | GlaxoSmithKline LLC | Methods of treatment |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK4108671T3 (da) | 2010-10-01 | 2025-01-06 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf |
| JP6005657B2 (ja) | 2010-12-16 | 2016-10-12 | ジェネンテック, インコーポレイテッド | Th2阻害に関連する診断及び治療 |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| JP6113737B2 (ja) | 2011-10-03 | 2017-04-12 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法 |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| BR112016008694A2 (pt) | 2013-10-23 | 2017-10-03 | Genentech Inc | Métodos de previsão da reação de pacientes com asma, de previsão da capacidade de reação de pacientes com asma, de identificação de pacientes com asma, de tratamento de pacientes portadores de asma e de tratamento de asma, uso de um kit e kit |
| CN106029693A (zh) | 2014-02-21 | 2016-10-12 | 豪夫迈·罗氏有限公司 | 抗il-13/il-17双特异性抗体及其用途 |
| CA2977285A1 (en) | 2015-03-16 | 2016-09-22 | F. Hoffmann-La Roche Ag | Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases |
| MA42692A (fr) | 2015-08-24 | 2018-07-04 | Glaxosmithkline Ip No 2 Ltd | Compositions biopharmaceutiques |
| TWI799417B (zh) | 2017-05-26 | 2023-04-21 | 英商葛蘭素史克智慧財產發展有限公司 | 生物製藥組成物及相關方法 |
| EP3634467A4 (en) | 2017-06-06 | 2021-07-28 | GlaxoSmithKline LLC | BIOPHARMACEUTICAL COMPOSITIONS AND PROCEDURES FOR PEDIATRIC PATIENTS |
| CN109942706A (zh) * | 2017-12-21 | 2019-06-28 | 三生国健药业(上海)股份有限公司 | 结合人il-5的单克隆抗体、其制备方法和用途 |
| EP3749362A1 (en) | 2018-02-09 | 2020-12-16 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| WO2023091608A2 (en) * | 2021-11-18 | 2023-05-25 | Memorial Sloan-Kettering Cancer Center | Methods for treating anti-cancer drug-related skin rashes using benralizumab |
| WO2025006973A2 (en) * | 2023-06-29 | 2025-01-02 | Board Of Regents, The University Of Texas System | Methods for treating immune related adverse events |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
| US5096704A (en) * | 1988-11-03 | 1992-03-17 | Schering Corporation | Method of treating eosinophilia |
| IT1237881B (it) | 1989-12-12 | 1993-06-18 | Fast Spa | Struttura a profilo complesso, applicabile su apparecchi agitatori, per il bloccaggio di barattoli di vernice, aventi coperchi comunque diversificati |
| PL176393B1 (pl) | 1992-02-06 | 1999-05-31 | Schering Corp | Monoklonalne przeciwciało lub jego fragment, które wiąże się swoiście z ludzką interleukiną-5, hybrydoma wydzielająca monoklonalne przeciwciało, które wiąże się swoiście z ludzką interleukiną-5, polipeptyd izolowany DNA, zrekombinowany wektor komórki gospodarza, humanizowane monoklonalne przeciwciało oraz sposób wytwarzania polipeptydu, sposób wytwarzania humanizowanego monoklonalnego przeciwciała i kompozycja farmaceutyczna |
| US6056957A (en) | 1994-08-04 | 2000-05-02 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-5 |
| ES2277336T3 (es) | 1994-12-23 | 2007-07-01 | Smithkline Beecham Corporation | Antagonistas de il-5 recombinantes utiles en el tratamiento de enfermadades mediadas por il-5. |
| US5783184A (en) * | 1994-12-23 | 1998-07-21 | Smithkline Beecham Corporation | Method for treatment and diagnosis of IL-5 mediated disorders |
| US5683892A (en) | 1994-12-23 | 1997-11-04 | Smithkline Beecham Corporation | DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| US7399837B2 (en) * | 1995-12-22 | 2008-07-15 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| US5696323A (en) * | 1996-06-25 | 1997-12-09 | Alliedsignal, Inc. | Two bar resonant beam Coriolis rate sensor |
| US6248723B1 (en) * | 1997-06-10 | 2001-06-19 | National Jewish Medical And Research Center | Method for treatment of inflammatory disease |
| US5858089A (en) * | 1997-08-26 | 1999-01-12 | Martinovic; Zoran | Corn buttering tool |
| KR20070069220A (ko) * | 1997-10-22 | 2007-07-02 | 젠스 포니카우 | 진균류에 의한 점막염을 국소 치료하기 위한 항진균제의용도 |
| CN1326879C (zh) * | 2002-03-29 | 2007-07-18 | 先灵公司 | 人源抗白细胞介素5单克隆抗体及其制备方法和包含这些抗体的组合物 |
| EP2152290B1 (en) * | 2007-04-30 | 2014-06-04 | GlaxoSmithKline LLC | Methods for administering anti-il-5 antibodies |
| US20090035216A1 (en) * | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
| JP5035153B2 (ja) * | 2008-07-14 | 2012-09-26 | 市光工業株式会社 | 車両用灯具 |
-
2008
- 2008-04-30 EP EP08747188.4A patent/EP2152290B1/en active Active
- 2008-04-30 EP EP14166504.2A patent/EP2777710A1/en not_active Withdrawn
- 2008-04-30 ES ES08747188.4T patent/ES2492943T3/es active Active
- 2008-04-30 US US12/598,319 patent/US20100086554A1/en not_active Abandoned
- 2008-04-30 EP EP13152633.7A patent/EP2606906A1/en not_active Withdrawn
- 2008-04-30 DK DK08747188.4T patent/DK2152290T3/da active
- 2008-04-30 WO PCT/US2008/062019 patent/WO2008134724A2/en not_active Ceased
- 2008-04-30 JP JP2010506604A patent/JP2010526088A/ja active Pending
- 2008-04-30 JP JP2010506602A patent/JP2010526087A/ja not_active Withdrawn
- 2008-04-30 PL PL08747188T patent/PL2152290T3/pl unknown
- 2008-04-30 WO PCT/US2008/062015 patent/WO2008134721A1/en not_active Ceased
- 2008-04-30 HR HRP20140789AT patent/HRP20140789T1/hr unknown
- 2008-04-30 SI SI200831253T patent/SI2152290T1/sl unknown
- 2008-04-30 EP EP08780583A patent/EP2152310A4/en not_active Withdrawn
- 2008-04-30 US US12/598,309 patent/US20100086547A1/en not_active Abandoned
- 2008-04-30 PT PT87471884T patent/PT2152290E/pt unknown
-
2014
- 2014-08-07 CY CY20141100618T patent/CY1115456T1/el unknown
- 2014-09-08 JP JP2014182614A patent/JP2015028042A/ja active Pending
-
2015
- 2015-12-10 US US14/965,130 patent/US20160096886A1/en not_active Abandoned
-
2016
- 2016-03-03 LT LTPA2016005C patent/LTC2152290I2/lt unknown
- 2016-09-26 JP JP2016186583A patent/JP2017036296A/ja active Pending
-
2017
- 2017-10-10 US US15/729,019 patent/US20180022799A1/en not_active Abandoned
-
2018
- 2018-06-06 JP JP2018108483A patent/JP2018158934A/ja active Pending
-
2019
- 2019-09-25 JP JP2019174641A patent/JP2020019781A/ja active Pending
- 2019-10-23 US US16/660,972 patent/US20200040073A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100086547A1 (en) | 2010-04-08 |
| JP2018158934A (ja) | 2018-10-11 |
| US20180022799A1 (en) | 2018-01-25 |
| EP2606906A1 (en) | 2013-06-26 |
| EP2777710A1 (en) | 2014-09-17 |
| JP2010526087A (ja) | 2010-07-29 |
| PT2152290E (pt) | 2014-09-03 |
| EP2152310A4 (en) | 2010-05-26 |
| EP2152290A1 (en) | 2010-02-17 |
| LTPA2016005I1 (lt) | 2018-11-12 |
| JP2020019781A (ja) | 2020-02-06 |
| US20160096886A1 (en) | 2016-04-07 |
| EP2152290A4 (en) | 2010-06-02 |
| CY1115456T1 (el) | 2017-01-04 |
| PL2152290T3 (pl) | 2014-11-28 |
| EP2152290B1 (en) | 2014-06-04 |
| SI2152290T1 (sl) | 2014-09-30 |
| WO2008134721A1 (en) | 2008-11-06 |
| WO2008134724A2 (en) | 2008-11-06 |
| HRP20140789T1 (hr) | 2014-10-10 |
| ES2492943T3 (es) | 2014-09-10 |
| US20100086554A1 (en) | 2010-04-08 |
| JP2010526088A (ja) | 2010-07-29 |
| DK2152290T3 (da) | 2014-08-18 |
| WO2008134724A3 (en) | 2009-02-12 |
| JP2015028042A (ja) | 2015-02-12 |
| US20200040073A1 (en) | 2020-02-06 |
| JP2017036296A (ja) | 2017-02-16 |
| EP2152310A2 (en) | 2010-02-17 |
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