LU103204B1 - Optical fluid verification for dispense volume evaluation - Google Patents
Optical fluid verification for dispense volume evaluation Download PDFInfo
- Publication number
- LU103204B1 LU103204B1 LU103204A LU103204A LU103204B1 LU 103204 B1 LU103204 B1 LU 103204B1 LU 103204 A LU103204 A LU 103204A LU 103204 A LU103204 A LU 103204A LU 103204 B1 LU103204 B1 LU 103204B1
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- Prior art keywords
- light
- fluid
- detector
- light beam
- array
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F13/00—Apparatus for measuring by volume and delivering fluids or fluent solid materials, not provided for in the preceding groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
- G01N21/532—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke with measurement of scattering and transmission
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Fluid Mechanics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present disclosure relates to optical fluid control for in vitro diagnostic applications where a fluid is dispensed in free space, e.g. into a sample vessel or similar container. The fluid control system detects whether a fluid and which volume has been dispensed. In addition, the system checks whether the correct fluid has been dispensed.
Description
LU
STRATEC SE Forfmann Te 9 efh off 30001.20400LU | Intellectual Property Altorneys
LU103204
OPTICAL FLUID VERIFICATION FOR DISPENSE VOLUME EVALUATION
[0001] The present disclosure relates to optical fluid control for in vitro diagnostic applications where a fluid is dispensed in free space, e.g. into a sample vessel or similar container. The fluid control system detects whether a fluid and which volume has been dispensed. In addition, the system checks whether the correct fluid has been dispensed.
[0002] Optical fluid control devices are known in the prior art. They relate to measuring a fluid flow in a hose. Sensors for fluid droplets are also known.
[0003] Published European patent EP 0 619 476 B1 discloses an optical detector system for determining the liquid level in a transparent container such as a capillary tube, with which pipetting can also be performed. The geometric position (height) of the liquid in the tube is determined here. Technically, this is accomplished with an illumination lens (homogeneous illumination over the entire height of the tube) and detection optics with a CCD camera (row).
The illumination and detection may take place at different angles to one another. The structure for optical determination is relatively large, so that it cannot be integrated into a pipetting needle. Furthermore, the capillary tube must be outwardly open to be able to evaluate the filling level with the lens, but this can lead to soiling. The use of a capillary tube and filling level analysis in an area prevents the evaluation of large volumes from being evaluable.
[0004] Published U.S. patent US 5,362,971 À discloses a fiber optic sensor that is immersed with the fiber area “to be measured” in the liquid “to be measured.” To do this, a loop of a waveguide is exchanged immersed in a liquid. Small volumes therefore cannot be differentiated 1
STRATECSE rortrmann Tegethoff 30001.20400LU Intellectual Property Attorneys
LU103204 merely on the basis of the dimensions. This is thus a level measuring device for liquids in containers. Furthermore, the fiber optics come in direct contact with the media.
[0005] Published British patent application GB 2 221 986 A discloses a fiber optic sensor which is immersed with the fiber area “to be measured” in the liquid “to be measured” to determine the optical density of the medium using the transmitted light method. To do this, light is introduced by waveguides into an area in a biochemical reactor that is detected again by a second waveguide. In the transmitted light method, the classical design of a photometer is implemented for measurement of the optical density of a medium. On the basis of the curvature of one of the fibers required for the transmitted light method, the sensor head must be designed with large dimensions. No “deflecting lens” is used to achieve “miniaturization.” Therefore, the sensor to be immersed can be immersed only in large volumes of liquid. This sensor along with the measurement area is also immersed completely in the medium to be tested.
[0006] Optical fluid verification systems which are known from the prior art only work for a fluid flow in a hose. The known technologies are sensitive to the material of the system and the diameter of the hose to which the sensor is attached. Other known systems include only a single detector so that the signal is dependent on the alignment of the fluid jet to the path of the emitter and the detector. The small distance between emitter and detector increases the risk of contamination of the sample.
[0007] There is a need for a fluid control system which does not interfere with the fluid and its distribution.
[0008] The present invention provides an optical control system comprising: - a light source for emitting a light beam in a beam direction; - an optical element for collimating the light beam; - a detector comprising a detector array of light detector cells; - and a fluidic path which crosses the collimated light beam perpendicular.
[0009] In a further aspect of the system according to the present disclosure, the light source is a LED, a plurality of LEDs or a laser. - 2 -
LU
STRATEC SE rortmann Tegethoft 30001.20400LU | Intellectual Property Attomeys
LU103204
[0010] In an embodiment of the system according to the present disclosure, the light source emits a light beam at a defined wavelength.
[0011] It is further envisaged that the optical element is a lens or an array of lenses.
[0012] The system may further comprise light detector cells of the array of light detector cells are arranged in rows and columns.
[0013] It is also intended that the system according to the present disclosure may comprise at least one further array of light detector cells which is arranged outside the path of the light beam.
[0014] Another aspect of the system of the present disclosure relates to the detector cells of the array of light detector cells are connected to a receiver for obtaining the light signals of each light detector cells.
[0015] In an embodiment, the system may comprise a receiver which is connected to a computer programmable unit configured for determining changes of the light beam comprising determining whether the light beam is focussed, absorbed, reflected and/or scattered.
[0016] The system may also comprise a computer programmable unit which is configured for evaluating properties of the fluid depending on determined changes of the light beam.
[0017] Another object of the present disclosure relates to a method for determining properties of a fluid, comprising the steps of: - arranging a fluid path perpendicular to a collimated light beam; - measuring changes of the light beam with at least one array of light detector cells comprising determining whether the light beam is focussed, absorbed, reflected and/or scattered; - evaluating determined changes of the light beam in a computer programmable unit which is connected to the light detector cells by comparing the detected changes with stored data relating changes in detected signals to properties of a fluid; - determining properties of the fluid in the fluidic path. 3
LU
STRATECSE Forman, Tegethoff 30001.20400LU | Intellectual Property Attomeys
LU103204
[0018] In another aspect, the method of the present disclosure may comprise the step of evaluating the signals from the detector cells for determining a spatially resolved detection of the deflected light.
[0019] In an embodiment of the method of the present disclosure, changes of the received light beam are detected for each detector cell of the detector array.
[0020] The method may further comprise the step of determining scattering properties of the fluid or fluid droplet by measuring side scattering of light with additional detector arrays.
[0021] The method may also comprise the step of determining the geometry of the beam and/or the spectral absorption of the liquid for providing information about properties of the dispensed fluid.
[0022] The foregoing summary is not intended to summarize each potential embodiment or every aspect of the present disclosure.
[0023] The invention will be described based on figures. It will be understood that the embodiments and aspects of the invention described in the figures are only examples and do not limit the protective scope of the claims in any way. The invention is defined by the claims and their equivalents. It will be understood that features of one aspect or embodiment of the invention can be combined with a feature of a different aspect or aspects of other embodiments of the invention, in which:
[0024] FIG. 1 shows an embodiment of an optical fluid control system according to the disclosure without a fluid flow in the optical path.
[0025] FIG. 2 shows an embodiment of an optical fluid control system according to the disclosure with a fluid flow-in the optical path.
[0026] FIG. 3 shows a perspective view on a fluid jet perpendicular crossing the light beam.
[0027] FIG. 4 shows an exemplary expected signal for detector cell. 4
LU
STRATECSE Forman, Tegethoff 30001.20400LU | Intellectual Property Attorneys
LU103204
[0028] FIG. 5 shows a droplet of a fluid in the measurement area.
[0029] FIG. 6 shows a decreased signal from a detector cell is determined.
[0030] FIG. 7 shows an exemplary setup for a system with two additional detectors 2 for determining the backscattering or side scattering of the fluid jet or fluid droplet.
Detailed Description of the Disclosure and the Figures
[0031] The technical problem is solved by the independent claims. The dependent claims cover further specific embodiments of the invention.
[0032] The present disclosure relates to an optical control system in which a fluid jet or fluid drop is detected in free space without affecting the fluid jet or fluid drop in its shape and direction of distribution. In addition, the control system requires only a very small installation space.
[0033] FIG. 1 shows an embodiment of an optical fluid control system. A first element of a system according to the present disclosure is a light source/emitter 1 like a LED or a laser. The wavelength of the emitted light can be adapted to optical properties of the fluid which is to be detected. A second element is an optical lens 5 that shapes the light beam 4 according to the geometry and dimensions of the detector 2 which is the third element of the system.
[0034] In the embodiment which is shown in FIG. 1, optical lens 5 collimates the light beam for increasing the distance between lens 5 and detector 2 which is arranged in line with the light source 1 and lens 5 and may comprise an array of detector cells 21 (2D array) with individual independent detector cells like photodiodes. The direction of the light beam 4 is perpendicular to the dispensing direction of a fluid jet. The array of detector cells 21 can consist of multiple rows and columns (comp. FIG. 3) to increase the tolerance range for the sensing region and reduce the alignment effort when setting up the detector 2.
[0035] The array of detector cells 21 is used to determine whether there is a liquid jet/drop in the measuring range. In the case that there is no liquid jet or drop in the measuring range, the
TE, EE OR
LU103204 light beam 4 hits the array of detector cells 21 without any deviations or changes of the light beam 4 (comp. FIG. 2).
[0036] If the light beam 4 hits a fluid jet or fluid droplet 3 in the measuring range, the light beam is focused, absorbed, reflected and/or scattered depending on the fluid used (comp. FIG. 2). The fluid jet or fluid drop 3 may act like a focussing lens and thus create a focal point between. the fluid jet or fluid drop 3 and the detector 2, as shown in FIG. 2. Depending on whether a droplet or fluid jet 3 is in the measuring range 10, different focal points can be created.
The focal length depends here on the size and geometry of the fluid jet or fluid droplet 3. The signals from the detector will differ depending on whether the focal point is before, on, or behind the detector array.
[0037] FIG. 3 shows a perspective view on a fluid jet perpendicular crossing the light beam.
The fluid jet acts like a focussing lens and creates a focal point between the liquid jet and the detector. Through the focal point, part of the light beam hits the detector array in a different manner than an unfocussed light beam producing an equal distribution of the light on the detector 2. The focal point before the detector will changes the light distribution on the detector so that the light intensity measured by the detector 2 will decrease in certain areas and increase in other areas. Information relating to the geometry of the detected light beam will be measured.
[0038] FIG. 4 shows an exemplary expected light signal from an array of detector cells 21 which can be exemplary received by a fist cell 211 and a second cell 212 shown in FIG. 3.
When a fluid jet is arranged in the light beam, the signal at detector cell 211 decreases and only increases again when the fluid jet is no longer present in the light area. Detector cell 212 has a smaller deflection than detector cell 211, which means that a higher total amount of light hits detector cell 212.
[0039] In order to draw conclusions about the dispensed fluid, the control system uses all detector cells which are arranged on the surface of the array of detector cells 21 for the evaluation. The signal from detector cells 211, 212 on the array of detector cells 21 depends on their position in the array of detector cells 21 which may exemplarily have two rows of four detector cells in each row. It is also possible that a single detector cell is not affected at all by a fluid which is arranged in the light beam and the collimated light beam from the lens still reaches the respective detector cell on the array of detector cells 21 directly. The control system uses the individual signals from all detector cells to determine a spatially resolved detection of 6 -———————————————
TE EE OT
LU103204 the deflected light and allows thus an evaluation with respect to the geometry and volume of the detected fluid. Using the temporal detection of the signals and the known system parameters, the emitted fluid volume can be determined.
[0040] The more detector cells the array of detector cells 21 comprises, the more detailed the edge effects on the detector cells are detected and more accurate information about the geometry of the fluid jet 30 can be determined.
[0041] The properties of the fluids used are used to determine which fluid crossed the light beam. With a transparent fluid, as described above, a focusing effect occurs due to the fluid beam and the signal decreases in the area of the detector array 21 where the scattered light beam is located and increases outside this area, so that the distribution of the light on the detector 2 is detected. For more opaque fluids, absorption effects arise in addition to the lens effect. The absorption properties of the fluid cause a decrease in the signal on the detector cells. Depending on the absorption properties of the fluid used, the signal pulses are higher or lower. In the case of non-transparent fluids, the light rays are completely absorbed, and no light rays hit the detector array in this area. The spectral absorption of the known fluids allows the system to provide information about which fluid was dispensed and crossed the light beam.
[0042] FIG. 5 shows an example with a droplet of a fluid in the measurement area 10. When the droplet 3 enters the measurement area 10, part of the light is reflected and/or scattered by the surface angles of the droplet, so that a decrease in the signal at the detector cell is determined (comp. FIG. 6). Due to the drop shape, the drop acts like a lens in the center and creates a focal point near the detector so that a focused beam of light hits the detector and the signal increases in this area. When the droplet leaves the measurement area, the droplet shape again creates surface angles that reflect or scatter the signal, so that a renewed decrease in the signal is detected.
[0043] By evaluating the signals on the detector array, the system can determine a spatially resolved detection of the deflected light (decrease of the signal in the area where the jet/drop is located and increase outside this area is detected). Furthermore, the system detects whether a fluid jet or droplet has been emitted. Using the information about the geometry of the beam — ———————
me, SO OT and/or the spectral absorption of the liquid, the system can provide information about properties 1010060 of the dispensed fluid.
[0044] With the integration of additional detectors, the system also provides information about the scattering properties of the fluid jet or fluid droplet. FIG. 7 shows an exemplary setup for a system with two additional detectors 2 for determining the backscattering or side scattering of the fluid jet or fluid droplet. If, for example, particles are present in the dispensed fluid, part of the light rays will be reflected back to detector 2a by the particles. Detector 2b provides additional information regarding the scattering properties of the liquid and can thus give further information about the geometry of the fluid jet or fluid droplet. The other light beams impinge on the detector 2 as described above.
[0045] The advantageous of a device according to the present disclosure can be summarised as follows: _ The detector arrangement makes the system less sensitive to positional tolerances of the fluid jet or fluid droplet with respect to the intersection line of the emitter/light source and detector. - À collimating lens increases the distance between the light source and the detector.
The increased distance reduces the risk of contamination. - The detector arrangement allows spatially resolved detection of the deflected light (decrease in signal in the area where the beam/droplet is located and increase outside this area can be detected). This can provide information about the geometry of the beam or, depending on the spectral absorption of the liquid, can provide information about properties of the fluid in the light beam. - No need for a hose, therefore no dependence on hose properties. ;
[0046] Alternative approaches to realize or to circumvent the invention - Optical fibers can be used in the liquid control system to guide the light from an ’ LED to the measurement region. - The opening of the fibers can contain structures for beam shaping (lenticular fiber, etc.). _ Plastic or glass fibers can be used. - The detector array can consist of an array of optical fibers connected to a patterned detector on the other side (shock-coupled to a photodiode array or camera) 8 ————————
STN
20001.20400LU {iret cion: Property Attamays ] : - Other optical components such as mirrors, etc., could be used to direct light to the liquid beam/droplet and detector. - Multiple detectors for e.g. back scattering or side scattering could be used around : the measurement area to obtain information about the fluid jet or fluid droplet. ; - Detection of air in the liquid jet
[0047] The foregoing description of preferred and other embodiments is not intended to limit ; or restrict the scope or applicability of the inventive concepts conceived of by the Applicants. :
It will be appreciated with the benefit of the present disclosure that features described above in ) accordance with any embodiment or aspect of the disclosed subject matter can be utilized, either A alone or in combination, with any other described feature, in any other embodiment or aspect of the disclosed subject matter. ; 9
N XN Ns se SES 30001.20400LU Hirdedinoinng Property sdlomeys r
LU103204 ,
Reference Numerals 1 light source/emitter ı 2 detector ı 3 fluid jet or fluid droplet ; 4 light beam optical lens measuring range 21 array of detector cells 511 first detector cell 312 second detector cell
Claims (14)
1. An optical control system comprising: - a light source for emitting a light beam in a beam direction; - an optical element for collimating the light beam; _ a detector comprising an array of light detector cells; - and a fluidic path which crosses the collimated light beam perpendicular.
2. The system of claim 1, wherein the light source is a LED, a plurality of LEDs or a laser.
3. The system of claim 1 or 2, wherein the light source emits a light beam at a defined wavelength.
4. The system of any one of claims 1 to 3, wherein the optical element is a lens or an array of lenses.
5. The system of any one of claims 1 to 4, wherein the light detector cells of the array of light detector cells are arranged in rows and columns.
6. The system of any one of claims 1 to 6, comprising at least one further array of light detector cells which is arranged outside the path of the light beam.
7. The system of any one of claims 1 to 7, wherein the detector cells of the array of light detector cells are connected to a receiver for obtaining the light signals of each light detector cells.
8. The system of any one of claims 1 to 8, wherein the receiver is connected to a computer programmable unit configured for determining changes of the light beam comprising determining whether the light beam is focussed, absorbed, reflected and/or scattered.
9. The system of any one of claims 1 to 9, wherein the computer programmable unit is configured for evaluating properties of the fluid depending on determined changes of the light beam. 11 —-—-—————————————————————————— =
— es : Lu Fortmann Tegethofl 2 STRATEC SE à Patents & Reahisninaliin > = 30001.20400LU Linea chad Sopa ATPINVE
. LU103204 .
10. A method for determining properties of a fluid, comprising the steps of:
. a. arranging a fluid path perpendicular to a collimated light beam;
. b. measuring changes of the light beam with at least one array of light detector cells
. comprising determining whether the light beam is focussed, absorbed, reflected
. and/or scattered;
c. evaluating determined changes of the light beam in a computer programmable = unit which is connected to the light detector cells by comparing the detected
. changes with stored data relating changes in detected signals to properties of a fic
. à. determining properties of the fluid in the fluidic path.
.
11. The method of claim 10, comprising the step of evaluating the signals from the detector = cells for determining a spatially resolved detection of the deflected light. …
12. The method of claim 10 or 11, wherein changes of the received light beam are detected … for each detector cell of the detector array, …
13. The method of any one of claims 10 to 12, comprising the step of determining scattering â properties of the fluid or fluid droplet by measuring side scattering of light with
.… additional detector arrays. -
14. The method of any one of claims 10 to 13, comprising the step of determining the … geometry of the beam and/or the spectral absorption of the liquid for providing â information about properties of the dispensed fluid. Ne a SS
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU103204A LU103204B1 (en) | 2023-10-13 | 2023-10-13 | Optical fluid verification for dispense volume evaluation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU103204A LU103204B1 (en) | 2023-10-13 | 2023-10-13 | Optical fluid verification for dispense volume evaluation |
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| Publication Number | Publication Date |
|---|---|
| LU103204B1 true LU103204B1 (en) | 2025-04-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU103204A LU103204B1 (en) | 2023-10-13 | 2023-10-13 | Optical fluid verification for dispense volume evaluation |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2221986A (en) | 1988-08-19 | 1990-02-21 | Mandel William R | Apparatus and method for optical density measurements of biomass processes |
| US5362971A (en) | 1993-03-10 | 1994-11-08 | Terrascope Systems, Inc. | Fiber optic detection system |
| EP0619476B1 (en) | 1992-12-19 | 1999-09-22 | Boehringer Mannheim Gmbh | Device for detection of a fluidic interface in a transparent measuring tube |
| US20080121026A1 (en) * | 2006-11-28 | 2008-05-29 | Cummins Filtration Ip, Inc. | Combination contaminant size and nature sensing system and method for diagnosing contamination issues in fluids |
| US20150115174A1 (en) * | 2012-05-30 | 2015-04-30 | Iris International, Inc. | Flow cytometer |
| US20160282264A1 (en) * | 2010-11-16 | 2016-09-29 | Premium Genetics (Uk) Ltd | Cytometry system with interferometric measurement |
| EP3224600B1 (en) * | 2014-11-24 | 2019-11-13 | ART Healthcare Ltd. | Drop and drip measurement |
-
2023
- 2023-10-13 LU LU103204A patent/LU103204B1/en active IP Right Grant
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2221986A (en) | 1988-08-19 | 1990-02-21 | Mandel William R | Apparatus and method for optical density measurements of biomass processes |
| EP0619476B1 (en) | 1992-12-19 | 1999-09-22 | Boehringer Mannheim Gmbh | Device for detection of a fluidic interface in a transparent measuring tube |
| US5362971A (en) | 1993-03-10 | 1994-11-08 | Terrascope Systems, Inc. | Fiber optic detection system |
| US20080121026A1 (en) * | 2006-11-28 | 2008-05-29 | Cummins Filtration Ip, Inc. | Combination contaminant size and nature sensing system and method for diagnosing contamination issues in fluids |
| US20160282264A1 (en) * | 2010-11-16 | 2016-09-29 | Premium Genetics (Uk) Ltd | Cytometry system with interferometric measurement |
| US20150115174A1 (en) * | 2012-05-30 | 2015-04-30 | Iris International, Inc. | Flow cytometer |
| EP3224600B1 (en) * | 2014-11-24 | 2019-11-13 | ART Healthcare Ltd. | Drop and drip measurement |
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Effective date: 20250422 |