LU81166A1 - Derives anti-tumoraux de carboxyhydrazide en c-3 de la 4-desacetyl vincaleucoblastine - Google Patents

Derives anti-tumoraux de carboxyhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Info

Publication number: LU81166A1
Authority: LU; Luxembourg
Prior art keywords: carboxyhydrazide; vincaleucoblastine; desacetyl; tumor; derivatives
Prior art date: 1978-04-20

Application number

LU81166A

Other languages

English (en)

French (fr)

Inventor

G Cullinan

K Gerzon

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-18

Publication date

1979-09-07

1979-04-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1979-09-07 Publication of LU81166A1 publication Critical patent/LU81166A1/xx

Links

LPGWZGMPDKDHEP-HLTPFJCJSA-N Leurosine Chemical compound C([C@]1([C@@H]2O1)CC)N(CCC=1C3=CC=CC=C3NC=11)C[C@H]2C[C@]1(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC LPGWZGMPDKDHEP-HLTPFJCJSA-N 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
229960003048 vinblastine Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

LU81166A 1978-04-20 1979-04-18 Derives anti-tumoraux de carboxyhydrazide en c-3 de la 4-desacetyl vincaleucoblastine LU81166A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
LU81166A1 true LU81166A1 (fr)	1979-09-07

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU81166A LU81166A1 (fr)	1978-04-20	1979-04-18	Derives anti-tumoraux de carboxyhydrazide en c-3 de la 4-desacetyl vincaleucoblastine

Country Status (32)

Country	Link
US (1)	US4166810A (cs)
EP (1)	EP0005051B1 (cs)
JP (1)	JPS54141798A (cs)
AR (1)	AR228940A1 (cs)
AT (1)	AT369010B (cs)
AU (1)	AU527109B2 (cs)
BE (1)	BE875652A (cs)
BG (3)	BG33297A3 (cs)
CA (1)	CA1097629A (cs)
CH (1)	CH643269A5 (cs)
CS (3)	CS218583B2 (cs)
DD (1)	DD143075A5 (cs)
DE (1)	DE2964130D1 (cs)
DK (1)	DK147484C (cs)
EG (1)	EG14867A (cs)
ES (2)	ES479754A1 (cs)
FI (1)	FI791286A7 (cs)
FR (1)	FR2423495A1 (cs)
GB (1)	GB2019396B (cs)
GR (1)	GR69987B (cs)
HU (1)	HU181431B (cs)
IE (1)	IE48213B1 (cs)
IL (1)	IL57168A (cs)
LU (1)	LU81166A1 (cs)
NZ (1)	NZ190213A (cs)
PH (1)	PH14163A (cs)
PL (3)	PL215911A1 (cs)
PT (1)	PT69496A (cs)
RO (3)	RO81114A (cs)
SU (3)	SU1225490A3 (cs)
YU (1)	YU93179A (cs)
ZA (1)	ZA791856B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DE3483336D1 (de) *	1983-03-30	1990-11-08	Lilly Industries Ltd	Vincaleukoblastin-derivate.
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
ATE427948T1 (de)	2001-04-24	2009-04-15	Purdue Research Foundation	Folat-mimetika und deren folatrezeptorbindende konjugate
CA2484640C (en) *	2002-05-15	2012-01-17	Endocyte, Inc.	Vitamin-mitomycin conjugates
WO2004069159A2 (en)	2003-01-27	2004-08-19	Endocyte, Inc.	Vitamin receptor binding drug delivery conjugates
CN101098854B (zh) *	2004-07-23	2012-12-05	恩多塞特公司	二价连接体及其轭合物
CN101175757B (zh) *	2005-03-16	2012-11-14	恩多塞特公司	蝶酸及其缀合物的合成和纯化
EP2382995A3 (en)	2005-08-19	2013-09-25	Endocyte, Inc.	Ligand conjugates of Vinca alkaloids, analogs and derivatives
BRPI0615354A2 (pt) *	2005-08-19	2011-05-17	Endocyte, Inc.	conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso
US20100087370A1 (en) *	2007-02-14	2010-04-08	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) *	2007-02-16	2010-04-29	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
AU2008224988A1 (en) *	2007-03-14	2008-09-18	Endocyte, Inc.	Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
CN101784565B (zh)	2007-06-25	2014-12-10	恩多塞特公司	含有亲水性间隔区接头的共轭物
CN101909441B (zh)	2007-10-25	2015-05-13	恩多塞特公司	微管蛋白抑制剂及其制备方法
EP2476414B1 (en) *	2009-09-07	2015-03-04	NIPRO Patch Co., Ltd.	Transdermally absorbable preparation
US10080805B2 (en)	2012-02-24	2018-09-25	Purdue Research Foundation	Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
BR112015008365A2 (pt)	2012-10-16	2017-07-04	Endocyte Inc	composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
IL48685A (en)	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 FI FI791286A patent/FI791286A7/fi not_active Application Discontinuation
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 BG BG056470A patent/BG33297A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 BG BG043323A patent/BG33294A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 BG BG056469A patent/BG33296A3/xx unknown
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
PH14163A (en)	1981-03-19
ZA791856B (en)	1980-11-26
PL119416B1 (en)	1981-12-31
CS218584B2 (en)	1983-02-25
AR228940A1 (es)	1983-05-13
DK147484B (da)	1984-08-27
NZ190213A (en)	1982-12-21
GB2019396B (en)	1982-09-15
GR69987B (cs)	1982-07-22
RO81037A (ro)	1983-02-01
BG33297A3 (bg)	1983-01-14
AU527109B2 (en)	1983-02-17
JPS54141798A (en)	1979-11-05
DK147484C (da)	1985-03-25
CS218583B2 (en)	1983-02-25
YU93179A (en)	1983-01-21
HU181431B (en)	1983-07-28
BG33294A3 (bg)	1983-01-14
CS218585B2 (en)	1983-02-25
PL215911A1 (cs)	1980-03-24
EP0005051B1 (en)	1982-12-01
FI791286A7 (fi)	1981-01-01
PT69496A (en)	1979-05-01
ES479753A1 (es)	1980-08-16
IE790795L (en)	1979-10-20
CA1097629A (en)	1981-03-17
SU893135A3 (ru)	1981-12-23
IL57168A (en)	1983-10-31
ATA291279A (de)	1982-04-15
PL125470B1 (en)	1983-05-31
IE48213B1 (en)	1984-10-31
SU1225490A3 (ru)	1986-04-15
ES479754A1 (es)	1980-08-16
BE875652A (fr)	1979-10-18
AT369010B (de)	1982-11-25
US4166810A (en)	1979-09-04
DE2964130D1 (en)	1983-01-05
IL57168A0 (en)	1979-07-25
SU1061698A3 (ru)	1983-12-15
EG14867A (en)	1986-09-30
AU4609779A (en)	1979-10-25
EP0005051A1 (en)	1979-10-31
JPS6245873B2 (cs)	1987-09-29
FR2423495A1 (fr)	1979-11-16
RO81037B (ro)	1983-01-30
RO80084B (ro)	1983-01-30
GB2019396A (en)	1979-10-31
DK160679A (da)	1979-10-21
RO80084A (ro)	1983-02-01
DD143075A5 (de)	1980-07-30
CH643269A5 (fr)	1984-05-30
BG33296A3 (bg)	1983-01-14
RO81114A (ro)	1983-02-01
RO81114B (ro)	1983-01-30
FR2423495B1 (cs)	1983-02-11

Publication	Publication Date	Title
BE875652A (fr)	1979-10-18	Derives anti-tumoraux decarboxhydrazide en c-3 de la 4-desacetyl vincaleucoblastine
LU80925A1 (fr)	1979-06-18	Derives de dehydrocyclicimino-acides
SE7907493L (sv)	1980-03-12	Anilinokinazolinderivat
SE7900380L (sv)	1979-07-21	Anisamidderivat
BE867269A (fr)	1978-11-20	Derives de thiopropanoylamino-acides
ES494635A0 (es)	1981-08-16	Procedimiento de preparacion de derivados de tiadiazol
FI791081A7 (fi)	1979-10-06	Tioetiansyraderivat
FI790486A7 (fi)	1979-08-15	Aminosocker-derivat
FR2510108B1 (fr)	1986-02-14	Derives de pyridine
BE863314A (fr)	1978-07-25	Derives enti-paludeens de la pyrimidine
DE2964681D1 (de)	1983-03-17	4-amino-3-sulfonamido pyridine derivatives
FR2301253A1 (fr)	1976-09-17	Derives de la
FR2350340A1 (fr)	1977-12-02	Derives de thiouree
BE877694A (fr)	1979-11-05	Derives de 1-phenyl-1-propanol.
BE859567A (fr)	1978-04-11	Derives piperidylideniques de benzo-xanthenes
DK152979A (da)	1979-10-13	Pyridinderivater
BE874488A (fr)	1979-08-27	Derives benzylideniques
BE875592A (fr)	1979-10-15	Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde et leur preparation
DK143979A (da)	1979-10-08	Chromanonderivater
BE866933A (fr)	1978-11-10	Nouveaux derives de fortmicine
DK320479A (da)	1980-02-01	Pyridoxinderivater
DK149809C (da)	1987-03-23	1-alkylsubstituerede pyrazolderivater
BE873799A (fr)	1979-05-16	Derives de phenylpyrrole
BE877099A (fr)	1979-12-19	Derives de phenylpiperazine
BE873266A (fr)	1979-07-02	Nouveaux derives de 11-alcanoyl-4"-deoxy-4"-isonitrilo-oleandomycine