LU84549A1 - Melange de cromoglycate de sodium et de xylometazoline et procede pour le preparer - Google Patents

Melange de cromoglycate de sodium et de xylometazoline et procede pour le preparer Download PDF

Info

Publication number: LU84549A1
Authority: LU; Luxembourg
Prior art keywords: xylometazoline; mixture according; mixture; sodium cromoglycate; solution
Prior art date: 1981-12-23

Application number

LU84549A

Other languages

English (en)

French (fr)

Inventor

Neil Arthur Stevenson

Wilfrid Tord Simpson

Original Assignee

Fisons Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-23

Filing date

1982-12-22

Publication date

1983-06-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10526808&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU84549(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1982-12-22 Application filed by Fisons Plc filed Critical Fisons Plc

1983-06-13 Publication of LU84549A1 publication Critical patent/LU84549A1/fr

Links

239000000203 mixture Substances 0.000 title claims description 40
HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 title claims description 29
229960000265 cromoglicic acid Drugs 0.000 title claims description 16
229960000833 xylometazoline Drugs 0.000 title claims description 13
238000004519 manufacturing process Methods 0.000 title claims description 3
IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 title description 14
239000000243 solution Substances 0.000 claims description 21
239000002738 chelating agent Substances 0.000 claims description 11
239000003352 sequestering agent Substances 0.000 claims description 11
239000003755 preservative agent Substances 0.000 claims description 10
230000002335 preservative effect Effects 0.000 claims description 7
239000007864 aqueous solution Substances 0.000 claims description 6
229960000686 benzalkonium chloride Drugs 0.000 claims description 6
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 2
229960001484 edetic acid Drugs 0.000 claims description 2
VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
MJOQJPYNENPSSS-XQHKEYJVSA-N [(3r,4s,5r,6s)-4,5,6-triacetyloxyoxan-3-yl] acetate Chemical compound CC(=O)O[C@@H]1CO[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O MJOQJPYNENPSSS-XQHKEYJVSA-N 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
YGWFCQYETHJKNX-UHFFFAOYSA-N 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1h-imidazol-3-ium;chloride Chemical compound [Cl-].CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCC[NH2+]1 YGWFCQYETHJKNX-UHFFFAOYSA-N 0.000 description 5
239000000872 buffer Substances 0.000 description 5
229910021645 metal ion Inorganic materials 0.000 description 5
208000024891 symptom Diseases 0.000 description 5
229960001095 xylometazoline hydrochloride Drugs 0.000 description 5
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
229940109248 cromoglycate Drugs 0.000 description 4
239000000546 pharmaceutical excipient Substances 0.000 description 4
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
-1 cromoglycate anion Chemical class 0.000 description 3
230000001954 sterilising effect Effects 0.000 description 3
239000005526 vasoconstrictor agent Substances 0.000 description 3
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
239000011575 calcium Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000001914 filtration Methods 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
230000014759 maintenance of location Effects 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
239000007922 nasal spray Substances 0.000 description 2
229940097496 nasal spray Drugs 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000001488 sodium phosphate Substances 0.000 description 2
229910000162 sodium phosphate Inorganic materials 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
239000011701 zinc Substances 0.000 description 2
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
206010027654 Allergic conditions Diseases 0.000 description 1
206010006784 Burning sensation Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
206010028735 Nasal congestion Diseases 0.000 description 1
208000002193 Pain Diseases 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
206010039085 Rhinitis allergic Diseases 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000172 allergic effect Effects 0.000 description 1
201000010105 allergic rhinitis Diseases 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
150000001805 chlorine compounds Chemical class 0.000 description 1
208000027744 congestion Diseases 0.000 description 1
210000000795 conjunctiva Anatomy 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
229940047135 glycate Drugs 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000002085 irritant Substances 0.000 description 1
231100000021 irritant Toxicity 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
210000001989 nasopharynx Anatomy 0.000 description 1
BEEDODBODQVSIM-UHFFFAOYSA-N oxymetazoline hydrochloride Chemical compound Cl.CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 BEEDODBODQVSIM-UHFFFAOYSA-N 0.000 description 1
229960005162 oxymetazoline hydrochloride Drugs 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000000047 product Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
206010041232 sneezing Diseases 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
238000011146 sterile filtration Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

LU84549A 1981-12-23 1982-12-22 Melange de cromoglycate de sodium et de xylometazoline et procede pour le preparer LU84549A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8138755		1981-12-23
GB8138755		1981-12-23

Publications (1)

Publication Number	Publication Date
LU84549A1 true LU84549A1 (fr)	1983-06-13

Family

ID=10526808

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU84549A LU84549A1 (fr)	1981-12-23	1982-12-22	Melange de cromoglycate de sodium et de xylometazoline et procede pour le preparer

Country Status (9)

Country	Link
EP (1)	EP0082546B2 (da)
JP (1)	JPS58110517A (da)
AU (1)	AU550653B2 (da)
BE (1)	BE895428A (da)
CH (1)	CH653258A5 (da)
DE (1)	DE3265462D1 (da)
FR (1)	FR2518405B1 (da)
HK (1)	HK56289A (da)
LU (1)	LU84549A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19539532C2 (de)	1995-10-24	1999-02-25	Mann Gerhard Chem Pharm Fab	Ophthalmisches Cromoglicat-Gelpräparat
RU2123840C1 (ru) *	1996-05-27	1998-12-27	Петросян Вилен Гургенович	Капли петросяна n 1a (n 2a - n 7a их варианты) для лечения аллергических и неатопических заболеваний глаз и носа
RU2657419C9 (ru) *	2017-03-01	2018-09-06	Сергей Николаевич Анисимов	Фармацевтическая композиция для назального применения

1982
- 1982-12-06 DE DE8282201545T patent/DE3265462D1/de not_active Expired
- 1982-12-06 EP EP82201545A patent/EP0082546B2/en not_active Expired - Lifetime
- 1982-12-17 AU AU91640/82A patent/AU550653B2/en not_active Expired
- 1982-12-21 CH CH7467/82A patent/CH653258A5/fr not_active IP Right Cessation
- 1982-12-21 BE BE0/209783A patent/BE895428A/fr not_active IP Right Cessation
- 1982-12-22 FR FR8221563A patent/FR2518405B1/fr not_active Expired
- 1982-12-22 JP JP57224089A patent/JPS58110517A/ja active Granted
- 1982-12-22 LU LU84549A patent/LU84549A1/fr unknown
1989
- 1989-07-13 HK HK562/89A patent/HK56289A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK56289A (en)	1989-07-21
AU9164082A (en)	1983-06-30
JPH0149244B2 (da)	1989-10-24
EP0082546B2 (en)	1992-03-25
BE895428A (fr)	1983-06-21
CH653258A5 (fr)	1985-12-31
DE3265462D1 (en)	1985-09-19
FR2518405A1 (fr)	1983-06-24
EP0082546B1 (en)	1985-08-14
JPS58110517A (ja)	1983-07-01
EP0082546A1 (en)	1983-06-29
AU550653B2 (en)	1986-03-27
FR2518405B1 (fr)	1986-08-14

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