LU90992I2 - Xigris-drotrécogine alfa(activée) et ses dérivés hpharmaceutiquement acceptables - Google Patents

Xigris-drotrécogine alfa(activée) et ses dérivés hpharmaceutiquement acceptables

Info

Publication number: LU90992I2
Authority: LU; Luxembourg
Prior art keywords: apc; activated; xigris; pharmaceutically acceptable; acceptable derivatives
Prior art date: 1994-01-05

Application number

LU90992C

Other languages

English (en)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-05

Filing date

2002-12-18

Publication date

2003-02-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22650141&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90992(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-12-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2003-02-18 Publication of LU90992I2 publication Critical patent/LU90992I2/fr

Links

229960000209 drotrecogin alfa (activated) Drugs 0.000 title 1
101800004937 Protein C Proteins 0.000 abstract 2
102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 2
101800001700 Saposin-D Proteins 0.000 abstract 2
239000003398 denaturant Substances 0.000 abstract 2
229960000856 protein c Drugs 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Microbiology (AREA)
Biophysics (AREA)
Immunology (AREA)
Diabetes (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

LU90992C 1994-01-05 2002-12-18 Xigris-drotrécogine alfa(activée) et ses dérivés hpharmaceutiquement acceptables LU90992I2 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17783294A	1994-01-05	1994-01-05

Publications (1)

Publication Number	Publication Date
LU90992I2 true LU90992I2 (fr)	2003-02-18

Family

ID=22650141

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LU90993C LU90993I2 (fr)	1994-01-05	2002-12-18	Xigris-drotrécogine alfa(activée) et ses dérivés pharmaceutiquement acceptables
LU90992C LU90992I2 (fr)	1994-01-05	2002-12-18	Xigris-drotrécogine alfa(activée) et ses dérivés hpharmaceutiquement acceptables

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LU90993C LU90993I2 (fr)	1994-01-05	2002-12-18	Xigris-drotrécogine alfa(activée) et ses dérivés pharmaceutiquement acceptables

Country Status (29)

Country	Link
EP (2)	EP1087011A3 (fr)
JP (1)	JP3778588B2 (fr)
KR (1)	KR950032287A (fr)
CN (1)	CN1109891A (fr)
AT (1)	ATE201045T1 (fr)
AU (1)	AU1003195A (fr)
BR (1)	BR9500017A (fr)
CA (1)	CA2139468C (fr)
CO (1)	CO4600680A1 (fr)
CZ (1)	CZ1395A3 (fr)
DE (2)	DE69520844T2 (fr)
DK (1)	DK0662513T3 (fr)
ES (1)	ES2156190T3 (fr)
FI (1)	FI115635B (fr)
GR (1)	GR3036277T3 (fr)
HU (1)	HUT70465A (fr)
IL (1)	IL112236A (fr)
LU (2)	LU90993I2 (fr)
NL (1)	NL300108I2 (fr)
NO (2)	NO320157B1 (fr)
NZ (1)	NZ270271A (fr)
PE (1)	PE43995A1 (fr)
PL (1)	PL180703B1 (fr)
PT (1)	PT662513E (fr)
RU (1)	RU2167936C2 (fr)
SI (1)	SI0662513T1 (fr)
UA (1)	UA39178C2 (fr)
YU (1)	YU295A (fr)
ZA (1)	ZA9514B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9809292A (pt)	1997-04-28	2000-07-04	Lilly Co Eli	Métodos aperfeiçoados para o processamento de proteìna c ativada
EP1557463A1 (fr) *	1997-04-28	2005-07-27	Eli Lilly & Company	Méthodes améliorées de traitement de protéine C activée
US6630137B1 (en)	1997-04-28	2003-10-07	Eli Lilly And Company	Activated protein C formulations
US7204981B2 (en)	2000-03-28	2007-04-17	Eli Lilly And Company	Methods of treating diseases with activated protein C
CA2410567A1 (fr)	2000-05-24	2001-11-29	Eli Lilly And Company	Preparations et techniques permettant de traiter des hypercoagulations
AU2007272412B2 (en) *	2006-07-14	2013-11-07	Genentech, Inc.	Refolding of recombinant proteins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3950513A (en) *	1965-12-03	1976-04-13	Novo Terapeutisk Laboratorium A/S	Process of stabilizing therapeutically useful plasmin solutions
US3557002A (en) *	1967-11-15	1971-01-19	Procter & Gamble	Stabilized aqueous enzyme preparation
GB2105521A (en) *	1981-08-12	1983-03-23	Univ Surrey	Antenna
AT402262B (de) *	1991-06-20	1997-03-25	Immuno Ag	Arzneimittel enthaltend aktiviertes protein c

1994
- 1994-12-22 NZ NZ270271A patent/NZ270271A/xx unknown
1995
- 1995-01-03 CZ CZ9513A patent/CZ1395A3/cs unknown
- 1995-01-03 CO CO95000126A patent/CO4600680A1/es unknown
- 1995-01-03 CA CA002139468A patent/CA2139468C/fr not_active Expired - Fee Related
- 1995-01-03 IL IL11223695A patent/IL112236A/xx not_active IP Right Cessation
- 1995-01-03 ZA ZA9514A patent/ZA9514B/xx unknown
- 1995-01-03 PE PE1995258411A patent/PE43995A1/es not_active Application Discontinuation
- 1995-01-03 PL PL95306671A patent/PL180703B1/pl unknown
- 1995-01-03 NO NO19950018A patent/NO320157B1/no not_active IP Right Cessation
- 1995-01-03 AU AU10031/95A patent/AU1003195A/en not_active Abandoned
- 1995-01-03 KR KR1019950000002A patent/KR950032287A/ko not_active Abandoned
- 1995-01-04 DK DK95300042T patent/DK0662513T3/da active
- 1995-01-04 BR BR9500017A patent/BR9500017A/pt not_active IP Right Cessation
- 1995-01-04 EP EP00203385A patent/EP1087011A3/fr not_active Withdrawn
- 1995-01-04 RU RU95100178/13A patent/RU2167936C2/ru active
- 1995-01-04 UA UA95018011A patent/UA39178C2/uk unknown
- 1995-01-04 HU HU9500021A patent/HUT70465A/hu unknown
- 1995-01-04 DE DE69520844T patent/DE69520844T2/de not_active Expired - Lifetime
- 1995-01-04 CN CN95101130A patent/CN1109891A/zh active Pending
- 1995-01-04 YU YU295A patent/YU295A/sh unknown
- 1995-01-04 SI SI9530503T patent/SI0662513T1/xx unknown
- 1995-01-04 ES ES95300042T patent/ES2156190T3/es not_active Expired - Lifetime
- 1995-01-04 AT AT95300042T patent/ATE201045T1/de active
- 1995-01-04 EP EP95300042A patent/EP0662513B1/fr not_active Expired - Lifetime
- 1995-01-04 JP JP00008695A patent/JP3778588B2/ja not_active Expired - Fee Related
- 1995-01-04 DE DE2002199053 patent/DE10299053I2/de active Active
- 1995-01-04 PT PT95300042T patent/PT662513E/pt unknown
- 1995-01-04 FI FI950044A patent/FI115635B/fi not_active IP Right Cessation
2001
- 2001-07-24 GR GR20010401126T patent/GR3036277T3/el unknown
2002
- 2002-12-03 NL NL300108C patent/NL300108I2/nl unknown
- 2002-12-18 LU LU90993C patent/LU90993I2/fr unknown
- 2002-12-18 LU LU90992C patent/LU90992I2/fr unknown
2006
- 2006-05-02 NO NO2006006C patent/NO2006006I1/no unknown

Also Published As

Publication number	Publication date
NO320157B1 (no)	2005-11-07
ATE201045T1 (de)	2001-05-15
ES2156190T3 (es)	2001-06-16
LU90993I2 (fr)	2003-02-18
EP1087011A2 (fr)	2001-03-28
PT662513E (pt)	2001-08-30
EP1087011A3 (fr)	2002-02-06
IL112236A0 (en)	1995-03-30
JPH07206704A (ja)	1995-08-08
NO2006006I1 (no)	2006-05-15
DE10299053I2 (de)	2004-04-01
FI950044A0 (fi)	1995-01-04
HU9500021D0 (en)	1995-03-28
UA39178C2 (uk)	2001-06-15
YU295A (sh)	1997-09-30
JP3778588B2 (ja)	2006-05-24
ZA9514B (en)	1996-07-03
RU95100178A (ru)	1997-03-27
CN1109891A (zh)	1995-10-11
PL180703B1 (pl)	2001-03-30
BR9500017A (pt)	1995-10-03
CA2139468A1 (fr)	1995-07-06
NO950018D0 (no)	1995-01-03
IL112236A (en)	1999-12-31
AU1003195A (en)	1995-07-13
DK0662513T3 (da)	2001-05-28
NZ270271A (en)	1996-07-26
GR3036277T3 (en)	2001-10-31
SI0662513T1 (en)	2001-10-31
CZ1395A3 (en)	1995-07-12
FI950044L (fi)	1995-07-06
RU2167936C2 (ru)	2001-05-27
KR950032287A (ko)	1995-12-20
EP0662513B1 (fr)	2001-05-09
NL300108I2 (nl)	2003-06-02
FI115635B (fi)	2005-06-15
CA2139468C (fr)	2007-08-21
PL306671A1 (en)	1995-07-10
CO4600680A1 (es)	1998-05-08
PE43995A1 (es)	1995-12-15
DE69520844T2 (de)	2001-11-08
DE69520844D1 (de)	2001-06-13
NO950018L (no)	1995-07-06
EP0662513A1 (fr)	1995-07-12
HUT70465A (en)	1995-10-30
NL300108I1 (nl)	2003-02-03
DE10299053I1 (de)	2003-05-22

Publication	Publication Date	Title
DE69432035D1 (de)	2003-02-27	Saccharinderivate als proteolytische Enzyminhibitoren
DE69232929D1 (de)	2003-04-03	Saccharinderivate als proteolytische Enzyminhibitoren
EA199800943A1 (ru)	1999-04-29	Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
EA199900980A1 (ru)	2000-04-24	Улучшенные способы приготовления активированного белка с
ES2164718T3 (es)	2002-03-01	Compuestos triciclicos de amida y urea utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
RU94017851A (ru)	1996-01-10	Ингибиторы протеолитических ферментов на основе производных сахарина, фармацевтическая композиция для лечения дегеративных заболеваний
UA26375A1 (uk)	1999-08-30	Спосіб очищеhhя іhсуліhу
DE69031656D1 (de)	1997-12-04	Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellung
DE69728869D1 (de)	2004-06-03	Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien
LU90992I2 (fr)	2003-02-18	Xigris-drotrécogine alfa(activée) et ses dérivés hpharmaceutiquement acceptables
MX9200882A (es)	1992-09-01	Preparacion de factor ix.
GR1001480B (el)	1994-02-28	Ενζυμικά σκευάσματα περιέχοντα παπαϊνη ή χυμο?ρυψίνη και μέ?οδοι μόνιμης ενζυμικής αποτρίχωσης.
SU1823184A1 (ru)	1996-10-20	Способ получения вещества, обладающего антипротеазным действием
TH19245A (th)	1996-06-21	วิธีป้องกันการสลายของโปรตีนซี