LU92098I2 - Adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) - Google Patents
Adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®)Info
- Publication number
- LU92098I2 LU92098I2 LU92098C LU92098C LU92098I2 LU 92098 I2 LU92098 I2 LU 92098I2 LU 92098 C LU92098 C LU 92098C LU 92098 C LU92098 C LU 92098C LU 92098 I2 LU92098 I2 LU 92098I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- humira
- adalimumab
- pharmaceutically acceptable
- acceptable derivatives
- tnf
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/690,775 US6270766B1 (en) | 1992-10-08 | 1996-08-01 | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU92098I2 true LU92098I2 (fr) | 2013-01-16 |
Family
ID=24773909
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU92005C LU92005I2 (fr) | 1996-08-01 | 2012-05-23 | golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) |
| LU92004C LU92004I2 (fr) | 1996-08-01 | 2012-05-23 | adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) |
| LU92099C LU92099I2 (fr) | 1996-08-01 | 2012-11-16 | Golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) |
| LU92098C LU92098I2 (fr) | 1996-08-01 | 2012-11-16 | Adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU92005C LU92005I2 (fr) | 1996-08-01 | 2012-05-23 | golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) |
| LU92004C LU92004I2 (fr) | 1996-08-01 | 2012-05-23 | adalimumab et ses dérivés pharmaceutiquement acceptables (HUMIRA®) |
| LU92099C LU92099I2 (fr) | 1996-08-01 | 2012-11-16 | Golimumab et ses dérivés pharmaceutiquement acceptables (SIMPONI®) |
Country Status (11)
| Country | Link |
|---|---|
| US (10) | US6270766B1 (fr) |
| EP (3) | EP1941904B1 (fr) |
| AT (2) | ATE305798T1 (fr) |
| AU (1) | AU719015B2 (fr) |
| CA (2) | CA2261630C (fr) |
| DE (1) | DE69734317T2 (fr) |
| DK (3) | DK1941904T3 (fr) |
| ES (3) | ES2247635T3 (fr) |
| LU (4) | LU92005I2 (fr) |
| PT (2) | PT1941904E (fr) |
| WO (1) | WO1998005357A1 (fr) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5959087A (en) * | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
| US20030225254A1 (en) * | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
| JP3443119B2 (ja) * | 1989-08-07 | 2003-09-02 | ペプテック リミテッド | 腫瘍壊死因子結合リガンド |
| US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US6764681B2 (en) * | 1991-10-07 | 2004-07-20 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
| US6270766B1 (en) * | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| US6770279B1 (en) * | 1992-10-08 | 2004-08-03 | The Kennedy Institute Of Rheumatology | TNFα antagonists and cyclosporin in therapy of rheumatoid arthritis |
| US7070783B1 (en) | 1995-05-09 | 2006-07-04 | The Mathilda And Terence Kennedy Institute Of Rheumatology | Small molecular weight TNF receptor multimeric molecule |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DE122004000004I1 (de) * | 1996-02-09 | 2004-08-12 | Abott Biotechnology Ltd | Humane Antikörper welche an Humanen TNFalpha binden. |
| TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| SI0942740T1 (en) * | 1996-12-06 | 2003-12-31 | Amgen Inc. | Combination therapy using a tnf binding protein for treating tnf-mediated diseases |
| ATE247974T1 (de) | 1996-12-06 | 2003-09-15 | Amgen Inc | Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen |
| JP2001525816A (ja) * | 1997-05-12 | 2001-12-11 | ザ ケネディー インスティチュート オブ リューマトロジー | 治療における腫瘍壊死因子アルファおよび血管内皮成長因子の抑制 |
| IL141486A0 (en) * | 1998-08-31 | 2002-03-10 | Biogen Inc | Pharmaceutical compositions containing a cd2 binding agent |
| US6015557A (en) * | 1999-02-24 | 2000-01-18 | Tobinick; Edward L. | Tumor necrosis factor antagonists for the treatment of neurological disorders |
| HK1043312B (en) | 1999-05-07 | 2006-07-28 | Genentech, Inc. | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| US6544504B1 (en) | 1999-07-28 | 2003-04-08 | Schering Corporation | Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy |
| AU6376700A (en) * | 1999-07-28 | 2001-02-19 | Schering Corporation | Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy |
| US8147824B2 (en) * | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| KR100840816B1 (ko) | 2000-05-12 | 2008-06-23 | 젠자임 코포레이션 | TNF-α시그널링의 조절물질 |
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| US6709655B2 (en) | 2001-02-28 | 2004-03-23 | Instituto Bioclon, S.A. De C.V. | Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof |
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| US7858095B2 (en) * | 2001-07-24 | 2010-12-28 | Astellas Us Llc | Method for treating or preventing sclerotic disorders using CD-2 binding agents |
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| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| US20030206898A1 (en) * | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| AR040603A1 (es) * | 2002-07-19 | 2005-04-13 | Abbott Lab S A | El uso de un anticuerpo anti-tnfalfa neutralizador de alta afinidad en la fabricacion de un medicamento y conjunto de elementos |
| MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| PT1562571E (pt) * | 2002-11-21 | 2011-11-25 | Genzyme Corp | Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica |
| DE60335652D1 (de) * | 2002-11-21 | 2011-02-17 | Genzyme Corp | Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung |
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| AU2003293366A1 (en) * | 2002-12-05 | 2004-06-30 | Pharmacia Corporation | Engineered fab'fragment anti-tumor necrosis factor alpha in combination with disease modifying anti-rheumatic drugs |
| US7101978B2 (en) * | 2003-01-08 | 2006-09-05 | Applied Molecular Evolution | TNF-α binding molecules |
| EP1460088A1 (fr) * | 2003-03-21 | 2004-09-22 | Biotest AG | Anticorps humanisé contre CD4 avec des caractéristiques immunosuppressives |
| GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| ATE412897T1 (de) | 2003-05-30 | 2008-11-15 | Purdue Research Foundation | Diagnoseverfahren für atherosklerose |
| PE20050232A1 (es) * | 2003-06-25 | 2005-04-01 | Elan Pharm Inc | Metodo y composiciones para tratar la artritis reumatoide |
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| US7435799B2 (en) * | 2004-01-08 | 2008-10-14 | Applied Molecular Evolution | TNF-α binding molecules |
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| TWI439284B (zh) * | 2004-04-09 | 2014-06-01 | Abbvie Biotechnology Ltd | 用於治療TNFα相關失調症之多重可變劑量療法 |
| KR20070011558A (ko) * | 2004-05-04 | 2007-01-24 | 제네상스 파머슈티컬스, 아이엔씨. | 일배체형 마커 및 치료에 대한 반응을 측정하기 위해 이를이용하는 방법 |
| CA2565259A1 (fr) * | 2004-05-07 | 2005-12-08 | Astellas Us Llc | Polypeptide lfa-3 soluble destine a traiter de troubles viraux |
| EP1807111A4 (fr) * | 2004-10-08 | 2009-05-27 | Abbott Biotech Ltd | Infection a virus respiratoire syncytial (rsv) |
| WO2006058024A2 (fr) * | 2004-11-22 | 2006-06-01 | Smith Henry J | Recepteurs cellulaires utilises comme excipients pour composes pharmaceutiques servant dans le traitement de l'arthrite, et des troubles inflammatoires et immunitaires |
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| US20090124993A1 (en) | 2005-02-17 | 2009-05-14 | Burkly Linda C | Treating neurological disorders |
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| AU2006246721B2 (en) | 2005-05-16 | 2012-12-13 | Abbvie Biotechnology Ltd | Use of TNF inhibitor for treatment of erosive polyarthritis |
| EP1904183B1 (fr) | 2005-07-05 | 2014-10-15 | Purdue Research Foundation | Composition pharmaceutique pour le traitement de l'arthrose |
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| AU2016203976B2 (en) * | 2005-11-09 | 2018-02-01 | Abt Holding Company | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
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| WO2008154543A2 (fr) | 2007-06-11 | 2008-12-18 | Abbott Biotechnology Ltd. | Procédés de traitement de l'arthrite idiopathique juvénile |
| BRPI0907186A2 (pt) | 2008-01-15 | 2015-07-14 | Abbott Gmbh & Co Kg | Composições proteicas pulverizadas e métodos para sua produção |
| CN102027016A (zh) * | 2008-03-13 | 2011-04-20 | 生物测试股份公司 | 一种治疗疾病的试剂 |
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1997
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- 1997-08-01 DK DK08005013.1T patent/DK1941904T3/da active
- 1997-08-01 CA CA2261630A patent/CA2261630C/fr not_active Expired - Lifetime
- 1997-08-01 PT PT08005013T patent/PT1941904E/pt unknown
- 1997-08-01 EP EP08005013A patent/EP1941904B1/fr not_active Revoked
- 1997-08-01 DE DE69734317T patent/DE69734317T2/de not_active Expired - Lifetime
- 1997-08-01 EP EP05076131A patent/EP1593393B1/fr not_active Revoked
- 1997-08-01 AT AT97933799T patent/ATE305798T1/de active
- 1997-08-01 AU AU37035/97A patent/AU719015B2/en not_active Withdrawn - After Issue
- 1997-08-01 ES ES08005013T patent/ES2388244T3/es not_active Expired - Lifetime
- 1997-08-01 AT AT05076131T patent/ATE535255T1/de active
- 1997-08-01 PT PT05076131T patent/PT1593393E/pt unknown
- 1997-08-01 EP EP97933799A patent/EP0914157B1/fr not_active Revoked
- 1997-08-01 DK DK05076131.1T patent/DK1593393T3/da active
- 1997-08-01 DK DK97933799T patent/DK0914157T3/da active
- 1997-08-01 ES ES05076131T patent/ES2378446T3/es not_active Expired - Lifetime
- 1997-08-01 CA CA2791778A patent/CA2791778A1/fr not_active Abandoned
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2001
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2005
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2008
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2009
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2012
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- 2012-01-13 US US13/350,065 patent/US8383120B2/en not_active Expired - Fee Related
- 2012-05-23 LU LU92005C patent/LU92005I2/fr unknown
- 2012-05-23 LU LU92004C patent/LU92004I2/fr unknown
- 2012-10-04 US US13/645,332 patent/US20130064816A1/en not_active Abandoned
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