LU92647I2 - Florbetaben (18f) - Google Patents

Florbetaben (18f) Download PDF

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Publication number
LU92647I2
LU92647I2 LU92647C LU92647C LU92647I2 LU 92647 I2 LU92647 I2 LU 92647I2 LU 92647 C LU92647 C LU 92647C LU 92647 C LU92647 C LU 92647C LU 92647 I2 LU92647 I2 LU 92647I2
Authority
LU
Luxembourg
Prior art keywords
florbetaben
Prior art date
Application number
LU92647C
Other languages
English (en)
French (fr)
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of LU92647I2 publication Critical patent/LU92647I2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/02—Monocyclic hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A61K31/115—Formaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LU92647C 2004-12-17 2015-02-04 Florbetaben (18f) LU92647I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63669604P 2004-12-17 2004-12-17
US68639505P 2005-06-02 2005-06-02
EP05854410A EP1841465A4 (en) 2004-12-17 2005-12-19 STYLENE DERIVATIVES AND THEIR USE OF THE BINDING AND IMAGE DISPLAY OF AMYLOID PLAQUE

Publications (1)

Publication Number Publication Date
LU92647I2 true LU92647I2 (fr) 2015-11-03

Family

ID=36588603

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92647C LU92647I2 (fr) 2004-12-17 2015-02-04 Florbetaben (18f)

Country Status (25)

Country Link
US (2) US7807135B2 (th)
EP (3) EP1841465A4 (th)
JP (1) JP5128956B2 (th)
KR (1) KR101321619B1 (th)
AU (1) AU2005316421B2 (th)
BE (1) BE2015C015I2 (th)
BR (1) BRPI0516408B8 (th)
CA (1) CA2591534C (th)
DK (1) DK2213652T3 (th)
EA (1) EA012334B1 (th)
ES (1) ES2526655T3 (th)
FR (1) FR15C0012I2 (th)
HU (1) HUS1500014I1 (th)
IL (2) IL183946A (th)
LT (1) LTC2213652I2 (th)
LU (1) LU92647I2 (th)
MX (1) MX2007007380A (th)
NL (1) NL300719I1 (th)
NO (1) NO339195B1 (th)
NZ (1) NZ555942A (th)
PL (1) PL2213652T3 (th)
PT (1) PT2213652E (th)
SG (1) SG194363A1 (th)
SI (1) SI2213652T1 (th)
WO (1) WO2006066104A2 (th)

Families Citing this family (37)

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ES2435070T3 (es) * 2001-08-27 2013-12-18 The Trustees Of The University Of Pennsylvania Derivados de estilbeno y su uso para unión y formación de imágenes de placas amiloides
EA012334B1 (ru) * 2004-12-17 2009-08-28 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Производные стильбена и их применение для связывания и визуализации амилоидных бляшек
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
AU2006261917A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
CN101522624B (zh) 2006-03-30 2013-11-06 宾夕法尼亚大学理事会 苯乙烯基吡啶衍生物及其用于结合和成像淀粉样蛋白斑的用途
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques
GB2463436A (en) * 2007-06-22 2010-03-17 Univ Aberdeen (11C)methoxy-radiolabelled 2,3',4,5'-tetramethylstilbene (TMS) and its preparation and use
US20100272642A1 (en) * 2007-07-04 2010-10-28 Tohoku University Pet probe having an alkoxy group substituted by fluorine and hydroxy group
EP2205072B1 (en) * 2007-10-15 2013-11-20 The Salk Institute for Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
KR20100135235A (ko) * 2008-02-14 2010-12-24 지멘스 메디컬 솔루션즈 유에스에이, 인크. 신경학적 기능이상을 검출하기 위한 조영제
WO2009108606A1 (en) * 2008-02-27 2009-09-03 Avid Radiopharmaceuticals, Inc. Gamma probe detection of amyloid plaque using radiolabeled a-beta binding compounds
US8557222B2 (en) * 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
WO2010056900A1 (en) * 2008-11-13 2010-05-20 Avid Radiopharmaceuticals, Inc. Histogram-based analysis method for the detection and diagnosis of neurodegenerative diseases
KR20110106895A (ko) * 2008-12-22 2011-09-29 바이엘 파마 악티엔게젤샤프트 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법
ES2620402T3 (es) * 2008-12-31 2017-06-28 Avid Radiopharmaceuticals, Inc. Sintesis de estirilpiridinas radiomarcadas con 18F a partir de precursores de tosilato y composiciones farmacéuticas estables de las mismas
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
US8968701B2 (en) 2009-07-10 2015-03-03 Piramal Imaging Sa Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
CN102762229B9 (zh) 2009-12-23 2020-12-01 皮拉马影像股份公司 适用于用疏水pet试剂pet成像的配方
HUE033237T2 (hu) * 2010-06-04 2017-11-28 Piramal Imaging Sa Eljárás F-18 jelölt béta-amiloid ligandumok elõállítására
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
JP2013532136A (ja) * 2010-06-04 2013-08-15 ピラマル イメージング ソシエテ アノニム Ｆ−１８標識アミロイド・ベータ・リガンドの製造方法
BR112012030944A2 (pt) 2010-06-04 2016-11-01 Piramal Imaging Sa método para a produção de ligantes para beta amiloide marcados com f-18
EP3263136A1 (en) * 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
EP3345545B1 (en) * 2011-04-21 2021-10-20 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
DK2723394T3 (en) 2011-06-21 2018-08-13 Piramal Imaging Sa FORMULA OF FLUORED STYLBONE SUITABLE FOR PET IMAGINATION
KR101291037B1 (ko) * 2011-10-12 2013-08-01 사회복지법인 삼성생명공익재단 레스베라트롤 유도체와 스티릴-오각형 방향족 화합물 및 이들의 베타-아밀로이드 플라그에 대한 결합제 및 진단영상제의 용도
RU2477726C1 (ru) * 2011-10-18 2013-03-20 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение
MX2014004274A (es) 2011-10-19 2014-07-09 Piramal Imaging Sa METODO MEJORADO PARA LA PRODUCCION DE LIGANDOS Aß MARCADOS CON F-18.
CN104244991A (zh) 2012-04-10 2014-12-24 蓝瑟斯医学影像公司 放射性药物合成方法
US9180212B2 (en) * 2012-05-22 2015-11-10 The Regents Of The University Of California β-amyloid plaque imaging agents
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
KR101891404B1 (ko) * 2015-12-18 2018-08-24 주식회사 엘지화학 변성 단량체, 이를 포함하는 변성 중합체 및 이들의 제조방법
WO2018062588A1 (ko) 2016-09-29 2018-04-05 한국원자력연구원 커큐민 유도체, 이의 제조방법 및 이를 포함하는 베타-아밀로이드 플라크 검출용 광음향 영상화제
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret

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US4500507A (en) * 1981-10-30 1985-02-19 Wong Dennis W Diagnostic composition for radiologic imaging of neoplasms in the body and method of preparation
JPS60247244A (ja) 1984-05-22 1985-12-06 Mitsubishi Paper Mills Ltd 電子写真感光体
DD234666A1 (de) 1984-11-01 1986-04-09 Univ Leipzig Verfahren zur herstellung von einfachen und substituierten 4-dimethylamino-alpha-halogenstilbenen
DD231432A1 (de) 1984-11-01 1985-12-24 Univ Leipzig Material zur silberfreien bildaufzeichnung
JPH06329566A (ja) 1993-05-21 1994-11-29 Asahi Glass Co Ltd ジフルオロスチルベン誘導体化合物およびそれを含有する液晶組成物
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
US5601801A (en) 1994-08-02 1997-02-11 Merck Frosst Canada, Inc. Radiolabelled angiotensin converting enzyme inhibitors
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WO2001084937A1 (en) * 2000-05-08 2001-11-15 Novozymes A/S Oxidoreductase mediated antimicrobial activity
ES2435070T3 (es) * 2001-08-27 2013-12-18 The Trustees Of The University Of Pennsylvania Derivados de estilbeno y su uso para unión y formación de imágenes de placas amiloides
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
WO2006078384A2 (en) 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
EA012334B1 (ru) * 2004-12-17 2009-08-28 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Производные стильбена и их применение для связывания и визуализации амилоидных бляшек
AU2006261917A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents

Also Published As

Publication number Publication date
EP1838298A2 (en) 2007-10-03
WO2006066104A2 (en) 2006-06-22
US8465726B2 (en) 2013-06-18
BRPI0516408A (pt) 2008-09-02
IL183946A0 (en) 2007-10-31
SG194363A1 (en) 2013-11-29
EP1841465A2 (en) 2007-10-10
JP2008524243A (ja) 2008-07-10
MX2007007380A (es) 2007-10-11
KR20070093427A (ko) 2007-09-18
CA2591534A1 (en) 2006-06-22
AU2005316421A1 (en) 2006-06-22
IL183946A (en) 2011-08-31
EP2213652A1 (en) 2010-08-04
IL206091A (en) 2013-08-29
NO339195B1 (no) 2016-11-14
DK2213652T3 (en) 2015-01-26
US7807135B2 (en) 2010-10-05
EA012334B1 (ru) 2009-08-28
EP2213652B1 (en) 2014-10-22
BE2015C015I2 (th) 2025-04-29
PT2213652E (pt) 2015-01-02
EA200701299A1 (ru) 2007-12-28
SI2213652T1 (sl) 2015-03-31
KR101321619B1 (ko) 2013-10-30
BRPI0516408B1 (pt) 2021-03-23
FR15C0012I1 (th) 2015-03-20
HUS1500014I1 (hu) 2016-11-28
CA2591534C (en) 2013-08-06
JP5128956B2 (ja) 2013-01-23
NZ555942A (en) 2011-01-28
PL2213652T3 (pl) 2015-04-30
ES2526655T3 (es) 2015-01-14
WO2006066104A3 (en) 2006-08-03
NO20073650L (no) 2007-09-14
EP1838298A4 (en) 2009-03-04
US20100266500A1 (en) 2010-10-21
EP1841465A4 (en) 2009-04-01
NL300719I2 (th) 2015-12-29
FR15C0012I2 (fr) 2015-11-20
BRPI0516408B8 (pt) 2021-05-25
LTC2213652I2 (lt) 2016-12-27
NL300719I1 (th) 2015-12-29
US20060269473A1 (en) 2006-11-30
AU2005316421B2 (en) 2012-04-05

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