LUC00013I2 - - Google Patents

Info

Publication number: LUC00013I2
Authority: LU; Luxembourg

Application number

LU00013C

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-06

Filing date

2017-04-05

Publication date

2017-06-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LUC00013(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2017-04-05 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2017-04-06 Publication of LUC00013I1 publication Critical patent/LUC00013I1/fr

2017-06-19 Publication of LUC00013I2 publication Critical patent/LUC00013I2/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

LU00013C 2007-08-06 2017-04-05 LUC00013I2 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2007/017440 WO2009020448A1 (fr)	2007-08-06	2007-08-06	Inhibiteurs de protéasomes

Publications (2)

Publication Number	Publication Date
LUC00013I1 LUC00013I1 (fr)	2017-04-06
LUC00013I2 true LUC00013I2 (fr)	2017-06-19

Family

ID=38691782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU00013C LUC00013I2 (fr)	2007-08-06	2017-04-05

Country Status (32)

Country	Link
EP (3)	EP2178888B1 (fr)
JP (1)	JP5261488B2 (fr)
KR (6)	KR20140042933A (fr)
CN (1)	CN101772507B (fr)
AU (1)	AU2007357338B2 (fr)
BR (1)	BRPI0721905B8 (fr)
CA (1)	CA2695082C (fr)
CY (2)	CY1113386T1 (fr)
DK (1)	DK2178888T3 (fr)
EA (1)	EA028622B1 (fr)
EC (1)	ECSP10010015A (fr)
ES (1)	ES2390606T3 (fr)
FR (1)	FR17C1011I2 (fr)
GE (1)	GEP20125599B (fr)
HR (1)	HRP20120745T1 (fr)
HU (1)	HUS1700018I1 (fr)
IL (4)	IL203641A (fr)
LT (1)	LTC2178888I2 (fr)
LU (1)	LUC00013I2 (fr)
MY (1)	MY161991A (fr)
NL (1)	NL300871I2 (fr)
NZ (1)	NZ582693A (fr)
PH (1)	PH12014500053A1 (fr)
PL (1)	PL2178888T3 (fr)
PT (1)	PT2178888E (fr)
RS (1)	RS52435B (fr)
SG (1)	SG10201508712QA (fr)
SI (1)	SI2178888T1 (fr)
TN (1)	TN2010000060A1 (fr)
UA (1)	UA97536C2 (fr)
WO (1)	WO2009020448A1 (fr)
ZA (1)	ZA201000348B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7576206B2 (en) †	2003-08-14	2009-08-18	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
US7468383B2 (en)	2005-02-11	2008-12-23	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
EP2623113B1 (fr)	2005-11-09	2017-05-31	Onyx Therapeutics, Inc.	Composé pour l'inhibition d'enzymes
NZ597545A (en)	2006-06-19	2013-07-26	Proteolix Inc	Peptide epoxyketones for proteasome inhibition
US7442830B1 (en)	2007-08-06	2008-10-28	Millenium Pharmaceuticals, Inc.	Proteasome inhibitors
CA2701778C (fr)	2007-10-04	2018-09-11	Onyx Therapeutics, Inc.	Inhibiteurs de protease epoxy-cetone peptidique cristalline, et synthese de ceto-epoxydes d'acides amines
SI2318419T2 (sl)	2008-06-17	2025-10-30	Takeda Pharmaceutical Company Limited	Spojine boronat estra in njihovi farmacevtski sestavki
AR075090A1 (es)	2008-09-29	2011-03-09	Millennium Pharm Inc	Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
JP5675629B2 (ja)	2008-10-21	2015-02-25	オニキスセラピューティクス，インク．ＯｎｙｘＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	ペプチドエポキシケトンを用いた併用療法
AR075899A1 (es)	2009-03-20	2011-05-04	Onyx Therapeutics Inc	Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
WO2011060179A1 (fr)	2009-11-13	2011-05-19	Onyx Therapeutics, Inc	Utilisation de peptides epoxycetones pour la suppression de la metastase
NZ600786A (en)	2009-12-22	2013-12-20	Cephalon Inc	Proteasome inhibitors and processes for their preparation, purification and use
AU2011223795B2 (en)	2010-03-01	2015-11-05	Onyx Therapeutics, Inc.	Compounds for immunoproteasome inhibition
AU2011235227B2 (en)	2010-03-31	2016-09-08	Millennium Pharmaceuticals, Inc.	Derivatives of 1-amino-2-cyclopropylethylboronic acid
WO2012177835A1 (fr) *	2011-06-22	2012-12-27	Cephalon, Inc.	Inhibiteurs du protéasome et leurs méthodes de préparation, de purification et d'utilisation
EP4706663A3 (fr) *	2011-08-30	2026-05-20	Trustees Of Tufts College	Inhibiteurs de protéasome activés par fap utilisés pour traiter les tumeurs solides
SG10201605152SA (en) *	2011-12-22	2016-08-30	Ares Trading Sa	Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
WO2013112598A1 (fr) *	2012-01-24	2013-08-01	Millennium Pharmaceuticals, Inc.	Méthode de traitement d'un cancer nasopharyngé
WO2013112601A1 (fr) *	2012-01-24	2013-08-01	Millennium Pharmaceuticals, Inc.	Méthodes de traitement du cancer
WO2014011695A2 (fr)	2012-07-09	2014-01-16	Onyx Therapeutics, Inc.	Promédicaments d'inhibiteurs d'époxy cétone protéase peptidique
CN109180780B (zh) *	2012-07-26	2022-03-18	圣特莱国际公司	多肽环氧酮化合物
JP2013006855A (ja) *	2012-09-03	2013-01-10	Millennium Pharmaceuticals Inc	プロテアソーム阻害剤
MX2015006715A (es) *	2012-12-03	2015-08-14	Hoffmann La Roche	Compuestos de acido triazolboronico sustituido.
US20160250238A1 (en)	2013-10-03	2016-09-01	Millennium Pharmaceuticals, Inc.	Method for the Prophylaxis or Treatment of Systemic Lupus Erythematosus and/or Lupus Nephritis
UA121389C2 (uk)	2014-05-20	2020-05-25	Мілленніум Фармасьютікалз, Інк.	Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії
WO2016022955A1 (fr)	2014-08-07	2016-02-11	Mayo Foundation For Medical Education And Research	Composés et méthodes de traitement du cancer
MA41555A (fr) *	2015-02-17	2017-12-26	Millennium Pharm Inc	Polythérapie pour le traitement du cancer
WO2016205790A2 (fr)	2015-06-19	2016-12-22	Hanlin Scientific, Inc.	Composés spécifiques chiraux à base de bore et leur utilisation dans le traitement du cancer ou de l'amyloïdose
CN106608883A (zh) *	2015-10-21	2017-05-03	北京大学	蛋白酶体抑制剂mln9708的合成方法
CN107400142B (zh) *	2016-05-19	2019-11-19	成都奥璟生物科技有限公司	一种硼酸和硼酸酯类化合物及其应用
CN106008572B (zh) *	2016-05-23	2018-08-17	成都千禧莱医药科技有限公司	一类二肽硼酸化合物及制备方法和用途
JP7164521B2 (ja)	2016-06-21	2022-11-01	オリオン・オフサルモロジー・エルエルシー	炭素環式プロリンアミド誘導体
JP7179721B2 (ja)	2016-06-21	2022-11-29	オリオン・オフサルモロジー・エルエルシー	複素環式プロリンアミド誘導体
JP6802899B2 (ja) *	2016-07-25	2020-12-23	深▲セン▼市塔吉瑞生物医▲薬▼有限公司ＳｈｅｎｚｈｅｎＴａｒｇｅｔＲｘ，Ｉｎｃ．	置換ボロン酸化合物、該化合物を含む医薬組成物およびその使用
CN108440583B (zh) *	2017-01-23	2020-12-04	成都奥璟生物科技有限公司	一种新的硼酸衍生物及其药物组合物
WO2018160717A1 (fr)	2017-02-28	2018-09-07	Mayo Foundation For Medical Education And Research	Composés et méthodes de traitement du cancer
CN108794516A (zh) *	2017-04-26	2018-11-13	上海时莱生物技术有限公司	硼酸和硼酸酯类化合物及其制备方法和用途
CN109305980B (zh) *	2017-07-28	2022-10-11	成都奥璟生物科技有限公司	一种硼酸酯化合物、其合成方法及其用途
ES2901022T3 (es)	2017-08-25	2022-03-21	Synthon Bv	Procedimiento para la preparación de ixazomib y sus intermedios
JP2018024694A (ja) *	2017-10-03	2018-02-15	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	プロテアソーム阻害剤
US11243207B2 (en)	2018-03-29	2022-02-08	Mayo Foundation For Medical Education And Research	Assessing and treating cancer
CN115403603A (zh) *	2018-09-14	2022-11-29	成都奥璟生物科技有限公司	一种硼酸酯类药物及其用途
CN110357787A (zh) *	2019-08-02	2019-10-22	苏州艾和医药科技有限公司	依沙佐米合成工艺研究
US12589103B2 (en)	2019-10-07	2026-03-31	Cornell University	Antimicrobial and antiviral effects of C2-C7 alkyl boronic acids
CN110950897B (zh) *	2019-12-12	2021-05-28	山东大学	一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4499082A (en)	1983-12-05	1985-02-12	E. I. Du Pont De Nemours And Company	α-Aminoboronic acid peptides
US5187157A (en)	1987-06-05	1993-02-16	Du Pont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
US5242904A (en)	1987-06-05	1993-09-07	The Dupont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
US5250720A (en)	1987-06-05	1993-10-05	The Dupont Merck Pharmaceutical Company	Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (fr)	1987-11-05	1990-08-22	Hoechst Aktiengesellschaft	Inhibiteurs de la rénine
US5106948A (en)	1988-05-27	1992-04-21	Mao Foundation For Medical Education And Research	Cytotoxic boronic acid peptide analogs
US6083903A (en)	1994-10-28	2000-07-04	Leukosite, Inc.	Boronic ester and acid compounds, synthesis and uses
CA2435146C (fr)	2001-01-25	2011-03-29	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Formulation de composes d'acide boronique
EP1399468B1 (fr)	2001-05-30	2006-02-15	Novartis AG	Derives d'acide 2-((n-(2-amino-3-(heteroaryl ou aryl)propionyl)-aminoacyl)-amino)-alkylboronique
US7223745B2 (en)	2003-08-14	2007-05-29	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
US7576206B2 (en) *	2003-08-14	2009-08-18	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
TWI345465B (en) *	2003-08-14	2011-07-21	Cephalon Inc	Proteasome inhibitors and methods of using the same
ES2899606T3 (es)	2004-03-30	2022-03-14	Millennium Pharm Inc	Síntesis de compuestos de ésteres y ácidos borónicos
WO2006008660A2 (fr)	2004-07-20	2006-01-26	Affinium Pharmaceuticals, Inc.	Nouveaux polypeptides purifies derives de streptococcus pneumoniae
TW200618820A (en) *	2004-11-05	2006-06-16	Alza Corp	Liposome formulations of boronic acid compounds
GB0513349D0 (en)	2005-06-29	2005-08-03	Torres Manel	Non-woven fabric
CN101247799B (zh)	2005-07-05	2013-03-27	塔夫茨大学信托人	成纤维细胞活化蛋白α的抑制剂

2007
- 2007-08-06 KR KR1020147007078A patent/KR20140042933A/ko not_active Abandoned
- 2007-08-06 KR KR1020107003809A patent/KR101474831B1/ko active Active
- 2007-08-06 CA CA2695082A patent/CA2695082C/fr active Active
- 2007-08-06 CN CN2007801001423A patent/CN101772507B/zh active Active
- 2007-08-06 MY MYPI2010000270A patent/MY161991A/en unknown
- 2007-08-06 EA EA201070247A patent/EA028622B1/ru not_active IP Right Cessation
- 2007-08-06 EP EP07811087A patent/EP2178888B1/fr active Active
- 2007-08-06 HR HRP20120745TT patent/HRP20120745T1/hr unknown
- 2007-08-06 AU AU2007357338A patent/AU2007357338B2/en active Active
- 2007-08-06 KR KR1020167036758A patent/KR101831674B1/ko active Active
- 2007-08-06 NZ NZ582693A patent/NZ582693A/en unknown
- 2007-08-06 EP EP16201780.0A patent/EP3210987A1/fr active Pending
- 2007-08-06 SG SG10201508712QA patent/SG10201508712QA/en unknown
- 2007-08-06 GE GEAP200711714A patent/GEP20125599B/en unknown
- 2007-08-06 EP EP12171220A patent/EP2527347A1/fr not_active Withdrawn
- 2007-08-06 RS RS20120405A patent/RS52435B/sr unknown
- 2007-08-06 DK DK07811087.1T patent/DK2178888T3/da active
- 2007-08-06 UA UAA201002409A patent/UA97536C2/ru unknown
- 2007-08-06 PL PL07811087T patent/PL2178888T3/pl unknown
- 2007-08-06 ES ES07811087T patent/ES2390606T3/es active Active
- 2007-08-06 WO PCT/US2007/017440 patent/WO2009020448A1/fr not_active Ceased
- 2007-08-06 BR BRPI0721905A patent/BRPI0721905B8/pt active IP Right Grant
- 2007-08-06 KR KR1020167008358A patent/KR20160040735A/ko not_active Ceased
- 2007-08-06 JP JP2010519898A patent/JP5261488B2/ja active Active
- 2007-08-06 SI SI200731030T patent/SI2178888T1/sl unknown
- 2007-08-06 KR KR1020147007077A patent/KR20140042932A/ko not_active Ceased
- 2007-08-06 KR KR1020157000064A patent/KR20150010802A/ko not_active Ceased
- 2007-08-06 PT PT07811087T patent/PT2178888E/pt unknown
2010
- 2010-01-18 ZA ZA2010/00348A patent/ZA201000348B/en unknown
- 2010-02-01 IL IL203641A patent/IL203641A/en active Protection Beyond IP Right Term
- 2010-02-05 TN TNP2010000060A patent/TN2010000060A1/fr unknown
- 2010-03-04 EC EC2010010015A patent/ECSP10010015A/es unknown
2012
- 2012-09-17 CY CY20121100845T patent/CY1113386T1/el unknown
2014
- 2014-01-06 PH PH12014500053A patent/PH12014500053A1/en unknown
2015
- 2015-10-26 IL IL242290A patent/IL242290A/en active IP Right Grant
- 2015-10-26 IL IL242292A patent/IL242292A/en active IP Right Grant
- 2015-10-26 IL IL242291A patent/IL242291A/en active IP Right Grant
2017
- 2017-04-05 LU LU00013C patent/LUC00013I2/fr unknown
- 2017-04-06 LT LTPA2017010C patent/LTC2178888I2/lt unknown
- 2017-04-14 FR FR17C1011C patent/FR17C1011I2/fr active Active
- 2017-04-26 CY CY2017016C patent/CY2017016I2/el unknown
- 2017-05-03 HU HUS1700018C patent/HUS1700018I1/hu unknown
- 2017-05-05 NL NL300871C patent/NL300871I2/nl unknown

Also Published As

Publication number	Publication date
LTC2178888I2 (lt)	2018-03-12
AU2007357338B2 (en)	2014-03-20
HK1143595A1 (en)	2011-01-07
LUC00013I1 (fr)	2017-04-06
CY2017016I1 (el)	2017-07-12
EP2178888A1 (fr)	2010-04-28
CN101772507A (zh)	2010-07-07
IL242292A (en)	2017-12-31
EA028622B1 (ru)	2017-12-29
SG10201508712QA (en)	2015-11-27
ES2390606T3 (es)	2012-11-14
EA201070247A1 (ru)	2010-06-30
KR20160040735A (ko)	2016-04-14
PH12014500053B1 (en)	2015-03-30
CN101772507B (zh)	2012-12-12
ZA201000348B (en)	2011-03-30
EP2178888B1 (fr)	2012-07-04
ECSP10010015A (es)	2010-04-30
RS52435B (sr)	2013-02-28
KR101831674B1 (ko)	2018-02-23
JP5261488B2 (ja)	2013-08-14
IL242290A (en)	2017-12-31
EP2527347A1 (fr)	2012-11-28
IL242290A0 (en)	2015-11-30
SI2178888T1 (sl)	2012-11-30
IL242292A0 (en)	2015-11-30
IL242291A0 (en)	2015-11-30
AU2007357338A1 (en)	2009-02-12
DK2178888T3 (da)	2012-10-01
CY1113386T1 (el)	2016-06-22
NL300871I2 (nl)	2017-12-07
NZ582693A (en)	2012-01-12
KR20140042932A (ko)	2014-04-07
IL203641A (en)	2015-11-30
KR20150010802A (ko)	2015-01-28
CY2017016I2 (el)	2017-07-12
MY161991A (en)	2017-05-31
BRPI0721905B1 (pt)	2020-11-17
HUS1700018I1 (hu)	2017-05-29
JP2010535759A (ja)	2010-11-25
GEP20125599B (en)	2012-08-10
EP3210987A1 (fr)	2017-08-30
PH12014500053A1 (en)	2015-03-30
FR17C1011I1 (fr)	2017-05-26
PL2178888T3 (pl)	2012-11-30
BRPI0721905A2 (pt)	2014-02-25
KR20170004031A (ko)	2017-01-10
KR20140042933A (ko)	2014-04-07
UA97536C2 (xx)	2012-02-27
BRPI0721905B8 (pt)	2021-05-25
WO2009020448A1 (fr)	2009-02-12
HRP20120745T1 (hr)	2012-10-31
IL242291A (en)	2017-12-31
FR17C1011I2 (fr)	2018-04-27
KR20100059811A (ko)	2010-06-04
TN2010000060A1 (en)	2011-09-26
KR101474831B1 (ko)	2014-12-19
CA2695082A1 (fr)	2009-02-12
LTPA2017010I1 (lt)	2017-05-10
CA2695082C (fr)	2015-07-28
PT2178888E (pt)	2012-10-04

Publication	Publication Date	Title
FR17C1011I1 (fr)	2017-05-26
BRPI0819773A2 (fr)	2009-06-04
CN300729898S (zh)	2008-01-09	电动车轮毂(五星前轮)
CN300811676S (zh)	2008-08-06	柜子
CN300726846S (zh)	2008-01-02	酒瓶(清样)
CN300731379S (zh)	2008-01-16	沙发(路易三人位)
CN300861177S (zh)	2008-12-17	包装盒(汽车芯片方向盘锁包装盒)
CN300729930S (zh)	2008-01-09	蓄电池盒(3-dm-200)
CN300727533S (zh)	2008-01-02	六氟化硫负荷开关侧倒柜
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