LV10959B - Novel 16,17-acetalsubstitute derivatives of pregnane-21-acid, method for their preparation, medicinal preparations of thereof - Google Patents

Novel 16,17-acetalsubstitute derivatives of pregnane-21-acid, method for their preparation, medicinal preparations of thereof Download PDF

Info

Publication number: LV10959B
Authority: LV; Latvia
Prior art keywords: formula; mji; hjih; compound; compound according
Prior art date: 1985-12-19

Application number

LVP-93-1046A

Other languages

English (en)

Latvian (lv)

Other versions

LV10959A (lv

Inventor

Paul Hakan Andersson

Per Ture Andersson

Bengt Ingemar Axelsson

Ralph Lennart Brattsand

Bror Arne Thalen

Jan William Trofast

Original Assignee

Draco Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-19

Filing date

1993-08-27

Publication date

1996-06-20

1993-08-27 Application filed by Draco Ab filed Critical Draco Ab

1995-12-20 Publication of LV10959A publication Critical patent/LV10959A/xx

1996-06-20 Publication of LV10959B publication Critical patent/LV10959B/lv

Links

238000000034 method Methods 0.000 title claims abstract 5
238000002360 preparation method Methods 0.000 title claims abstract 4
239000002253 acid Substances 0.000 title claims 3
150000001875 compounds Chemical class 0.000 claims abstract description 18
230000000172 allergic effect Effects 0.000 claims abstract 4
208000010668 atopic eczema Diseases 0.000 claims abstract 4
230000002757 inflammatory effect Effects 0.000 claims abstract 4
239000000825 pharmaceutical preparation Substances 0.000 claims abstract 4
125000004432 carbon atom Chemical group C* 0.000 claims abstract 3
125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 3
239000000203 mixture Substances 0.000 claims description 9
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
201000010099 disease Diseases 0.000 claims 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
239000004215 Carbon black (E152) Substances 0.000 claims 1
XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
241000124008 Mammalia Species 0.000 claims 1
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
239000004480 active ingredient Substances 0.000 claims 1
239000013543 active substance Substances 0.000 claims 1
150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
150000008049 diazo compounds Chemical class 0.000 claims 1
239000002552 dosage form Substances 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
230000032050 esterification Effects 0.000 claims 1
238000005886 esterification reaction Methods 0.000 claims 1
150000002148 esters Chemical class 0.000 claims 1
229930195733 hydrocarbon Natural products 0.000 claims 1
150000002430 hydrocarbons Chemical class 0.000 claims 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
230000001590 oxidative effect Effects 0.000 claims 1
230000002265 prevention Effects 0.000 claims 1
238000000638 solvent extraction Methods 0.000 claims 1
230000000694 effects Effects 0.000 abstract 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
101150115538 nero gene Proteins 0.000 description 6
101100397240 Arabidopsis thaliana ISPD gene Proteins 0.000 description 5
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
101150096418 Mepe gene Proteins 0.000 description 2
125000000896 monocarboxylic acid group Chemical group 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
241000191291 Abies alba Species 0.000 description 1
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
241001669680 Dormitator maculatus Species 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
206010022998 Irritability Diseases 0.000 description 1
101100366940 Mus musculus Stom gene Proteins 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
230000007815 allergy Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(I) nitrate Inorganic materials [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Immunology (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

LVP-93-1046A 1985-12-19 1993-08-27 Novel 16,17-acetalsubstitute derivatives of pregnane-21-acid, method for their preparation, medicinal preparations of thereof LV10959B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8506015A SE8506015D0 (sv)	1985-12-19	1985-12-19	Novel 16,17-acetalsubstituted pregnane 21-oic acid derivatives

Publications (2)

Publication Number	Publication Date
LV10959A LV10959A (lv)	1995-12-20
LV10959B true LV10959B (en)	1996-06-20

Family

ID=20362521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-93-1046A LV10959B (en)	1985-12-19	1993-08-27	Novel 16,17-acetalsubstitute derivatives of pregnane-21-acid, method for their preparation, medicinal preparations of thereof

Country Status (31)

Country	Link
EP (1)	EP0232690B1 (de)
JP (1)	JPH0780900B2 (de)
KR (1)	KR940004067B1 (de)
CN (1)	CN1016508B (de)
AR (1)	AR242797A1 (de)
AT (1)	ATE57935T1 (de)
AU (1)	AU591950B2 (de)
CA (1)	CA1318664C (de)
CS (1)	CS266597B2 (de)
DD (1)	DD256703A5 (de)
DE (1)	DE3675378D1 (de)
DK (1)	DK168601B1 (de)
ES (1)	ES2018656B3 (de)
FI (1)	FI84488C (de)
GR (1)	GR3001052T3 (de)
HU (1)	HU196831B (de)
IE (1)	IE59241B1 (de)
IL (1)	IL80679A (de)
IS (1)	IS1559B (de)
JO (1)	JO1499B1 (de)
LT (1)	LT3912B (de)
LV (1)	LV10959B (de)
MY (1)	MY100750A (de)
NO (1)	NO164243C (de)
NZ (1)	NZ218614A (de)
PH (1)	PH23237A (de)
PL (1)	PL151627B1 (de)
PT (1)	PT83984B (de)
RU (1)	RU1839673C (de)
SE (1)	SE8506015D0 (de)
ZA (1)	ZA868750B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU203769B (en) *	1989-03-09	1991-09-30	Richter Gedeon Vegyeszet	Process for producing new steroide derivatives and pharmaceutical compositions containing them
US5643602A (en) *	1989-11-22	1997-07-01	Astra Aktiebolag	Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv)	1989-11-22	1989-11-22	Draco Ab	Oral composition for the treatment of inflammatory bowel diseases
US6166024A (en) *	1995-03-30	2000-12-26	Mayo Foundation For Medical Education And Research	Use of topical azathioprine and thioguanine to treat colorectal adenomas
CA2936741C (en)	2014-10-31	2018-11-06	Purdue Pharma	Methods and compositions particularly for treatment of attention deficit disorder
US10722473B2 (en)	2018-11-19	2020-07-28	Purdue Pharma L.P.	Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2150268C3 (de) *	1971-10-04	1980-11-06	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Pregnansäure-Derivate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
DE2204360C2 (de) *	1972-01-27	1982-11-04	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue Pregnansäure-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
YU35148B (en) *	1971-10-04	1980-09-25	Schering Ag	Process for obtaining pregnane acid derivatives
SE378109B (de) *	1972-05-19	1975-08-18	Bofors Ab
DE2264003C2 (de) *	1972-12-22	1982-11-04	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue Pregnansäure-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
IE38659B1 (en) *	1972-12-22	1978-05-10	Schering Ag	New pregnane acid derivatives
SE8403905D0 (sv) *	1984-07-30	1984-07-30	Draco Ab	Liposomes and steroid esters

1985
- 1985-12-19 SE SE8506015A patent/SE8506015D0/xx unknown
1986
- 1986-11-18 ZA ZA868750A patent/ZA868750B/xx unknown
- 1986-11-18 IL IL80679A patent/IL80679A/xx not_active IP Right Cessation
- 1986-12-11 IE IE324586A patent/IE59241B1/en not_active IP Right Cessation
- 1986-12-11 NO NO865004A patent/NO164243C/no unknown
- 1986-12-12 ES ES86850436T patent/ES2018656B3/es not_active Expired - Lifetime
- 1986-12-12 EP EP86850436A patent/EP0232690B1/de not_active Expired - Lifetime
- 1986-12-12 DE DE8686850436T patent/DE3675378D1/de not_active Expired - Lifetime
- 1986-12-12 AT AT86850436T patent/ATE57935T1/de not_active IP Right Cessation
- 1986-12-12 NZ NZ218614A patent/NZ218614A/xx unknown
- 1986-12-12 AU AU66448/86A patent/AU591950B2/en not_active Ceased
- 1986-12-15 JO JO19861499A patent/JO1499B1/en active
- 1986-12-15 PH PH34590A patent/PH23237A/en unknown
- 1986-12-16 FI FI865128A patent/FI84488C/fi not_active IP Right Cessation
- 1986-12-16 DK DK605186A patent/DK168601B1/da not_active IP Right Cessation
- 1986-12-17 MY MYPI86000221A patent/MY100750A/en unknown
- 1986-12-17 PL PL1986263041A patent/PL151627B1/pl unknown
- 1986-12-18 CA CA000525677A patent/CA1318664C/en not_active Expired - Fee Related
- 1986-12-18 RU SU864028689A patent/RU1839673C/ru active
- 1986-12-18 AR AR86306261A patent/AR242797A1/es active
- 1986-12-18 JP JP61300242A patent/JPH0780900B2/ja not_active Expired - Lifetime
- 1986-12-18 HU HU865302A patent/HU196831B/hu not_active IP Right Cessation
- 1986-12-18 KR KR1019860010870A patent/KR940004067B1/ko not_active Expired - Fee Related
- 1986-12-18 DD DD86297902A patent/DD256703A5/de unknown
- 1986-12-19 CN CN86108634A patent/CN1016508B/zh not_active Expired
- 1986-12-19 PT PT83984A patent/PT83984B/pt not_active IP Right Cessation
- 1986-12-19 IS IS3179A patent/IS1559B/is unknown
- 1986-12-19 CS CS869604A patent/CS266597B2/cs unknown
1990
- 1990-11-06 GR GR90400871T patent/GR3001052T3/el unknown
1993
- 1993-08-27 LV LVP-93-1046A patent/LV10959B/lv unknown
- 1993-12-28 LT LTIP1682A patent/LT3912B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2018656B3 (es)	1991-05-01
CS960486A2 (en)	1989-04-14
FI84488B (fi)	1991-08-30
NO164243C (no)	1990-09-19
PT83984A (en)	1987-01-01
HUT44273A (en)	1988-02-29
DK605186D0 (da)	1986-12-16
IE59241B1 (en)	1994-01-26
MY100750A (en)	1991-02-14
DE3675378D1 (de)	1990-12-06
ZA868750B (en)	1987-08-26
AU591950B2 (en)	1989-12-21
SE8506015D0 (sv)	1985-12-19
CN86108634A (zh)	1987-07-22
JPS62155296A (ja)	1987-07-10
IL80679A (en)	1992-03-29
PT83984B (pt)	1989-07-31
EP0232690B1 (de)	1990-10-31
NO865004D0 (no)	1986-12-11
PH23237A (en)	1989-06-06
NO164243B (no)	1990-06-05
EP0232690A1 (de)	1987-08-19
AR242797A1 (es)	1993-05-31
JPH0780900B2 (ja)	1995-08-30
DK168601B1 (da)	1994-05-02
DD256703A5 (de)	1988-05-18
IS3179A7 (is)	1987-06-20
IL80679A0 (en)	1987-02-27
IS1559B (is)	1994-10-05
FI84488C (fi)	1991-12-10
DK605186A (da)	1987-06-20
IE863245L (en)	1987-06-19
KR940004067B1 (ko)	1994-05-11
JO1499B1 (en)	1988-03-10
PL151627B1 (en)	1990-09-28
KR870006081A (ko)	1987-07-09
NO865004L (no)	1987-06-22
CA1318664C (en)	1993-06-01
LV10959A (lv)	1995-12-20
ATE57935T1 (de)	1990-11-15
PL263041A1 (en)	1988-07-21
LT3912B (en)	1996-04-25
GR3001052T3 (en)	1992-03-20
RU1839673C (ru)	1993-12-30
CS266597B2 (en)	1990-01-12
AU6644886A (en)	1987-06-25
LTIP1682A (en)	1995-07-25
FI865128A0 (fi)	1986-12-16
NZ218614A (en)	1989-02-24
HU196831B (en)	1989-01-30
FI865128L (fi)	1987-06-20
CN1016508B (zh)	1992-05-06

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Samsioe	1982	Comparative effects of the oral contraceptive combinations 0.150 mg desogestrel+ 0.030 mg ethinyloestradiol and 0.150 mg levonorgestrel+ 0.030 mg ethinyloestradiol on lipid and lipoprotein metabolism in healthy female volunteers
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Kuroki et al.	1987	Comparative effects of deoxycholate and 7‐methyl‐deoxycholate in the hamster
Forbes et al.	1953	Effect of lntraperitoneal Administration of Alcohol on the Adrenal Levels of Cholesterol and Ascorbic Acid in Rats and Guinea Pigs
Singh et al.	1988	Mobilization of aged in vivo cadmium deposits by diethyl dimercaptosuccinate
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