LV12557B - MATERIALS AND APPARATUS FOR MANUFACTURING PHARMACEUTICAL CELLULOSE CAPSULES - FULL GELATING - Google Patents

MATERIALS AND APPARATUS FOR MANUFACTURING PHARMACEUTICAL CELLULOSE CAPSULES - FULL GELATING Download PDF

Info

Publication number: LV12557B
Authority: LV; Latvia
Prior art keywords: capsule; pins; solution; drying; molds
Prior art date: 1991-05-31

Application number

LVP-00-116A

Other languages

English (en)

Latvian (lv)

Other versions

LV12557A (en

Inventor

Ralph R. Grosswald

Jeffory B. Anderson

Clair S. ANDREW

Original Assignee

American Home Products Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-31

Filing date

2000-09-06

Publication date

2001-02-20

2000-09-06 Application filed by American Home Products Corporation filed Critical American Home Products Corporation

2000-11-20 Publication of LV12557A publication Critical patent/LV12557A/xx

2001-02-20 Publication of LV12557B publication Critical patent/LV12557B/en

Links

238000000034 method Methods 0.000 title claims abstract description 73
238000004519 manufacturing process Methods 0.000 title claims abstract description 41
229920002678 cellulose Polymers 0.000 title claims description 67
235000010980 cellulose Nutrition 0.000 title description 65
239000002775 capsule Substances 0.000 claims abstract description 311
238000001035 drying Methods 0.000 claims abstract description 115
239000000243 solution Substances 0.000 claims abstract description 99
238000010438 heat treatment Methods 0.000 claims abstract description 71
239000000203 mixture Substances 0.000 claims abstract description 34
239000007864 aqueous solution Substances 0.000 claims abstract description 13
229920003086 cellulose ether Polymers 0.000 claims abstract description 11
239000001913 cellulose Substances 0.000 claims description 65
238000011049 filling Methods 0.000 claims description 36
230000008569 process Effects 0.000 claims description 34
238000007654 immersion Methods 0.000 claims description 7
238000000926 separation method Methods 0.000 claims 2
238000005266 casting Methods 0.000 claims 1
238000006073 displacement reaction Methods 0.000 claims 1
238000003780 insertion Methods 0.000 claims 1
230000037431 insertion Effects 0.000 claims 1
230000005855 radiation Effects 0.000 claims 1
238000010792 warming Methods 0.000 claims 1
238000007598 dipping method Methods 0.000 abstract description 74
241000235388 Mucorales Species 0.000 abstract 1
238000010276 construction Methods 0.000 abstract 1
239000000499 gel Substances 0.000 description 30
239000007903 gelatin capsule Substances 0.000 description 22
108010010803 Gelatin Proteins 0.000 description 14
239000008273 gelatin Substances 0.000 description 14
229920000159 gelatin Polymers 0.000 description 14
235000019322 gelatine Nutrition 0.000 description 14
235000011852 gelatine desserts Nutrition 0.000 description 14
238000001816 cooling Methods 0.000 description 12
239000000314 lubricant Substances 0.000 description 11
YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 9
230000032258 transport Effects 0.000 description 7
208000031968 Cadaver Diseases 0.000 description 6
238000013459 approach Methods 0.000 description 6
230000001447 compensatory effect Effects 0.000 description 6
229920000609 methyl cellulose Polymers 0.000 description 6
239000001923 methylcellulose Substances 0.000 description 6
235000010981 methylcellulose Nutrition 0.000 description 6
230000009467 reduction Effects 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
206010013786 Dry skin Diseases 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
238000000576 coating method Methods 0.000 description 4
238000001879 gelation Methods 0.000 description 4
238000009413 insulation Methods 0.000 description 4
PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 3
208000012886 Vertigo Diseases 0.000 description 3
238000013461 design Methods 0.000 description 3
238000003618 dip coating Methods 0.000 description 3
238000005461 lubrication Methods 0.000 description 3
239000002245 particle Substances 0.000 description 3
238000012545 processing Methods 0.000 description 3
230000003014 reinforcing effect Effects 0.000 description 3
238000009966 trimming Methods 0.000 description 3
230000009471 action Effects 0.000 description 2
239000008186 active pharmaceutical agent Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
238000010420 art technique Methods 0.000 description 2
239000011324 bead Substances 0.000 description 2
210000002249 digestive system Anatomy 0.000 description 2
239000012530 fluid Substances 0.000 description 2
125000002768 hydroxyalkyl group Chemical group 0.000 description 2
230000006698 induction Effects 0.000 description 2
230000007257 malfunction Effects 0.000 description 2
239000000463 material Substances 0.000 description 2
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 2
238000009987 spinning Methods 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
229920000875 Dissolving pulp Polymers 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
239000004235 Orange GGN Substances 0.000 description 1
241000833020 Padilla Species 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
238000013019 agitation Methods 0.000 description 1
238000004378 air conditioning Methods 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
230000008859 change Effects 0.000 description 1
238000010961 commercial manufacture process Methods 0.000 description 1
239000000498 cooling water Substances 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000004519 grease Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000007373 indentation Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000005304 joining Methods 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
229940059904 light mineral oil Drugs 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000001248 thermal gelation Methods 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/02—Moulds or cores; Details thereof or accessories therefor with incorporated heating or cooling means
- B29C33/06—Moulds or cores; Details thereof or accessories therefor with incorporated heating or cooling means using radiation, e.g. electro-magnetic waves, induction heating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/077—Manufacturing capsule shells
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/30—Mounting, exchanging or centering
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
- B29C35/0277—Apparatus with continuous transport of the material to be cured
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
- B29C35/04—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/34—Moulds or cores; Details thereof or accessories therefor movable, e.g. to or from the moulding station
- B29C33/36—Moulds or cores; Details thereof or accessories therefor movable, e.g. to or from the moulding station continuously movable in one direction, e.g. in a closed circuit
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/44—Moulds or cores; Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/56—Coatings, e.g. enameled or galvanised; Releasing, lubricating or separating agents
- B29C33/60—Releasing, lubricating or separating agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
- B29C35/04—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam
- B29C35/045—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam using gas or flames
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
- B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
- B29C35/0805—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2001/00—Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Mechanical Engineering (AREA)
Physics & Mathematics (AREA)
Thermal Sciences (AREA)
Oral & Maxillofacial Surgery (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Manufacturing & Machinery (AREA)
Toxicology (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

LVP-00-116A 1991-05-31 2000-09-06 MATERIALS AND APPARATUS FOR MANUFACTURING PHARMACEUTICAL CELLULOSE CAPSULES - FULL GELATING LV12557B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US70802391A	1991-05-31	1991-05-31

Publications (2)

Publication Number	Publication Date
LV12557A LV12557A (en)	2000-11-20
LV12557B true LV12557B (en)	2001-02-20

Family

ID=24844076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-00-116A LV12557B (en)	1991-05-31	2000-09-06	MATERIALS AND APPARATUS FOR MANUFACTURING PHARMACEUTICAL CELLULOSE CAPSULES - FULL GELATING

Country Status (12)

Country	Link
EP (5)	EP0781542B1 (fr)
JP (1)	JP3299744B2 (fr)
AT (4)	ATE156003T1 (fr)
AU (1)	AU2159892A (fr)
CA (1)	CA2108768A1 (fr)
DE (4)	DE69221300D1 (fr)
DK (2)	DK0781542T3 (fr)
ES (3)	ES2181935T3 (fr)
LV (1)	LV12557B (fr)
RO (1)	RO118521B1 (fr)
SG (1)	SG46227A1 (fr)
WO (1)	WO1992021311A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104786411A (zh) *	2015-04-29	2015-07-22	青岛微恒工程有限公司	一种伺服蘸胶装置

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US5698155A (en) *	1991-05-31	1997-12-16	Gs Technologies, Inc.	Method for the manufacture of pharmaceutical cellulose capsules
DK106293D0 (da) *	1993-09-22	1993-09-22	Joergen Rasmussen	Kapsel til indbringning af laegemidler i kreaturmaver
US5993185A (en) *	1996-03-21	1999-11-30	Farmacapsulas S.A.	Deck plate assemblies for forming capsules
US6000928A (en) *	1997-04-03	1999-12-14	Technophar Equipment & Service Limited	Capsule making machine having improved pin bars and air flow characteristics
US5945136A (en) *	1997-04-03	1999-08-31	Technophar Equipment & Service Limited	Heating elevator for capsule making machine
KR100661918B1 (ko) *	1999-04-01	2006-12-28	다우 글로벌 테크놀로지스 인크.	겔 강도가 증가된 메틸셀룰로스, 이의 제조방법 및 이를 포함하는 식품 조성물
US6306333B1 (en) *	1999-06-24	2001-10-23	The Dow Chemical Company	Process for making cellulose ethers having reduced yellowing and discoloration
JP4634796B2 (ja) *	2002-06-24	2011-02-16	中外製薬株式会社	非球形シームレスカプセルの製造装置
GB0314832D0 (en) *	2003-06-25	2003-07-30	Phoqus Pharmaceuticals Ltd	Production of capsule shells and capsules
ES2357452T3 (es) *	2006-10-26	2011-04-26	Pfizer Products Inc.	Formación de cápsulas.
WO2012029887A1 (fr) *	2010-08-31	2012-03-08	独立行政法人農業生物資源研究所	Structure cylindrique et procédé de production de cette structure
US20140150787A1 (en)	2012-12-04	2014-06-05	Civitas Therapeutics, Inc.	Devices and methods for puncturing a capsule to release a powdered medicament therefrom
CN103202767B (zh) *	2013-03-22	2014-07-02	新昌县祥瑞机械设备有限公司	胶板翻转装置
CN103482341B (zh) *	2013-09-26	2015-08-26	新昌县宏海机械有限公司	一种胶板输送翻板一体化设备
WO2016157213A2 (fr) *	2015-03-28	2016-10-06	Anand Goldie	Système de préhension de capsule
CN105596215B (zh) *	2015-12-30	2019-02-15	新昌县捷奥激光制品有限公司	一种胶囊的打孔设备
ES2984091T3 (es) *	2017-12-06	2024-10-28	Qualicaps Co Ltd	Dispositivo de secado para estructura columnar, y procedimiento para fabricar una estructura columnar
CN111251521B (zh) *	2018-12-03	2022-07-22	沈欣	液态珠丸的制造方法

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Publication number	Priority date	Publication date	Assignee	Title
US1787777A (en)	1926-12-10	1931-01-06	Parke Davis & Co	Capsule machine
US1978829A (en)	1930-07-21	1934-10-30	Parke Davis & Co	Method and apparatus for drying capsules
US2526683A (en) *	1946-04-13	1950-10-24	Lilly Co Eli	Methyl cellulose capsules and process of manufacture
US2671245A (en)	1949-02-03	1954-03-09	Lilly Co Eli	Capsule machine
US2869178A (en) *	1953-12-07	1959-01-20	Scherer Corp R P	Machine for making hard-shell gelatine capsules
US2887440A (en)	1957-08-12	1959-05-19	Dow Chemical Co	Enteric coating
US3399803A (en)	1966-10-11	1968-09-03	Parke Davis & Co	Self-locking medicament capsule
US3508678A (en)	1968-04-29	1970-04-28	Parke Davis & Co	Locking capsule
US3617588A (en)	1969-06-16	1971-11-02	Dow Chemical Co	Dip-coating process for preparing cellulose ether capsule shells
US3632700A (en)	1970-03-23	1972-01-04	Parke Davis & Co	Capsule production apparatus and method
US3664495A (en)	1970-12-21	1972-05-23	Parke Davis & Co	Locking capsule
US3794453A (en)	1972-08-02	1974-02-26	S Padilla	Capsule making apparatus
DE2259387C2 (de) *	1972-12-05	1981-11-26	Kupferberg-Odle, geb. Kupferberg, Murielle, 8011 Vaterstetten	Verfahren zum Herstellen von Steckkapseln mit zusätzlicher Beschichtung
US3842242A (en)	1974-02-01	1974-10-15	Dow Chemical Co	Apparatus for heating capsule forming pins
US4001211A (en)	1974-12-02	1977-01-04	The Dow Chemical Company	Pharmaceutical capsules from improved thermogelling methyl cellulose ethers
DE2722806C2 (de)	1977-05-20	1984-12-13	Capsugel AG, Basel	Kapselkörper für eine Steckkapsel für Arzneimittel oder andere portionsweise zu verpackende Stoffe, sowie Verfahren zu seiner Herstellung
CA1151823A (fr) *	1982-09-02	1983-08-16	Leonard Mackie	Dispositif et methode d'enrobage de capsules de gelatine a enveloppe dure
US4705658A (en)	1986-04-07	1987-11-10	Capsule Technology International, Ltd.	Method for drying gelatin in the manufacture of hard shell gelatin capsules
KR900000254B1 (ko)	1986-05-12	1990-01-24	신에쯔까 가가꾸 고우교우 가부시끼가이샤	의약용 경질 캅셀의 제조방법과 그 제조장치
US4997359A (en)	1989-07-17	1991-03-05	Warner-Lambert Company	Multi-well dish for capsule making

1992
- 1992-05-29 DE DE69221300T patent/DE69221300D1/de not_active Expired - Lifetime
- 1992-05-29 CA CA002108768A patent/CA2108768A1/fr not_active Abandoned
- 1992-05-29 DE DE69230770T patent/DE69230770T2/de not_active Expired - Fee Related
- 1992-05-29 AU AU21598/92A patent/AU2159892A/en not_active Abandoned
- 1992-05-29 JP JP50054293A patent/JP3299744B2/ja not_active Expired - Fee Related
- 1992-05-29 DE DE69232423T patent/DE69232423T2/de not_active Expired - Fee Related
- 1992-05-29 AT AT92913599T patent/ATE156003T1/de not_active IP Right Cessation
- 1992-05-29 ES ES97100247T patent/ES2181935T3/es not_active Expired - Lifetime
- 1992-05-29 RO RO93-01577A patent/RO118521B1/ro unknown
- 1992-05-29 DK DK97100248T patent/DK0781542T3/da active
- 1992-05-29 ES ES97100246T patent/ES2170288T3/es not_active Expired - Lifetime
- 1992-05-29 ES ES97100248T patent/ES2143259T3/es not_active Expired - Lifetime
- 1992-05-29 SG SG1996001220A patent/SG46227A1/en unknown
- 1992-05-29 DK DK97100246T patent/DK0781540T3/da active
- 1992-05-29 AT AT97100246T patent/ATE213147T1/de active
- 1992-05-29 EP EP97100248A patent/EP0781542B1/fr not_active Expired - Lifetime
- 1992-05-29 EP EP97100245A patent/EP0784969A2/fr not_active Withdrawn
- 1992-05-29 AT AT97100248T patent/ATE190221T1/de not_active IP Right Cessation
- 1992-05-29 AT AT97100247T patent/ATE225640T1/de not_active IP Right Cessation
- 1992-05-29 EP EP97100247A patent/EP0781541B1/fr not_active Expired - Lifetime
- 1992-05-29 EP EP92913599A patent/EP0587773B1/fr not_active Expired - Lifetime
- 1992-05-29 WO PCT/US1992/004457 patent/WO1992021311A1/fr not_active Ceased
- 1992-05-29 EP EP97100246A patent/EP0781540B1/fr not_active Expired - Lifetime
- 1992-05-29 DE DE69232809T patent/DE69232809T2/de not_active Expired - Fee Related
2000
- 2000-09-06 LV LVP-00-116A patent/LV12557B/en unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104786411A (zh) *	2015-04-29	2015-07-22	青岛微恒工程有限公司	一种伺服蘸胶装置

Also Published As

Publication number	Publication date
EP0781542B1 (fr)	2000-03-08
ES2170288T3 (es)	2002-08-01
EP0587773A1 (fr)	1994-03-23
EP0781540B1 (fr)	2002-02-13
CA2108768A1 (fr)	1992-12-01
DK0781540T3 (da)	2002-05-27
EP0781540A3 (fr)	1997-07-16
RO118521B1 (ro)	2003-06-30
ES2143259T3 (es)	2000-05-01
EP0781540A2 (fr)	1997-07-02
EP0781541A2 (fr)	1997-07-02
JP3299744B2 (ja)	2002-07-08
DK0781542T3 (da)	2000-07-17
DE69232423D1 (de)	2002-03-21
WO1992021311A1 (fr)	1992-12-10
ES2181935T3 (es)	2003-03-01
DE69230770T2 (de)	2000-08-10
EP0781542A3 (fr)	1997-07-16
EP0781542A2 (fr)	1997-07-02
AU2159892A (en)	1993-01-08
EP0587773B1 (fr)	1997-07-30
ATE225640T1 (de)	2002-10-15
ATE213147T1 (de)	2002-02-15
EP0784969A2 (fr)	1997-07-23
DE69232809T2 (de)	2003-06-18
SG46227A1 (en)	1998-02-20
DE69232809D1 (de)	2002-11-14
JPH06508051A (ja)	1994-09-14
DE69221300D1 (de)	1997-09-04
ATE190221T1 (de)	2000-03-15
EP0781541B1 (fr)	2002-10-09
ATE156003T1 (de)	1997-08-15
DE69232423T2 (de)	2002-10-10
EP0781541A3 (fr)	1997-07-16
DE69230770D1 (de)	2000-04-13
LV12557A (en)	2000-11-20

Publication	Publication Date	Title
US5698155A (en)	1997-12-16	Method for the manufacture of pharmaceutical cellulose capsules
EP0781542B1 (fr)	2000-03-08	Procédé et dispositif de production de capsules pharmaceutiques en cellulose avec gélatinisation complète
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US20140203478A1 (en)	2014-07-24	System and method for molding soft fluid-filled implant shells
JPS61127315A (ja)	1986-06-14	熱融合性材料から物品を成形するための方法および装置
US4683098A (en)	1987-07-28	Apparatus for reducing waste in a plastic mold
US2469892A (en)	1949-05-10	Hollow article and method and apparatus for producing the same
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TWI285104B (en)	2007-08-11	Manufacture method and manufacture device for a non-spherical seamless capsule
CA2234029C (fr)	2002-02-12	Elevateur chauffant pour machine a fabriquer des capsules
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US3679342A (en)	1972-07-25	Dipping form for making skin-type articles from plastic material
US3079274A (en)	1963-02-26	Production of articles of protective clothing
JPH09136140A5 (fr)	2007-03-08
WO2006043284A1 (fr)	2006-04-27	Procédé de fabrication d’une capsule de dérivés de cellulose neutraceutique, pharmaceutique
CN104161719B (zh)	2017-06-16	一种分体式栓剂及其制备方法和用途
US338754A (en)	1886-03-30	John keehbiel
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JPWO2018025442A1 (ja)	2019-03-14	パウダースラッシュ成形機及びパウダースラッシュ成形方法
JP3357995B2 (ja)	2002-12-16	棒状化粧料製品製造装置
CN120587405B (zh)	2025-09-30	一种失蜡法铸造制壳装置
RU2363239C1 (ru)	2009-08-10	Способ нанесения защитного покрытия на подкормку для пчел
JPH07251239A (ja)	1995-10-03	金型の塗型方法及びこれに用いる塗型装置

LV12557B - MATERIALS AND APPARATUS FOR MANUFACTURING PHARMACEUTICAL CELLULOSE CAPSULES - FULL GELATING - Google Patents

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