LV12792B - Formyl- or cyano- substituted indole derivatives having dopaminergic activity - Google Patents

Formyl- or cyano- substituted indole derivatives having dopaminergic activity

Info

Publication number: LV12792B
Authority: LV; Latvia
Prior art keywords: 6alkyl; dopamine; independently hydrogen; formyl; cyano
Prior art date: 1993-03-25

Application number

LVP-01-129A

Other languages

English (en)

Latvian (lv)

Other versions

LV12792A (en

Inventor

Bengt Ronny Andersson

Per Arvid Emil Carlsson

Lars Olor HANSSON

Clas Ake Sonesson

Nils Peter Stjernlof

Kjell Anders Ivan Svensson

Ross Nicholas Waters

Susanne R. Haadsma-Svensson

Original Assignee

Pharmacia & Upjohn Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-25

Filing date

2001-08-30

Publication date

2002-06-20

2001-08-30 Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company

2002-02-20 Publication of LV12792A publication Critical patent/LV12792A/en

2002-06-20 Publication of LV12792B publication Critical patent/LV12792B/xx

Links

229940054051 antipsychotic indole derivative Drugs 0.000 title 1
-1 cyano- substituted indole Chemical class 0.000 title 1
230000003291 dopaminomimetic effect Effects 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
102000015554 Dopamine receptor Human genes 0.000 abstract 2
108050004812 Dopamine receptor Proteins 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
208000015114 central nervous system disease Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
DCLKZMQLRCOSOE-UHFFFAOYSA-N 6,7,8,9-tetrahydro-3h-benzo[e]indol-1-amine Chemical class C1CCCC2=C3C(N)=CNC3=CC=C21 DCLKZMQLRCOSOE-UHFFFAOYSA-N 0.000 abstract 1
206010000599 Acromegaly Diseases 0.000 abstract 1
201000000736 Amenorrhea Diseases 0.000 abstract 1
206010001928 Amenorrhoea Diseases 0.000 abstract 1
208000001287 Galactorrhea Diseases 0.000 abstract 1
206010017600 Galactorrhoea Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000027089 Parkinsonian disease Diseases 0.000 abstract 1
206010034010 Parkinsonism Diseases 0.000 abstract 1
231100000540 amenorrhea Toxicity 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
208000031424 hyperprolactinemia Diseases 0.000 abstract 1
201000001881 impotence Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

LVP-01-129A 1993-03-25 2001-08-30 Formyl- or cyano- substituted indole derivatives having dopaminergic activity LV12792B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3756893A	1993-03-25	1993-03-25

Publications (2)

Publication Number	Publication Date
LV12792A LV12792A (en)	2002-02-20
LV12792B true LV12792B (en)	2002-06-20

Family

ID=21895045

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-01-129A LV12792B (en)	1993-03-25	2001-08-30	Formyl- or cyano- substituted indole derivatives having dopaminergic activity

Country Status (13)

Country	Link
US (1)	US5639778A (de)
EP (1)	EP0690843B1 (de)
JP (1)	JP3298885B2 (de)
AT (1)	ATE195935T1 (de)
AU (1)	AU679053B2 (de)
DE (1)	DE69425736T2 (de)
DK (1)	DK0690843T3 (de)
ES (1)	ES2149869T3 (de)
GR (1)	GR3034906T3 (de)
LV (1)	LV12792B (de)
NZ (1)	NZ263403A (de)
PT (1)	PT690843E (de)
WO (1)	WO1994021608A1 (de)

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FR2763335B1 (fr) *	1997-05-16	2000-11-24	Adir	Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1292155B1 (it) *	1997-06-13	1999-01-25	Zambon Spa	Derivati naftotiazolonici attivi sul recettore dopaminergico d 3
CA2430808A1 (en) *	2000-12-18	2002-06-27	Eli Lilly And Company	Cycloalkylfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases
AU2002238106A1 (en) *	2001-02-13	2002-08-28	Palatin Technologies, Inc.	Melanocortin metallopeptides for treatment of sexual dysfunction
WO2003013571A1 (en) *	2001-08-10	2003-02-20	Palatin Technologies, Inc.	Peptidomimetics of biologically active metallopeptides
US7718802B2 (en)	2001-08-10	2010-05-18	Palatin Technologies, Inc.	Substituted melanocortin receptor-specific piperazine compounds
US7655658B2 (en) *	2001-08-10	2010-02-02	Palatin Technologies, Inc.	Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7732451B2 (en) *	2001-08-10	2010-06-08	Palatin Technologies, Inc.	Naphthalene-containing melanocortin receptor-specific small molecule
US7456184B2 (en) *	2003-05-01	2008-11-25	Palatin Technologies Inc.	Melanocortin receptor-specific compounds
US7053223B2 (en) *	2003-02-14	2006-05-30	Bristol-Myers Squibb Company	Inhibitors of farnesyl protein transferase
US7227023B2 (en)	2003-04-30	2007-06-05	Wyeth	Quinoline 3-amino chroman derivatives
US7727990B2 (en)	2003-05-01	2010-06-01	Palatin Technologies, Inc.	Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en) *	2003-05-01	2011-06-28	Palatin Technologies, Inc.	Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en)	2003-05-01	2010-06-01	Palatin Technologies, Inc.	Substituted melanocortin receptor-specific single acyl piperazine compounds
US7709484B1 (en)	2004-04-19	2010-05-04	Palatin Technologies, Inc.	Substituted melanocortin receptor-specific piperazine compounds
EP2439203B1 (de) *	2004-10-14	2014-11-19	AbbVie Deutschland GmbH & Co KG	Arylsulfonylmethyl- oder Arylsulfonamid-substituierte aromatische Verbindungen zur Behandlung von Krankheiten betreffend die Modulation von Dopamin-D3-Rezeptoren
US7834017B2 (en)	2006-08-11	2010-11-16	Palatin Technologies, Inc.	Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
AR075401A1 (es) *	2009-02-13	2011-03-30	Sanofi Aventis	Indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento
WO2015112806A2 (en)	2014-01-24	2015-07-30	Tp Therapeutics, Inc.	Diaryl macrocycles as modulators of protein kinases
RU2732405C2 (ru)	2015-07-02	2020-09-16	Тёрнинг Поинт Терапьютикс, Инк.	Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ
BR112018000297A2 (pt)	2015-07-06	2018-09-04	Tp Therapeutics Inc	polimorfo de macrociclo de diarila
WO2017015367A1 (en)	2015-07-21	2017-01-26	Tp Therapeutics, Inc.	Chiral diaryl macrocycles and uses thereof
AU2017302019A1 (en)	2016-07-28	2019-02-07	Turning Point Therapeutics, Inc.	Macrocycle kinase inhibitors
TWI808958B (zh)	2017-01-25	2023-07-21	美商特普醫葯公司	涉及二芳基巨環化合物之組合療法
WO2018151240A1 (ja) *	2017-02-17	2018-08-23	第一三共株式会社	３，６，７，８－テトラヒドロシクロペンタ［ｅ］インドール化合物
PT3658148T (pt)	2017-07-28	2024-08-26	Turning Point Therapeutics Inc	Compostos macrocíclicos e utilizações dos mesmos
RS63787B1 (sr)	2017-12-19	2022-12-30	Turning Point Therapeutics Inc	Makrociklična jedinjenja za lečenje bolesti
US20210087206A1 (en) *	2017-12-19	2021-03-25	Turning Point Therapeutics, Inc.	Macrocyclic kinase inhibitors and their use
AU2021322291A1 (en) *	2020-08-06	2023-04-06	Tactogen Inc	2-aminoindane compounds for mental disorders or enhancement
CN112724068A (zh) *	2020-12-30	2021-04-30	蔡桂坡	具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用

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US4060626A (en) *	1972-01-26	1977-11-29	Boehringer Mannheim G.M.B.H.	Indole-carboxylic carbon compounds and pharmaceutical compositions containing them
DE2740836A1 (de) *	1977-09-10	1979-03-22	Troponwerke Gmbh & Co Kg	Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
CA1159459A (en) *	1980-12-11	1983-12-27	Andre A. Asselin	6,7,8,9-tetrahydro-3h-benz¬e\| indolamine derivatives
US4510157A (en) *	1982-12-27	1985-04-09	Ayerst, Mckenna & Harrison, Inc.	6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives
US4470990A (en) *	1983-03-14	1984-09-11	Ayerst, Mckenna & Harrison Inc.	6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants
FR2613365B1 (fr) *	1987-04-01	1989-07-28	Adir	Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613364B1 (fr) *	1987-04-01	1989-06-09	Adir	Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
ATE178893T1 (de) *	1990-01-11	1999-04-15	Upjohn Co	6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem

1994
- 1994-03-21 ES ES94911606T patent/ES2149869T3/es not_active Expired - Lifetime
- 1994-03-21 AU AU64086/94A patent/AU679053B2/en not_active Ceased
- 1994-03-21 US US08/522,290 patent/US5639778A/en not_active Expired - Fee Related
- 1994-03-21 WO PCT/US1994/002800 patent/WO1994021608A1/en not_active Ceased
- 1994-03-21 PT PT94911606T patent/PT690843E/pt unknown
- 1994-03-21 EP EP94911606A patent/EP0690843B1/de not_active Expired - Lifetime
- 1994-03-21 NZ NZ263403A patent/NZ263403A/en not_active IP Right Cessation
- 1994-03-21 DK DK94911606T patent/DK0690843T3/da active
- 1994-03-21 AT AT94911606T patent/ATE195935T1/de not_active IP Right Cessation
- 1994-03-21 DE DE69425736T patent/DE69425736T2/de not_active Expired - Fee Related
- 1994-03-21 JP JP52118994A patent/JP3298885B2/ja not_active Expired - Fee Related
2000
- 2000-11-24 GR GR20000402612T patent/GR3034906T3/el not_active IP Right Cessation
2001
- 2001-08-30 LV LVP-01-129A patent/LV12792B/xx unknown

Also Published As

Publication number	Publication date
JPH08508251A (ja)	1996-09-03
ATE195935T1 (de)	2000-09-15
AU679053B2 (en)	1997-06-19
AU6408694A (en)	1994-10-11
EP0690843B1 (de)	2000-08-30
ES2149869T3 (es)	2000-11-16
DK0690843T3 (da)	2000-11-13
DE69425736D1 (de)	2000-10-05
US5639778A (en)	1997-06-17
PT690843E (pt)	2001-01-31
LV12792A (en)	2002-02-20
NZ263403A (en)	1996-10-28
JP3298885B2 (ja)	2002-07-08
GR3034906T3 (en)	2001-02-28
DE69425736T2 (de)	2001-04-12
WO1994021608A1 (en)	1994-09-29
EP0690843A1 (de)	1996-01-10

Publication	Publication Date	Title
CA2118704A1 (en)	1993-04-01	Fused Tricyclic Nitrogen Containing Heterocycles as Substance P Receptor Antagonists
ATE119522T1 (de)	1995-03-15	Substituierte cyclohexanole mit zentraler nervensystemwirkung.
PL315193A1 (en)	1996-10-14	Diazabicyclic antagonists of neurokinin
HUT70520A (en)	1995-10-30	1,3-substituted cycloalkenes and cycloalkanes
GR3019782T3 (en)	1996-07-31	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
ATE131056T1 (de)	1995-12-15	Verwendung von 2,3,4,5-tetrahydro-1h-3- benzazepinen bei der behandlung von neurologischen störungen.
DE69523155D1 (de)	2001-11-15	Benzimidazolonderivate mit zentraler dopaminerger aktivität
DE69616792D1 (de)	2001-12-13	Verwendung von lemellarin alkaloiden in therapeutischen verfahren
MX9702350A (es)	1997-06-28	Derivados 2,7-sustituidos de octahidro-1h-pirido (1,2-a) pirazina.
PH27326A (en)	1993-06-08	Substituted cyclohexenes as central nervous system agents
BG103089A (en)	1999-09-30	Indoline derivatives useful as 5-ht-2c-receptor antagonists
AR029331A1 (es)	2003-06-25	Uso de derivados anticonvulsivos para la manufactura de un medicamento en el tratamiento de la bulimia nerviosa
IL104657A0 (en)	1993-06-10	Benzazepine derivatives,their preparation and pharmaceutical compositions containing them
ES8604843A1 (es)	1986-03-01	Un metodo para la preparacion de un derivado de acetileno
NO180635C (no)	1997-05-21	Analogifremgangsmåte for fremstilling av en terapeutisk aktiv tetracyklisk imidazolinforbindelse
ES8506032A1 (es)	1985-06-16	Un procedimiento para la preparacion de un derivado de ergolina
IE812898L (en)	1982-06-11	TETRAHYDRO-3H-BENZ(e) INDOLAMINE DERIVATIVES
CA2157586A1 (en)	1994-09-29	Indoletetralins having dopaminergic activity