MA19783A1 - PROCESS FOR THE PREPARATION OF BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES. - Google Patents

PROCESS FOR THE PREPARATION OF BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES.

Info

Publication number
MA19783A1
MA19783A1 MA20003A MA20003A MA19783A1 MA 19783 A1 MA19783 A1 MA 19783A1 MA 20003 A MA20003 A MA 20003A MA 20003 A MA20003 A MA 20003A MA 19783 A1 MA19783 A1 MA 19783A1
Authority
MA
Morocco
Prior art keywords
benzoazacycloalkyl
imidazolidines
spiro
preparation
Prior art date
Application number
MA20003A
Other languages
French (fr)
Inventor
Malen Charles
Duhault Jacques
Peglion Jean-Louis
Boulanger Michelle
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of MA19783A1 publication Critical patent/MA19783A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA20003A 1982-04-27 1983-04-27 PROCESS FOR THE PREPARATION OF BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES. MA19783A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8207203A FR2525603A1 (en) 1982-04-27 1982-04-27 BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
MA19783A1 true MA19783A1 (en) 1983-12-31

Family

ID=9273425

Family Applications (1)

Application Number Title Priority Date Filing Date
MA20003A MA19783A1 (en) 1982-04-27 1983-04-27 PROCESS FOR THE PREPARATION OF BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES.

Country Status (22)

Country Link
JP (1) JPS5910584A (en)
KR (1) KR840004428A (en)
AT (1) ATA125383A (en)
AU (1) AU1395383A (en)
BE (1) BE896572A (en)
DD (1) DD209833A5 (en)
DE (1) DE3315106A1 (en)
DK (1) DK183583A (en)
ES (1) ES521895A0 (en)
FR (1) FR2525603A1 (en)
GB (1) GB2133401B (en)
GR (1) GR78481B (en)
IL (1) IL68497A0 (en)
IT (1) IT1167123B (en)
LU (1) LU84770A1 (en)
MA (1) MA19783A1 (en)
NL (1) NL8301476A (en)
NO (1) NO831473L (en)
OA (1) OA07412A (en)
PT (1) PT76595B (en)
SE (1) SE8302347L (en)
ZA (1) ZA832927B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927831A (en) * 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
HUE028976T2 (en) 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride
CN1805938B (en) 2003-06-17 2010-06-16 艾尼纳制药公司 Benzazepine derivatives for the treatment of 5HT2C receptor-related diseases
SI1838677T1 (en) 2004-12-21 2010-01-29 Arena Pharm Inc Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
SG158168A1 (en) 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
EP2471779A1 (en) 2006-04-03 2012-07-04 Arena Pharmaceuticals, Inc. Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8299241B2 (en) 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
CN102015591B (en) 2008-03-04 2014-01-29 艾尼纳制药公司 Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-choro-i-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (en) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. Processes for the preparation of 5-ht2c receptor agonists
JP2013536859A (en) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ, インコーポレイテッド Non-hygroscopic salt of 5-HT2C agonist
KR20140091458A (en) 2010-09-01 2014-07-21 아레나 파마슈티칼스, 인크. Administration of lorcaserin to individuals with renal impairment
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
KR20130138770A (en) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. Salts of lorcaserin with optically active acids
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives

Also Published As

Publication number Publication date
FR2525603A1 (en) 1983-10-28
GB8311508D0 (en) 1983-06-02
ATA125383A (en) 1986-05-15
FR2525603B1 (en) 1984-09-14
NL8301476A (en) 1983-11-16
DE3315106A1 (en) 1983-11-03
PT76595B (en) 1986-01-21
KR840004428A (en) 1984-10-15
ES8405796A1 (en) 1984-06-16
GB2133401A (en) 1984-07-25
GB2133401B (en) 1985-10-23
ZA832927B (en) 1984-06-27
SE8302347L (en) 1983-10-28
PT76595A (en) 1983-05-01
SE8302347D0 (en) 1983-04-26
IT1167123B (en) 1987-05-13
NO831473L (en) 1983-10-28
DK183583A (en) 1983-10-28
AU1395383A (en) 1983-11-03
JPS5910584A (en) 1984-01-20
DK183583D0 (en) 1983-04-26
IT8348155A0 (en) 1983-04-26
OA07412A (en) 1984-11-30
DD209833A5 (en) 1984-05-23
ES521895A0 (en) 1984-06-16
IL68497A0 (en) 1983-07-31
LU84770A1 (en) 1984-11-28
BE896572A (en) 1983-10-26
GR78481B (en) 1984-09-27

Similar Documents

Publication Publication Date Title
FR2479187B1 (en) PROCESS FOR THE PREPARATION OF N-OCTADIENOL
RO81944A (en) PROCESS FOR THE PREPARATION OF IMIDOSULFAMIDES
FR2527615B1 (en) PROCESS FOR THE PREPARATION OF 26,26,26,27,27,27-HEXAFLUORO-1A, 25-DIHYDROXYCHOLESTEROL
MA19783A1 (en) PROCESS FOR THE PREPARATION OF BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLIDINES.
FI832004A7 (en) Process for the preparation of 1-sulfo-2-oxoazetidine derivatives.
FI810505A7 (en) Process for the preparation of 3-iodomethylcephalosporins.
FR2532318B1 (en) PROCESS FOR THE PREPARATION OF SULPHONE TRIARYLPHOSPHINES
FI831192A7 (en) Process for the preparation of substituted 2-aminobenzimidazoles.
MA19925A1 (en) Process for the preparation of 3-aryl-7chloro-3, 4-dihydroacridine-1, 9- (2H-10H) -dione-1-oxines and -1-hydrazones
FR2555575B1 (en) PROCESS FOR THE PREPARATION OF 4-ALCOXYANILINES
FR2496660B1 (en) PROCESS FOR THE PREPARATION OF N-ACYLCARNOSINE
FR2524316B1 (en) PHOTODECONTAMINATION PROCESS
FR2525219B1 (en) PROCESS FOR THE PREPARATION OF 4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE-1-1-DIOXYDES
BE889546A (en) PROCESS FOR THE PREPARATION OF N-CYCLOHEXYLBENZOTHIAZOLE-2-SULFENAMIDE
FR2534905B1 (en) PROCESS FOR THE PREPARATION OF PHENYLCETONES
PT74559A (en) PROCESS FOR THE PREPARATION OF SUBSTITUTED TRIFLUOROMETHYLPHENYL-TETRAHYDROPYRI-DINES
FR2549039B1 (en) PROCESS FOR THE PREPARATION OF 3,3,3-TRIFLUORO-2-TRIFLUORO-MEHYLPROPENE
FR2550190B1 (en) PROCESS FOR THE PREPARATION OF B-PHENYLSERINE
FR2528825B1 (en) PROCESS FOR THE PREPARATION OF META-CHLOROBENZOTRIFLUORIDE
FR2527202B1 (en) PROCESS FOR THE PREPARATION OF TERT.BUTYL-ALKYL ETHERS
BE896599A (en) IMPROVED PROCESS FOR THE PREPARATION OF L-LYSINE.
FR2527603B1 (en) CATALYTIC PROCESS FOR THE PREPARATION OF THIO-BIS-PHENOLS
FR2521556B1 (en) PROCESS FOR THE PREPARATION OF 3, 3'-DIAMINO-DIPHENYLSULFONES
FR2493310B1 (en) PROCESS FOR THE PREPARATION OF THYMOSINE A1
FR2499068B1 (en) PROCESS FOR THE PREPARATION OF TERT-ALKYL HYPOHALOGENITES