MA21944A1 - Procede de preparation de nouvelles benzoylguanidines . - Google Patents

Procede de preparation de nouvelles benzoylguanidines .

Info

Publication number: MA21944A1
Authority: MA; Morocco
Prior art keywords: equal; alkyl; benzoylguanidines; preparation; new
Prior art date: 1989-09-06

Application number

MA22216A

Other languages

English (en)

Inventor

J Lang H

Linz W

Englert Hc

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-06

Filing date

1990-09-05

Publication date

1991-04-01

1990-09-05 Application filed by Hoechst Ag filed Critical Hoechst Ag

1991-04-01 Publication of MA21944A1 publication Critical patent/MA21944A1/fr

Links

125000000217 alkyl group Chemical group 0.000 abstract 4
UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 abstract 2
LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical compound C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 abstract 1
AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/65—N-sulfonylisocyanates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
- C07C317/42—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Compositions Of Macromolecular Compounds (AREA)

MA22216A 1989-09-06 1990-09-05 Procede de preparation de nouvelles benzoylguanidines . MA21944A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3929582A DE3929582A1 (de)	1989-09-06	1989-09-06	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament

Publications (1)

Publication Number	Publication Date
MA21944A1 true MA21944A1 (fr)	1991-04-01

Family

ID=6388731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA22216A MA21944A1 (fr)	1989-09-06	1990-09-05	Procede de preparation de nouvelles benzoylguanidines .

Country Status (32)

Country	Link
US (2)	US5091394A (fr)
EP (1)	EP0416499B1 (fr)
JP (1)	JPH07592B2 (fr)
KR (1)	KR0159095B1 (fr)
CN (1)	CN1049888C (fr)
AT (1)	ATE121738T1 (fr)
AU (1)	AU631007B2 (fr)
CA (1)	CA2024700C (fr)
CY (1)	CY2030A (fr)
CZ (1)	CZ278318B6 (fr)
DE (2)	DE3929582A1 (fr)
DK (1)	DK0416499T3 (fr)
ES (1)	ES2073487T3 (fr)
FI (1)	FI105182B (fr)
HK (1)	HK1008843A1 (fr)
HR (1)	HRP940702B1 (fr)
HU (1)	HU210770B (fr)
IE (1)	IE67451B1 (fr)
IL (1)	IL95581A (fr)
LT (1)	LT3771B (fr)
LV (1)	LV10427B (fr)
MA (1)	MA21944A1 (fr)
MX (1)	MX22240A (fr)
NO (1)	NO179371C (fr)
NZ (1)	NZ235168A (fr)
PH (1)	PH30477A (fr)
PL (1)	PL164167B1 (fr)
PT (1)	PT95206B (fr)
RU (1)	RU1836338C (fr)
SK (1)	SK431890A3 (fr)
YU (1)	YU48468B (fr)
ZA (1)	ZA907062B (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5274162A (en) *	1991-12-13	1993-12-28	Arnold Glazier	Antineoplastic drugs with bipolar toxification/detoxification functionalities
EP0556674B1 (fr) *	1992-02-15	1996-06-19	Hoechst Aktiengesellschaft	Benzoylguanidines 3,5-substitués avec une activité antiarrhythmique et une activité inhibitrice de la prolifération des cellules
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
CN1036267C (zh) *	1992-02-15	1997-10-29	赫彻斯特股份公司	氨基取代的苯甲酰胍的制备方法
ATE158278T1 (de) *	1992-02-15	1997-10-15	Hoechst Ag	Ortho-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
DK0577024T3 (fr) *	1992-07-01	1997-02-24	Hoechst Ag
EP0589336B1 (fr) *	1992-09-22	1997-01-08	Hoechst Aktiengesellschaft	Benzoylguanidines, leur procédé de préparation et leur utilisation comme agents antiarrhythmiques
ES2129485T3 (es) *	1992-12-02	1999-06-16	Hoechst Ag	Derivados de acidos guanidinoalquil-1,1-bisfosfonicos, procedimiento para su preparacion y su utilizacion.
TW250477B (fr) *	1992-12-15	1995-07-01	Hoechst Ag
US5665739A (en) *	1992-12-15	1997-09-09	Hoechst Aktiengesellschaft	Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
TW250479B (fr) *	1992-12-15	1995-07-01	Hoechst Ag
ES2100435T3 (es) *	1992-12-16	1997-06-16	Hoechst Ag	Aminobenzoilguanidinas 3,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
EP0604852A1 (fr) *	1992-12-28	1994-07-06	Hoechst Aktiengesellschaft	5-Sulfamoylbenzoylguanidines 2,4,N-substituées, comme agents antiarhythmiques, inhibiteurs de la prolifération des cellules, et inhibiteurs de l'écharge sodium-hydrogène
DE59403818D1 (de) *	1993-02-20	1997-10-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
CA2121391A1 (fr) *	1993-04-28	1994-10-29	Atsuyuki Kojima	Derives d'indoloylguanidine
US6169107B1 (en)	1993-04-28	2001-01-02	Sumitomo Pharmaceutical Co., Ltd.	Indoloylguanidine derivatives
DE4318658A1 (de) *	1993-06-04	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4318756A1 (de) *	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4325822A1 (de) *	1993-07-31	1995-02-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0639573A1 (fr) *	1993-08-03	1995-02-22	Hoechst Aktiengesellschaft	Hétérocycles à cinq chaînons benzocondensés, procédé pour leur préparation, leur utilisation comme médicament et comme diagnostique aussi bien que les produits pharmaceutiques le contenant
US5852046A (en) *	1993-08-03	1998-12-22	Hoechst Aktiengesellschaft	Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
DE4327244A1 (de) *	1993-08-13	1995-02-16	Hoechst Ag	Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328352A1 (de) *	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) *	1993-08-27	1995-03-02	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4337611A1 (de) *	1993-11-04	1995-05-11	Boehringer Ingelheim Kg	Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE4344550A1 (de) *	1993-12-24	1995-06-29	Hoechst Ag	Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen
TW415937B (en) *	1994-01-25	2000-12-21	Hoechst Ag	Phenyl-substituted alkylcarboxylic acid guanidides bearing perfluoroalkyl groups, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
DE4404183A1 (de) *	1994-02-10	1995-08-17	Merck Patent Gmbh	4-Amino-1-piperidylbenzoylguanidine
DE4412334A1 (de) *	1994-04-11	1995-10-19	Hoechst Ag	Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
FR2719310B1 (fr) *	1994-04-29	1996-07-19	Hoechst France	Nouveaux dérivés de l'acétaldéhyde, leur procédé de préparation et leur application.
DE4415873A1 (de) *	1994-05-05	1995-11-09	Hoechst Ag	Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) *	1994-05-13	1995-11-16	Hoechst Ag	Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421495A1 (de) *	1994-06-20	1995-12-21	Merck Patent Gmbh	Heterocyclyloxy-benzoylguanidine
DE4430213A1 (de) *	1994-08-28	1996-02-29	Merck Patent Gmbh	Arylbenzoylguanidine
DE4430212A1 (de) *	1994-08-28	1996-02-29	Merck Patent Gmbh	Ortho-substituierte Benzoesäure-Derivate
DE4430861A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Heterocyclyl-benzoylguanidine
DE4430916A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Alkyl-benzoylguanidin-Derivate
DE4432101A1 (de)	1994-09-09	1996-03-14	Hoechst Ag	Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4432105A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Fluoro-alkyl/alkenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4432106A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung
CA2160600A1 (fr) *	1994-10-18	1996-04-19	Masahumi Kitano	Derives de l'indoloylguanidine
DE4437874A1 (de) *	1994-10-22	1996-04-25	Merck Patent Gmbh	Alkyl-5-methylsulfonyl-benzoylguanidin-Derivate
TW372967B (en) *	1994-12-27	1999-11-01	Kanebo Ltd	1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
DE19502644A1 (de) *	1995-01-28	1996-08-01	Merck Patent Gmbh	4-Amino-benzoylguanidin-Derivate
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1989
- 1989-09-06 DE DE3929582A patent/DE3929582A1/de not_active Withdrawn
1990
- 1990-09-03 ES ES90116859T patent/ES2073487T3/es not_active Expired - Lifetime
- 1990-09-03 DE DE59008959T patent/DE59008959D1/de not_active Expired - Lifetime
- 1990-09-03 EP EP90116859A patent/EP0416499B1/fr not_active Expired - Lifetime
- 1990-09-03 AT AT90116859T patent/ATE121738T1/de not_active IP Right Cessation
- 1990-09-03 DK DK90116859.1T patent/DK0416499T3/da active
- 1990-09-04 IL IL9558190A patent/IL95581A/en active IP Right Grant
- 1990-09-04 HU HU905773A patent/HU210770B/hu unknown
- 1990-09-04 NZ NZ235168A patent/NZ235168A/en unknown
- 1990-09-04 RU SU904831136A patent/RU1836338C/ru active
- 1990-09-04 FI FI904362A patent/FI105182B/fi active IP Right Grant
- 1990-09-04 US US07/576,937 patent/US5091394A/en not_active Expired - Lifetime
- 1990-09-05 MA MA22216A patent/MA21944A1/fr unknown
- 1990-09-05 JP JP2233444A patent/JPH07592B2/ja not_active Expired - Lifetime
- 1990-09-05 PL PL90286747A patent/PL164167B1/pl unknown
- 1990-09-05 ZA ZA907062A patent/ZA907062B/xx unknown
- 1990-09-05 NO NO903872A patent/NO179371C/no not_active IP Right Cessation
- 1990-09-05 YU YU169190A patent/YU48468B/sh unknown
- 1990-09-05 PT PT95206A patent/PT95206B/pt not_active IP Right Cessation
- 1990-09-05 AU AU62178/90A patent/AU631007B2/en not_active Expired
- 1990-09-05 CA CA002024700A patent/CA2024700C/fr not_active Expired - Lifetime
- 1990-09-05 MX MX2224090A patent/MX22240A/es unknown
- 1990-09-05 SK SK4318-90A patent/SK431890A3/sk not_active IP Right Cessation
- 1990-09-05 IE IE322990A patent/IE67451B1/en not_active IP Right Cessation
- 1990-09-05 CN CN90107457A patent/CN1049888C/zh not_active Expired - Lifetime
- 1990-09-05 CZ CS904318A patent/CZ278318B6/cs not_active IP Right Cessation
- 1990-09-06 KR KR1019900014031A patent/KR0159095B1/ko not_active Expired - Lifetime
1992
- 1992-01-31 US US07/830,355 patent/US5292755A/en not_active Expired - Lifetime
1993
- 1993-05-05 LV LVP-93-287A patent/LV10427B/lv unknown
- 1993-11-12 LT LTIP1459A patent/LT3771B/lt not_active IP Right Cessation
1994
- 1994-06-24 PH PH48506A patent/PH30477A/en unknown
- 1994-10-19 HR HRP-1691/90A patent/HRP940702B1/xx not_active IP Right Cessation
1998
- 1998-02-20 CY CY203098A patent/CY2030A/xx unknown
- 1998-06-22 HK HK98105880A patent/HK1008843A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1049888C (zh)	2000-03-01
HU210770B (en)	1995-07-28
RU1836338C (ru)	1993-08-23
JPH07592B2 (ja)	1995-01-11
PT95206B (pt)	1997-06-30
NO903872L (no)	1991-03-07
HRP940702B1 (en)	1999-10-31
SK278583B6 (en)	1997-10-08
IE67451B1 (en)	1996-04-03
PT95206A (pt)	1991-05-22
AU6217890A (en)	1991-03-14
KR910006225A (ko)	1991-04-27
HU905773D0 (en)	1991-03-28
EP0416499A3 (en)	1991-07-17
CA2024700A1 (fr)	1991-03-07
CZ431890A3 (en)	1993-05-12
JPH03106858A (ja)	1991-05-07
EP0416499A2 (fr)	1991-03-13
LV10427B (en)	1996-02-20
PL164167B1 (pl)	1994-06-30
DK0416499T3 (da)	1995-09-04
NZ235168A (en)	1992-09-25
LTIP1459A (en)	1995-05-25
NO179371B (no)	1996-06-17
LV10427A (lv)	1995-02-20
EP0416499B1 (fr)	1995-04-26
YU48468B (sh)	1998-08-14
CZ278318B6 (en)	1993-11-17
PL286747A1 (en)	1991-09-23
DE3929582A1 (de)	1991-03-07
DE59008959D1 (de)	1995-06-01
SK431890A3 (en)	1997-10-08
HK1008843A1 (en)	1999-05-21
KR0159095B1 (ko)	1999-01-15
MX22240A (es)	1993-04-01
YU169190A (sh)	1993-05-28
HUT55750A (en)	1991-06-28
NO179371C (no)	1996-09-25
US5292755A (en)	1994-03-08
NO903872D0 (no)	1990-09-05
LT3771B (en)	1996-03-25
ATE121738T1 (de)	1995-05-15
AU631007B2 (en)	1992-11-12
IL95581A (en)	1999-03-12
HRP940702A2 (en)	1997-02-28
CY2030A (en)	1998-02-20
IE903229A1 (en)	1991-03-13
IL95581A0 (en)	1991-06-30
CA2024700C (fr)	1999-04-06
ZA907062B (en)	1991-06-26
ES2073487T3 (es)	1995-08-16
FI105182B (fi)	2000-06-30
PH30477A (en)	1997-05-28
CN1050018A (zh)	1991-03-20
FI904362A0 (fi)	1990-09-04
US5091394A (en)	1992-02-25

Publication	Publication Date	Title
AU631007B2 (en)	1992-11-12	Benzoylguanidines, process for their preparation, their use as drugs and drugs in which they are present
NZ333095A (en)	2000-08-25	Use of inhibitors of the cellular Na+/H+ exchanger (NHE) for preparing a medicament for normalizing serum lipids
NO933351L (no)	1994-03-23	Benzoylguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament samt medikament inneholdende disse
ES8702907A1 (es)	1987-01-16	Procedimiento para la obtencion de acidos 7-amino-1-ciclopropil-6,8-dihalogeno-1,4-dihidro-4-oxo-3-quinolincarboxilico
PT82854B (pt)	1988-05-27	Processo para a preparacao de derivados do acido piridono-carboxilico
GEP19970818B (en)	1997-01-30	Method of n-/2-/4-fluorphenyl/-1-methyl/-ethyl-n-methyl-n-propinylamine production
ES2046229T3 (es)	1994-02-01	Composicion antiulcerosa.
ATE73810T1 (de)	1992-04-15	Amifloxacin-zwischenverbindung.
TH3474A (th)	1986-09-01	อนุพันธ์ของกรดควิโนโลนคาร์บอกซิลิค