MA24569A1 - Inhibiteurs de farnesyl-transferase en association avec des inhibiteurs de hmg-coa-reductase pour le traitement du cancer - Google Patents

Inhibiteurs de farnesyl-transferase en association avec des inhibiteurs de hmg-coa-reductase pour le traitement du cancer

Info

Publication number
MA24569A1
MA24569A1 MA25114A MA25114A MA24569A1 MA 24569 A1 MA24569 A1 MA 24569A1 MA 25114 A MA25114 A MA 25114A MA 25114 A MA25114 A MA 25114A MA 24569 A1 MA24569 A1 MA 24569A1
Authority
MA
Morocco
Prior art keywords
inhibitors
farnesyl
hmg
coa
cancer
Prior art date
Application number
MA25114A
Other languages
English (en)
Inventor
Mohamed Kajiji Shama
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA24569A1 publication Critical patent/MA24569A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA25114A 1997-06-16 1998-06-15 Inhibiteurs de farnesyl-transferase en association avec des inhibiteurs de hmg-coa-reductase pour le traitement du cancer MA24569A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4963897P 1997-06-16 1997-06-16

Publications (1)

Publication Number Publication Date
MA24569A1 true MA24569A1 (fr) 1998-12-31

Family

ID=21960890

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25114A MA24569A1 (fr) 1997-06-16 1998-06-15 Inhibiteurs de farnesyl-transferase en association avec des inhibiteurs de hmg-coa-reductase pour le traitement du cancer

Country Status (37)

Country Link
EP (1) EP0986387B1 (fr)
JP (1) JP3713051B2 (fr)
KR (1) KR100392573B1 (fr)
CN (1) CN1259868A (fr)
AP (1) AP9801261A0 (fr)
AR (1) AR013090A1 (fr)
AT (1) ATE235905T1 (fr)
BG (1) BG103946A (fr)
BR (1) BR9810616A (fr)
CA (1) CA2294399C (fr)
CO (1) CO4950607A1 (fr)
DE (1) DE69812933T2 (fr)
DK (1) DK0986387T3 (fr)
DZ (1) DZ2518A1 (fr)
EA (1) EA199901043A1 (fr)
ES (1) ES2196559T3 (fr)
GT (1) GT199800081A (fr)
HN (1) HN1998000091A (fr)
HR (1) HRP980328B1 (fr)
HU (1) HUP0004624A3 (fr)
ID (1) ID23014A (fr)
IL (1) IL132765A0 (fr)
IS (1) IS5259A (fr)
MA (1) MA24569A1 (fr)
NO (1) NO996206L (fr)
NZ (1) NZ500662A (fr)
OA (1) OA11231A (fr)
PA (1) PA8453601A1 (fr)
PE (1) PE82899A1 (fr)
PL (1) PL337651A1 (fr)
PT (1) PT986387E (fr)
SK (1) SK169699A3 (fr)
TN (1) TNSN98088A1 (fr)
TR (1) TR199903074T2 (fr)
UA (1) UA57081C2 (fr)
WO (1) WO1998057633A1 (fr)
ZA (1) ZA985182B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID27933A (id) 1998-05-12 2001-05-03 Warner Lambert Co Gabungan protein farnesiltransferase dan inhibitor hmg-coa reduktase serta penggunaannya untuk mengobati kanker
AU6256499A (en) * 1998-09-24 2000-04-10 Merck & Co., Inc. A method of treating cancer
EP1006113A1 (fr) 1998-12-02 2000-06-07 Pfizer Products Inc. Dérivés de 2-(2-oxo-éthylidène)-imidazolidin-4-one et leur utilisation pour inhiber la croissance anormale des cellules
WO2000067737A2 (fr) * 1999-05-07 2000-11-16 The Brigham And Women's Hospital, Inc. UTILISATION D'INHIBITEURS DE HMGCoA REDUCTASE POUR LA PREVENTION DE MALADIES DONT LA PATHOGENESE DEPEND D'UNE NEOFORMATION DE VAISSEAUX SANGUINS
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
EP1395577A1 (fr) 2000-12-19 2004-03-10 Pfizer Products Inc. Formes cristallines de sels de 6- (4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-1-methyl-1h-quinoleine-2-one, 2,3-dihydroxybutanedioate et procede de preparation
CA2432642A1 (fr) 2000-12-21 2002-08-08 Subhash P. Khanapure Composes aryle substitues en tant que nouveaux inhibiteurs selectifs de la cyclo-oxygenase-2, compositions et methodes d'utilisation
US20020151563A1 (en) * 2001-03-29 2002-10-17 Pfizer Inc. Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the inhibition of abnormal cell growth
US6740757B2 (en) 2001-08-29 2004-05-25 Pfizer Inc Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer
JP2005200419A (ja) * 2004-01-16 2005-07-28 National Health Research Inst 癌治療法
US8168667B2 (en) 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
GB2463514C (en) 2008-09-11 2018-09-26 Galapagos Nv Imidazolidine compounds and uses therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69635114T2 (de) * 1995-08-09 2006-03-02 Banyu Pharmaceutical Co., Ltd. Proteinfarnesyltransferase-inhibitoren in kombination mit hmgcoa-reduktase-inhibitoren zur behandlung von aids

Also Published As

Publication number Publication date
HN1998000091A (es) 1999-09-29
AP9801261A0 (en) 1999-12-11
HUP0004624A2 (hu) 2001-10-28
GT199800081A (es) 1999-12-07
DE69812933T2 (de) 2003-11-06
WO1998057633A1 (fr) 1998-12-23
SK169699A3 (en) 2000-06-12
PL337651A1 (en) 2000-08-28
KR20010013839A (ko) 2001-02-26
CO4950607A1 (es) 2000-09-01
JP2000513031A (ja) 2000-10-03
DE69812933D1 (de) 2003-05-08
ATE235905T1 (de) 2003-04-15
JP3713051B2 (ja) 2005-11-02
DK0986387T3 (da) 2003-07-14
UA57081C2 (uk) 2003-06-16
CN1259868A (zh) 2000-07-12
PE82899A1 (es) 1999-08-26
NO996206D0 (no) 1999-12-15
NO996206L (no) 2000-02-15
CA2294399C (fr) 2004-03-16
TR199903074T2 (xx) 2000-05-22
IL132765A0 (en) 2001-03-19
PA8453601A1 (es) 2000-05-24
KR100392573B1 (ko) 2003-07-23
EP0986387B1 (fr) 2003-04-02
ID23014A (id) 1999-12-30
TNSN98088A1 (fr) 2005-03-15
BR9810616A (pt) 2000-09-12
ZA985182B (en) 1999-12-17
AU7445998A (en) 1999-01-04
AU724676B2 (en) 2000-09-28
DZ2518A1 (fr) 2003-02-01
PT986387E (pt) 2003-06-30
OA11231A (en) 2003-05-26
IS5259A (is) 1999-11-19
NZ500662A (en) 2001-10-26
EA199901043A1 (ru) 2000-06-26
CA2294399A1 (fr) 1998-12-23
HUP0004624A3 (en) 2002-11-28
HRP980328A2 (en) 1999-04-30
EP0986387A1 (fr) 2000-03-22
BG103946A (bg) 2000-07-31
HRP980328B1 (en) 2002-06-30
ES2196559T3 (es) 2003-12-16
AR013090A1 (es) 2000-12-13

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