MA26513A1 - Derives du bis-indole ayant une activite antimetastasique, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives du bis-indole ayant une activite antimetastasique, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
MA26513A1
MA26513A1 MA25125A MA25125A MA26513A1 MA 26513 A1 MA26513 A1 MA 26513A1 MA 25125 A MA25125 A MA 25125A MA 25125 A MA25125 A MA 25125A MA 26513 A1 MA26513 A1 MA 26513A1
Authority
MA
Morocco
Prior art keywords
antimetastastic
bis
activity
preparation
pharmaceutical compositions
Prior art date
Application number
MA25125A
Other languages
English (en)
Inventor
Livi Valeria
Menta Ernesto
Oliva Ambrogio
Grams Frank
Krell Hans-Willi
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of MA26513A1 publication Critical patent/MA26513A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
MA25125A 1997-06-25 1998-06-19 Derives du bis-indole ayant une activite antimetastasique, procede pour leur preparation et compositions pharmaceutiques les contenant MA26513A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97110336A EP0887348A1 (fr) 1997-06-25 1997-06-25 Dérivés de bisindole ayant une activité antimétastatique, leur procédé de préparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
MA26513A1 true MA26513A1 (fr) 2004-12-20

Family

ID=8226954

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25125A MA26513A1 (fr) 1997-06-25 1998-06-19 Derives du bis-indole ayant une activite antimetastasique, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (14)

Country Link
EP (2) EP0887348A1 (fr)
JP (1) JP2002507206A (fr)
KR (1) KR20010014215A (fr)
CN (1) CN1268134A (fr)
AR (1) AR016283A1 (fr)
AU (1) AU8629598A (fr)
BR (1) BR9810947A (fr)
CA (1) CA2294250A1 (fr)
CO (1) CO4940464A1 (fr)
HR (1) HRP980357A2 (fr)
MA (1) MA26513A1 (fr)
TR (1) TR199903218T2 (fr)
WO (1) WO1999000381A1 (fr)
ZA (1) ZA985482B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69920455T2 (de) 1998-07-08 2005-01-20 Harbor Branch Oceanographic Institution Inc., Fort Pierce Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
US7709520B2 (en) * 2000-10-06 2010-05-04 The Texas A&M University System Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
IT1317925B1 (it) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
GB2368843A (en) * 2000-11-08 2002-05-15 Leuven K U Res & Dev Non-porphyrin multipurpose contrast agents
CN100352805C (zh) * 2000-11-08 2007-12-05 鲁汶天主教大学研究开发部 用作造影剂的取代的联吲哚衍生物、包含它们的药物组合物以及制造它们的中间体
EP1438044A1 (fr) 2001-10-19 2004-07-21 Transtech Pharma, Inc. Bis-heteroaryl alcanes utilises comme agents therapeutiques
WO2004076386A2 (fr) 2003-02-25 2004-09-10 Topotarget Uk Limited Composes d'acide carbamique comprenant un groupe heteroaryle bicyclique utilises en tant qu'inhibiteurs de hdac
BRPI0511722A (pt) 2004-06-01 2008-01-08 Hoffmann La Roche 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina
WO2006023891A2 (fr) * 2004-08-23 2006-03-02 The Texas A & M University System Activation dependant des ligands de nur77 et ses applications
CN100412058C (zh) * 2005-05-12 2008-08-20 苏州大学 一种双吲哚烷基化合物的合成方法
CN1332948C (zh) * 2005-05-12 2007-08-22 苏州大学 双吲哚烷基衍生物的合成方法
TW200716545A (en) * 2005-06-10 2007-05-01 Sigma Tau Ind Farmaceuti Indole derivatives having anti-tumor activity
AU2006319229B2 (en) 2005-11-30 2011-09-15 F. Hoffmann-La Roche Ag Methods for synthesis of 3-amino-1-arylpropyl indoles
AU2006319231A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP2009517432A (ja) 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−２−アリールプロピルアザインドールおよびその使用
CN105669540A (zh) * 2009-01-28 2016-06-15 卡鲁斯治疗有限公司 Scriptaid电子等排体及其在治疗中的用途
CN101585800B (zh) * 2009-06-19 2011-06-15 中国科学院上海有机化学研究所 具有生物活性双吲哚甲烷类化合物
US9249087B2 (en) 2011-02-01 2016-02-02 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods using the same
IN2015DN03235A (fr) 2012-11-07 2015-10-02 Karus Therapeutics Ltd
ES2688815T3 (es) 2013-05-10 2018-11-07 Karus Therapeutics Limited Inhibidores de histona desacetilasa novedosos
CN103274987A (zh) * 2013-06-07 2013-09-04 华东师范大学 3,3-二取代氧化吲哚衍生物及其合成方法和应用
CN104030964B (zh) * 2014-06-05 2016-06-29 天津科技大学 双吲哚类化合物及合成方法
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
CN107698658B (zh) * 2015-06-23 2021-02-12 首都医科大学 双[3-(乙酰-Lys-AA-OBzl)-吲哚-2-基]乙烷,其制备,活性和应用
WO2019032902A1 (fr) 2017-08-10 2019-02-14 The Texas A & M University System Ligands de nr4a1, compositions pharmaceutiques et procédés d'utilisation associés
US12285407B2 (en) 2018-11-21 2025-04-29 The University Of The West Indies Bis-indolylmethane derivatives and uses thereof
IL295835B2 (en) 2020-02-25 2026-05-01 The Texas A& M Univ System Methods for treating endometritis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866084A (en) * 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs

Also Published As

Publication number Publication date
BR9810947A (pt) 2000-09-26
EP0887348A1 (fr) 1998-12-30
KR20010014215A (ko) 2001-02-26
AU8629598A (en) 1999-01-19
CN1268134A (zh) 2000-09-27
JP2002507206A (ja) 2002-03-05
TR199903218T2 (xx) 2000-07-21
CO4940464A1 (es) 2000-07-24
HRP980357A2 (en) 1999-02-28
EP0991645A1 (fr) 2000-04-12
WO1999000381A1 (fr) 1999-01-07
AR016283A1 (es) 2001-07-04
ZA985482B (en) 1999-12-24
CA2294250A1 (fr) 1999-01-07

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