MA26919A1 - 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3'] bipyridinyle sous une forme cristalline pure et procede de synthese. - Google Patents

5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3'] bipyridinyle sous une forme cristalline pure et procede de synthese.

Info

Publication number
MA26919A1
MA26919A1 MA26971A MA26971A MA26919A1 MA 26919 A1 MA26919 A1 MA 26919A1 MA 26971 A MA26971 A MA 26971A MA 26971 A MA26971 A MA 26971A MA 26919 A1 MA26919 A1 MA 26919A1
Authority
MA
Morocco
Prior art keywords
methanesulfonylphenyl
bipyridinyl
chloro
methyl
crystalline form
Prior art date
Application number
MA26971A
Other languages
English (en)
Inventor
Ian W Davies
Andrew Kotliar
Louis S Crocker
Richard G Osifchin
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22772880&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA26919(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA26919A1 publication Critical patent/MA26919A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA26971A 2000-05-26 2002-12-23 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3'] bipyridinyle sous une forme cristalline pure et procede de synthese. MA26919A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20801700P 2000-05-26 2000-05-26

Publications (1)

Publication Number Publication Date
MA26919A1 true MA26919A1 (fr) 2004-12-20

Family

ID=22772880

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26971A MA26919A1 (fr) 2000-05-26 2002-12-23 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3'] bipyridinyle sous une forme cristalline pure et procede de synthese.

Country Status (48)

Country Link
EP (1) EP1296951B1 (fr)
JP (2) JP3665053B2 (fr)
KR (1) KR100757699B1 (fr)
CN (1) CN1227233C (fr)
AR (1) AR028577A1 (fr)
AT (1) ATE483687T1 (fr)
AU (2) AU2001264804B2 (fr)
BG (1) BG65855B1 (fr)
BR (1) BRPI0111140B8 (fr)
CA (1) CA2410234C (fr)
CR (1) CR6606A (fr)
CY (1) CY1111440T1 (fr)
CZ (1) CZ20023888A3 (fr)
DE (1) DE60143197D1 (fr)
DK (1) DK1296951T3 (fr)
EA (1) EA004809B1 (fr)
EE (1) EE05242B1 (fr)
EG (1) EG24189A (fr)
ES (1) ES2351958T3 (fr)
GC (1) GC0000362A (fr)
GE (1) GEP20053492B (fr)
GT (1) GT200100091A (fr)
HN (1) HN2001000110A (fr)
HR (1) HRP20020934B1 (fr)
HU (1) HU228423B1 (fr)
IL (1) IL152582A0 (fr)
IN (2) IN2002CH02089A (fr)
IS (1) IS2806B (fr)
JO (1) JO2216B1 (fr)
MA (1) MA26919A1 (fr)
ME (1) ME00428B (fr)
MX (1) MX230696B (fr)
MY (1) MY123569A (fr)
NO (1) NO324495B1 (fr)
NZ (1) NZ522394A (fr)
PA (1) PA8516901A1 (fr)
PE (1) PE20011324A1 (fr)
PH (1) PH12001001175B1 (fr)
PL (1) PL358153A1 (fr)
PT (1) PT1296951E (fr)
RS (1) RS51541B (fr)
SI (1) SI1296951T1 (fr)
SK (1) SK287174B6 (fr)
SV (1) SV2002000462A (fr)
TW (1) TWI303634B (fr)
UA (1) UA73355C2 (fr)
WO (1) WO2001092230A1 (fr)
ZA (1) ZA200209558B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2391650C (fr) 1999-11-29 2011-01-25 Merck & Co., Inc. Formes polymorphes, amorphes et hydratees de 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyle
US6858631B1 (en) 1999-11-29 2005-02-22 Merck & Co., Inc. Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl
US6521642B2 (en) * 2000-05-26 2003-02-18 Merck & Co., Inc. 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis
HUE028730T2 (en) 2009-02-27 2017-01-30 Cadila Healthcare Ltd Process for the preparation of etoricoxib
WO2012004677A1 (fr) 2010-07-05 2012-01-12 Actavis Group Ptc Ehf Formes à l'état solide de sels d'étoricoxib
WO2012163839A1 (fr) 2011-05-27 2012-12-06 Farma Grs, D.O.O. Procédé pour la préparation de la forme polymorphe i de l'étoricoxib
EP2773618A1 (fr) 2011-11-03 2014-09-10 Cadila Healthcare Limited Procédé amélioré pour la préparation d'étoricoxibe et de polymorphes de celui-ci
WO2013075732A1 (fr) 2011-11-21 2013-05-30 Synthon Bv Procédé de préparation d'une forme cristalline i de l'étoricoxib
EP2601952A1 (fr) 2011-12-07 2013-06-12 Zentiva, k.s. Nouveaux sels et cocrristaux pharmaceutiqement acceptables du 5- chloro-3-(4-méthanesulfonylphényl)-6'-méthyl-[2,3'] bipyridinyle et leurs utilisations thérapeutiques
HUE033525T2 (en) 2012-08-27 2017-12-28 Cadila Healthcare Ltd Pharmaceuticals containing Etoricoxib
WO2014041558A2 (fr) 2012-08-27 2014-03-20 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Procédé de préparation d'étoricoxib cristallin
CN104418799A (zh) * 2013-09-03 2015-03-18 天津药物研究院 一种依托考昔的晶型及其制备方法和应用
WO2015036550A1 (fr) 2013-09-13 2015-03-19 Synthon B.V. Procédé pour la préparation d'étoricoxib
CN106632003B (zh) * 2015-12-31 2019-02-12 上海博志研新药物技术有限公司 一种依托考昔的制备方法
CN108069896B (zh) * 2016-11-11 2022-08-12 昆明积大制药股份有限公司 一种依托考昔晶型的制备方法
CN107417599B (zh) * 2017-06-21 2020-06-09 四川尚锐生物医药有限公司 一种依托考昔晶型的制备方法
CN107056691B (zh) * 2017-06-21 2020-03-10 四川尚锐生物医药有限公司 一种制备依托考昔晶型v的方法
MX2017009660A (es) 2017-07-26 2017-11-23 Laboratorios Liomont S A De C V Composicion farmaceutica con un rango de relacion entre el clorhidrato de tramadol y el etoricoxib para su administracion para el tratamiento del dolor.
CN107556231A (zh) * 2017-09-23 2018-01-09 江苏正大清江制药有限公司 一种依托考昔与对硝基苯甲酸形成的盐的晶型及制备方法
CN107417600A (zh) * 2017-09-26 2017-12-01 江苏正大清江制药有限公司 一种依托考昔与呋喃甲酸形成盐的新晶型及制备方法
CN107898787B (zh) * 2017-12-15 2018-11-30 扬子江药业集团上海海尼药业有限公司 一种药物组合物及其制剂和制备方法
WO2019130049A1 (fr) 2017-12-29 2019-07-04 Grünenthal GmbH Combinaison pharmaceutique comprenant du chlorhydrate de tramadol à libération prolongée et de l'étoricoxib à libération immédiate, et son utilisation pour le traitement de la douleur
CN110143915A (zh) * 2019-06-03 2019-08-20 蚌埠学院 一种依托考昔与对甲苯磺酸形成盐的新晶型及制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593994A (en) * 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
US5739166A (en) * 1994-11-29 1998-04-14 G.D. Searle & Co. Substituted terphenyl compounds for the treatment of inflammation
SI0912518T1 (en) * 1996-07-18 2003-12-31 Merck Frosst Canada & Co. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US5861419A (en) * 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
UA57143C2 (uk) * 1998-04-24 2003-06-16 Мерк Енд Ко., Інк. Спосіб синтезу інгібіторів сох-2 (циклооксигенази-2) та проміжні сполуки для їх одержання
CA2391650C (fr) * 1999-11-29 2011-01-25 Merck & Co., Inc. Formes polymorphes, amorphes et hydratees de 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyle

Also Published As

Publication number Publication date
PT1296951E (pt) 2010-12-07
CY1111440T1 (el) 2015-08-05
WO2001092230A1 (fr) 2001-12-06
IS6630A (is) 2002-11-20
JP2004501116A (ja) 2004-01-15
EP1296951B1 (fr) 2010-10-06
AU6480401A (en) 2001-12-11
ZA200209558B (en) 2003-10-28
CZ20023888A3 (cs) 2003-02-12
JP2005047927A (ja) 2005-02-24
NZ522394A (en) 2004-05-28
SV2002000462A (es) 2002-03-08
ATE483687T1 (de) 2010-10-15
PA8516901A1 (es) 2002-04-25
IS2806B (is) 2012-09-15
EA200201264A1 (ru) 2003-04-24
ES2351958T3 (es) 2011-02-14
NO324495B1 (no) 2007-10-29
IL152582A0 (en) 2003-05-29
DE60143197D1 (de) 2010-11-18
GEP20053492B (en) 2005-04-25
PH12001001175B1 (en) 2006-08-10
EA004809B1 (ru) 2004-08-26
HN2001000110A (es) 2002-03-06
EE05242B1 (et) 2009-12-15
AR028577A1 (es) 2003-05-14
EE200200655A (et) 2004-08-16
TWI303634B (en) 2008-12-01
GC0000362A (en) 2007-03-31
JP3665053B2 (ja) 2005-06-29
SI1296951T1 (sl) 2011-01-31
KR100757699B1 (ko) 2007-09-13
PE20011324A1 (es) 2002-01-28
BG65855B1 (bg) 2010-03-31
YU89402A (sh) 2005-11-28
HRP20020934A2 (en) 2005-02-28
HRP20020934B1 (en) 2012-01-31
CA2410234A1 (fr) 2001-12-06
JP4142621B2 (ja) 2008-09-03
EP1296951A1 (fr) 2003-04-02
CR6606A (es) 2006-02-06
RS51541B (sr) 2011-06-30
IN2002CH02089A (fr) 2005-02-25
NO20025674D0 (no) 2002-11-26
HK1058932A1 (en) 2004-06-11
SK287174B6 (sk) 2010-02-08
MY123569A (en) 2006-05-31
CN1227233C (zh) 2005-11-16
KR20030003762A (ko) 2003-01-10
PL358153A1 (en) 2004-08-09
CN1443168A (zh) 2003-09-17
BRPI0111140B1 (pt) 2018-03-13
EG24189A (en) 2008-10-08
IN2007CH05103A (fr) 2008-08-27
JO2216B1 (en) 2004-10-07
DK1296951T3 (da) 2011-01-24
ME00428B (me) 2011-10-10
MXPA02011619A (es) 2003-03-27
AU2001264804B2 (en) 2006-04-06
SK16702002A3 (sk) 2003-05-02
BR0111140A (pt) 2005-01-11
NO20025674L (no) 2002-11-26
HU228423B1 (en) 2013-03-28
CA2410234C (fr) 2008-05-13
BG107237A (bg) 2003-05-30
UA73355C2 (en) 2005-07-15
MX230696B (es) 2005-09-19
GT200100091A (es) 2001-12-28
BRPI0111140B8 (pt) 2021-05-25
HUP0302336A2 (hu) 2003-11-28

Similar Documents

Publication Publication Date Title
GC0000362A (en) 5-Chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl in pure crystalline form and process for synthesis
FR2817865B1 (fr) Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
HUP0000748A2 (en) 4-phenyl-piridine derivatives, process for producing them and pharmaceutical compositions containing them
HUP0302257A3 (en) 4-hydrazino-5-hydroxy-5-pyrazol derivatives, pharmaceutical compositions containing them, process for producing them and their intermediates
HUP0301651A2 (en) Indolylmaleimide derivatives, pharmaceutical compositions containing them, process for producing them and their use
PL349863A1 (en) 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use
MXPA01011039A (es) Derivados de 6-alquenilo, 6-alquinilo y 6-epoxi-epotilona, procesos para su produccion y su uso en preparaciones farmaceuticas..
HUP0303109A3 (en) Indolin-2-one derivatives, process for producing them and pharmaceutical compositions containing them
FR2780728B1 (fr) Sel de paroxetine nouveau, procede pour sa preparation et compositions pharmaceutiques le contenant
HUP0302295A3 (en) Thienodibenzoazulene derivatives, process for their preparation and use thereof
HUP0202736A3 (en) Substituted aromatic-ring compounds, process for producing the same, and pharmaceutical compositions containing them and use thereof
PL359373A1 (en) New substituted phthalides, a process for their preparation and pharmaceutical compositions containing them
HUP0105479A3 (en) Betha-alanine derivatives, process for producing them and pharmaceutical compositions containing them
MXPA01013412A (es) Composiciones de citrato de calcio potasico y metodos de produccion.
ZA200100864B (en) Piperidine-4-sulphonamides compounds, a process for their preparation and pharmaceutical compositions containing them.
EP1395562A4 (fr) 5-chloro-3-(4-methanesulfonylphenyle)-6'-methyle- 2,3'|bipyridinyle sous forme cristalline pure et procede de synthese
HUP0201785A3 (en) Dihydrobenzodiazepins, process for producing them, their use and pharmaceutical compositions containing them
HUP0302429A3 (en) 4-amino-quinazolines, process for producing them, pharmaceutical compositions containing them and their use
HUP0201916A3 (en) Ethanesulfonyl-piperidine derivatives, process for producing them and pharmaceutical compositions containing them
HUP0201693A3 (en) Diphosphate salt of a 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin derivative, process for producing it and its pharmaceutical composition
EE200200385A (et) Alfa-(2,4-disulfofenüül)-N-tert-butüülnitrooni jaselle farmatseutiliselt vastuvõetavate soolade uus valmistamise meetod
HUP9900263A3 (en) 11-acetyl-12,13-dioxabicyclo[8.2.1.]tridecenon derivatives, process for producing them and pharmaceutical compositions containing them
ZA200101340B (en) 6-amino or 6-hydrazino-sulphonyl-3-quinolinylphosphonic acid compounds, a process for their preparation and pharmaceutical composition containing them.
ZA200103065B (en) Heterocycloalkylbenzocyclobutane and heteroarylbenzocyclobutane compounds, a process for their preparation and pharmaceutical compositions containing them.
IL128738A0 (en) Magnesium and potassium double salts, process for their preparation and uses thereof