MA26952A1 - Derives d'imidazole a noyau aryle ou heteroaryle condense, utiles comme agents anti-inflammatoires et analgesiques. - Google Patents

Derives d'imidazole a noyau aryle ou heteroaryle condense, utiles comme agents anti-inflammatoires et analgesiques.

Info

Publication number
MA26952A1
MA26952A1 MA27097A MA27097A MA26952A1 MA 26952 A1 MA26952 A1 MA 26952A1 MA 27097 A MA27097 A MA 27097A MA 27097 A MA27097 A MA 27097A MA 26952 A1 MA26952 A1 MA 26952A1
Authority
MA
Morocco
Prior art keywords
monocyclic
group
penta
optionally containing
alkyl group
Prior art date
Application number
MA27097A
Other languages
English (en)
Inventor
Nakao Kazunari
Okumura Yoshiyuki
Matsumizu Miyako
Ueno Naomi
Hashizume Yoshinobu
Kato Tomoki
Kawai Akiyoshi
Nukui Seiji
Shinjyo Katsuhiro
Taniguchi Kana
Miyake Yoriko
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA26952A1 publication Critical patent/MA26952A1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Dérivés d'imidazole à noyau aryle ou hétéroaryle condensé, servant d'agents anti-inflammatoires et analgésiques La présente invention propose un composé de formule (I) : ou ses sels pharmaceutiquement acceptables, formule dans laquelle Y1, Y2, Y3 et Y4 sont choisis indépendamment entre N, CH, etc. ; R1 représente H, un groupe alkyle en C1 à C8, etc. ; Q1 représente un noyau aromatique penta- à dodécagonal monocyclique ou bicyclique contenant facultativement jusqu'à 4 hétéroatomes choisis entre 0, N et S, etc. ; A représente un noyau aromatique monocyclique penta- ou hexagonal monocyclique contenant facultativement jusqu'à 3 hétéroatomes choisis entre 0, N et S, etc. ; B représente un groupe alkylène en C1 à C6, facultativement substitué avec un groupe oxo, etc. ; W représente un groupe NH, 0, etc. ; R2 représente H, un groupe alkyle en C1 à C4, etc. ; Z représente un noyau aromatique penta- à dodécagonal monocyclique ou bicyclique contenant facultativement jusqu'à 3 hétéroatomes choisis entre 0, N et S, etc. ; L représente un groupe halogéno, alkyle en C1 à C4, etc. ; m est égal à 0, 1 ou 2, R3 et R4 sont choisis indépendamment entre H et un groupe alkyle en C1 à C4 ; R5 représente H, un groupe alkyle en C1 à C4, etc. ; Q2 représente un noyau aromatique monocyclique ou bicyclique, ou un noyau tricyclique, penta- à dodécagonal, contenant facultativement jusqu'à 3 hétéroatomes choisis entre 0, N et S, etc. Ces composés sont utiles pour le traitement d'états médicaux à médiation par une prostaglandine, tels que la douleur, la fièvre ou l'inflammation, etc. La présente invention propose également une composition pharmaceutique comprenant le composé précité.
MA27097A 2000-10-19 2003-04-08 Derives d'imidazole a noyau aryle ou heteroaryle condense, utiles comme agents anti-inflammatoires et analgesiques. MA26952A1 (fr)

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MA27107A MA26955A1 (fr) 2000-10-19 2003-04-15 INHIBITEURS DES RECEPTEURS EP4 POUR LE TRAITEMENT DE L'ARTHRITE RHUMATOiDE

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