MA27103A1 - Nouveaux derives de 3-aryl-2,5-dihydroxy-1,4-benzoquinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives de 3-aryl-2,5-dihydroxy-1,4-benzoquinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
MA27103A1
MA27103A1 MA27795A MA27795A MA27103A1 MA 27103 A1 MA27103 A1 MA 27103A1 MA 27795 A MA27795 A MA 27795A MA 27795 A MA27795 A MA 27795A MA 27103 A1 MA27103 A1 MA 27103A1
Authority
MA
Morocco
Prior art keywords
dihydroxy
aryl
group
benzoquinones
derivatives
Prior art date
Application number
MA27795A
Other languages
English (en)
Inventor
Alexandra Dassonville
Anne Breteche
Muriel Duflos
Baut Guillaume Le
Bruno Pfeiffer
Pierre Renard
Nigel Levens
Bernadette Husson-Robert
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MA27103A1 publication Critical patent/MA27103A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

NOUVEAUX DERIVES DE 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT Composé de formule (I): dans laquelle : R1 et R2, identiques ou différents, représentent chacun un atome d'hydrogène ou un groupement acyle ou alkyle, Ar représente un groupement aryle ou hétéroaryle, A représente un groupement choisi parmi: R4 représente un atome d'hydrogène ou un groupement alkyle, R5 représente un atome d'hydrogène ou un groupement choisi parmi alkyle, aryle et hétéroaryle, R3 représente un groupement aryle, hétéroaryle, dicyclopropylméthyle ou benzhydryle, ou A-R3 représente un groupement naphtyle éventuellement substitué, à l'exclusion de la 2,5-dihydroxy-3-(4-méthoxyphényl)-6-(2-phényléthényl)-1,4-benzoquinone, de la 2,5-dihydroxy-3-(4-méthoxyphényl)-6-(2-naphtyl)-1,4-benzoquinone, et de la 2,5-dihydroxy-3-(2-naphtyl)-6-phényl-1,4-benzoquinone. Médicaments.
MA27795A 2002-02-06 2004-07-21 Nouveaux derives de 3-aryl-2,5-dihydroxy-1,4-benzoquinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent MA27103A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0201409A FR2835523B1 (fr) 2002-02-06 2002-02-06 Nouveaux derives de 3-aryl-2,5-dihydroxy-1,4-benzoquinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
MA27103A1 true MA27103A1 (fr) 2004-12-20

Family

ID=27619936

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27795A MA27103A1 (fr) 2002-02-06 2004-07-21 Nouveaux derives de 3-aryl-2,5-dihydroxy-1,4-benzoquinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (20)

Country Link
US (1) US20050085644A1 (fr)
EP (1) EP1472208A1 (fr)
JP (1) JP4098248B2 (fr)
KR (1) KR100605805B1 (fr)
CN (1) CN1274655C (fr)
AR (1) AR038397A1 (fr)
AU (1) AU2003226860B9 (fr)
BR (1) BR0307465A (fr)
CA (1) CA2474533A1 (fr)
EA (1) EA006775B1 (fr)
FR (1) FR2835523B1 (fr)
GE (1) GEP20063900B (fr)
MA (1) MA27103A1 (fr)
MX (1) MXPA04007684A (fr)
NO (1) NO20043532L (fr)
NZ (1) NZ534099A (fr)
PL (1) PL370773A1 (fr)
UA (1) UA79448C2 (fr)
WO (1) WO2003066561A1 (fr)
ZA (1) ZA200405446B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103058846B (zh) * 2013-01-17 2014-07-30 福州大学 一种源于棘孢曲霉的苯醌衍生物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8702330A1 (es) * 1984-01-26 1986-12-16 Otsuka Pharma Co Ltd Un procedimiento para preparar un derivado de 1,4-benzoquinona.
US7057052B2 (en) * 2002-09-26 2006-06-06 Duke University Heterocyclic quinones as pharmaceutical agents

Also Published As

Publication number Publication date
PL370773A1 (en) 2005-05-30
BR0307465A (pt) 2004-11-09
AU2003226860A1 (en) 2003-09-02
FR2835523A1 (fr) 2003-08-08
FR2835523B1 (fr) 2004-04-16
AU2003226860B8 (en) 2008-07-10
WO2003066561A1 (fr) 2003-08-14
UA79448C2 (en) 2007-06-25
EA200400992A1 (ru) 2005-02-24
US20050085644A1 (en) 2005-04-21
EA006775B1 (ru) 2006-04-28
KR100605805B1 (ko) 2006-08-01
NO20043532L (no) 2004-08-24
EP1472208A1 (fr) 2004-11-03
HK1078566A1 (en) 2006-03-17
JP2005517001A (ja) 2005-06-09
MXPA04007684A (es) 2005-07-13
GEP20063900B (en) 2006-08-10
CN1274655C (zh) 2006-09-13
NZ534099A (en) 2006-09-29
ZA200405446B (en) 2005-07-08
KR20040086352A (ko) 2004-10-08
CA2474533A1 (fr) 2003-08-14
CN1628088A (zh) 2005-06-15
AR038397A1 (es) 2005-01-12
AU2003226860B2 (en) 2008-06-26
AU2003226860B9 (en) 2008-08-14
JP4098248B2 (ja) 2008-06-11

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