MA27124A1 - 4-(heterocyclysulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2-phenyl ou pyridylpyrimidines utilisees en tant qu'antagonistes des recepteurs d'endotheline. - Google Patents

4-(heterocyclysulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2-phenyl ou pyridylpyrimidines utilisees en tant qu'antagonistes des recepteurs d'endotheline.

Info

Publication number: MA27124A1
Authority: MA; Morocco
Prior art keywords: heterocyclysulfonamido; pyridylpyrimidines; methoxyphenoxy; methoxy; phenyl
Prior art date: 1999-01-18

Application number

MA26270A

Other languages

English (en)

Inventor

Volker Breu

Philippe Coassolo

Werner Neidhart

Sebastien Roux

Hans Peter Wessel

Rolf Huber

Henri Ramuz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-18

Filing date

2001-07-17

Publication date

2005-01-03

2001-07-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-01-03 Publication of MA27124A1 publication Critical patent/MA27124A1/fr

Links

-1 2-METHOXYPHENOXY Chemical class 0.000 title 1
229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
239000002308 endothelin receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)

MA26270A 1999-01-18 2001-07-17 4-(heterocyclysulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2-phenyl ou pyridylpyrimidines utilisees en tant qu'antagonistes des recepteurs d'endotheline. MA27124A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99100784		1999-01-18

Publications (1)

Publication Number	Publication Date
MA27124A1 true MA27124A1 (fr)	2005-01-03

Family

ID=8237359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA26270A MA27124A1 (fr)	1999-01-18	2001-07-17	4-(heterocyclysulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2-phenyl ou pyridylpyrimidines utilisees en tant qu'antagonistes des recepteurs d'endotheline.

Country Status (31)

Country	Link
US (1)	US6242601B1 (fr)
EP (1)	EP1149091B1 (fr)
JP (1)	JP3983477B2 (fr)
KR (1)	KR100478797B1 (fr)
CN (1)	CN1340049A (fr)
AR (1)	AR029879A1 (fr)
AT (1)	ATE389648T1 (fr)
AU (1)	AU763112B2 (fr)
BR (1)	BR0007595A (fr)
CA (1)	CA2359363C (fr)
CO (1)	CO5150187A1 (fr)
CZ (1)	CZ20012546A3 (fr)
DE (1)	DE60038365D1 (fr)
ES (1)	ES2301476T3 (fr)
GC (1)	GC0000248A (fr)
HR (1)	HRP20010515A2 (fr)
HU (1)	HUP0200021A3 (fr)
IL (2)	IL144055A0 (fr)
MA (1)	MA27124A1 (fr)
MY (1)	MY121136A (fr)
NO (1)	NO322800B1 (fr)
NZ (1)	NZ512662A (fr)
PE (1)	PE20001421A1 (fr)
PL (1)	PL350093A1 (fr)
RU (1)	RU2224757C2 (fr)
TR (1)	TR200102071T2 (fr)
TW (1)	TWI284642B (fr)
UY (1)	UY25904A1 (fr)
WO (1)	WO2000042035A1 (fr)
YU (1)	YU50001A (fr)
ZA (1)	ZA200105279B (fr)

Families Citing this family (35)

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US7329670B1 (en)	1997-12-22	2008-02-12	Bayer Pharmaceuticals Corporation	Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US20080300281A1 (en) *	1997-12-22	2008-12-04	Jacques Dumas	Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7517880B2 (en)	1997-12-22	2009-04-14	Bayer Pharmaceuticals Corporation	Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080269265A1 (en) *	1998-12-22	2008-10-30	Scott Miller	Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
CA2359244C (fr)	1999-01-13	2013-10-08	Bayer Healthcare Llc	Diphenyle urees a substitution .omega.-carboxy aryle en tant qu'inhibiteurs de la kinase p38
US7351834B1 (en) *	1999-01-13	2008-04-01	Bayer Pharmaceuticals Corporation	ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US8124630B2 (en)	1999-01-13	2012-02-28	Bayer Healthcare Llc	ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (fr)	1999-01-13	2006-03-22	Bayer Pharmaceuticals Corp.	Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf
US7928239B2 (en)	1999-01-13	2011-04-19	Bayer Healthcare Llc	Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
US6417360B1 (en) *	1999-03-03	2002-07-09	Hoffmann-La Roche Inc.	Heterocyclic sulfonamides
MY140724A (en)	2000-07-21	2010-01-15	Actelion Pharmaceuticals Ltd	Novel arylethene-sulfonamides
WO2002053557A1 (fr) *	2000-12-18	2002-07-11	Actelion Pharmaceuticals Ltd	Nouveaux sulfamides et leur utilisation comme antagonistes du recepteur de l'endotheline
US7235576B1 (en)	2001-01-12	2007-06-26	Bayer Pharmaceuticals Corporation	Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) *	2001-04-20	2008-05-13	Bayer Pharmaceuticals Corporation	Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
AU2002351196A1 (en) *	2001-12-03	2003-06-17	Bayer Pharmaceuticals Corporation	Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
EP2324825A1 (fr)	2002-02-11	2011-05-25	Bayer Healthcare LLC	Arylurées dotées d'une activité d'inhibition de l'angiogenèse
WO2003068223A1 (fr) *	2002-02-11	2003-08-21	Bayer Corporation	Urees aryliques a kinase de raf et activite inhibitrice d'angiogenese
SI1580188T1 (sl) *	2002-02-11	2012-02-29	Bayer Healthcare Llc	Aril sečnine kot kinazni inhibitorji
US20030216396A1 (en) *	2002-02-11	2003-11-20	Bayer Corporation	Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
EP1569914B1 (fr) *	2002-12-02	2009-02-18	Actelion Pharmaceuticals Ltd.	Pyrimidine-sulfamides et leur utilisation comme antagoniste du recepteur d'endotheline
US7269460B2 (en) *	2003-02-28	2007-09-11	Medtronic, Inc.	Method and apparatus for evaluating and optimizing ventricular synchronization
UY28213A1 (es) *	2003-02-28	2004-09-30	Bayer Pharmaceuticals Corp	Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
DE602004007382T2 (de)	2003-05-20	2008-04-17	Bayer Pharmaceuticals Corp., West Haven	Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
DK1663978T3 (da)	2003-07-23	2008-04-07	Bayer Pharmaceuticals Corp	Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser
EP1595880A1 (fr) *	2004-05-13	2005-11-16	Speedel Pharma AG	Formes crystallines d'un pyridinylsulphonamide et leur utilisation comme antagonistes du récepteur de l'endothéline
CR9465A (es) *	2005-03-25	2008-06-19	Surface Logix Inc	Compuestos mejorados farmacocineticamente
US20100022568A1 (en) *	2006-04-13	2010-01-28	Actelion Pharmaceeuticals Ltd.	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
ATE537144T1 (de)	2006-05-29	2011-12-15	Nicox Sa	Nitrierte heterocyclische verbindungen als endothelinrezeptorantagonisten
AR062501A1 (es)	2006-08-29	2008-11-12	Actelion Pharmaceuticals Ltd	Composiciones terapeuticas
MX2010001837A (es)	2007-08-17	2010-03-10	Actelion Pharmaceuticals Ltd	Derivados de 4-pirimidinasulfamida.
HUE054520T2 (hu) *	2014-11-21	2021-09-28	Daikin Ind Ltd	Fluorozott telítetlen ciklusos karbonát, és eljárás ennek elõállítására
CN109260164A (zh) *	2018-10-07	2019-01-25	威海贯标信息科技有限公司	一种阿伏生坦片剂组合物
CN112778215B (zh) *	2021-01-29	2023-06-20	中国医科大学	2-甲氧基苯氧基嘧啶类抗肿瘤化合物及其制备方法和应用
CN112898208B (zh) *	2021-01-29	2023-06-20	中国医科大学	苯基嘧啶胺类抗肿瘤化合物及其制备方法和应用
KR20240121242A (ko)	2021-12-17	2024-08-08	넥세라 파마 씨오., 엘티디.	클라조센탄 디소듐 염, 이의 제조 및 이를 포함하는 약학 조성물

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CA2162630C (fr) *	1994-11-25	2007-05-01	Volker Breu	Sulfonamides
WO1996016963A1 (fr) *	1994-11-25	1996-06-06	F. Hoffmann-La Roche Ag	Sulfonamides et leur utilisation comme medicaments
US5837708A (en)	1994-11-25	1998-11-17	Hoffmann-La Roche Inc.	Sulphonamides
TW313568B (fr) *	1994-12-20	1997-08-21	Hoffmann La Roche
WO1997022595A1 (fr) *	1995-12-20	1997-06-26	Yamanouchi Pharmaceutical Co., Ltd.	Derives arylethenesulfonamide et composition de medicaments renfermant ces derives

2000
- 2000-01-07 TW TW089100181A patent/TWI284642B/zh not_active IP Right Cessation
- 2000-01-10 HU HU0200021A patent/HUP0200021A3/hu unknown
- 2000-01-10 CZ CZ20012546A patent/CZ20012546A3/cs unknown
- 2000-01-10 RU RU2001122114/04A patent/RU2224757C2/ru not_active IP Right Cessation
- 2000-01-10 DE DE60038365T patent/DE60038365D1/de not_active Expired - Lifetime
- 2000-01-10 CA CA002359363A patent/CA2359363C/fr not_active Expired - Fee Related
- 2000-01-10 KR KR10-2001-7008996A patent/KR100478797B1/ko not_active Expired - Fee Related
- 2000-01-10 PL PL00350093A patent/PL350093A1/xx not_active Application Discontinuation
- 2000-01-10 JP JP2000593603A patent/JP3983477B2/ja not_active Expired - Lifetime
- 2000-01-10 AT AT00904889T patent/ATE389648T1/de not_active IP Right Cessation
- 2000-01-10 ES ES00904889T patent/ES2301476T3/es not_active Expired - Lifetime
- 2000-01-10 HR HR20010515A patent/HRP20010515A2/hr not_active Application Discontinuation
- 2000-01-10 WO PCT/EP2000/000103 patent/WO2000042035A1/fr not_active Ceased
- 2000-01-10 AU AU26630/00A patent/AU763112B2/en not_active Ceased
- 2000-01-10 TR TR2001/02071T patent/TR200102071T2/xx unknown
- 2000-01-10 EP EP00904889A patent/EP1149091B1/fr not_active Expired - Lifetime
- 2000-01-10 BR BR0007595-7A patent/BR0007595A/pt not_active Application Discontinuation
- 2000-01-10 YU YU50001A patent/YU50001A/sh unknown
- 2000-01-10 NZ NZ512662A patent/NZ512662A/en unknown
- 2000-01-10 CN CN00803754A patent/CN1340049A/zh active Pending
- 2000-01-10 IL IL14405500A patent/IL144055A0/xx not_active IP Right Cessation
- 2000-01-13 US US09/482,810 patent/US6242601B1/en not_active Expired - Fee Related
- 2000-01-13 PE PE2000000025A patent/PE20001421A1/es not_active Application Discontinuation
- 2000-01-14 AR ARP000100159A patent/AR029879A1/es unknown
- 2000-01-14 MY MYPI20000124A patent/MY121136A/en unknown
- 2000-01-14 CO CO00001821A patent/CO5150187A1/es unknown
- 2000-01-14 UY UY25904A patent/UY25904A1/es unknown
- 2000-01-17 GC GCP2000481 patent/GC0000248A/en active
2001
- 2001-06-26 ZA ZA200105279A patent/ZA200105279B/en unknown
- 2001-06-28 IL IL144055A patent/IL144055A/en unknown
- 2001-07-12 NO NO20013454A patent/NO322800B1/no unknown
- 2001-07-17 MA MA26270A patent/MA27124A1/fr unknown

Also Published As

Publication number	Publication date
AU763112B2 (en)	2003-07-10
HRP20010515A2 (en)	2003-06-30
CN1340049A (zh)	2002-03-13
KR20010094746A (ko)	2001-11-01
JP3983477B2 (ja)	2007-09-26
BR0007595A (pt)	2001-10-16
NO20013454L (no)	2001-07-12
TR200102071T2 (tr)	2002-03-21
ES2301476T3 (es)	2008-07-01
NO20013454D0 (no)	2001-07-12
DE60038365D1 (en)	2008-04-30
CA2359363C (fr)	2006-03-14
CO5150187A1 (es)	2002-04-29
PE20001421A1 (es)	2000-12-18
NO322800B1 (no)	2006-12-11
YU50001A (sh)	2004-03-12
EP1149091B1 (fr)	2008-03-19
GC0000248A (en)	2006-11-01
KR100478797B1 (ko)	2005-03-24
UY25904A1 (es)	2001-07-31
MY121136A (en)	2005-12-30
AU2663000A (en)	2000-08-01
CZ20012546A3 (cs)	2001-12-12
AR029879A1 (es)	2003-07-23
IL144055A (en)	2007-07-24
TWI284642B (en)	2007-08-01
CA2359363A1 (fr)	2000-07-20
EP1149091A1 (fr)	2001-10-31
ATE389648T1 (de)	2008-04-15
HUP0200021A3 (en)	2003-01-28
PL350093A1 (en)	2002-11-04
US6242601B1 (en)	2001-06-05
JP2002534518A (ja)	2002-10-15
ZA200105279B (en)	2002-10-07
RU2224757C2 (ru)	2004-02-27
NZ512662A (en)	2003-11-28
IL144055A0 (en)	2002-04-21
HUP0200021A2 (hu)	2002-05-29
WO2000042035A1 (fr)	2000-07-20

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ZA985277B (en)	1999-12-20	Novel ß-amino and ß-azido carboxylic and acid derivatives, their preparation and use as endothelin receptor antagonists.
ATE220673T1 (de)	2002-08-15	4-(benzo-1,3-dioxolyl)-pyrrolidin-3-carbonsaure derivate als endothelin-antagonisten
FR2806864B1 (fr)	2002-07-05	Dispositif d'affichage connecte au reseau internet utilisant le web
ITPC990021V0 (it)	1999-11-12	Dispositivo di comando per l'azionamento dell'acqua di cacciata per se rvizi igienici particolarmente per disabili o simili.