MA27532A1 - Piperidines a substituant phenyle, destinees a etre utilisees comme activateurs de ppar - Google Patents

Piperidines a substituant phenyle, destinees a etre utilisees comme activateurs de ppar

Info

Publication number
MA27532A1
MA27532A1 MA28299A MA28299A MA27532A1 MA 27532 A1 MA27532 A1 MA 27532A1 MA 28299 A MA28299 A MA 28299A MA 28299 A MA28299 A MA 28299A MA 27532 A1 MA27532 A1 MA 27532A1
Authority
MA
Morocco
Prior art keywords
cholesterol
substituted piperidines
phenyl substituted
activators
ppar activators
Prior art date
Application number
MA28299A
Other languages
English (en)
Inventor
Scott William Bagley
Thomas Andrew Brandt
Robert Wayne Dugger
William Andrew Hada
Cheryl Myers Hayward
Zhengyu Liu
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA27532A1 publication Critical patent/MA27532A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Pipéridines à substituant phényle, destinées à être utilisées comme activateurs de PPAR Des activateurs de PPAR alpha, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés pour élever les taux plasmatiques de certains lipides, comprenant le cholestérol-lipoprotéines haute densité, et pour abaisser les taux plasmatiques de certains autres lipides, tels que le cholestérol-LDL et les triglycérides et, en conséquence, pour le traitement de maladies qui sont exacerbées par des taux bas de cholestérol-HDL et/ou des taux élevés de cholestérol-LDL et de triglycérides, tels que l'athérosclérose et des maladies cardio-vasculaires, chez des mammifères, y compris l'homme.
MA28299A 2002-11-26 2005-05-26 Piperidines a substituant phenyle, destinees a etre utilisees comme activateurs de ppar MA27532A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42950602P 2002-11-26 2002-11-26

Publications (1)

Publication Number Publication Date
MA27532A1 true MA27532A1 (fr) 2005-09-01

Family

ID=32393563

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28299A MA27532A1 (fr) 2002-11-26 2005-05-26 Piperidines a substituant phenyle, destinees a etre utilisees comme activateurs de ppar

Country Status (33)

Country Link
US (2) US7199243B2 (fr)
EP (1) EP1567493B1 (fr)
JP (1) JP4029091B2 (fr)
KR (2) KR100760055B1 (fr)
CN (1) CN100439337C (fr)
AR (1) AR042131A1 (fr)
AT (1) ATE425966T1 (fr)
AU (1) AU2003276596B8 (fr)
BR (1) BR0316521A (fr)
CA (1) CA2507465C (fr)
CO (1) CO5570701A2 (fr)
DE (1) DE60326752D1 (fr)
DK (1) DK1567493T3 (fr)
EA (1) EA008928B1 (fr)
ES (1) ES2321509T3 (fr)
GT (1) GT200300258A (fr)
HR (1) HRP20050437A2 (fr)
IS (1) IS7816A (fr)
MA (1) MA27532A1 (fr)
MX (1) MXPA05005583A (fr)
NL (1) NL1024881C2 (fr)
NO (1) NO20052921L (fr)
NZ (1) NZ539546A (fr)
PE (1) PE20040699A1 (fr)
PL (1) PL378268A1 (fr)
PT (1) PT1567493E (fr)
SI (1) SI1567493T1 (fr)
TN (1) TNSN05146A1 (fr)
TW (1) TW200424172A (fr)
UA (1) UA83202C2 (fr)
UY (1) UY28097A1 (fr)
WO (1) WO2004048334A1 (fr)
ZA (1) ZA200503104B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1567493T3 (da) * 2002-11-26 2009-06-08 Pfizer Prod Inc Phenyl-substituerede piperidin-forbindelser til anvendelse som PPAR-aktivatorer
WO2005115389A2 (fr) * 2004-05-25 2005-12-08 Pfizer Products Inc. Nouvelle utilisation
RU2342130C2 (ru) * 2004-05-25 2008-12-27 Пфайзер Продактс Инк. Применение агониста рецептора, активируемого пероксисомным пролифератором, для увеличения концентрации сывороточной глюкозы у жвачного животного
MX2007001634A (es) 2004-08-11 2007-04-23 Kyorin Seiyaku Kk Nuevo derivado de acido amino benzoico ciclico.
ES2328384T3 (es) * 2004-11-23 2009-11-12 Warner-Lambert Company Llc Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
US20090036489A1 (en) * 2005-03-22 2009-02-05 Masahiro Nomura Novel Cyclic Aminophenylalkanoic Acid Derivative
GB0510141D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
CN101296914B (zh) * 2005-08-26 2012-07-18 盐野义制药株式会社 具有ppar激动活性的衍生物
WO2007120605A2 (fr) * 2006-04-11 2007-10-25 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Traitement d'une maladie pulmonaire induite par la nicotine utilisant des agonistes gamma du recepteur active du proliferateur du peroxisome
CN101568533A (zh) * 2006-12-01 2009-10-28 埃科特莱茵药品有限公司 3-异芳基(氨基或酰胺基)-1-(联苯或苯基噻唑基)羰基哌啶衍生物食欲素受体抑制剂
WO2009011872A1 (fr) * 2007-07-17 2009-01-22 Merck & Co., Inc. Inhibiteurs époxyde hydrolase solubles, compositions contenant de tels composés et procédés de traitement
CN101711245B (zh) * 2007-07-19 2015-03-25 H.隆德贝克有限公司 5元杂环酰胺及相关的化合物
TW201006816A (en) 2008-05-15 2010-02-16 Organon Nv Hexafluoroisopropanol derivatives
FR2935510B1 (fr) 2008-08-28 2010-12-10 Oberthur Technologies Procede d'echange de donnees entre deux entites electroniques
FR2935511B1 (fr) 2008-08-28 2010-12-10 Oberthur Technologies Procede d'echange de donnees entre deux entites electroniques
UA107938C2 (en) * 2009-08-12 2015-03-10 Syngenta Participations Ag Heterocycles with microbicidal properties
US8716482B2 (en) * 2009-09-25 2014-05-06 Merck Sharp & Dohme Corp. Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
TWI513695B (zh) * 2009-10-27 2015-12-21 Merck Sharp & Dohme （１，１，１，３，３，３－六氟－２－羥基丙－２－基）苯基衍生物
EP2363825B1 (fr) 2010-03-04 2016-04-27 Inside Secure Procédé pour conduire une transaction au moyen d'un dispositif NFC
US20130345392A1 (en) 2011-03-04 2013-12-26 Pfizer Inc Edn3-like peptides and uses thereof
GB201314286D0 (en) 2013-08-08 2013-09-25 Takeda Pharmaceutical Therapeutic Compounds
RU2615769C2 (ru) * 2015-07-29 2017-04-11 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Уфимский Государственный Университет Экономики И Сервиса" Средство для ингибирования фермента альфа-амилазы
US20220411372A1 (en) * 2019-09-20 2022-12-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small-molecule inhibitors for the b-catenin/b-cell lymphoma 9 protein-protein interaction
CN116162056A (zh) * 2021-11-24 2023-05-26 上海医药工业研究院 β-catenin/BCL9蛋白-蛋白相互作用的小分子抑制剂及其应用
WO2024022521A1 (fr) * 2022-07-28 2024-02-01 南通环聚泰生物科技有限公司 Composé à petites molécules ciblant l'interaction bcl9/beta-caténine
WO2024145931A1 (fr) * 2023-01-06 2024-07-11 上海医药工业研究院有限公司 INHIBITEUR À PETITES MOLÉCULES POUR L'INTERACTION PROTÉINE-PROTÉINE β-CATÉNINE/BCL9 ET UTILISATION ASSOCIÉE

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2025518A1 (fr) 1969-06-05 1970-12-10
US4476311A (en) 1980-03-12 1984-10-09 The Purdue Frederick Company Analgesic 4-carboxy-pyrrolidin-2-one compound
EP0077607A1 (fr) * 1981-09-17 1983-04-27 Beecham Group Plc 3-Arylpipéridines N-substitués et leur dérivés
EP0115607A1 (fr) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Dérivés de tétrahydrocarbazole
GB9027023D0 (en) 1990-12-12 1991-01-30 Wellcome Found Anti-atherosclerotic aryl compounds
PT100441A (pt) 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
US5274143A (en) 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
AU2869092A (en) 1991-10-11 1993-05-03 Smithkline Beecham Corporation Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production
WO1993012086A1 (fr) * 1991-12-11 1993-06-24 Ss Pharmaceutical Co., Ltd. Derive d'arylamide
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
JP3233991B2 (ja) * 1992-06-26 2001-12-04 株式会社ソフィア 遊技機
DE69329894T2 (de) 1992-12-08 2001-05-03 Ss Pharmaceutical Co., Ltd. Arylamidderivate
AU3138595A (en) 1994-07-20 1996-02-16 Acea Pharmaceuticals, Inc. Haloperidol analogs and the use thereof
GB9606805D0 (en) 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
DE19614204A1 (de) 1996-04-10 1997-10-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JPH09312086A (ja) * 1996-05-22 1997-12-02 Matsushita Electric Ind Co Ltd 光ディスク再生システム、光ディスク再生方法および光ディスク
EP0930882A2 (fr) 1996-08-02 1999-07-28 Institut Pasteur De Lille Prevention ou traitement de diabetes non insulinodependants ou de maladies cardiovasculaires avec des modulateurs ppar
IT1286497B1 (it) 1996-11-20 1998-07-15 Italfarmaco Sud Spa Difosfine di tipo misto eteroariliche-ariliche come leganti chirali, relativi complessi con metalli di transizione e impiego di detti
ID24878A (id) * 1997-12-19 2000-08-31 Merck & Co Inc Turunan ariltiazolidinedion
ES2226284T3 (es) 1998-04-16 2005-03-16 Pfizer Products Inc. N-acil y n-aroil-aralquilamidas.
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
HN1999000149A (es) 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina
GB9822473D0 (en) 1998-10-16 1998-12-09 Glaxo Group Ltd Chemical compounds
US6303637B1 (en) 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
CA2324330A1 (fr) 1999-11-08 2001-05-08 Ssp Co., Ltd. Derives de la 4-hydroxy-4-phenylpiperidine et produits pharmaceutiques a base de ceux-ci
US20020045613A1 (en) 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
AU2000258650A1 (en) 2000-05-11 2001-11-20 Eli Lilly And Co 2-piperidone compounds for the treatment of cancer
DZ3347A1 (fr) 2000-05-22 2001-11-29 Aventis Pharma Inc Dérivés d'arylméthylamine pour leur utilisation comme inhibiteurs de la tryptase
AU2001211337A1 (en) 2000-10-06 2002-04-15 Smithkline Beecham Plc Process for the preparation of aryl-piperidine carbinols and intermediates thereof
EP1325912A4 (fr) 2000-10-12 2004-05-12 Ssp Co Ltd Derives 2,2-diphenylbutanamide et agents pharmaceutiques contenant ces composes
JP2002173426A (ja) 2000-12-05 2002-06-21 Ss Pharmaceut Co Ltd 血糖低下剤
US20040063742A1 (en) * 2001-02-15 2004-04-01 Dan Peters Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
MXPA03007284A (es) * 2001-02-15 2003-12-04 Pfizer Prod Inc Agonistas de receptor activador del proliferador de peroxisomas.
DK1567493T3 (da) * 2002-11-26 2009-06-08 Pfizer Prod Inc Phenyl-substituerede piperidin-forbindelser til anvendelse som PPAR-aktivatorer

Also Published As

Publication number Publication date
EA008928B1 (ru) 2007-08-31
HK1083502A1 (zh) 2006-07-07
EA200500629A1 (ru) 2005-12-29
DE60326752D1 (de) 2009-04-30
SI1567493T1 (sl) 2009-06-30
HRP20050437A2 (en) 2005-10-31
UY28097A1 (es) 2004-06-30
ZA200503104B (en) 2006-12-27
AR042131A1 (es) 2005-06-08
BR0316521A (pt) 2005-10-04
TW200424172A (en) 2004-11-16
ES2321509T3 (es) 2009-06-08
KR100875318B1 (ko) 2008-12-22
KR20070063051A (ko) 2007-06-18
NL1024881C2 (nl) 2009-09-16
PL378268A1 (pl) 2006-03-20
ATE425966T1 (de) 2009-04-15
CO5570701A2 (es) 2005-10-31
CN1717389A (zh) 2006-01-04
KR20050086794A (ko) 2005-08-30
MXPA05005583A (es) 2005-07-27
IS7816A (is) 2005-04-20
CA2507465C (fr) 2009-04-28
US7199243B2 (en) 2007-04-03
UA83202C2 (ru) 2008-06-25
US20070191429A1 (en) 2007-08-16
AU2003276596B8 (en) 2009-03-05
KR100760055B1 (ko) 2007-09-18
NL1024881A1 (nl) 2004-05-27
EP1567493A1 (fr) 2005-08-31
WO2004048334A1 (fr) 2004-06-10
CA2507465A1 (fr) 2004-06-10
AU2003276596A1 (en) 2004-06-18
NZ539546A (en) 2007-11-30
TNSN05146A1 (fr) 2007-05-14
EP1567493B1 (fr) 2009-03-18
JP2006509001A (ja) 2006-03-16
GT200300258A (es) 2004-11-30
JP4029091B2 (ja) 2008-01-09
NO20052921L (no) 2005-08-18
NO20052921D0 (no) 2005-06-15
PT1567493E (pt) 2009-04-09
DK1567493T3 (da) 2009-06-08
AU2003276596B2 (en) 2009-02-12
PE20040699A1 (es) 2004-10-23
US20040157885A1 (en) 2004-08-12
CN100439337C (zh) 2008-12-03

Similar Documents

Publication Publication Date Title
TNSN05146A1 (fr) Piperidines a substituant phenyle,destinees a etre utilisees comme activateurs de ppar
TNSN06447A1 (fr) Composes heteroaryle et phenylsulfamoyle substitues
MA27828A1 (fr) Dérivés de 1,2,3,4-tétrahydro- et 1,2-dihydro-quinoléine et 1,2,3,4-tétrahydroquinoxaline 1,2,4-substitués servant d'inhibiteurs de CETP pour le traitement de l'athérosclérose et de l'obésité
TNSN04164A1 (fr) Inhibiteurs de acc.
TNSN07100A1 (fr) Derives de 1, 2, 3, 4- tetrahydroquinoleine substitues en position 2 et a substituant 4-amino
MA26688A1 (fr) 4-carboxamino-2-substitue-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA27728A1 (fr) Antagonistes des recepteurs de cgrp
MA27774A1 (fr) Inhibiteurs de phosphatidylinositol 3-kinase
MY121838A (en) 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
AP2002002426A0 (en) Ppar agonists
IS4695A (is) (Metýlsúlfónýl)fenýl-2-(5H)-fúranón sem sýklóoxýgenasa-2 tálmar
UA70960C2 (uk) 4-амінозаміщені-2-заміщені-1,2,3,4-тетрагідрохіноліни як інгібітори протеїну, який переносить холестериловий етер
MA31087B1 (fr) Derives d'amide et d'ester d'indazolyle pour traiter des troubles medies par le recepteur de glucocorticoïde.
DE60329316D1 (de) Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
FI972415A0 (fi) Käänteismiselli-(L2) tai normaalin misellirakenteen (L1) muodostava koostumus, josta vapautuminen on säädeltyä
EP1961312A3 (fr) Mélanges d'huiles microbiennes et utilisations de ces mélanges
ES2154345T3 (es) Mezclas polimeras y su empleo como aditivo para destilados medios de petroleo.
TNSN00033A1 (fr) Composes nouveaux inhibiteurs de reabsorption de monoamines, procede pour leur preparation, et compositions pharmaceutiques les contenant
TNSN05073A1 (fr) Quinazolinones spirocondensees nouvelles et leur utilisation comme inhibiteurs de phosphodiesterase
TW200610525A (en) Substituted heteroaryl-and phenylsulfamoyl compounds
ATE217616T1 (de) Tetrasubstituierte imidazolderivate, verfahren zu ihrer herstellung, ihre anwendung als medikamente und diese enthaltende pharmazeutischen zusammensetzungen
FR2869611A1 (fr) Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
TNSN08347A1 (fr) Dibenzylamines et derives
FR2869615A1 (fr) Derives de l'acide butanoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques
IL113706A (en) N-hydroxyurea alkyl phenyl oxazoles and thiazoles uses thereof as anti-inflammatory agents and pharmaceutical compositions containing them