MA28271A1 - Dérivés de benzènesulfonylamino-pyridine -2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta- hydroxystéroïde-déshydrogénase de type 1(11-bêta-HSD-1)pour le traitement du diabète et de l'obésité - Google Patents

Dérivés de benzènesulfonylamino-pyridine -2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta- hydroxystéroïde-déshydrogénase de type 1(11-bêta-HSD-1)pour le traitement du diabète et de l'obésité

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Publication number
MA28271A1
MA28271A1 MA29114A MA29114A MA28271A1 MA 28271 A1 MA28271 A1 MA 28271A1 MA 29114 A MA29114 A MA 29114A MA 29114 A MA29114 A MA 29114A MA 28271 A1 MA28271 A1 MA 28271A1
Authority
MA
Morocco
Prior art keywords
beta
cr3r4
hsd
obesity
diabetes
Prior art date
Application number
MA29114A
Other languages
English (en)
Inventor
Martin Paul Edwards
Theodore Otto Johnson Jr
Sajiv Krishnan Nair
Michael Siu
Wendy Dianne Taylor
Stephan James Cripps
Yong Wang
Hengmiao Cheng
Christopher Ronald Smith
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA28271A1 publication Critical patent/MA28271A1/fr

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    • C07D209/04—Indoles; Hydrogenated indoles
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Abstract

Dérivés de benzènesulfonylamino-pyridine-2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta-hydroxystéroïde-déshydrogénase de type 1 (11-bêta-HSD-l) pour le traitement du diabète et de l'obésité La présente invention concerne des composés répondant à la formule (I), ou un de leurs sels pharmaceutiquement acceptables, dans laquelle : R1 est choisi dans le groupe consistant en des groupes alkyle en C1 à C6, - (CR3R4)t-(cycloalkyle en C3 à C12) , - (CR3R4)t(aryle en C6 à C12) et - ( CR3R4 ) t (hétéro-cyclyle tétra- à décagonal ; b et k sont choisis chacun indépendamment entre 1 et 2 ; j est choisi dans le groupe consistant en 0, 1 et 2 ; t, u, p, q et v sont choisis chacun indépendamment dans le groupe consistant en 0, 1, 2, 3, 4 et 5 ; T représente un groupe hétérocyclyle hexa- à décagonal contenant au moins un atome d'azote ; R2 est choisi dans le groupe consistant en H, des groupes alkyle en C1 à C6, - (CR3R4) t (cycloalkyle en C3 à C12) , - (CR3R4) t (aryle en C6 à C12) et - (CR3R4) t (hétérocyclyle tétra- à décagonal) ; chacun des groupes R3 et R4 est choisi indépendamment entre H et un groupe alkyle en Cx à C6, les atomes de carbone de T, R1, R2, R3 et R4 peuvent être chacun facultativement substitués avec 1 à 5 groupes R5 ; R5 est défini dans les revendications. Les composés de la présente invention sont des inhibiteurs de 11-(béta)-hsd-1 et il est considéré qu'ils sont utiles dans le traitement du diabète, de l'obésité, du glaucome, de 1'ostéoporose, de troubles cognitifs, de troubles immunitaires, de la dépression, de l'hypertension et de maladies métaboliques.
MA29114A 2003-12-19 2006-06-19 Dérivés de benzènesulfonylamino-pyridine -2-yle et composés apparentés servant d'inhibiteurs de la 11-bêta- hydroxystéroïde-déshydrogénase de type 1(11-bêta-HSD-1)pour le traitement du diabète et de l'obésité MA28271A1 (fr)

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