MA28454B1 - Utilisation d'antagonistes du recepteur cb1 pour preparer une composition utile pour le traitement des maladies hepatiques - Google Patents

Utilisation d'antagonistes du recepteur cb1 pour preparer une composition utile pour le traitement des maladies hepatiques

Info

Publication number
MA28454B1
MA28454B1 MA29302A MA29302A MA28454B1 MA 28454 B1 MA28454 B1 MA 28454B1 MA 29302 A MA29302 A MA 29302A MA 29302 A MA29302 A MA 29302A MA 28454 B1 MA28454 B1 MA 28454B1
Authority
MA
Morocco
Prior art keywords
treatment
receptor antagonists
preparing
composition useful
hepatic diseases
Prior art date
Application number
MA29302A
Other languages
English (en)
Inventor
Sophie Lotersztajn
Ariane Mallat
Pascale Grenard
Boris Julien
Van Nhieu Jeanne Tran
Original Assignee
Inst Nat Sante Rech Med
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Sanofi Aventis filed Critical Inst Nat Sante Rech Med
Publication of MA28454B1 publication Critical patent/MA28454B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne l'utilisation d'antagonistes du récepteur CB1 pour préparer une composition destinée au traitement des maladies hépatiques et se rapporte préférablement à l'utilisation de N-pipéridino-5 5-(4-chlorophényl)-l-(2, 4-dichlorophényl)-4-méthylpyrazole-3- carboxamide.
MA29302A 2004-03-09 2006-09-06 Utilisation d'antagonistes du recepteur cb1 pour preparer une composition utile pour le traitement des maladies hepatiques MA28454B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04290633A EP1574211A1 (fr) 2004-03-09 2004-03-09 Utilisation d'antagonistes des récepteurs CB1 pour la fabrication d'un médicament destiné au traitement des maladies hépatiques

Publications (1)

Publication Number Publication Date
MA28454B1 true MA28454B1 (fr) 2007-03-01

Family

ID=34814417

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29302A MA28454B1 (fr) 2004-03-09 2006-09-06 Utilisation d'antagonistes du recepteur cb1 pour preparer une composition utile pour le traitement des maladies hepatiques

Country Status (26)

Country Link
US (2) US8236763B2 (fr)
EP (3) EP1574211A1 (fr)
JP (1) JP2007527893A (fr)
KR (1) KR20070026415A (fr)
CN (1) CN1929828A (fr)
AR (1) AR048087A1 (fr)
AT (1) ATE520393T1 (fr)
AU (1) AU2005218937B2 (fr)
BR (1) BRPI0508560A (fr)
CA (1) CA2557976A1 (fr)
CY (1) CY1112078T1 (fr)
DK (1) DK1725223T3 (fr)
ES (1) ES2371552T3 (fr)
IL (1) IL177465A0 (fr)
MA (1) MA28454B1 (fr)
MX (1) MXPA06010287A (fr)
NO (1) NO20064603L (fr)
PL (1) PL1725223T3 (fr)
PT (1) PT1725223E (fr)
RU (1) RU2402328C2 (fr)
SI (1) SI1725223T1 (fr)
TN (1) TNSN06272A1 (fr)
TW (1) TWI337540B (fr)
UA (1) UA94025C2 (fr)
WO (1) WO2005084652A2 (fr)
ZA (1) ZA200607159B (fr)

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FR2861303A1 (fr) * 2003-10-24 2005-04-29 Sanofi Synthelabo Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
US7875647B2 (en) 2006-09-29 2011-01-25 Green Cross Corporation Heteroaryl-pyrazole derivatives as cannabinoid CB1 receptor antagonists
EP2593477A2 (fr) * 2010-07-15 2013-05-22 Oleg Iliich Epshtein Compositions pharmaceutiques et méthodes de traitement
US20120288442A1 (en) * 2011-05-11 2012-11-15 Atomic Energy Council-Institute Of Nuclear Energy Research Nuclear Imaging Method Using Molecular Target Detection Agent for Liver Fibrosis
CN104884057B (zh) * 2012-11-13 2019-08-20 美国政府(由卫生和人类服务部的部长所代表) 大麻素受体介导的化合物
US11155521B2 (en) 2012-11-13 2021-10-26 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor mediating compounds
KR102553870B1 (ko) 2014-03-27 2023-07-10 버드 락 바이오, 인크. 인간 카나비노이드 1(cb1) 수용체 결합 항체
JP6762930B2 (ja) 2014-05-09 2020-09-30 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ カンナビノイド受容体メディエータとしてのピラゾール誘導体およびそれらの使用
PE20181199A1 (es) 2015-09-30 2018-07-23 Bird Rock Bio Inc Anticuerpos que se unen al receptor cannabinoide 1 (cb1) humano
WO2017184412A1 (fr) * 2016-04-18 2017-10-26 Eli Lilly And Company Agoniste cannabinoïde de la purine pour traiter la stéatohépatite non alcoolique et la fibrose
WO2025260042A1 (fr) * 2024-06-14 2025-12-18 Amgen Inc. Constructions d'arni et procédés d'inhibition de l'expression de cnr1

Family Cites Families (34)

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US4100293A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids
AT394493B (de) * 1989-05-11 1992-04-10 Homosan Ag Pharmazeutisches praeparat zur behandlung von lebererkrankungen
US5492891A (en) * 1991-09-05 1996-02-20 Novo Nordisk A/S Method for treatment of patients with chronic liver disease
FR2713225B1 (fr) 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5596106A (en) 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
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US5939429A (en) * 1997-09-30 1999-08-17 Virginia Commonwealth University Cardiovascular uses of cannabinoid compounds
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
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FR2805818B1 (fr) 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
FR2805810B1 (fr) 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives de 3- amino-azetidine, les nouveaux derives et leur preparation
FR2809621B1 (fr) 2000-05-12 2002-09-06 Sanofi Synthelabo Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles comme antidiarrheiques
WO2001091746A1 (fr) * 2000-06-01 2001-12-06 The Mclean Hospital Corporation Procede pour traiter l'intoxication alcoolique et l'abus d'alcool
AR028800A1 (es) * 2000-07-11 2003-05-21 Bayer Ag Uso de cepas de parapoxvirus ovis contra fibrosis de organos
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FR2837706A1 (fr) 2002-03-28 2003-10-03 Sanofi Synthelabo Utilisation d'un antagoniste des recepteurs aux cannabinoides cb1 pour la preparation de medicaments utiles pour traiter les dysfonctionnements sexuels et/ou ameliorer les performances sexuelles
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FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
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Also Published As

Publication number Publication date
KR20070026415A (ko) 2007-03-08
AU2005218937B2 (en) 2011-07-07
IL177465A0 (en) 2007-07-04
CA2557976A1 (fr) 2005-09-15
AU2005218937A1 (en) 2005-09-15
ES2371552T3 (es) 2012-01-05
PL1725223T3 (pl) 2012-01-31
TW200534851A (en) 2005-11-01
RU2006134707A (ru) 2008-04-20
UA94025C2 (ru) 2011-04-11
RU2402328C2 (ru) 2010-10-27
CY1112078T1 (el) 2015-11-04
SI1725223T1 (sl) 2012-01-31
EP2305220A3 (fr) 2011-05-18
JP2007527893A (ja) 2007-10-04
BRPI0508560A (pt) 2007-08-14
ZA200607159B (en) 2008-02-27
EP2305220A2 (fr) 2011-04-06
EP1574211A1 (fr) 2005-09-14
US8604060B2 (en) 2013-12-10
CN1929828A (zh) 2007-03-14
US20120329833A1 (en) 2012-12-27
WO2005084652A2 (fr) 2005-09-15
MXPA06010287A (es) 2007-02-14
US20080214449A1 (en) 2008-09-04
TWI337540B (en) 2011-02-21
US8236763B2 (en) 2012-08-07
TNSN06272A1 (en) 2007-12-03
DK1725223T3 (da) 2011-11-28
HK1094674A1 (en) 2007-05-18
AR048087A1 (es) 2006-03-29
EP2305220B1 (fr) 2014-07-30
ATE520393T1 (de) 2011-09-15
EP1725223A2 (fr) 2006-11-29
NO20064603L (no) 2006-10-09
PT1725223E (pt) 2011-12-02
WO2005084652A3 (fr) 2005-12-08
EP1725223B1 (fr) 2011-08-17

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