MA28588B1 - Formes polymorphes d'hydrobromure d'acetate de methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, hydrobromure de clopidrogel - Google Patents

Formes polymorphes d'hydrobromure d'acetate de methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, hydrobromure de clopidrogel

Info

Publication number
MA28588B1
MA28588B1 MA29464A MA29464A MA28588B1 MA 28588 B1 MA28588 B1 MA 28588B1 MA 29464 A MA29464 A MA 29464A MA 29464 A MA29464 A MA 29464A MA 28588 B1 MA28588 B1 MA 28588B1
Authority
MA
Morocco
Prior art keywords
hydrobromide
dihydrothieno
chlorophenyl
pyridine
alpha
Prior art date
Application number
MA29464A
Other languages
English (en)
Inventor
Keith Richard Lorimer
Alicia Tee Fuay Ng
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA28588B1 publication Critical patent/MA28588B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
MA29464A 2004-04-20 2006-11-20 Formes polymorphes d'hydrobromure d'acetate de methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, hydrobromure de clopidrogel MA28588B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56379604P 2004-04-20 2004-04-20

Publications (1)

Publication Number Publication Date
MA28588B1 true MA28588B1 (fr) 2007-05-02

Family

ID=34966201

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29464A MA28588B1 (fr) 2004-04-20 2006-11-20 Formes polymorphes d'hydrobromure d'acetate de methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, hydrobromure de clopidrogel

Country Status (20)

Country Link
US (1) US20070088049A1 (fr)
EP (1) EP1756116A1 (fr)
JP (1) JP2007533744A (fr)
KR (1) KR20070012675A (fr)
CN (1) CN1997648A (fr)
AU (1) AU2005236034A1 (fr)
BR (1) BRPI0509997A (fr)
CA (1) CA2562507A1 (fr)
CR (1) CR8678A (fr)
EA (1) EA010831B1 (fr)
EC (1) ECSP066932A (fr)
IL (1) IL178680A0 (fr)
MA (1) MA28588B1 (fr)
MX (1) MXPA06012205A (fr)
NO (1) NO20065233L (fr)
NZ (1) NZ551371A (fr)
TN (1) TNSN06331A1 (fr)
UA (1) UA83919C2 (fr)
WO (1) WO2005103058A1 (fr)
ZA (1) ZA200608569B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
WO2006034451A2 (fr) * 2004-09-21 2006-03-30 Teva Pharmaceutical Industries Ltd. Bromhydrate de clopidogrel cristallin et procede de preparation correspondant
SI22492A (sl) * 2007-03-08 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Polimorfne oblike klopidogrel hidrobromida
UY31531A1 (es) * 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
ES2376057T3 (es) * 2008-02-26 2012-03-08 Laboratorios Lesvi, S.L. Formulaciones farmacéuticas que contienen clopidogrel.
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
JP2003524634A (ja) * 1999-12-06 2003-08-19 ユーロ−セルティーク，エス．エイ． ノシセプチン受容体親和性を有するベンズイミダゾール化合物
AU2002366383B2 (en) * 2001-12-18 2007-06-14 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
GB0325603D0 (en) * 2003-11-03 2003-12-10 Sandoz Ag Organic compounds
EA008972B1 (ru) * 2004-01-13 2007-10-26 Зентива А.С. Новые кристаллические формы гидробромида клопидогреля и способы их получения
EP1720884A1 (fr) * 2004-02-24 2006-11-15 Siegfried Generics International AG Sels de clopidogrel acceptables d'un point de vue pharmacologique

Also Published As

Publication number Publication date
AU2005236034A1 (en) 2005-11-03
ECSP066932A (es) 2006-12-20
CR8678A (es) 2007-08-28
JP2007533744A (ja) 2007-11-22
EP1756116A1 (fr) 2007-02-28
IL178680A0 (en) 2007-02-11
BRPI0509997A (pt) 2007-10-16
EA200601921A1 (ru) 2007-02-27
KR20070012675A (ko) 2007-01-26
EA010831B1 (ru) 2008-12-30
NO20065233L (no) 2006-11-14
MXPA06012205A (es) 2007-01-31
CN1997648A (zh) 2007-07-11
WO2005103058A1 (fr) 2005-11-03
TNSN06331A1 (en) 2008-02-22
UA83919C2 (en) 2008-08-26
CA2562507A1 (fr) 2005-11-03
ZA200608569B (en) 2007-12-27
NZ551371A (en) 2010-07-30
US20070088049A1 (en) 2007-04-19

Similar Documents

Publication Publication Date Title
DK1309597T3 (da) Polymorfer af en epothilonanalog
IL176607A0 (en) Benzo[d] isoxazol-3-ol daao inhibitors
HRP20040741A2 (en) Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
IL181867A0 (en) Crystalline clopidogrel hydrobromide and processes for preparation thereof
WO2007125544A3 (fr) Procédé de préparation de formes polymorphiques d'hydrogénosulfate de clopidogrel
IL178019A0 (en) METHODS FOR THE PREPARATION OF (3R,3aS,6aR)HEXAHYDRO-FURO[2,3-b]FURAN-3OL
ZA200608569B (en) Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
DK1620439T3 (da) Hidtil ukendte polymorfer af olanzapinhydrochlorid
ZA201000627B (en) 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1h-pyrrol[3,2-c]pyridine-4(5h)-one compounds and use as protein kinase inhibitors
EP1723149A4 (fr) Methode de fabrication de derives de thieno [3,2-c]pyridine et intermediaires utilises dans ces composes
EA200601922A1 (ru) Клопидогрель и его полиморфные формы
DK1246827T3 (da) Nye polymorfe former af olanzapin
PL357928A1 (en) Method of obtaining pharmaceutically pure polymorphic form of i olanzapine
ATE282042T1 (de) Thienopyridinderivate zur verwendung als entzündungshemmende mittel
FR2814167B1 (fr) Preparation de la camptothecine et de ses derives
WO2007087555A3 (fr) Novel polymorph e of olanzapine and preparation of anhydrous non-solvated crystaline polymorphic form i of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2,3-b][1,5]benzodiazepine (olansapine form i) from the polymorphic olanzapine form e
WO2008108742A3 (fr) Formes polymorphes de bromhydrate de clopidogrel
DK1392698T3 (da) Fremgangsmåde til fremstilling af 6-aryl-4H-s-triazolo-[3,4-c]thieno[2,3-e]-1,4-diazepiner
HU0700809D0 (en) Racemisation process for producing methyl (r,s)-(+)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4h)-acetate hydrogene sulfate intermediate
PL380849A1 (pl) Krystaliczna postać racemicznego -(2-chlorofenylo)-6,7-dihydrotieno[3,2-c]pirydylo-5(4H)-octanu metylu, sposób jej wytwarzania i zastosowanie
ATE513834T1 (de) Verfahren zur herstellung von (s)-(+)- clopidogrelbase und deren salzen
ATE291025T1 (de) Thienopyrimidine
NO20035523D0 (no) (Pyrido/tieno)-[f]-oksazepin-5-on-derivater
DK1590351T3 (da) Fremgangsmåder til fremstilling af chinazolinalkaloider
HK1076631A (zh) 噻嗯並[3，2-b]吡啶-6-腈及噻嗯並[2，3-b]吡啶-5-腈作為蛋白激酶抑制物