MA29643B1 - Benzocycloheptapyridines comme inhibiteurs du recepteur tyrozine kinase met - Google Patents

Benzocycloheptapyridines comme inhibiteurs du recepteur tyrozine kinase met

Info

Publication number
MA29643B1
MA29643B1 MA30591A MA30591A MA29643B1 MA 29643 B1 MA29643 B1 MA 29643B1 MA 30591 A MA30591 A MA 30591A MA 30591 A MA30591 A MA 30591A MA 29643 B1 MA29643 B1 MA 29643B1
Authority
MA
Morocco
Prior art keywords
tyrozine
benzocycloheptapyridines
receptor inhibitors
met receptor
kinase met
Prior art date
Application number
MA30591A
Other languages
English (en)
Inventor
Christopher J Dinsmore
James P Jewell
Jason D Katz
Michelle R Machacek
Ryan D Otte
Jonathan R Young
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA29643B1 publication Critical patent/MA29643B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des dérivés de 5H-benzo[4,5]cyclohepta[1,2-b] pyridine, qui sont utiles pour le traitement des maladies de prolifération cellulaire, pour le traitement des troubles associés à l'activité MET, et pour l'inhibition du récepteur tyrosine-kinase MET. L'invention concerne aussi des compositions qui comprennent ces composés, et des procédés les utilisant pour traiter le cancer chez les mammifères.
MA30591A 2005-06-23 2008-01-23 Benzocycloheptapyridines comme inhibiteurs du recepteur tyrozine kinase met MA29643B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69322905P 2005-06-23 2005-06-23
US72906105P 2005-10-21 2005-10-21
US78947306P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
MA29643B1 true MA29643B1 (fr) 2008-07-01

Family

ID=37595817

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30591A MA29643B1 (fr) 2005-06-23 2008-01-23 Benzocycloheptapyridines comme inhibiteurs du recepteur tyrozine kinase met

Country Status (21)

Country Link
EP (1) EP1896422B1 (fr)
KR (1) KR20080018907A (fr)
AR (1) AR057377A1 (fr)
AT (1) ATE520664T1 (fr)
BR (1) BRPI0612518A2 (fr)
CR (1) CR9579A (fr)
CY (1) CY1112038T1 (fr)
DO (1) DOP2006000143A (fr)
EC (1) ECSP078017A (fr)
IL (1) IL187895A0 (fr)
MA (1) MA29643B1 (fr)
MX (1) MX2007016533A (fr)
NI (1) NI200700318A (fr)
NO (1) NO20080417L (fr)
NZ (1) NZ563711A (fr)
PE (1) PE20070167A1 (fr)
PL (1) PL1896422T3 (fr)
PT (1) PT1896422E (fr)
SI (1) SI1896422T1 (fr)
TW (1) TW200738638A (fr)
WO (1) WO2007002258A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
US7893081B2 (en) * 2007-12-20 2011-02-22 Merck & Co., Inc. Tyrosine kinase inhibitors
US9238571B2 (en) 2009-09-30 2016-01-19 Merck Sharp & Dohme Limited Formulations for c-Met kinase inhibitors
JP5785171B2 (ja) 2009-09-30 2015-09-24 メルク・シャープ・エンド・ドーム・コーポレイション Ｃ−ｍｅｔキナーゼ阻害剤の結晶性塩酸塩
EP2588107A1 (fr) 2010-07-01 2013-05-08 Takeda Pharmaceutical Company Limited Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
WO2016135041A1 (fr) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Protéines de fusion et anticorps les contenant pour favoriser l'apoptose
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CA3159348A1 (fr) 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methodes pour le traitement de cancers qui ont acquis une resistance aux inhibiteurs de kinase
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2286275T3 (es) * 2001-09-19 2007-12-01 Pharmacia Corporation Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
WO2003084931A1 (fr) * 2002-04-02 2003-10-16 Merck & Co., Inc. Antagonistes 5h-benzo[4,5]cyclohepta[1,2-b]pyridines de nmda/nr2b

Also Published As

Publication number Publication date
NI200700318A (es) 2008-05-23
WO2007002258A2 (fr) 2007-01-04
ATE520664T1 (de) 2011-09-15
EP1896422B1 (fr) 2011-08-17
SI1896422T1 (sl) 2011-11-30
PE20070167A1 (es) 2007-04-16
IL187895A0 (en) 2008-03-20
KR20080018907A (ko) 2008-02-28
PT1896422E (pt) 2011-11-08
PL1896422T3 (pl) 2012-01-31
WO2007002258A3 (fr) 2007-06-07
CR9579A (es) 2008-03-06
NO20080417L (no) 2008-03-18
TW200738638A (en) 2007-10-16
NZ563711A (en) 2010-12-24
AR057377A1 (es) 2007-11-28
CY1112038T1 (el) 2015-11-04
ECSP078017A (es) 2008-01-23
BRPI0612518A2 (pt) 2010-11-23
MX2007016533A (es) 2008-03-06
DOP2006000143A (es) 2007-02-28
EP1896422A2 (fr) 2008-03-12

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