MA29788B1 - Combinaisons comprenant un inhibiteur des recepteurs vegf - Google Patents

Combinaisons comprenant un inhibiteur des recepteurs vegf

Info

Publication number
MA29788B1
MA29788B1 MA30759A MA30759A MA29788B1 MA 29788 B1 MA29788 B1 MA 29788B1 MA 30759 A MA30759 A MA 30759A MA 30759 A MA30759 A MA 30759A MA 29788 B1 MA29788 B1 MA 29788B1
Authority
MA
Morocco
Prior art keywords
vegf receptor
receptor inhibitor
combinations
composition
relates
Prior art date
Application number
MA30759A
Other languages
English (en)
Inventor
Andreas Billich
Anton Stuetz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0518671A external-priority patent/GB0518671D0/en
Priority claimed from GB0518672A external-priority patent/GB0518672D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA29788B1 publication Critical patent/MA29788B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

CETTE INVENTION CONCERNE UNE COMPOSITION COMPRENANT UN INHIBITEUR DES RÉCEPTEURS VEGF AINSI QU'UN AGENT FACILITANT LA PÉNÉTRATION. L'INVENTION CONCERNE ÉGALEMENT DES MÉTHODES PERMETTANT D'UTILISER UNE TELLE COMPOSITION.
MA30759A 2005-09-13 2008-03-17 Combinaisons comprenant un inhibiteur des recepteurs vegf MA29788B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0518671A GB0518671D0 (en) 2005-09-13 2005-09-13 Organic compounds
GB0518672A GB0518672D0 (en) 2005-09-13 2005-09-13 Organic compounds

Publications (1)

Publication Number Publication Date
MA29788B1 true MA29788B1 (fr) 2008-09-01

Family

ID=37663150

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30759A MA29788B1 (fr) 2005-09-13 2008-03-17 Combinaisons comprenant un inhibiteur des recepteurs vegf

Country Status (23)

Country Link
US (2) US20080306058A1 (fr)
EP (1) EP1945217B1 (fr)
JP (1) JP2009507871A (fr)
KR (1) KR20080058376A (fr)
AR (1) AR056194A1 (fr)
AT (1) ATE555790T1 (fr)
AU (1) AU2006291526B2 (fr)
BR (1) BRPI0615881A2 (fr)
CA (1) CA2621399A1 (fr)
EC (1) ECSP088259A (fr)
GT (1) GT200600411A (fr)
IL (1) IL189984A0 (fr)
MA (1) MA29788B1 (fr)
MY (1) MY145751A (fr)
NO (1) NO20081807L (fr)
NZ (1) NZ566474A (fr)
PE (1) PE20070457A1 (fr)
RU (1) RU2424804C2 (fr)
SA (1) SA06270315B1 (fr)
SG (1) SG165371A1 (fr)
TN (1) TNSN08112A1 (fr)
TW (1) TWI325321B (fr)
WO (1) WO2007031265A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0605120D0 (en) * 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
CA2683049A1 (fr) 2007-04-17 2008-10-23 Novartis Ag Composes organiques
AU2008288898B2 (en) * 2007-08-22 2014-08-07 Allergan, Inc. Therapeutic quinoline and naphthalene derivatives
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
US20110112121A1 (en) * 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
EP2661434A4 (fr) * 2011-01-06 2014-07-09 Beta Pharma Canada Inc Nouvelles urées pour le traitement et la prévention du cancer
US10149834B2 (en) 2011-12-01 2018-12-11 Teikoku Seiyaku Co., Ltd. Ropinirole-containing adhesive patch
EP2786752B1 (fr) * 2011-12-01 2019-06-12 Teikoku Seiyaku Co., Ltd. Timbre adhésif contenant du ropinirole
CA2908849C (fr) * 2013-04-09 2017-11-07 Guangzhou Hui Bo Rui Biological Pharmaceutical Technology Co., Ltd. Compose anti-angiogenese, intermediaire et son utilisation
CN106414402A (zh) * 2013-11-01 2017-02-15 宇部兴产株式会社 丙烯酰(氧基或氨基)五氟硫烷基苯化合物、其药学可接受的盐及其前药
US9856223B2 (en) 2013-12-13 2018-01-02 Dana-Farber Cancer Institute, Inc. Methods to treat lymphoplasmacytic lymphoma
CN104860885B (zh) 2014-02-24 2017-11-17 中国科学院上海药物研究所 萘酰胺类化合物、其制备方法和用途
JO3705B1 (ar) * 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
CN107098884A (zh) * 2016-02-19 2017-08-29 中国科学院上海药物研究所 一类取代的氨基吡啶类化合物及其制备和用途
MY199070A (en) 2016-06-01 2023-10-12 Bayer Pharma AG Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseaes in animals
CN113318110B (zh) 2020-02-28 2023-08-11 上海润石医药科技有限公司 一种csf-1r激酶抑制剂的用途

Family Cites Families (18)

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GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US5879690A (en) * 1995-09-07 1999-03-09 Perricone; Nicholas V. Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers
US6355657B1 (en) * 1998-12-30 2002-03-12 Atrix Laboratories, Inc. System for percutaneous delivery of opioid analgesics
CA2381821A1 (fr) * 1999-08-27 2001-03-08 Boehringer Ingelheim Pharma Kg Indolinones substitues, leurs fabrications et leurs utilisations comme medicaments
CN1400897A (zh) * 2000-06-01 2003-03-05 沃特森药物公司 Lasofoxifene的经皮转运
CA2423050A1 (fr) * 2000-09-20 2002-03-28 Ortho-Mcneil Pharmaceutical, Inc. Derives de pyrazine tenant lieu de modulateurs de tyrosine kinase
DE60137273D1 (de) * 2000-10-20 2009-02-12 Eisai R&D Man Co Ltd Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten
DE60223694T2 (de) * 2001-09-04 2008-10-30 Trommsdorff Gmbh & Co. Kg Arzneimittel Pflaster zur behandlung von funktionsstörungen und störungen des nagelwachstums
MXPA04007832A (es) * 2002-02-11 2005-09-08 Bayer Pharmaceuticals Corp Aril-ureas con actividad inhibitoria de angiogenesis.
EP1509236A4 (fr) * 2002-05-13 2008-07-30 Children S Hospital Los Angele Traitement et prevention d'une formation de cicatrices anormales dans des cheloides et d'autres blessures ou lesions cutanees ou internes
TW200406374A (en) 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
WO2004020434A1 (fr) * 2002-08-30 2004-03-11 Eisai Co., Ltd. Derives d'azaarene
US20040266688A1 (en) * 2003-05-14 2004-12-30 Nayak Nihar R Methods for modulating endometrium
EP1660503A1 (fr) * 2003-08-29 2006-05-31 Pfizer Inc. Carboxamides de naphtalene et leurs derives utiles comme nouveaux agents anti-angiogeniques
US20090155266A1 (en) * 2004-01-16 2009-06-18 Yale University Methods and Compositions Relating to Vascular Endothelial Growth Factor and TH2 Mediated Inflammatory Diseases
JP4932495B2 (ja) * 2004-01-23 2012-05-16 アムゲン インコーポレイテッド 化合物及び使用方法
EP1568368A1 (fr) * 2004-02-26 2005-08-31 Schering Aktiengesellschaft Combinaison pharmaceutique comprenant un inhibiteur de CDK et un inhibiteur du recepteur VEGF
PE20060664A1 (es) * 2004-09-15 2006-08-04 Novartis Ag Amidas biciclicas como inhibidores de cinasa

Also Published As

Publication number Publication date
AU2006291526B2 (en) 2010-07-29
NO20081807L (no) 2008-05-16
NZ566474A (en) 2011-05-27
KR20080058376A (ko) 2008-06-25
RU2008114048A (ru) 2009-10-20
TWI325321B (en) 2010-06-01
PE20070457A1 (es) 2007-06-06
CA2621399A1 (fr) 2007-03-22
IL189984A0 (en) 2008-11-03
ECSP088259A (es) 2008-04-28
WO2007031265A3 (fr) 2007-07-12
AU2006291526A1 (en) 2007-03-22
RU2424804C2 (ru) 2011-07-27
AR056194A1 (es) 2007-09-26
SA06270315B1 (ar) 2010-12-21
ATE555790T1 (de) 2012-05-15
US20120172386A1 (en) 2012-07-05
TNSN08112A1 (en) 2009-07-14
EP1945217B1 (fr) 2012-05-02
MY145751A (en) 2012-03-30
JP2009507871A (ja) 2009-02-26
WO2007031265A2 (fr) 2007-03-22
US20080306058A1 (en) 2008-12-11
SG165371A1 (en) 2010-10-28
BRPI0615881A2 (pt) 2011-05-31
EP1945217A2 (fr) 2008-07-23
TW200744600A (en) 2007-12-16
GT200600411A (es) 2007-05-21

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