MA30252B1 - Vaccin therapeutique - Google Patents

Vaccin therapeutique

Info

Publication number
MA30252B1
MA30252B1 MA31115A MA31115A MA30252B1 MA 30252 B1 MA30252 B1 MA 30252B1 MA 31115 A MA31115 A MA 31115A MA 31115 A MA31115 A MA 31115A MA 30252 B1 MA30252 B1 MA 30252B1
Authority
MA
Morocco
Prior art keywords
amyloidosis
amyloid
diseases
disorders
compositions
Prior art date
Application number
MA31115A
Other languages
English (en)
Inventor
Andrea Pfeifer
Claude Nicolau
Original Assignee
Ac Immune Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37836865&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30252(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ac Immune Sa filed Critical Ac Immune Sa
Publication of MA30252B1 publication Critical patent/MA30252B1/fr

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    • A61K39/002—Protozoa antigens
    • A61K39/008—Leishmania antigens
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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Abstract

La présente invention concerne des procédés et des compositions d'utilisation thérapeutique et diagnostique dans le traitement de maladies et de troubles causés par des protéines amyloïde ou de type amyloïde ou associés à ces protéines, notamment l'amylose. Cette invention concerne en particulier de nouveaux procédés et de nouvelles compositions permettant d'éliciter une réponse immunitaire hautement spécifique et hautement sélective dans un organisme, mais plus particulièrement chez un mammifère ou chez un humain, qui est capable de prévenir ou d'atténuer l'amylose, ou les symptômes associés à l'amylose, un groupe de maladies et de troubles associés à la formation de plaque d'amyloïdes notamment l'amylose secondaire et l'amylose liée à l'âge, notamment des troubles neurologiques tels que la maladie d'Alzheimer (AD), notamment des maladies ou des pathologies caractérisées par une perte de capacité de mémoire cognitive, telles que par exemple la déficience intellectuelle légère (MCI).
MA31115A 2005-12-12 2008-07-11 Vaccin therapeutique MA30252B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05027091 2005-12-12
EP06009098 2006-05-02

Publications (1)

Publication Number Publication Date
MA30252B1 true MA30252B1 (fr) 2009-03-02

Family

ID=37836865

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Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
BRPI0619249A2 (pt) 2005-11-30 2011-09-20 Abbott Lab anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
PT1976877E (pt) 2005-11-30 2014-04-29 Abbvie Inc Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações
CN104761637B (zh) 2006-03-31 2021-10-15 中外制药株式会社 调控抗体血液动力学的方法
BRPI0719379A2 (pt) 2006-11-24 2014-02-11 Ac Immune Sa Composto, composição farmacêutica, uso de composto, mistura, métodos para coletar dados para o diagnóstico de uma doença ou condição associada com amilóide em uma amostra ou um paciente, para determinar a extensão da carga de placa amiloidogênica em um tecido e/ou um fluido corporal, para coletar dados para determinar a predisposição a uma doença ou condição associada com amilóide em um paciente, para coletar dados para monitorar a doença residual mínima em um paciente seguindo o tratamento com um anticorpo ou uma composição de vacina e para coletar dados para predizer a responsividade de um paciente sendo tratado com um anticorpo ou uma composição de vacina, e, kit de teste
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2124952A2 (fr) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Méthode de traitement d'amyloïdoses
EP2481408A3 (fr) 2007-03-01 2013-01-09 Probiodrug AG Nouvelle utilisation d'inhibiteurs glutaminyle cyclase
WO2008128985A1 (fr) 2007-04-18 2008-10-30 Probiodrug Ag Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
EP2106802A1 (fr) 2008-04-02 2009-10-07 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Peptides modifiés en tant que vaccins synthétiques dans une maladie associée à l'amyloïde
EP2275443B1 (fr) 2008-04-11 2015-12-02 Chugai Seiyaku Kabushiki Kaisha Molécule de liaison à l antigène capable de se lier à deux molécules d antigène ou plus de manière répétée
EP3936122A1 (fr) 2008-11-24 2022-01-12 Massachusetts Institute Of Technology Procédés et compositions pour l'administration localisée d'un agent
EP3978517A1 (fr) * 2009-03-18 2022-04-06 AC Immune SA Procédé d'utilisation thérapeutique
UA107571C2 (xx) 2009-04-03 2015-01-26 Фармацевтична композиція
KR100929372B1 (ko) * 2009-05-22 2009-12-02 고려대학교 산학협력단 아밀로이드 베타 단편을 유효성분으로 포함하는 돌연변이 ｓｏｄ1에 의한 ａｌｓ 예방 및 치료용 조성물
AT508638B1 (de) * 2009-08-21 2011-08-15 Affiris Ag Verwendung von peptiden und polypeptiden zur behandlung und/oder prävention von synukleinopathien
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
EP2311823A1 (fr) 2009-10-15 2011-04-20 AC Immune S.A. Composés de 2,6-diaminopyridine appropriés pour le traitement de maladies liées à des protéines amyloïdes ou pour le traitement de maladies oculaires
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
US9149432B2 (en) 2010-03-19 2015-10-06 Massachusetts Institute Of Technology Lipid vesicle compositions and methods of use
WO2011115684A2 (fr) 2010-03-19 2011-09-22 Massachusetts Institute Of Technology Compositions de vésicules lipidiques et procédés pour les utiliser
US20110229556A1 (en) * 2010-03-19 2011-09-22 Massachusetts Institute Of Technology Lipid-coated polymer particles for immune stimulation
EP2558494B1 (fr) 2010-04-15 2018-05-23 AbbVie Inc. Protéines de liaison à la bêta amyloïde
US20110256064A1 (en) 2010-04-16 2011-10-20 Ac Immune, S.A. Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins
AU2011239966B2 (en) 2010-04-16 2014-05-08 Ac Immune S.A. Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
WO2011131748A2 (fr) 2010-04-21 2011-10-27 Probiodrug Ag Nouveaux inhibiteurs
EP2603233A1 (fr) 2010-08-12 2013-06-19 AC Immune S.A. Vaccin obtenu par génie génétique
CN105348387B (zh) 2010-08-14 2020-08-25 Abbvie 公司 β淀粉样蛋白结合蛋白
JP6027011B2 (ja) 2010-10-26 2016-11-16 エーシー イミューン ソシエテ アノニム 疎水性部分によって修飾されたペプチドを含むリポソームベースの構築物
TWI654204B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
US20120148542A1 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
KR20160005380A (ko) * 2011-09-23 2016-01-15 에이씨 이뮨 에스.에이. 백신 요법
EP2834270B1 (fr) 2012-04-05 2019-10-30 AC Immune S.A. Anticorps tau humanisé
BR112015023262B8 (pt) 2013-03-15 2024-02-06 Ac Immune Sa Anticorpo isolado, imunoconjugado, formulação farmacêutica e usos do anticorpo
CA2925304C (fr) 2013-09-27 2023-04-18 Massachusetts Institute Of Technology Nanostructures proteiques biologiquement actives sans entraineur
WO2015095780A1 (fr) * 2013-12-20 2015-06-25 The University Of Kansas Agonistes des récepteurs toll-like 8
SG10201710322VA (en) * 2014-12-19 2018-02-27 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
NZ730607A (en) 2014-12-19 2022-07-01 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
WO2016125495A1 (fr) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Anticorps comprenant un domaine se liant à l'antigène dépendant de la concentration d'ions, variants de la région fc, anticorps se liant à l'il-8, et leurs utilisations
FI3273986T3 (fi) * 2015-03-27 2024-02-07 Immatics Biotechnologies Gmbh Uusia peptidejä ja peptidien yhdistelmiä käytettäväksi immunoterapiassa eri syöpiä vastaan
AU2016305087B2 (en) 2015-08-12 2022-01-20 Massachusetts Institute Of Technology Cell surface coupling of nanoparticles
US11472856B2 (en) 2016-06-13 2022-10-18 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
BR112019001902A2 (pt) 2016-08-05 2019-07-09 Chugai Seiyaku Kabushiki Kaisha composição para profilaxia ou tratamento de doenças relacionadas à il-8
WO2018081085A1 (fr) * 2016-10-25 2018-05-03 The Regents Of The University Of California Méthodes de diagnostic et de traitement de la maladie d'alzheimer
US11389465B2 (en) 2017-05-01 2022-07-19 Vanderbilt University Phosphorylated hexaacyl disaccharides (PHADs) for treating or preventing infections
KR20210032924A (ko) 2017-09-05 2021-03-25 토크 테라퓨틱스, 인코포레이티드 치료용 단백질 조성물 및 그의 제조 및 사용 방법
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
EA202091012A1 (ru) 2017-10-25 2020-08-27 Янссен Фармасьютикалз, Инк. Композиции фосфорилированных тау-пептидов и их применения
CN108037277A (zh) * 2017-12-07 2018-05-15 中国兽医药品监察所 一种区分牛布鲁氏菌疫苗免疫与自然感染状态的方法
PE20201344A1 (es) 2018-04-10 2020-11-25 Ac Immune Sa Vacunas terapeuticas anti-abeta
CN112165956A (zh) * 2018-04-10 2021-01-01 Ac免疫有限公司 抗Aβ治疗性疫苗
US12016885B2 (en) 2018-11-06 2024-06-25 Alsatech, Inc. Method of solubilizing TDP-43 protein aggregates in amyotrophic lateral sclerosis using a microvascular endothelial cell expressing an anti-TDP-43 Fab
CN113710269A (zh) 2019-02-08 2021-11-26 Ac免疫有限公司 磷酸化Tau肽疫苗的安全施用方法
MA55902A (fr) 2019-04-24 2022-03-16 Ac Immune Sa Administration hétérologue de vaccins tau
EP3972633A1 (fr) 2019-05-21 2022-03-30 AC Immune SA Vaccinothérapie anti-abêta
WO2021207303A1 (fr) * 2020-04-07 2021-10-14 Alsatech, Inc. Stimulation immunitaire contre des infections à coronavirus
KR20250137159A (ko) 2023-01-26 2025-09-17 에이씨 이뮨 에스에이 항-a베타 백신 요법
WO2025109524A1 (fr) 2023-11-22 2025-05-30 Ac Immune Sa Dosages et procédés d'évaluation de préparations vaccinales
WO2025196262A1 (fr) 2024-03-22 2025-09-25 Ac Immune Sa Dosage immunologique impliquant des anticorps se liant à des adjuvants vaccinaux

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847082A (en) 1987-01-21 1989-07-11 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US6787523B1 (en) * 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
NZ540564A (en) * 1999-11-29 2007-04-27 Neurochem Int Ltd Vaccine for the prevention and treatment of Alzheimer's and amyloid related diseases
DE10003992A1 (de) * 2000-01-29 2001-08-09 Bosch Gmbh Robert Sensoranordnung
WO2002021141A2 (fr) * 2000-09-06 2002-03-14 Aventis Pharma S.A. Procedes et compositions relatifs a des maladies associees a l'amyloide
EP1203614A1 (fr) 2000-11-03 2002-05-08 Polymun Scientific Immunbiologische Forschung GmbH Procédé et dispositif pour la préparation de vésicules de lipides
US6906169B2 (en) * 2001-05-25 2005-06-14 United Biomedical, Inc. Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide
CA2488230C (fr) * 2002-04-29 2013-04-09 Yves Claude Nicolau Inositol pyrophosphates et procede d'utilisation desdits composes
WO2004058239A1 (fr) 2002-12-24 2004-07-15 Neurochem (International) Limited Formulations therapeutiques destinees au traitement de maladies liees au peptide beta-amyloide
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
EP1629098B1 (fr) * 2003-06-02 2009-04-01 Varleigh Limited Inhibiteurs du complement
WO2005012330A2 (fr) * 2003-07-30 2005-02-10 Brigham And Women's Hospital, Inc. Peptide $g(b)-amyloide et procedes pour l'utiliser
US20060257396A1 (en) * 2004-12-15 2006-11-16 Jacobsen Jack S Abeta antibodies for use in improving cognition
EP1676859A1 (fr) * 2004-12-30 2006-07-05 Pevion Biotech Ltd. Compositions immunogènes contenant des peptides cycliques derivés du peptide beta-amyloide
MX2008007477A (es) * 2005-12-12 2008-09-03 Ac Immune Sa Anticuerpos monoclonales especificos 1-42 beta con propiedades terapeuticas.

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