MA30425B1 - ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE - Google Patents

ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE

Info

Publication number
MA30425B1
MA30425B1 MA31403A MA31403A MA30425B1 MA 30425 B1 MA30425 B1 MA 30425B1 MA 31403 A MA31403 A MA 31403A MA 31403 A MA31403 A MA 31403A MA 30425 B1 MA30425 B1 MA 30425B1
Authority
MA
Morocco
Prior art keywords
high affinity
human
antiintegrin
blockage
reduced immunogenicity
Prior art date
Application number
MA31403A
Other languages
English (en)
Inventor
Andreas Menrad
Joerg Willuda
Klaus Bosslet
Dieter Zopf
Heike Petrul
Stefan Steidl
Josef Prassler
Corinne Petit-Frere
Original Assignee
Bayer Schering Pharma Ag
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Morphosys Ag filed Critical Bayer Schering Pharma Ag
Publication of MA30425B1 publication Critical patent/MA30425B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES POLYPEPTIDES RECOMBINANTS HUMAINS OU HUMANISÉS QUI SE LIENT À L'INTÉGRINE A5ß1 AVEC UNE AFFINITÉ ÉLEVÉE ET QUI ONT UNE FONCTION DE BLOCAGE. L'INVENTION CONCERNE EN OUTRE DES APPLICATIONS DIAGNOSTIQUES ET PHARMACEUTIQUES DES POLYPEPTIDES
MA31403A 2006-05-24 2008-11-21 ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE MA30425B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06010779 2006-05-24

Publications (1)

Publication Number Publication Date
MA30425B1 true MA30425B1 (fr) 2009-05-04

Family

ID=38659612

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31403A MA30425B1 (fr) 2006-05-24 2008-11-21 ANTICORPS D'AFFINITE ELEVEE HUMAINS ET HUMANISES A FONCTION DE BLOCAGE ANTI-INTEGRINE a5ß1 AYANT UNE IMMUNOGENICITE REDUITE

Country Status (23)

Country Link
US (1) US20090081207A1 (fr)
EP (1) EP2032605A2 (fr)
JP (1) JP2009537158A (fr)
KR (1) KR20090027218A (fr)
CN (1) CN101495515A (fr)
AR (1) AR061107A1 (fr)
AU (1) AU2007253586A1 (fr)
BR (1) BRPI0711796A2 (fr)
CA (1) CA2652886A1 (fr)
CL (1) CL2007001488A1 (fr)
CR (1) CR10456A (fr)
DO (2) DOP20070101A (fr)
EA (1) EA200802348A1 (fr)
EC (1) ECSP088909A (fr)
MA (1) MA30425B1 (fr)
MX (1) MX2008014910A (fr)
NO (1) NO20085362L (fr)
PE (1) PE20080100A1 (fr)
TN (1) TNSN08469A1 (fr)
TW (1) TW200817433A (fr)
UY (1) UY30362A1 (fr)
WO (1) WO2007134876A2 (fr)
ZA (1) ZA200810850B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2511298B1 (fr) 2005-10-31 2019-01-16 Oncomed Pharmaceuticals, Inc. Compositions et procédés pour le traitement du cancer utilisant des recepteurs FZD humains
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
CA2646611A1 (fr) 2006-03-21 2008-05-22 Genentech, Inc. Therapies combinatoires
US7973138B2 (en) 2007-09-26 2011-07-05 Genentech, Inc. Antibodies
AU2009212442C1 (en) * 2008-02-05 2014-07-17 Bristol-Myers Squibb Company Alpha 5 - beta 1 antibodies and their uses
TWI506037B (zh) 2008-09-26 2015-11-01 Oncomed Pharm Inc 捲曲結合劑類及彼等之用途
WO2010054212A1 (fr) * 2008-11-06 2010-05-14 Alexion Pharmaceuticals, Inc. Mise au point d’anticorps à immunogénicité réduite et méthodes de fabrication associées
JP2012513194A (ja) 2008-12-23 2012-06-14 アストラゼネカ アクチボラグ α５β１に向けられた標的結合剤およびその使用
JP6051048B2 (ja) * 2009-03-25 2016-12-21 ジェネンテック， インコーポレイテッド 新規な抗α５β１抗体及びその使用
GB0918249D0 (en) 2009-10-19 2009-12-02 Respivert Ltd Compounds
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
WO2011123785A2 (fr) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Agents de liaison aux récepteurs frizzled et leurs utilisations
NZ604805A (en) * 2010-07-09 2014-09-26 Affibody Ab Polypeptides
UY33337A (es) 2010-10-18 2011-10-31 Respivert Ltd DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
EP2545905A1 (fr) 2011-07-11 2013-01-16 Britannia Pharmaceuticals Limited Nouvelle composition thérapeutique contenant de l'apomorphine en tant que principe actif
JP6189874B2 (ja) 2012-03-13 2017-08-30 レスピバート・リミテツド 新規製薬学的製剤
EP2911691B1 (fr) 2012-10-23 2018-10-10 OncoMed Pharmaceuticals, Inc. Méthodes de traitement de tumeurs neuro-endocrines à l'aide d'agents liants de parcours wnt
US10023638B2 (en) * 2012-12-26 2018-07-17 Oncosynergy, Inc. Anti-integrin β1 antibody compositions and methods of use thereof
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
CN108430489B (zh) 2015-06-28 2022-03-25 新源生物科技股份有限公司 用于抑制血管新生的融合蛋白
WO2021015336A1 (fr) * 2019-07-24 2021-01-28 가톨릭대학교 산학협력단 ANTICORPS À DOMAINE UNIQUE CIBLANT L'INTÉGRINE αVβ3
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013495A (en) * 1994-10-21 2000-01-11 The Scripps Research Institute Methods of use for integrin B1C cell growth inhibitor
US6852318B1 (en) * 1998-05-08 2005-02-08 The Regents Of The University Of California Methods for detecting and inhibiting angiogenesis
US7285268B2 (en) * 2002-11-26 2007-10-23 Pdl Biopharma, Inc. Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
US7276589B2 (en) * 2002-11-26 2007-10-02 Pdl Biopharma, Inc. Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
EP1575516B1 (fr) * 2002-11-26 2012-05-30 Abbott Biotherapeutics Corp. Anticorps chimeriques et humanises diriges contre l'integrine alpha5 beta1 modulant l'angiogenese
ATE531388T1 (de) * 2004-03-24 2011-11-15 Abbott Biotherapeutics Corp Verwendung von anti-alpha5beta1-antikörpern zur hemmung der krebszellproliferation
CA2646611A1 (fr) * 2006-03-21 2008-05-22 Genentech, Inc. Therapies combinatoires

Also Published As

Publication number Publication date
CL2007001488A1 (es) 2008-01-04
CR10456A (es) 2009-02-26
DOP2007000101A (es) 2007-12-31
AU2007253586A1 (en) 2007-11-29
KR20090027218A (ko) 2009-03-16
WO2007134876A2 (fr) 2007-11-29
WO2007134876A3 (fr) 2008-03-27
UY30362A1 (es) 2008-01-02
NO20085362L (no) 2009-02-23
MX2008014910A (es) 2009-01-23
EP2032605A2 (fr) 2009-03-11
CN101495515A (zh) 2009-07-29
AR061107A1 (es) 2008-08-06
EA200802348A1 (ru) 2009-08-28
CA2652886A1 (fr) 2007-11-29
DOP20070101A (es) 2007-12-30
TW200817433A (en) 2008-04-16
ZA200810850B (en) 2010-05-26
US20090081207A1 (en) 2009-03-26
TNSN08469A1 (en) 2010-04-14
BRPI0711796A2 (pt) 2011-12-06
ECSP088909A (es) 2008-12-30
WO2007134876A8 (fr) 2009-07-02
JP2009537158A (ja) 2009-10-29
PE20080100A1 (es) 2008-04-18

Similar Documents

Publication Publication Date Title
CU20080088A7 (es) Anticuerpos antagonistas dirigidos contra el péptido relacionado con el gen de calcitonina
WO2006105062A3 (fr) Régions fc d'anticorps altérées et utilisations de celles-ci
WO2007117505A3 (fr) Polypeptides presentant des proprietes anti-inflammatoires accrues et des proprietes cytotoxiques reduites, et procedes coorespondants
TNSN08469A1 (en) HIGH AFFINITY HUMAN AND HUMANIZED ANTI-α5β1 INTEGRIN FUNCTION BLOCKING ANTIBODIES WITH REDUCED IMMUNOGENICITY
TW200709817A (en) Platform antibody compositions
LUC00075I2 (en) Glycerol linked pegylated sugars and glycopeptides
MA32892B1 (fr) Anticorps anti-cmet
WO2008002933A3 (fr) COMBINAISON D'ANTICORPS DE FCγRIIB ET D'ANTICORPS SPÉCIFIQUES DE CD20 ET LEURS PROCÉDÉS D'UTILISATION
MA31092B1 (fr) Anticorps humains contre le delta-like ligand 4 humain.
CA2668898C (fr) Systemes d'agents tensioactifs epaissis comprenant de la cellulose microfibreuse, et leurs procedes de fabrication
TR200202254T2 (tr) IL-18 Kaynaklı rahatsızlıkların tedavisinde faydalı rekombinant IL-18 antagonistleri.
MX337423B (es) Antagonistas anti-beta7 humanizados y usos para los mismos.
WO2007011941A3 (fr) Anticorps neutralisants anti-b7rp1 humains
MA33470B1 (fr) Polythérapie à base d'un anticorps afucosylé anti-cd20 et de fludarabine et/ou mitoxantrone
TW200714290A (en) Anti-M-CSF antibody compositions having reduced levels of endotoxin
EP2025749A4 (fr) Anticorps d'ostéopontine anti-humains humanisés
WO2004108766A3 (fr) Anticorps anti-hgf-r et leur utilisation
AU306659S (en) Two-way flashlight
MA33380B1 (fr) Dispositif de profile pour plancher
SG170804A1 (en) Pseudomonas aeruginosa outer membrane protein pa0427
EP1976878A4 (fr) Séquence d'une région varibale de l'anticorps stro-1
MA35890B1 (fr) Élément de liaison doté de parties en saillie de section conique ou semi-conique
EP2084180A4 (fr) Préparation d'un facteur de transcription artificielle comprenant une protéine à doigts de zinc et un facteur de transcription de procaryote, et utilisation de cette préparation
WO2007033140A3 (fr) Antagonistes prok2 et leurs procedes d'utilisation
WO2006109045A3 (fr) Anticorps et leurs utilisations