MA30565B1 - Procede de diagnostic et traitement anticancereux - Google Patents
Procede de diagnostic et traitement anticancereuxInfo
- Publication number
- MA30565B1 MA30565B1 MA31490A MA31490A MA30565B1 MA 30565 B1 MA30565 B1 MA 30565B1 MA 31490 A MA31490 A MA 31490A MA 31490 A MA31490 A MA 31490A MA 30565 B1 MA30565 B1 MA 30565B1
- Authority
- MA
- Morocco
- Prior art keywords
- diagnostic method
- anticancer treatment
- mage
- gene
- specific
- Prior art date
Links
- 238000002405 diagnostic procedure Methods 0.000 title abstract 2
- 238000011394 anticancer treatment Methods 0.000 title 1
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Manufacturing & Machinery (AREA)
- Epidemiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La présente invention concerne des amorces et des sondes spécifiques au gène MAGE-A3 destinées à être utilisées dans de nouveaux procédés et kits de diagnostic. L'invention concerne en outre le traitement immunothérapeutique de populations spécifiques de patients atteints de cancer souffrant de tumeurs exprimant le gène MAGE-A3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0612342.6A GB0612342D0 (en) | 2006-06-21 | 2006-06-21 | Method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30565B1 true MA30565B1 (fr) | 2009-07-01 |
Family
ID=36803668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA31490A MA30565B1 (fr) | 2006-06-21 | 2008-12-19 | Procede de diagnostic et traitement anticancereux |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8936919B2 (fr) |
| EP (1) | EP2041308B1 (fr) |
| JP (2) | JP2009540812A (fr) |
| KR (1) | KR101455589B1 (fr) |
| CN (1) | CN101506383B (fr) |
| AU (1) | AU2007263019B2 (fr) |
| BR (1) | BRPI0713599A2 (fr) |
| CA (1) | CA2656909A1 (fr) |
| CO (1) | CO6140072A2 (fr) |
| CY (1) | CY1113290T1 (fr) |
| DK (1) | DK2041308T3 (fr) |
| EA (1) | EA016347B1 (fr) |
| ES (1) | ES2389513T3 (fr) |
| GB (1) | GB0612342D0 (fr) |
| HR (1) | HRP20120761T1 (fr) |
| IL (1) | IL195975A (fr) |
| MA (1) | MA30565B1 (fr) |
| MX (1) | MX2008016493A (fr) |
| MY (1) | MY147511A (fr) |
| NO (1) | NO20085290L (fr) |
| NZ (1) | NZ573809A (fr) |
| PL (1) | PL2041308T3 (fr) |
| PT (1) | PT2041308E (fr) |
| SI (1) | SI2041308T1 (fr) |
| UA (1) | UA95956C2 (fr) |
| WO (1) | WO2007147876A2 (fr) |
| ZA (1) | ZA200810695B (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008300397A1 (en) | 2007-09-17 | 2009-03-26 | Glaxosmithkline Biologicals S.A. | Improved detection of MAGE-A expression |
| JP5883443B2 (ja) * | 2010-07-22 | 2016-03-15 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規の抗原結合タンパク質 |
| CN102251033B (zh) * | 2011-07-05 | 2013-03-20 | 北京大学人民医院 | 基于mage-a3基因辅助诊断多发性骨髓瘤患者的定量检测试剂盒 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612201A (en) * | 1991-05-23 | 1997-03-18 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules useful in determining expression of a tumor rejection antigen precursor |
| WO1994003205A1 (fr) * | 1992-08-07 | 1994-02-17 | Cytel Corporation | Peptides de liaison de hla, et leurs utilisations |
| CA2184482A1 (fr) * | 1994-03-01 | 1995-09-08 | Etienne De Plaen | Determination d'etats cancereux par l'expression de genes mage |
| US5985571A (en) * | 1998-02-04 | 1999-11-16 | Ludwig Institute For Cancer Research | Method for determining multiple myeloma by assaying for expression of mage genes |
| CZ298364B6 (cs) * | 1998-02-05 | 2007-09-05 | Smithkline Beecham Biologicals S. A. | Deriváty antigenu asociovaných s nádory z MAGE rodiny a sekvence nukleových kyselin kodující tyto deriváty, jejich použití pro prípravu fúzních proteinu a prostredku pro vakcinaci |
| WO2000020445A2 (fr) * | 1998-10-02 | 2000-04-13 | Ludwig Institute For Cancer Research | Antigenes tumoraux et clones de lymphocyte t cytotoxique (ctl) isoles grace a un nouveau procede |
| JP3603138B2 (ja) * | 2000-02-18 | 2004-12-22 | 独立行政法人理化学研究所 | 細胞死抑制タンパク質 |
| US6358679B1 (en) * | 2000-08-24 | 2002-03-19 | Pe Corporation (Ny) | Methods for external controls for nucleic acid amplification |
| US6635425B2 (en) * | 2001-01-05 | 2003-10-21 | Molecular Staging, Inc. | 5′-thio phosphate directed ligation of oligonucleotides and use in detection of single nucleotide polymorphisms |
| US7771998B2 (en) * | 2001-11-29 | 2010-08-10 | Dandrit Biotech A/S | Pharmaceutical composition for inducing an immune response in a human or animal |
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| EP1572105B1 (fr) * | 2002-11-14 | 2011-08-31 | John Wayne Cancer Institute | Detection de micro metastases de melanomes et de cancer du sein dans des ganglions lymphatiques drainant des tumeurs incorporees dans de la paraffine par rt-pcr quantitative a l'aide de marqueurs multiples |
| GB0409940D0 (en) * | 2004-05-04 | 2004-06-09 | Glaxosmithkline Biolog Sa | Vaccine |
| US20070231822A1 (en) * | 2006-02-28 | 2007-10-04 | Michael Mitas | Methods for the detection and treatment of cancer |
-
2006
- 2006-06-21 GB GBGB0612342.6A patent/GB0612342D0/en not_active Ceased
-
2007
- 2007-06-21 PT PT07786793T patent/PT2041308E/pt unknown
- 2007-06-21 US US12/305,742 patent/US8936919B2/en not_active Expired - Fee Related
- 2007-06-21 PL PL07786793T patent/PL2041308T3/pl unknown
- 2007-06-21 CA CA002656909A patent/CA2656909A1/fr not_active Abandoned
- 2007-06-21 DK DK07786793.5T patent/DK2041308T3/da active
- 2007-06-21 UA UAA200814634A patent/UA95956C2/uk unknown
- 2007-06-21 WO PCT/EP2007/056219 patent/WO2007147876A2/fr not_active Ceased
- 2007-06-21 CN CN2007800309371A patent/CN101506383B/zh not_active Expired - Fee Related
- 2007-06-21 EA EA200802356A patent/EA016347B1/ru not_active IP Right Cessation
- 2007-06-21 HR HRP20120761TT patent/HRP20120761T1/hr unknown
- 2007-06-21 ES ES07786793T patent/ES2389513T3/es active Active
- 2007-06-21 AU AU2007263019A patent/AU2007263019B2/en not_active Ceased
- 2007-06-21 MX MX2008016493A patent/MX2008016493A/es active IP Right Grant
- 2007-06-21 NZ NZ573809A patent/NZ573809A/en not_active IP Right Cessation
- 2007-06-21 SI SI200731011T patent/SI2041308T1/sl unknown
- 2007-06-21 EP EP07786793A patent/EP2041308B1/fr not_active Not-in-force
- 2007-06-21 KR KR1020097001326A patent/KR101455589B1/ko not_active Expired - Fee Related
- 2007-06-21 MY MYPI20085210A patent/MY147511A/en unknown
- 2007-06-21 BR BRPI0713599-8A patent/BRPI0713599A2/pt not_active IP Right Cessation
- 2007-06-21 JP JP2009515886A patent/JP2009540812A/ja active Pending
-
2008
- 2008-12-16 IL IL195975A patent/IL195975A/en not_active IP Right Cessation
- 2008-12-18 NO NO20085290A patent/NO20085290L/no not_active Application Discontinuation
- 2008-12-18 ZA ZA2008/10695A patent/ZA200810695B/en unknown
- 2008-12-19 MA MA31490A patent/MA30565B1/fr unknown
- 2008-12-24 CO CO08136749A patent/CO6140072A2/es unknown
-
2012
- 2012-10-02 CY CY20121100908T patent/CY1113290T1/el unknown
- 2012-11-08 JP JP2012245934A patent/JP5705191B2/ja not_active Expired - Fee Related
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