MA30637B1 - Vaccins et procedes pour controler l'adiposite - Google Patents

Vaccins et procedes pour controler l'adiposite

Info

Publication number
MA30637B1
MA30637B1 MA31629A MA31629A MA30637B1 MA 30637 B1 MA30637 B1 MA 30637B1 MA 31629 A MA31629 A MA 31629A MA 31629 A MA31629 A MA 31629A MA 30637 B1 MA30637 B1 MA 30637B1
Authority
MA
Morocco
Prior art keywords
vaccines
methods
controlling adiposity
adiposity
controlling
Prior art date
Application number
MA31629A
Other languages
English (en)
Inventor
Eric P Zorrilla
Michael M Meijler
Kim D Janda
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of MA30637B1 publication Critical patent/MA30637B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention présente des immunoconjugués destinés à entraver la prise de poids et à traiter l'obésité chez un sujet. Les immunoconjugués comprennent des polypeptides de ghréline particuliers et une fraction support appropriée.
MA31629A 2006-08-01 2009-02-11 Vaccins et procedes pour controler l'adiposite MA30637B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82107106P 2006-08-01 2006-08-01

Publications (1)

Publication Number Publication Date
MA30637B1 true MA30637B1 (fr) 2009-08-03

Family

ID=38997839

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31629A MA30637B1 (fr) 2006-08-01 2009-02-11 Vaccins et procedes pour controler l'adiposite

Country Status (15)

Country Link
US (1) US9675679B2 (fr)
EP (1) EP2046376B1 (fr)
JP (1) JP2009545618A (fr)
KR (1) KR101510082B1 (fr)
CN (1) CN101500602A (fr)
AU (1) AU2007281131B2 (fr)
BR (1) BRPI0715345A8 (fr)
CA (1) CA2659264C (fr)
CR (1) CR10644A (fr)
EA (1) EA200970166A1 (fr)
IL (1) IL196720A0 (fr)
MA (1) MA30637B1 (fr)
MX (1) MX2009001133A (fr)
NO (1) NO20090439L (fr)
WO (1) WO2008016976A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992928B2 (en) 2006-02-11 2015-03-31 Victor Raso Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin
WO2010089757A2 (fr) * 2008-11-07 2010-08-12 Usv Limited Procédé amélioré de synthèse d'un octapeptide cyclique
CA2826853C (fr) * 2011-02-09 2020-10-27 The Scripps Research Institute Immunoconjugues d'haptene polypeptidique mimetique de ghreline ayant une solubilite et une immunogeneicite ameliorees et leurs procedes d'utilisation
WO2013119800A1 (fr) 2012-02-07 2013-08-15 Massachusetts Institute Of Technology Utilisation d'antagonistes de ghréline ou de récepteur de ghréline pour prévenir ou traiter une maladie psychiatrique sensible au stress
US9724396B2 (en) 2013-03-15 2017-08-08 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
US10317418B2 (en) 2015-02-24 2019-06-11 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
WO2017170494A1 (fr) * 2016-03-29 2017-10-05 国立大学法人東京大学 Vaccin contre l'obésité

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596792A (en) 1981-09-04 1986-06-24 The Regents Of The University Of California Safe vaccine for hepatitis containing polymerized serum albumin
JPS5938877A (ja) 1982-08-30 1984-03-02 Musashi Eng Kk 紙葉判別方法
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
CA2380058C (fr) * 1999-07-23 2011-08-09 Kenji Kangawa Nouveaux peptides
GB2357084A (en) * 1999-12-06 2001-06-13 Amersham Pharm Biotech Uk Ltd A hydrophobic carrier peptide
CA2411667A1 (fr) * 2000-05-30 2001-12-06 Merck & Co. Inc. Analogues de la ghreline
RU2325202C2 (ru) * 2002-07-19 2008-05-27 Цитос Байотекнолоджи Аг Конъюгаты грелин-носитель
EP1407779A1 (fr) * 2002-10-10 2004-04-14 Gastrotech A/S Utilisation de ghrelin pour traitement de poids corporel réduit et de graisse corporelle réduite dans des individus avec gastrectomie
SG149013A1 (en) * 2003-12-17 2009-01-29 Wyeth Corp Immunogenic peptide carrier conjugates and methods of producing same
EP1706152A2 (fr) * 2004-01-20 2006-10-04 Cytos Biotechnology AG Conjugues a base de ghreline et d'un vehicule
JP2007532495A (ja) * 2004-04-07 2007-11-15 ガストロテック・ファルマ・アクティーゼルスカブ グレリン欠乏を治療するための分泌促進薬の使用
US20070237775A1 (en) * 2004-07-14 2007-10-11 Eli Lilly And Company Anti-Ghrelin Antibodies
NZ554386A (en) * 2004-10-25 2009-12-24 Cytos Biotechnology Ag Gastric inhibtory polypeptide (GIP) antigen arrays with VLPs and uses thereof
US8992928B2 (en) * 2006-02-11 2015-03-31 Victor Raso Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin

Also Published As

Publication number Publication date
WO2008016976A8 (fr) 2009-08-06
JP2009545618A (ja) 2009-12-24
EP2046376A4 (fr) 2010-01-27
EA200970166A1 (ru) 2009-06-30
WO2008016976A3 (fr) 2008-09-25
CR10644A (es) 2009-04-16
AU2007281131B2 (en) 2012-11-29
IL196720A0 (en) 2011-08-01
BRPI0715345A8 (pt) 2019-01-08
KR20090041416A (ko) 2009-04-28
CA2659264C (fr) 2016-01-26
US20100021487A1 (en) 2010-01-28
NO20090439L (no) 2009-03-19
AU2007281131A1 (en) 2008-02-07
BRPI0715345A2 (pt) 2013-06-18
WO2008016976B1 (fr) 2008-11-06
MX2009001133A (es) 2009-02-11
CN101500602A (zh) 2009-08-05
KR101510082B1 (ko) 2015-04-10
CA2659264A1 (fr) 2008-02-07
EP2046376A2 (fr) 2009-04-15
US9675679B2 (en) 2017-06-13
WO2008016976A2 (fr) 2008-02-07
EP2046376B1 (fr) 2018-08-01

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