MA30792B1 - DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO [1,2-a] PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE - Google Patents

DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO [1,2-a] PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Info

Publication number
MA30792B1
MA30792B1 MA31788A MA31788A MA30792B1 MA 30792 B1 MA30792 B1 MA 30792B1 MA 31788 A MA31788 A MA 31788A MA 31788 A MA31788 A MA 31788A MA 30792 B1 MA30792 B1 MA 30792B1
Authority
MA
Morocco
Prior art keywords
possibly substituted
cycloalkyl
derivatives
aryl
phenyl
Prior art date
Application number
MA31788A
Other languages
French (fr)
Inventor
Garcia Antonio Almario
Patrick Lardenois
Anne Olivier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA30792B1 publication Critical patent/MA30792B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE LES DÉRIVÉS DE FORMULE GÉNÉRALE (I) DANS LAQUELLE : R1 REPRÉSENTE : UN GROUPE PHÉNYLE OU UN GROUPE NAPHTHYLE, CES DEUX GROUPES POUVANT ÉVENTUELLEMENT ÊTRE SUBSTITUÉS; R2, R3 REPRÉSENTENT, INDÉPENDAMMENT L'UN DE L'AUTRE, UN ATOME HYDROGÈNE, UN GROUPE (C1-C6)ALKYLE, (C3-C7)CYCLOALKYLE (C3- C7)CYCLOALKYL(C1-C3)ALKYLÈNE, ÉVENTUELLEMENT SUBSTITUÉ; UN GROUPE ARYLE ÉVENTUELLEMENT SUBSTITUÉ; R4 REPRÉSENTE : UN ATOME D'HYDROGÈNE, UN GROUPE (C1-C6)ALKYLE, (C3-C7)CYCLOALKYLE (C3- C7)CYCLOALKYL(C1-C3)ALKYLÈNE, ÉVENTUELLEMENT SUBSTITUÉ; UN GROUPE ARYLE ÉVENTUELLEMENT SUBSTITUÉ PAR UN OU PLUSIEURS SUBSTITUANTS À L'ÉTAT DE BASE OU DE SEL D'ADDITION À UN ACIDE.THE INVENTION CONCERNS THE DERIVATIVES OF GENERAL FORMULA (I) IN WHICH: R1 REPRESENTS: A PHENYL GROUP OR A NAPHTHYL GROUP, THESE TWO GROUPS POSSIBLY SUBSTITUTED; R2, R3 REPRESENT, INDEPENDENTLY OF EACH OTHER, A HYDROGENIC ATOM, A (C1-C6) ALKYL, (C3-C7) CYCLOALKYL (C3-C7) CYCLOALKYL (C1-C3) ALKYLENE GROUP, WHICH IS POSSIBLY SUBSTITUTED; AN ARYL GROUP POSSIBLY SUBSTITUTED; R4 REPRESENTS: A HYDROGEN ATOM, A (C1-C6) ALKYL, (C3-C7) CYCLOALKYL (C3-C7) CYCLOALKYL (C1-C3) ALKYLENE GROUP, POSSIBLY SUBSTITUTED; AN ARYL GROUP POSSIBLY SUBSTITUTED BY ONE OR MORE SUBSTITUENTS IN THE BASIC STATE OR SALT OF ADDITION TO AN ACID.

MA31788A 2006-09-22 2009-04-16 DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO [1,2-a] PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE MA30792B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (en) 2006-09-22 2006-09-22 DERIVATIVES OF 2-ARYL-6PHENYL-IMIDAZO (1,2-A) PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Publications (1)

Publication Number Publication Date
MA30792B1 true MA30792B1 (en) 2009-10-01

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31788A MA30792B1 (en) 2006-09-22 2009-04-16 DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO [1,2-a] PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Country Status (43)

Country Link
US (1) US7915284B2 (en)
EP (1) EP2069342B1 (en)
JP (1) JP5336378B2 (en)
KR (1) KR101470039B1 (en)
CN (1) CN101516881B (en)
AR (1) AR062897A1 (en)
AT (1) ATE467633T1 (en)
AU (1) AU2007298856B2 (en)
BR (1) BRPI0718517A2 (en)
CA (1) CA2662848C (en)
CL (1) CL2007002733A1 (en)
CO (1) CO6160308A2 (en)
CR (1) CR10643A (en)
CY (1) CY1110232T1 (en)
DE (1) DE602007006525D1 (en)
DK (1) DK2069342T3 (en)
EA (1) EA017442B1 (en)
ES (1) ES2345016T3 (en)
FR (1) FR2906250B1 (en)
GT (1) GT200900049A (en)
HN (1) HN2009000502A (en)
HR (1) HRP20100408T1 (en)
IL (1) IL197352A (en)
JO (1) JO2643B1 (en)
MA (1) MA30792B1 (en)
ME (1) MEP10709A (en)
MX (1) MX2009002802A (en)
MY (1) MY145603A (en)
NI (1) NI200900037A (en)
NO (1) NO20091562L (en)
NZ (1) NZ575337A (en)
PE (1) PE20080671A1 (en)
PL (1) PL2069342T3 (en)
PT (1) PT2069342E (en)
RS (1) RS51412B (en)
SI (1) SI2069342T1 (en)
SV (1) SV2009003193A (en)
TN (1) TN2009000081A1 (en)
TW (1) TWI381837B (en)
UA (1) UA95976C2 (en)
UY (1) UY30603A1 (en)
WO (1) WO2008034974A1 (en)
ZA (1) ZA200901551B (en)

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FR2928923B1 (en) * 2008-03-21 2010-04-23 Sanofi Aventis POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS
FR2928922B1 (en) * 2008-03-21 2010-04-23 Sanofi Aventis DERIVATIVES OF POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2928921B1 (en) * 2008-03-21 2010-04-23 Sanofi Aventis POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
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FR2953520B1 (en) * 2009-12-04 2011-11-25 Sanofi Aventis DIPHENYL-PYRAZOLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
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KR102685249B1 (en) 2016-06-20 2024-07-17 인사이트 코포레이션 Heterocyclic Compounds as Immunomodulators
MA45669A (en) 2016-07-14 2019-05-22 Incyte Corp HETEROCYCLIC COMPOUNDS USED AS IMMUNOMODULATORS
WO2018044783A1 (en) 2016-08-29 2018-03-08 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3515914A4 (en) 2016-09-24 2020-04-15 BeiGene, Ltd. NEW IMIDAZO [1,5-A] PYRIDINES SUBSTITUTED IN POSITION 5 OR 8 AS INDOLEAMINE AND / OR TRYPTOPHANE 2,3-DIOXYGENASES
WO2018119224A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
EP3558973B1 (en) 2016-12-22 2021-09-15 Incyte Corporation Pyridine derivatives as immunomodulators
PE20191532A1 (en) 2016-12-22 2019-10-23 Incyte Corp HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
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Also Published As

Publication number Publication date
ME00615B (en) 2011-12-20
IL197352A (en) 2014-11-30
JO2643B1 (en) 2012-06-17
IL197352A0 (en) 2009-12-24
HK1135388A1 (en) 2010-06-04
FR2906250A1 (en) 2008-03-28
WO2008034974A1 (en) 2008-03-27
MY145603A (en) 2012-03-15
JP2010504309A (en) 2010-02-12
EA017442B1 (en) 2012-12-28
HN2009000502A (en) 2011-07-11
TN2009000081A1 (en) 2010-08-19
PE20080671A1 (en) 2008-07-14
BRPI0718517A2 (en) 2013-11-19
NI200900037A (en) 2014-02-20
RS51412B (en) 2011-02-28
AU2007298856B2 (en) 2012-08-09
TWI381837B (en) 2013-01-11
SV2009003193A (en) 2010-02-01
US20090253735A1 (en) 2009-10-08
FR2906250B1 (en) 2008-10-31
ATE467633T1 (en) 2010-05-15
CL2007002733A1 (en) 2008-04-11
DK2069342T3 (en) 2010-08-23
ZA200901551B (en) 2010-06-30
SI2069342T1 (en) 2010-09-30
US7915284B2 (en) 2011-03-29
CN101516881B (en) 2012-07-18
AU2007298856A1 (en) 2008-03-27
NZ575337A (en) 2011-12-22
JP5336378B2 (en) 2013-11-06
AR062897A1 (en) 2008-12-10
GT200900049A (en) 2010-03-04
CA2662848A1 (en) 2008-03-27
MEP10709A (en) 2011-12-20
PL2069342T3 (en) 2010-10-29
NO20091562L (en) 2009-04-20
HRP20100408T1 (en) 2010-09-30
KR101470039B1 (en) 2014-12-05
ES2345016T3 (en) 2010-09-13
UA95976C2 (en) 2011-09-26
UY30603A1 (en) 2008-05-02
CR10643A (en) 2009-04-29
CY1110232T1 (en) 2015-01-14
EA200970311A1 (en) 2009-08-28
CO6160308A2 (en) 2010-05-20
EP2069342B1 (en) 2010-05-12
KR20090054449A (en) 2009-05-29
DE602007006525D1 (en) 2010-06-24
PT2069342E (en) 2010-07-19
CN101516881A (en) 2009-08-26
EP2069342A1 (en) 2009-06-17
MX2009002802A (en) 2009-04-01
CA2662848C (en) 2014-12-23
TW200833329A (en) 2008-08-16

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