MA30878B1 - 4-[4-({[4-chloro-3-(trifluorométhyl) phényl]carbamoyl}amino)-3-fluorophénoxy]-n-méthylpyridine-2-carboxamide monohydraté - Google Patents

4-[4-({[4-chloro-3-(trifluorométhyl) phényl]carbamoyl}amino)-3-fluorophénoxy]-n-méthylpyridine-2-carboxamide monohydraté

Info

Publication number: MA30878B1
Authority: MA; Morocco
Prior art keywords: fluorophenoxy; methylpyridine; carbamoyl; trifluoromethyl; chloro
Prior art date: 2006-10-11

Application number

MA31857A

Other languages

English (en)

Inventor

Alfons Grunenberg

Juergen Stiehl

Katharina Tenbieg

Birgit Keil

Original Assignee

Bayer Schering Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-11

Filing date

2009-05-08

Publication date

2009-11-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38972960&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30878(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-05-08 Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag

2009-11-02 Publication of MA30878B1 publication Critical patent/MA30878B1/fr

Links

ZOPOQLDXFHBOIH-UHFFFAOYSA-N regorafenib hydrate Chemical compound O.C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 ZOPOQLDXFHBOIH-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

MA31857A 2006-10-11 2009-05-08 4-[4-({[4-chloro-3-(trifluorométhyl) phényl]carbamoyl}amino)-3-fluorophénoxy]-n-méthylpyridine-2-carboxamide monohydraté MA30878B1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06021296		2006-10-11

Publications (1)

Publication Number	Publication Date
MA30878B1 true MA30878B1 (fr)	2009-11-02

Family

ID=38972960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA31857A MA30878B1 (fr)	2006-10-11	2009-05-08	4-[4-({[4-chloro-3-(trifluorométhyl) phényl]carbamoyl}amino)-3-fluorophénoxy]-n-méthylpyridine-2-carboxamide monohydraté

Country Status (37)

Country	Link
US (3)	US9957232B2 (fr)
EP (1)	EP2097381B1 (fr)
JP (1)	JP5346293B2 (fr)
KR (1)	KR101418623B1 (fr)
CN (1)	CN101547903B (fr)
AR (1)	AR062927A1 (fr)
AU (1)	AU2007306716B2 (fr)
BR (1)	BRPI0719828B1 (fr)
CA (1)	CA2666170C (fr)
CL (1)	CL2007002930A1 (fr)
CO (1)	CO6150132A2 (fr)
CR (1)	CR10663A (fr)
CY (1)	CY1114637T1 (fr)
DK (1)	DK2097381T3 (fr)
ES (1)	ES2427358T3 (fr)
GT (1)	GT200900057A (fr)
HN (1)	HN2009000499A (fr)
IL (1)	IL197369A (fr)
JO (1)	JO3021B1 (fr)
MA (1)	MA30878B1 (fr)
MX (1)	MX2009002642A (fr)
MY (1)	MY152595A (fr)
NZ (1)	NZ576153A (fr)
PA (1)	PA8750301A1 (fr)
PE (1)	PE20081459A1 (fr)
PL (1)	PL2097381T3 (fr)
PT (1)	PT2097381E (fr)
RU (1)	RU2466992C2 (fr)
SG (1)	SG175584A1 (fr)
SI (1)	SI2097381T1 (fr)
SV (1)	SV2009003187A (fr)
TN (1)	TN2009000072A1 (fr)
TW (1)	TWI428322B (fr)
UA (1)	UA95984C2 (fr)
UY (1)	UY30633A1 (fr)
WO (1)	WO2008043446A1 (fr)
ZA (1)	ZA200902469B (fr)

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CN104829523B (zh) *	2014-04-30	2017-10-31	药源药物化学（上海）有限公司	瑞戈非尼盐及其晶型、制备方法
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- 2007-09-20 AR ARP070104168A patent/AR062927A1/es unknown
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Also Published As

Publication number	Publication date
WO2008043446A1 (fr)	2008-04-17
UA95984C2 (en)	2011-09-26
MY152595A (en)	2014-10-31
BRPI0719828A2 (pt)	2014-02-04
ES2427358T3 (es)	2013-10-30
MX2009002642A (es)	2009-05-28
PE20081459A1 (es)	2008-12-18
TWI428322B (zh)	2014-03-01
HN2009000499A (es)	2012-03-07
GT200900057A (es)	2009-12-09
NZ576153A (en)	2012-02-24
TN2009000072A1 (en)	2010-08-19
US20100173953A1 (en)	2010-07-08
HK1136287A1 (en)	2010-06-25
DK2097381T3 (da)	2013-09-23
EP2097381B1 (fr)	2013-06-19
CN101547903A (zh)	2009-09-30
SG175584A1 (en)	2011-11-28
PA8750301A1 (es)	2009-01-23
UY30633A1 (es)	2008-05-31
PL2097381T3 (pl)	2013-11-29
US20180194730A1 (en)	2018-07-12
ZA200902469B (en)	2010-06-30
KR101418623B1 (ko)	2014-07-14
SV2009003187A (es)	2009-11-26
CL2007002930A1 (es)	2008-04-04
CA2666170A1 (fr)	2008-04-17
US9957232B2 (en)	2018-05-01
TW200831465A (en)	2008-08-01
IL197369A0 (en)	2009-12-24
US20140315958A1 (en)	2014-10-23
AR062927A1 (es)	2008-12-17
IL197369A (en)	2015-06-30
CR10663A (es)	2009-07-31
JP2010505888A (ja)	2010-02-25
AU2007306716B2 (en)	2013-06-20
SI2097381T1 (sl)	2013-11-29
CN101547903B (zh)	2014-01-15
PT2097381E (pt)	2013-09-17
RU2009117388A (ru)	2010-11-20
CO6150132A2 (es)	2010-04-20
BRPI0719828B1 (pt)	2022-05-17
JO3021B1 (ar)	2016-09-05
CY1114637T1 (el)	2016-10-05
EP2097381A1 (fr)	2009-09-09
RU2466992C2 (ru)	2012-11-20
CA2666170C (fr)	2016-05-24
JP5346293B2 (ja)	2013-11-20
AU2007306716A1 (en)	2008-04-17
KR20090061043A (ko)	2009-06-15

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