MA31704B1 - Composés et compositions de 5-(4- (haloalkoxy) phényl) pyrimidine-2-amine utilisés comme inhibiteurs de kinases - Google Patents

Composés et compositions de 5-(4- (haloalkoxy) phényl) pyrimidine-2-amine utilisés comme inhibiteurs de kinases

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Publication number
MA31704B1
MA31704B1 MA32694A MA32694A MA31704B1 MA 31704 B1 MA31704 B1 MA 31704B1 MA 32694 A MA32694 A MA 32694A MA 32694 A MA32694 A MA 32694A MA 31704 B1 MA31704 B1 MA 31704B1
Authority
MA
Morocco
Prior art keywords
compounds
kinases
raf
inhibitors
haloalkoxy
Prior art date
Application number
MA32694A
Other languages
Arabic (ar)
English (en)
Inventor
Valentina Molteni
Xiaolin Li
Xiaodong Liu
Donatella Chianelli
Juliet Nabakka
Jon Loren
Shuli You
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39929716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31704(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of MA31704B1 publication Critical patent/MA31704B1/fr

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

L'invention porte sur des composés de formule (1) et sur des compositions pharmaceutiques les contenant, qui sont utiles en tant qu'inhibiteurs de protéine kinases, ainsi que sur des procédés d'utilisation de ces composés pour traiter, améliorer ou prévenir une affection associée à une activité kinase anormale ou dérégulée. Dans certains modes de réalisation, l'invention porte sur des procédés d'utilisation de ces composés pour traiter, améliorer ou prévenir des maladies ou troubles associés à une activation anormale des kinases c-kit, pdgfra, pdgfrß, csf1r, abl, bcr-abl, csk, jnk1, jnk2, p38, p70s6k, tgfß, src, egfr, trkb, fgfr3, fes, lck, syk, raf, mkk4, mkk6, sapk2ß, brk, fms, kdr, c-raf ou b-raf.
MA32694A 2007-08-22 2010-03-12 Composés et compositions de 5-(4- (haloalkoxy) phényl) pyrimidine-2-amine utilisés comme inhibiteurs de kinases MA31704B1 (fr)

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US95726007P 2007-08-22 2007-08-22
PCT/US2008/073573 WO2009026276A1 (fr) 2007-08-22 2008-08-19 Composés et compositions de 5- (4- (haloalkoxy) phényl) pyrimidine-2-amine utilisés comme inhibiteurs de kinases

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MA31704B1 true MA31704B1 (fr) 2010-09-01

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EP (1) EP2190825B1 (fr)
JP (2) JP5599312B2 (fr)
KR (2) KR20120107538A (fr)
CN (1) CN101784530A (fr)
AR (1) AR068014A1 (fr)
AU (1) AU2008289037B2 (fr)
BR (1) BRPI0815715A8 (fr)
CA (1) CA2697081C (fr)
CL (1) CL2008002478A1 (fr)
CO (1) CO6260074A2 (fr)
CR (1) CR11264A (fr)
EC (1) ECSP10010044A (fr)
ES (1) ES2477878T3 (fr)
MA (1) MA31704B1 (fr)
MX (1) MX2010002004A (fr)
PE (1) PE20090992A1 (fr)
PL (1) PL2190825T3 (fr)
PT (1) PT2190825E (fr)
RU (1) RU2455288C2 (fr)
TN (1) TN2010000087A1 (fr)
TW (1) TW200914023A (fr)
WO (1) WO2009026276A1 (fr)
ZA (1) ZA201001513B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2697081C (fr) * 2007-08-22 2013-04-23 Irm Llc Composes et compositions de 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine utilises comme inhibiteurs de kinases
CA2697077C (fr) 2007-08-22 2012-10-16 Irm Llc Derives de 2-heteroarylamino-pyrimidine en tant qu'inhibiteurs de kinase
MX361539B (es) 2012-04-25 2018-12-10 Takeda Pharmaceuticals Co Compuesto heterociclico nitrogenado.
EP2863915B1 (fr) * 2012-06-22 2017-12-06 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinase splénique (syk) diazines et triazines substituées
EP2863916B1 (fr) * 2012-06-22 2018-07-18 Merck Sharp & Dohme Corp. Inhibiteurs à pyridine substituée de la tyrosine kinase de la rate (syk)
EP2873669A4 (fr) 2012-07-13 2015-11-25 Takeda Pharmaceutical Composé hétérocyclique
EP2884982B1 (fr) * 2012-08-20 2017-09-20 Merck Sharp & Dohme Corp. Inhibiteurs de la phényle tyrosine kinase de la rate (syk) substitués
EP3007689B1 (fr) 2013-01-10 2018-03-07 Pulmokine, Inc. Inhibiteurs de kinase non sélectifs
EP2975031A4 (fr) 2013-03-14 2017-04-19 Takeda Pharmaceutical Company Limited Composé hétérocyclique
JP6427491B2 (ja) 2013-07-03 2018-11-21 武田薬品工業株式会社 複素環化合物
ES2950424T3 (es) 2013-07-03 2023-10-09 Takeda Pharmaceuticals Co Compuesto de amida
JPWO2015012328A1 (ja) 2013-07-24 2017-03-02 武田薬品工業株式会社 複素環化合物
CN104458674A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选血管内皮生长因子1激酶抑制剂高通量筛选方法
CN104458675A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选干细胞因子受体激酶抑制剂高通量筛选方法
US9925184B2 (en) 2013-10-11 2018-03-27 Pulmokine, Inc. Spray-dry formulations
TWI714528B (zh) 2014-05-14 2021-01-01 瑞士商諾華公司 甲醯胺衍生物
KR101694753B1 (ko) * 2015-08-28 2017-01-11 주식회사 온코크로스 크로몰린 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 간질환 예방 및 치료용 약학적 조성물
RU2763525C2 (ru) 2016-10-27 2021-12-30 Пульмокин, Инк. Комбинированная терапия для лечения легочной гипертензии
KR101974145B1 (ko) * 2017-12-22 2019-04-30 한국생명공학연구원 보풀 추출물을 유효성분으로 함유하는 아토피 피부염의 예방, 개선 또는 치료용 조성물
TWI893032B (zh) 2019-12-13 2025-08-11 日商日本新藥股份有限公司 作為pdgf受體激酶抑制劑之化合物及組合物
US20240351996A1 (en) * 2021-07-09 2024-10-24 Cz Biohub Sf, Llc Cdk19-selective inhibitors, and methods of use thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0164204A1 (fr) * 1984-05-12 1985-12-11 FISONS plc Pyrimidines utiles dans des préparations pharmaceutiques
US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
JPH08503971A (ja) 1993-10-01 1996-04-30 チバ−ガイギー アクチェンゲゼルシャフト ピリミジンアミン誘導体及びその調製のための方法
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
NZ506101A (en) 1998-01-28 2003-06-30 Shionogi & Co Tricyclic immunosupressant, anti-allergic and IgE production suppressant compounds
JP4969010B2 (ja) 2000-05-08 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ複製阻害性ピリミジンのプロドラッグ
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
US7129242B2 (en) 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
US7429599B2 (en) 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
AU2002342878A1 (en) 2001-05-16 2002-11-25 Axxima Pharmaceuticals Ag Pyridylpyrimidine derivatives as effective compounds against prion diseases
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) 2002-09-27 2002-11-06 Novartis Ag Organic compounds
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
JP4847868B2 (ja) 2003-05-14 2011-12-28 ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド 化合物、及び、アミロイドベータの調節におけるその使用
EP1663204B1 (fr) 2003-08-29 2014-05-07 Exelixis, Inc. Modulateurs c-kit et leurs procedes d'utilisation
ES2229928B1 (es) 2003-10-02 2006-07-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirimidin-2-amina.
JPWO2005040135A1 (ja) 2003-10-24 2007-03-08 小野薬品工業株式会社 抗ストレス薬およびその医薬用途
UA94570C2 (en) 2004-09-09 2011-05-25 Натко Фарма Лимитед Phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase
MX2007004488A (es) 2004-10-13 2007-09-11 Wyeth Corp Analogos de anilino-pirimidina n-bencenosulfonilo sustituidos.
EP1814856A1 (fr) 2004-11-12 2007-08-08 Galapagos N.V. Composés hétéroaromatiques de l'azote qui se lient au site actif d'enzymes de type protéines kinases
AU2005325676A1 (en) 2004-12-23 2006-08-03 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
JP5118029B2 (ja) 2005-06-14 2013-01-16 タイゲン バイオテクノロジー カンパニー，リミテッド ピリミジン化合物
EP1928236B1 (fr) * 2005-09-27 2011-11-23 Irm Llc Composes et compositions contenant de la diarylamine, et utilisation en tant que modulateurs de recepteurs de c-kit
JP2009514876A (ja) 2005-11-03 2009-04-09 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼのための化合物および組成物
WO2008058037A1 (fr) 2006-11-03 2008-05-15 Irm Llc Composés et compositions en tant qu'inhibiteurs des protéines kinases
EP2152688A1 (fr) 2007-05-04 2010-02-17 Irm Llc Composés et compositions utiles en tant qu'inhibiteurs des kinases c-kit et pdgfr
EP2148874B1 (fr) 2007-05-04 2012-02-08 Irm Llc Dérivés de pyrimidine et compositions utiles en tant qu'inhibiteurs des kinases c-kit et pdgfr
CA2697081C (fr) * 2007-08-22 2013-04-23 Irm Llc Composes et compositions de 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine utilises comme inhibiteurs de kinases
CA2697077C (fr) 2007-08-22 2012-10-16 Irm Llc Derives de 2-heteroarylamino-pyrimidine en tant qu'inhibiteurs de kinase

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PT2190825E (pt) 2014-07-16
JP5599312B2 (ja) 2014-10-01
JP2014177486A (ja) 2014-09-25
AR068014A1 (es) 2009-10-28
BRPI0815715A2 (pt) 2017-06-13
US20110301175A1 (en) 2011-12-08
WO2009026276A1 (fr) 2009-02-26
MX2010002004A (es) 2010-03-11
CL2008002478A1 (es) 2009-05-15
JP2010536867A (ja) 2010-12-02
AU2008289037A1 (en) 2009-02-26
CA2697081C (fr) 2013-04-23
ES2477878T3 (es) 2014-07-18
RU2010110640A (ru) 2011-09-27
TW200914023A (en) 2009-04-01
EP2190825A1 (fr) 2010-06-02
RU2455288C2 (ru) 2012-07-10
ZA201001513B (en) 2010-10-27
KR101218926B1 (ko) 2013-01-04
EP2190825B1 (fr) 2014-04-09
AU2008289037B2 (en) 2012-03-01
KR20120107538A (ko) 2012-10-02
ECSP10010044A (es) 2010-04-30
TN2010000087A1 (en) 2011-09-26
US8293757B2 (en) 2012-10-23
CN101784530A (zh) 2010-07-21
CA2697081A1 (fr) 2009-02-26
KR20100043288A (ko) 2010-04-28
PL2190825T3 (pl) 2014-09-30
CO6260074A2 (es) 2011-03-22
BRPI0815715A8 (pt) 2017-07-04
PE20090992A1 (es) 2009-08-14
CR11264A (es) 2010-04-19

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