MA31895B1 - (alkyl en c<sb>2</sb>-c<sb>5</sb>) imidazole - bisphosphonates - Google Patents

(alkyl en c<sb>2</sb>-c<sb>5</sb>) imidazole - bisphosphonates

Info

Publication number
MA31895B1
MA31895B1 MA32880A MA32880A MA31895B1 MA 31895 B1 MA31895 B1 MA 31895B1 MA 32880 A MA32880 A MA 32880A MA 32880 A MA32880 A MA 32880A MA 31895 B1 MA31895 B1 MA 31895B1
Authority
MA
Morocco
Prior art keywords
diseases
treatment
compounds
alkyl
branched
Prior art date
Application number
MA32880A
Other languages
English (en)
Inventor
Sven Weiler
Leo Widler
Jean-Michel Rondeau
Simona Cotesta
Wolfgang Jahnke
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39154111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31895(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA31895B1 publication Critical patent/MA31895B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION PORTE SUR DES ACIDES [(IMIDAZOL-1-YL)-1-HYDROXY-1-PHOSPHONOÉTHYL] PHOSPHONIQUES SUBSTITUÉS PAR ALKYLE EN C2-C5, AINSI QUE SUR DES MÉTHODES OU DES PROCÉDÉS PERMETTANT DE LES FABRIQUER, SUR LEUR UTILISATION DANS LA FABRICATION DE FORMULATIONS PHARMACEUTIQUES, SUR LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES, SUR DES PROCÉDÉS D'UTILISATION DE CEUX-CI DANS LE TRAITEMENT DE MALADIES, SUR DES FORMULATIONS PHARMACEUTIQUES LES ENGLOBANT ET/OU SUR LES COMPOSÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES. LES COMPOSÉS SONT CAPABLES D'INHIBER UNE RÉSORPTION OSSEUSE EXCESSIVE OU INAPPROPRIÉE ET SONT APPROPRIÉS POUR LE TRAITEMENT D'AUTRES MALADIES QUI SONT PROVOQUÉES PAR UNE PRÉNYLATION EXCESSIVE DE PROTÉINES CIBLES, TELLES QUE LE SYNDROME DE PROGÉRIE D'HUTCHINSON-GILFORD. LES COMPOSÉS SONT REPRÉSENTÉS PAR LA FORMULE (I), DANS LAQUELLE L'UN PARMI R1 ET R2 REPRÉSENTE HYDROGÈNE ET L'AUTRE REPRÉSENTE ALKYLE EN C2-C5 QUI EST RAMIFIÉ OU NON RAMIFIÉ, ET PEUVENT SE PRÉSENTER SOUS UNE FORME LIBRE, SOUS LA FORME D'UN ESTER ET/OU D'UN SEL.
MA32880A 2007-11-30 2010-05-31 (alkyl en c<sb>2</sb>-c<sb>5</sb>) imidazole - bisphosphonates MA31895B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07122016 2007-11-30

Publications (1)

Publication Number Publication Date
MA31895B1 true MA31895B1 (fr) 2010-12-01

Family

ID=39154111

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32880A MA31895B1 (fr) 2007-11-30 2010-05-31 (alkyl en c<sb>2</sb>-c<sb>5</sb>) imidazole - bisphosphonates

Country Status (24)

Country Link
US (2) US7977323B2 (fr)
EP (1) EP2225252B1 (fr)
JP (1) JP5244917B2 (fr)
KR (1) KR20100092035A (fr)
CN (1) CN101835787A (fr)
AR (1) AR069437A1 (fr)
AU (1) AU2008328797B2 (fr)
BR (1) BRPI0819902A2 (fr)
CA (1) CA2701516A1 (fr)
CL (1) CL2008003545A1 (fr)
CO (1) CO6280421A2 (fr)
CR (1) CR11362A (fr)
EA (1) EA201000860A1 (fr)
EC (1) ECSP10010321A (fr)
ES (1) ES2386851T3 (fr)
IL (1) IL204657A0 (fr)
MA (1) MA31895B1 (fr)
MX (1) MX2010005786A (fr)
NZ (1) NZ584219A (fr)
PE (1) PE20091038A1 (fr)
TN (1) TN2010000138A1 (fr)
TW (1) TW200932248A (fr)
WO (1) WO2009068567A1 (fr)
ZA (1) ZA201001992B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2273980A2 (fr) * 2008-04-04 2011-01-19 Novartis AG Composition pharmaceutique avec bisphosphonate
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
DK2459176T3 (en) 2009-07-31 2017-12-04 Gruenenthal Gmbh Crystallization process and bioavailability
CA2836175A1 (fr) 2010-05-28 2011-12-01 The Royal Institution For The Advancement Of Learning/Mcgill University Acide heterocyclyle-pyridinyle bisphosphonique, sel pharmaceutiquement acceptable de celui-ci, composition en contenant et son procede d'utilisation
US9290526B2 (en) 2010-05-28 2016-03-22 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
US9340565B2 (en) 2010-11-24 2016-05-17 Thar Pharmaceuticals, Inc. Crystalline forms
CN102659840B (zh) * 2012-05-10 2013-08-14 苏州普瑞诺药物技术有限公司 咪唑双膦酸类化合物及其可药用盐及药物用途
US10195218B2 (en) 2016-05-31 2019-02-05 Grunenthal Gmbh Crystallization method and bioavailability
EP3698797A1 (fr) 2017-10-16 2020-08-26 Tsinghua University Inhibiteur de la voie de l'acide mévalonique et composition pharmaceutique correspondante
CN112980809B (zh) * 2021-03-17 2023-04-11 云南中烟工业有限责任公司 一种烟草法尼基焦磷酸合酶基因及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2038692T4 (es) 1986-11-21 2012-02-10 Novartis Ag Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos.
AU664368B2 (en) * 1991-02-26 1995-11-16 Norwich Eaton Pharmaceuticals, Inc. Methods for the treatment of osteoporosis
GB9324143D0 (en) 1993-11-24 1994-01-12 Schering Agrochemicals Ltd Triazole phosphonate pesticides
GB0029018D0 (en) * 2000-11-28 2001-01-10 Strakan Group Plc Dermatological formulations
GB0029111D0 (en) * 2000-11-29 2001-01-10 Novartis Ag Organic compounds
US8012949B2 (en) 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
EP1802641B8 (fr) 2004-10-08 2012-03-07 The Board Of Trustees Of The University Of Illinois Composes de bisphosphonate et methodes de traitement de maladies de resorption osseuse, de cancers, de douleurs osseuses, de troubles immunitaires et de maladies infectieuses
AR063121A1 (es) 2006-10-05 2008-12-30 Novartis Ag Composicion farmaceutica
US20100144751A1 (en) 2007-03-28 2010-06-10 Array Biopharma Inc. IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS

Also Published As

Publication number Publication date
US7977323B2 (en) 2011-07-12
EP2225252A1 (fr) 2010-09-08
ZA201001992B (en) 2010-12-29
EA201000860A1 (ru) 2010-12-30
BRPI0819902A2 (pt) 2015-05-19
TW200932248A (en) 2009-08-01
US20110224173A1 (en) 2011-09-15
CL2008003545A1 (es) 2009-06-05
CO6280421A2 (es) 2011-05-20
AU2008328797A1 (en) 2009-06-04
EP2225252B1 (fr) 2012-06-27
MX2010005786A (es) 2010-06-09
ES2386851T3 (es) 2012-09-03
CA2701516A1 (fr) 2009-06-04
AR069437A1 (es) 2010-01-20
CN101835787A (zh) 2010-09-15
AU2008328797B2 (en) 2011-11-03
CR11362A (es) 2010-06-14
KR20100092035A (ko) 2010-08-19
PE20091038A1 (es) 2009-08-19
NZ584219A (en) 2012-03-30
WO2009068567A1 (fr) 2009-06-04
ECSP10010321A (es) 2010-08-31
US20090143337A1 (en) 2009-06-04
JP2011504908A (ja) 2011-02-17
IL204657A0 (en) 2010-11-30
TN2010000138A1 (en) 2011-09-26
JP5244917B2 (ja) 2013-07-24

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