MA32081B1 - Dérivés de 6,7-dialcoxyquinazoline utiles pour traiter des troubles apparentés au cancer - Google Patents

Dérivés de 6,7-dialcoxyquinazoline utiles pour traiter des troubles apparentés au cancer

Info

Publication number
MA32081B1
MA32081B1 MA33089A MA33089A MA32081B1 MA 32081 B1 MA32081 B1 MA 32081B1 MA 33089 A MA33089 A MA 33089A MA 33089 A MA33089 A MA 33089A MA 32081 B1 MA32081 B1 MA 32081B1
Authority
MA
Morocco
Prior art keywords
quinazolines
dialkoxyquinazoline
surprisingly
class
treating cancer
Prior art date
Application number
MA33089A
Other languages
Arabic (ar)
English (en)
Inventor
Prasad Ramanadham Jyothi
Kali Satya Bhujanga Rao Adibhatla
Rao Bollepalli Nageshwara
Chowdary Nannapaneni Venkaiah
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of MA32081B1 publication Critical patent/MA32081B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compte tenu du potentiel important offert par la classe de composés formés par les quinazolines, la synthèse et le criblage d'un grand nombre de nouvelles entités chimiques à nouvelles caractéristiques structurales a été entreprise. De façon surprenante et inattendue, il a été prouvé que les quinazolines ayant un groupe 3- éthynylanilino en position 4 et des groupes alcoxy substitués de façon spécifique dans les positions 6 et 7 confèrent propriétés antiprolifératives très améliorées et spéciales par rapport à d'autres éléments importants de la classe de médicaments formée par les quinazolines. Egalement, de façon surprenante, les composés de cette invention sont bien moins toxiques et le profil d'innocuité est extrêmement avantageux pour les applications thérapeutiques. Les nouvelles entités chimiques décrites dans cette invention sont représentées par la structure générale (i) et n'ont jamais été synthétisées ou étudiées pour leurs avantages thérapeutiques et leur profil d'innocuité. Le composé (i) est le nrc-2694, de structure (a).
MA33089A 2008-01-18 2010-08-13 Dérivés de 6,7-dialcoxyquinazoline utiles pour traiter des troubles apparentés au cancer MA32081B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2008/000036 WO2009090661A1 (fr) 2008-01-18 2008-01-18 Dérivés de 6,7-dialcoxyquinazoline utiles pour traiter des troubles apparentés au cancer

Publications (1)

Publication Number Publication Date
MA32081B1 true MA32081B1 (fr) 2011-02-01

Family

ID=39769348

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33089A MA32081B1 (fr) 2008-01-18 2010-08-13 Dérivés de 6,7-dialcoxyquinazoline utiles pour traiter des troubles apparentés au cancer

Country Status (27)

Country Link
US (5) US8143250B2 (fr)
EP (2) EP2229369B1 (fr)
JP (1) JP2011509995A (fr)
KR (2) KR101762306B1 (fr)
CN (1) CN101918374A (fr)
AP (1) AP2886A (fr)
AU (1) AU2008347940A1 (fr)
BR (1) BRPI0822012A2 (fr)
CA (1) CA2711737C (fr)
CY (1) CY1118193T1 (fr)
DK (2) DK3012251T3 (fr)
EA (1) EA018514B1 (fr)
ES (2) ES2593321T3 (fr)
HR (1) HRP20161522T1 (fr)
HU (1) HUE030640T2 (fr)
IL (1) IL207046A (fr)
LT (1) LT2229369T (fr)
MA (1) MA32081B1 (fr)
MX (1) MX2010007852A (fr)
NZ (1) NZ586946A (fr)
PL (1) PL2229369T3 (fr)
PT (1) PT2229369T (fr)
SG (1) SG187490A1 (fr)
SI (1) SI2229369T1 (fr)
UA (1) UA101010C2 (fr)
WO (1) WO2009090661A1 (fr)
ZA (1) ZA201005116B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101762306B1 (ko) * 2008-01-18 2017-07-27 낫코 파마 리미티드 암과 관련된 질환의 치료에 유용한 6,7-디알콕시 퀴나졸린 유도체
US9050341B2 (en) * 2009-07-14 2015-06-09 Natco Pharma Limited Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives
CN101857618B (zh) * 2010-06-13 2015-11-25 中国海洋大学 作为蛋白酪氨酸激酶抑制剂的一系列喹唑啉糖衍生物，其制备方法和应用
US9388160B2 (en) * 2011-10-12 2016-07-12 Teligene Ltd Quinazoline derivatives as kinases inhibitors and methods of use thereof
TWI577671B (zh) 2011-11-14 2017-04-11 Sunshine Lake Pharma Co Ltd Aminoquinazoline derivatives and salts thereof and methods of use thereof
CN103172641B (zh) * 2011-12-20 2014-06-11 钱卫 杂环胺基烷氧基取代的喹唑啉衍生物及其用途
WO2013142817A2 (fr) 2012-03-23 2013-09-26 Dennis Brown Compositions et procédés d'amélioration du bénéfice thérapeutique de l'indirubine et de ses analogues y compris du mésoindigo
CN105916506B (zh) 2013-11-20 2020-01-07 圣诺康生命科学公司 作为tam家族激酶抑制剂的喹唑啉衍生物
WO2017062500A2 (fr) 2015-10-05 2017-04-13 The Trustees Of Columbia University In The City Of New York Activateurs de flux autophagique et de phospholipase d et clairance d'agrégats de protéines comprenant tau et traitement de protéinopathies
ES2899145T3 (es) * 2017-04-15 2022-03-10 Natco Pharma Ltd Un proceso mejorado para la preparación de diclorhidrato de N-(3-etinilfenil)-7-metoxi-6-(3-morfolinopropoxi)quinazolin-4-amina
CN111499577A (zh) * 2019-01-30 2020-08-07 华东师范大学 邻二苯基取代五元含氮芳杂环类类化合物及其应用
PT4337191T (pt) * 2021-06-10 2025-01-20 Natco Pharma Ltd Inibidor de egfr para o tratamento de cancro da cabeça e pescoço
CN115518071B (zh) * 2021-06-24 2024-03-19 中国人民解放军联勤保障部队第九〇一医院 一种化合物在制备抗食管癌的药物中的应用
WO2024121861A1 (fr) * 2022-12-08 2024-06-13 Natco Pharma Limited Inhibiteur d'egfr pour traiter le cancer de la tête et du cou

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US690221A (en) 1901-06-20 1901-12-31 Frederik Christian Viggo Arp Stand for cycles.
US5332671A (en) * 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
US5183884A (en) * 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
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GB9323290D0 (en) 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
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DE69522717T2 (de) 1995-03-30 2002-02-14 Pfizer Inc., New York Chinazolinderivate
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US6706721B1 (en) * 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
WO2005070909A1 (fr) 2004-01-22 2005-08-04 Natco Pharma Limited Procede ameliore de preparation de gefitinib
WO2006090413A1 (fr) 2005-02-23 2006-08-31 Natco Pharma Limited Nouvelle forme cristalline de gefitinib et son procede de preparation
PE20070207A1 (es) * 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
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KR101762306B1 (ko) * 2008-01-18 2017-07-27 낫코 파마 리미티드 암과 관련된 질환의 치료에 유용한 6,7-디알콕시 퀴나졸린 유도체

Also Published As

Publication number Publication date
MX2010007852A (es) 2010-11-30
DK3012251T3 (en) 2017-10-09
HRP20161522T1 (hr) 2017-02-10
SI2229369T1 (sl) 2016-11-30
IL207046A0 (en) 2010-12-30
CY1118193T1 (el) 2017-06-28
US8921362B2 (en) 2014-12-30
US20110034459A1 (en) 2011-02-10
WO2009090661A1 (fr) 2009-07-23
KR20100121468A (ko) 2010-11-17
LT2229369T (lt) 2016-09-26
CA2711737A1 (fr) 2009-07-23
ES2593321T3 (es) 2016-12-07
PT2229369T (pt) 2016-11-24
SG187490A1 (en) 2013-02-28
EP2229369A1 (fr) 2010-09-22
WO2009090661A9 (fr) 2010-06-17
KR101640161B1 (ko) 2016-07-15
EA201001173A1 (ru) 2011-04-29
AU2008347940A1 (en) 2009-07-23
KR20160086969A (ko) 2016-07-20
DK2229369T3 (en) 2016-12-12
US9481655B2 (en) 2016-11-01
BRPI0822012A2 (pt) 2015-07-21
AP2886A (en) 2014-05-31
KR101762306B1 (ko) 2017-07-27
HUE030640T2 (en) 2017-06-28
UA101010C2 (ru) 2013-02-25
EP3012251A1 (fr) 2016-04-27
CN101918374A (zh) 2010-12-15
US20110039844A1 (en) 2011-02-17
US20190201408A1 (en) 2019-07-04
AP2010005357A0 (en) 2010-08-31
EP3012251B1 (fr) 2017-08-30
ZA201005116B (en) 2011-03-30
IL207046A (en) 2015-09-24
CA2711737C (fr) 2015-03-31
EP2229369B1 (fr) 2016-08-17
EA018514B1 (ru) 2013-08-30
US20150141421A1 (en) 2015-05-21
NZ586946A (en) 2012-06-29
ES2642159T3 (es) 2017-11-15
JP2011509995A (ja) 2011-03-31
US20170079983A1 (en) 2017-03-23
PL2229369T3 (pl) 2017-01-31
US8143250B2 (en) 2012-03-27

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