MA33244B1 - Composes de vinylindazolyle - Google Patents

Composes de vinylindazolyle

Info

Publication number
MA33244B1
MA33244B1 MA34312A MA34312A MA33244B1 MA 33244 B1 MA33244 B1 MA 33244B1 MA 34312 A MA34312 A MA 34312A MA 34312 A MA34312 A MA 34312A MA 33244 B1 MA33244 B1 MA 33244B1
Authority
MA
Morocco
Prior art keywords
vinylindazolyl
compounds
indazolyl
cancer
treatment
Prior art date
Application number
MA34312A
Other languages
English (en)
Inventor
Daohong Chen
Hong-Yu Li
Genshi Zhao
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA33244B1 publication Critical patent/MA33244B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention porte sur des composés vinyl indazolylés utiles dans le traitement du cancer.
MA34312A 2009-05-07 2010-05-04 Composes de vinylindazolyle MA33244B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17629009P 2009-05-07 2009-05-07
US30141610P 2010-02-04 2010-02-04
PCT/US2010/033487 WO2010129509A1 (fr) 2009-05-07 2010-05-04 Composés vinyl indazolylés

Publications (1)

Publication Number Publication Date
MA33244B1 true MA33244B1 (fr) 2012-05-02

Family

ID=42238704

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34312A MA33244B1 (fr) 2009-05-07 2010-05-04 Composes de vinylindazolyle

Country Status (34)

Country Link
US (1) US8268869B2 (fr)
EP (1) EP2427449B1 (fr)
JP (1) JP5555314B2 (fr)
KR (1) KR101373910B1 (fr)
CN (1) CN102421769B (fr)
AR (1) AR078411A1 (fr)
AU (1) AU2010246114B2 (fr)
BR (1) BRPI1013748A2 (fr)
CA (1) CA2760535C (fr)
CL (1) CL2011002781A1 (fr)
CO (1) CO6450624A2 (fr)
CR (1) CR20110580A (fr)
DK (1) DK2427449T3 (fr)
EA (1) EA018149B1 (fr)
EC (1) ECSP11011441A (fr)
ES (1) ES2408117T3 (fr)
HN (1) HN2011002809A (fr)
HR (1) HRP20130323T1 (fr)
IL (1) IL216004A (fr)
JO (1) JO2860B1 (fr)
MA (1) MA33244B1 (fr)
ME (1) ME01462B (fr)
MX (1) MX2011011342A (fr)
MY (1) MY160390A (fr)
NZ (1) NZ595553A (fr)
PE (2) PE20120812A1 (fr)
PL (1) PL2427449T3 (fr)
PT (1) PT2427449E (fr)
RS (1) RS52795B (fr)
SG (1) SG175909A1 (fr)
SI (1) SI2427449T1 (fr)
TW (1) TWI382982B (fr)
UA (1) UA104756C2 (fr)
WO (1) WO2010129509A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3062B1 (ar) * 2010-10-05 2017-03-15 Lilly Co Eli R)-(e)-2-(4-(2-(5-(1-(3، 5-داي كلورو بيريدين-4-يل)إيثوكسي)-1h-إندازول-3-يل)?ينيل)-1h-بيرازول-1-يل)إيثانول بلوري
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
PL2824181T3 (pl) 2012-03-08 2019-02-28 Astellas Pharma Inc. Nowa fuzja fgfr3
RS58514B1 (sr) 2012-06-13 2019-04-30 Incyte Holdings Corp Supstituisana triciklična jedinjenja kao inhibitori fgfr
US20150203589A1 (en) 2012-07-24 2015-07-23 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EP2968551B1 (fr) 2013-03-15 2021-05-05 The Trustees of Columbia University in the City of New York Protéines de fusion et procédés correspondants
PH12015502383B1 (en) 2013-04-19 2023-02-03 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
CN103819396B (zh) * 2014-02-26 2016-06-15 四川大学 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
EP3925979A3 (fr) 2014-12-23 2022-03-23 The Trustees of Columbia University in the City of New York Protéines de fusion fgfr-tacc et utilisations associées
TWI712601B (zh) 2015-02-20 2020-12-11 美商英塞特公司 作為fgfr抑制劑之雙環雜環
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN105906621A (zh) * 2015-04-06 2016-08-31 四川百利药业有限责任公司 用作fgfr抑制剂的乙醇类化合物
WO2016187767A1 (fr) * 2015-05-25 2016-12-01 Hutchison Medipharma Limited Compositions pharmaceutiques et utilisation de celles-ci
EP3333157B1 (fr) * 2015-08-07 2020-12-23 Harbin Zhenbao Pharmaceutical Co., Ltd. Composés vinyliques utilisés comme inhibiteurs du fgfr et du vegfr
WO2017028816A1 (fr) 2015-08-20 2017-02-23 浙江海正药业股份有限公司 Dérivé d'indole, son procédé de préparation et son utilisation dans un médicament pharmaceutique
CN107459519A (zh) 2016-06-06 2017-12-12 上海艾力斯医药科技有限公司 稠合嘧啶哌啶环衍生物及其制备方法和应用
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
AU2019262579B2 (en) 2018-05-04 2024-09-12 Incyte Corporation Salts of an FGFR inhibitor
HRP20241288T1 (hr) 2018-05-04 2024-12-06 Incyte Corporation Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (fr) 2019-10-01 2021-04-08 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
CA3157361A1 (fr) 2019-10-14 2021-04-22 Incyte Corporation Heterocycles bicycliques utilises en tant qu'inhibiteurs de fgfr
WO2021076728A1 (fr) 2019-10-16 2021-04-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
CN114072387B (zh) * 2019-11-06 2024-03-08 暨南大学 吲唑类化合物及其药用组合物和应用
JP7832891B2 (ja) 2019-12-04 2026-03-18 インサイト・コーポレイション Ｆｇｆｒ阻害剤の誘導体
CA3163875A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4186894B1 (fr) * 2020-08-11 2024-12-04 Henan Medinno Pharmaceutical Technology Co., Ltd. Composé inhibiteur de fgfr et son utilisation
WO2022221170A1 (fr) 2021-04-12 2022-10-20 Incyte Corporation Polythérapie comprenant un inhibiteur de fgfr et un agent de ciblage de nectine-4
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
CA3220155A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Heterocycles tricycliques utiles en tant qu'inhibiteurs de fgfr
CN116554148B (zh) * 2022-12-13 2025-01-28 药康众拓(北京)医药科技有限公司 一种乙烯基吲唑类氘代fgfr抑制剂药物及用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
DE60115069T2 (de) 2000-09-11 2006-08-03 Chiron Corp., Emeryville Chinolinonderivate als tyrosin-kinase inhibitoren
EP1447405A4 (fr) * 2001-10-17 2005-01-12 Kirin Brewery Derives de quinoline ou de quinazoline inhibant l'autophosphorylation de recepteurs du facteur de croissance des fibroblastes
US7429609B2 (en) 2002-05-31 2008-09-30 Eisai R & D Management Co., Ltd. Pyrazole compound and medicinal composition containing the same
DE10342503A1 (de) * 2003-09-12 2005-04-14 Merck Patent Gmbh Benzyl-Benzimidazolylderivate
JP4093588B2 (ja) 2004-05-26 2008-06-04 ファイザー・インク 新規インダゾール及びインドロン誘導体及び調合剤としてのそれらの使用
WO2007058626A1 (fr) 2005-11-16 2007-05-24 S*Bio Pte Ltd Composes d'indazole
WO2007067537A1 (fr) * 2005-12-07 2007-06-14 Osi Pharmaceuticals, Inc. Composés inhibant les pyrrolopyridine kinases
MX2009006401A (es) 2006-12-20 2009-06-23 Nerviano Medical Sciences Srl Derivados de indazol como inhibidores de cinasa para el tratamiento del cancer.
US7737149B2 (en) * 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
MY148609A (en) 2007-06-05 2013-05-15 Merck Sharp & Dohme Polycyclic indazole derivatives and their use as erk inhibitors for the treatment of cancer
DE102007028521A1 (de) 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
EP2265270A1 (fr) * 2008-02-04 2010-12-29 OSI Pharmaceuticals, Inc. Inhibiteurs de 2-aminopyridine kinases

Also Published As

Publication number Publication date
CL2011002781A1 (es) 2012-05-25
MY160390A (en) 2017-03-15
CO6450624A2 (es) 2012-05-31
EP2427449B1 (fr) 2013-04-03
TWI382982B (zh) 2013-01-21
IL216004A (en) 2014-01-30
KR20120004511A (ko) 2012-01-12
NZ595553A (en) 2013-05-31
ME01462B (me) 2014-04-20
CN102421769B (zh) 2014-04-02
MX2011011342A (es) 2011-11-18
PL2427449T3 (pl) 2013-08-30
CA2760535A1 (fr) 2010-11-11
SI2427449T1 (sl) 2013-05-31
US8268869B2 (en) 2012-09-18
IL216004A0 (en) 2012-01-31
UA104756C2 (uk) 2014-03-11
CN102421769A (zh) 2012-04-18
ES2408117T3 (es) 2013-06-18
ECSP11011441A (es) 2011-12-30
EA201171367A1 (ru) 2012-04-30
JP5555314B2 (ja) 2014-07-23
HN2011002809A (es) 2013-07-22
JP2012526126A (ja) 2012-10-25
AU2010246114A1 (en) 2011-11-03
HRP20130323T1 (en) 2013-05-31
EP2427449A1 (fr) 2012-03-14
CA2760535C (fr) 2014-01-14
AU2010246114B2 (en) 2012-12-06
JO2860B1 (en) 2015-03-15
PE20120812A1 (es) 2012-07-08
EA018149B1 (ru) 2013-05-30
WO2010129509A1 (fr) 2010-11-11
CR20110580A (es) 2012-01-06
SG175909A1 (en) 2011-12-29
KR101373910B1 (ko) 2014-03-12
PT2427449E (pt) 2013-05-06
HK1163665A1 (en) 2012-09-14
PE20160124A1 (es) 2016-02-24
DK2427449T3 (da) 2013-04-22
US20100286209A1 (en) 2010-11-11
BRPI1013748A2 (pt) 2016-04-05
RS52795B (sr) 2013-10-31
AR078411A1 (es) 2011-11-09
TW201105652A (en) 2011-02-16

Similar Documents

Publication Publication Date Title
MA33244B1 (fr) Composes de vinylindazolyle
EP2482849A4 (fr) Immunothérapie combinée pour le traitement du cancer
FR2932478B1 (fr) Composes utiles pour le traitement des cancers.
EP2391316A4 (fr) Traitement de l'obésité
FR2948016B1 (fr) Orthese pour le traitement de la rhizarthrose
EP2555765A4 (fr) Traitement de l'ataxie télangiectasie
MX364200B (es) Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad.
EP2310006A4 (fr) Traitement du cancer
ES2661055T8 (es) Determinación de haplotipos de KIR por amplificación de exones
EP2389388A4 (fr) Traitement de l'obésité
EP2338519A4 (fr) Agent de traitement d'une myélofibrose
EP2493820A4 (fr) Traitement de l'eau
EA201270619A1 (ru) Применение бетанехола для лечения ксеростомии
EP2496244A4 (fr) Immunothérapie pharmacorésistante pour le traitement d'un cancer
EP1996612A4 (fr) Compositions destinee au traitement des cancers
PH12012501542A1 (en) Treatment of inflammatory bowel diseases with mammal beta defensis
PH12012501680A1 (en) Compositions and methods for the diagnosis and treatment of tumor
MA32617B1 (fr) Traitement de l'hypertension arterielle pulmonaire
EP2582391A4 (fr) Traitement de l'arthrite
EP2382329A4 (fr) Utilisations de bortézomib pour prédire la survie de patients atteints d'un myélome multiple
IN2012DN00539A (fr)
MY151104A (en) Novel use
EP2608671A4 (fr) Composés utilisés dans le traitement du cancer
EP2517095A4 (fr) Traitement de recouvrements
GB0904427D0 (en) Treatment of diseases related to hyperactivity of the complement system