MA33540B1 - Dérivés de la pyridine et de la pyrazine en tant que modulateurs de la protéine kinase - Google Patents

Dérivés de la pyridine et de la pyrazine en tant que modulateurs de la protéine kinase

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Publication number
MA33540B1
MA33540B1 MA34654A MA34654A MA33540B1 MA 33540 B1 MA33540 B1 MA 33540B1 MA 34654 A MA34654 A MA 34654A MA 34654 A MA34654 A MA 34654A MA 33540 B1 MA33540 B1 MA 33540B1
Authority
MA
Morocco
Prior art keywords
protein kinase
pyrazine derivatives
kinase modulator
pyridine pyrazine
pyridine
Prior art date
Application number
MA34654A
Other languages
Arabic (ar)
English (en)
Inventor
Paul A Barsanti
Cheng Hu
Jeff Jin
Robert Keyes
Robert Kucejko
Xiaodong Lin
Yue Pan
Keith B Pfister
Martin Sendzik
James Sutton
Lifeng Wan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42727614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33540(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA33540B1 publication Critical patent/MA33540B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
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  • Psychiatry (AREA)
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Abstract

Cette invention concerne un composé représenté par la formule (i) : ainsi que des sels, énantiomères, stéréoisomères, rotamères, tautamères, diastereomères ou racemates pharmaceutiquement acceptables de ce composé. Est également décrit un procédé d traitement d'une maladie ou un état pathologique induit par cdk9.
MA34654A 2009-07-30 2012-02-27 Dérivés de la pyridine et de la pyrazine en tant que modulateurs de la protéine kinase MA33540B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27315409P 2009-07-30 2009-07-30
US35772010P 2010-06-23 2010-06-23
PCT/EP2010/060984 WO2011012661A1 (fr) 2009-07-30 2010-07-28 Dérivés de la pyridine et de la pyrazine en tant que modulateurs de la protéine kinase

Publications (1)

Publication Number Publication Date
MA33540B1 true MA33540B1 (fr) 2012-08-01

Family

ID=42727614

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34654A MA33540B1 (fr) 2009-07-30 2012-02-27 Dérivés de la pyridine et de la pyrazine en tant que modulateurs de la protéine kinase

Country Status (31)

Country Link
US (3) US8415381B2 (fr)
EP (1) EP2459535B1 (fr)
JP (2) JP5650735B2 (fr)
KR (1) KR101464052B1 (fr)
CN (1) CN102482218B (fr)
AR (1) AR077505A1 (fr)
AU (1) AU2010277588B2 (fr)
BR (1) BR112012008074A2 (fr)
CA (1) CA2767066A1 (fr)
CL (1) CL2012000092A1 (fr)
CO (1) CO6612188A2 (fr)
CR (1) CR20120051A (fr)
CU (1) CU24091B1 (fr)
DO (1) DOP2012000025A (fr)
EA (1) EA023561B1 (fr)
EC (1) ECSP12011638A (fr)
ES (1) ES2536479T3 (fr)
GE (1) GEP20146101B (fr)
GT (1) GT201200022A (fr)
IL (2) IL217524A0 (fr)
MA (1) MA33540B1 (fr)
MX (1) MX2012001281A (fr)
MY (1) MY183373A (fr)
NI (1) NI201200016A (fr)
NZ (1) NZ597551A (fr)
PE (1) PE20121127A1 (fr)
SG (1) SG177660A1 (fr)
TW (1) TW201107307A (fr)
UY (1) UY32810A (fr)
WO (1) WO2011012661A1 (fr)
ZA (1) ZA201109166B (fr)

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BRPI1008498B8 (pt) 2009-02-05 2021-05-25 Takeda Pharmaceuticals Co compostos de piridazinona úteis como inibidores da fosfodiesterase 10a, composição farmacêutica, e, uso de um composto
US8415381B2 (en) * 2009-07-30 2013-04-09 Novartis Ag Heteroaryl compounds and their uses
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
WO2012101062A1 (fr) * 2011-01-28 2012-08-02 Novartis Ag Composés bi-hétéroaryles substitués en tant qu'inhibiteurs de cdk9 et leurs utilisations
JP5947818B2 (ja) 2011-03-02 2016-07-06 リード ディスカバリー センター ゲーエムベーハー 薬学的活性化二置換ピリジン誘導体
WO2012117048A1 (fr) 2011-03-02 2012-09-07 Lead Discovery Center Gmbh Dérivés de triazine disubstitués pharmaceutiquement actifs
AU2012244745A1 (en) * 2011-04-19 2013-09-19 Bayer Intellectual Property Gmbh Substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines
TW201636330A (zh) 2011-05-24 2016-10-16 拜耳知識產權公司 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
EP2527332A1 (fr) 2011-05-24 2012-11-28 Bayer Intellectual Property GmbH 4-Aryl-N-phényl-1,3,5-triazin-2-amines portant un groupe sulfoximine en tant qu'inhibiteurs de CDK9
EP2561867A1 (fr) 2011-08-22 2013-02-27 Lead Discovery Center GmbH Inhibiteurs de CDK9 pour le traitement du carcinome de la ligne médiane
EP2562265A1 (fr) 2011-08-22 2013-02-27 Lead Discovery Center GmbH Sensibilité à des inhibiteurs sélectifs de CDK9
CN103917527B (zh) 2011-09-16 2017-05-31 拜耳知识产权有限责任公司 二取代的5‑氟‑嘧啶
CN103930399B (zh) 2011-09-16 2016-03-16 拜耳知识产权有限责任公司 包含亚氨基亚磺酰基的二取代的5-氟嘧啶衍生物
WO2013059634A1 (fr) 2011-10-20 2013-04-25 The Regents Of The University Of California Utilisation d'inhibiteurs de cdk9 pour réduire la dégradation cartilagineuse
HK1209414A1 (en) 2012-10-18 2016-04-01 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
CN105102434A (zh) 2012-10-18 2015-11-25 拜耳药业股份公司 含砜基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺
ES2616441T3 (es) 2012-10-18 2017-06-13 Bayer Pharma Aktiengesellschaft Derivados de N-(piridin-2-il))pirimidin-4-amina que contienen un grupo sulfona
ME02880B (fr) 2012-11-15 2018-04-20 Bayer Pharma AG Dérivés de 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine contenant un groupe de sulfoximines
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之ｎ－（吡啶－２－基）嘧啶－４－胺衍生物
EP3016945B1 (fr) 2013-07-04 2017-05-03 Bayer Pharma Aktiengesellschaft Dérivés de 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine substitués par sulfoximine et leurs utilisation en tant qu'inhibiteurs de kinase cdk9
US9856242B2 (en) 2014-03-13 2018-01-02 Bayer Pharma Aktiengesellscaft 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
EP3126338B1 (fr) 2014-04-01 2019-09-04 Bayer Pharma Aktiengesellschaft Dérivés de 5-fluoropyrimidine disubstitués contenant un groupe sulfone diimine
US9963464B2 (en) 2014-04-11 2018-05-08 Bayer Pharma Aktiengesellschaft Macrocyclic compounds
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
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