MA34525B1 - Nouveau conjugué de facteur de croissance hématopoïétique g-csf et de polyéthylène glycol - Google Patents

Nouveau conjugué de facteur de croissance hématopoïétique g-csf et de polyéthylène glycol

Info

Publication number
MA34525B1
MA34525B1 MA35731A MA35731A MA34525B1 MA 34525 B1 MA34525 B1 MA 34525B1 MA 35731 A MA35731 A MA 35731A MA 35731 A MA35731 A MA 35731A MA 34525 B1 MA34525 B1 MA 34525B1
Authority
MA
Morocco
Prior art keywords
csf
growth factor
conjugate
hematopoietic growth
polyethylene glycol
Prior art date
Application number
MA35731A
Other languages
English (en)
Inventor
Dmitriy Valentinovich Morozov
Lev Alexandrovich Denisov
Elena Georgievna Rudenko
Elena Leonidovna Morozova
Tatyana Veniaminovna Chernovskaya
Original Assignee
Biocad Cjsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45567857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34525(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biocad Cjsc filed Critical Biocad Cjsc
Publication of MA34525B1 publication Critical patent/MA34525B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES AGENTS PHARMACEUTIQUES ET UN MÉDICAMENT, À SAVOIR, DE NOUVEAUX CONJUGUÉS PHYSIOLOGIQUEMENT ACTIFS DU FACTEUR DE CROISSANCE HÉMATOPOÏÉTIQUE G-CSF REPRÉSENTÉ PAR LA FORMULE GÉNÉRALE (I) DANS LAQUELLE : N DÉSIGNE DES ENTIERS DE 681 À 1 000; M DÉSIGNE UN ENTIER > 4; NAH-G-CSFDÉSIGNE UN POLYPEPTIDE NATUREL OU RECOMBINANT, AYANT L'ACTIVITÉ DE G-CSF. L'INVENTION CONCERNE EN OUTRE DES MÉDICAMENTS CONTENANT LE CONJUGUÉ DE FORMULE (I) REVENDIQUÉ, DES COMPOSITIONS PHARMACEUTIQUES, L'UTILISATION D'UN CONJUGUÉ DE FORMULE (I) POUR DES AGENTS PHARMACEUTIQUES ET DES MÉDICAMENTS PRÉSENTANT LE FACTEUR DE CROISSANCE HÉMATOPOÏÉTIQUE G-CSF EN TANT QUE SUBSTANCE ACTIVE, DES APPROCHES POUR PRÉVENIR ET/OU TRAITER LA NEUTROPÉNIE, LE CONTENANT QUI COMPREND LA COMPOSITION PHARMACEUTIQUE.
MA35731A 2010-08-13 2011-07-19 Nouveau conjugué de facteur de croissance hématopoïétique g-csf et de polyéthylène glycol MA34525B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2010133875/10A RU2446173C1 (ru) 2010-08-13 2010-08-13 Новый функционально активный, высокоочищенный стабильный конъюгат гранулоцитарного колониестимулирующего фактора (г-ксф) с полиэтиленгликолем с пролонгированным биологическим действием, пригодный для медицинского применения, и иммунобиологическое средство на его основе
PCT/RU2011/000532 WO2012021088A1 (fr) 2010-08-13 2011-07-19 Nouveau conjugué de facteur de croissance hématopoïétique g-csf et de polyéthylène glycol

Publications (1)

Publication Number Publication Date
MA34525B1 true MA34525B1 (fr) 2013-09-02

Family

ID=45567857

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35731A MA34525B1 (fr) 2010-08-13 2011-07-19 Nouveau conjugué de facteur de croissance hématopoïétique g-csf et de polyéthylène glycol

Country Status (18)

Country Link
KR (1) KR101549457B1 (fr)
CN (1) CN103140499B (fr)
CL (1) CL2013000400A1 (fr)
CO (1) CO6670557A2 (fr)
CR (1) CR20130020A (fr)
CU (1) CU24139B1 (fr)
DO (1) DOP2013000003A (fr)
EA (1) EA019043B1 (fr)
EC (1) ECSP13012399A (fr)
MA (1) MA34525B1 (fr)
MY (1) MY160732A (fr)
NI (1) NI201300007A (fr)
PE (1) PE20131085A1 (fr)
PH (1) PH12012502426A1 (fr)
RS (1) RS20130094A1 (fr)
RU (1) RU2446173C1 (fr)
SG (1) SG187572A1 (fr)
WO (1) WO2012021088A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012110057A1 (fr) 2011-02-15 2012-08-23 Chemisches Institut Schaefer Ag Kits de sécurité de céfuroxime
EP2858636B1 (fr) 2012-06-07 2018-09-05 Childrens Hospital Los Angeles Méthodes de traitement de la neutropénie à l'aide d'agonistes de rétinoïde
CN103908427B (zh) * 2013-01-05 2014-12-17 石药集团百克(山东)生物制药有限公司 一种聚乙二醇修饰的rhG-CSF注射液及其制备方法
RU2535002C2 (ru) * 2013-04-04 2014-12-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии" Сибирского отделения Российской академии медицинских наук Средство коррекции отдаленных последствий нарушений сперматогенеза, вызванных цитостатическим воздействием
MX2016010699A (es) 2014-02-18 2017-10-11 Children's Hospital Los Angeles Composiciones y metodos para tratar neutropenia.
US10519209B2 (en) * 2014-07-14 2019-12-31 Gennova Biopharmaceuticals Limited Process for purification of rHu-GCSF
IL247369B (en) * 2016-08-18 2018-08-30 B G Negev Tech And Applications Ltd Polypeptides derived from CSF-m and their uses
KR102020995B1 (ko) * 2017-10-30 2019-09-16 한국코러스 주식회사 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법
IL295406B1 (en) * 2020-03-17 2026-06-01 Drugrecure Aps Liquid formulation of GM-CSF for inhalation
EP4121448A2 (fr) * 2020-03-20 2023-01-25 Amgen Inc. Détermination de l'extrémité n-terminale libre de pegfilgrastim à l'aide d'une protéase acide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0401384B1 (fr) * 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Facteur de stimulation de colonies de granulocytes modifies chimiquement
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
KR20040083268A (ko) * 2003-03-21 2004-10-01 한미약품 주식회사 안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법
RU2278870C2 (ru) * 2004-08-30 2006-06-27 Закрытое Акционерное Общество "Биокад" Способ получения, выделения, очистки и стабилизации рекомбинантного гранулоцитарного колониестимулирующего фактора человека, пригодного для медицинского применения, и иммунобиологическое средство на его основе
CA2637569C (fr) * 2006-01-18 2013-01-08 Yuhua Li Compositions pharmaceutiques a stabilite amelioree
US8840882B2 (en) * 2006-06-23 2014-09-23 Quintessence Biosciences, Inc. Modified ribonucleases

Also Published As

Publication number Publication date
MY160732A (en) 2017-03-15
CU20130012A7 (es) 2013-04-19
RS20130094A1 (sr) 2013-08-30
WO2012021088A1 (fr) 2012-02-16
DOP2013000003A (es) 2013-07-31
SG187572A1 (en) 2013-03-28
KR101549457B1 (ko) 2015-09-02
EA201101035A1 (ru) 2012-02-28
RU2446173C1 (ru) 2012-03-27
CU24139B1 (es) 2015-12-23
CN103140499A (zh) 2013-06-05
NI201300007A (es) 2014-05-26
KR20130043167A (ko) 2013-04-29
CO6670557A2 (es) 2013-05-15
PE20131085A1 (es) 2013-10-10
CL2013000400A1 (es) 2013-07-26
CR20130020A (es) 2013-02-20
CN103140499B (zh) 2014-12-17
ECSP13012399A (es) 2013-05-31
PH12012502426A1 (en) 2021-06-02
EA019043B1 (ru) 2013-12-30

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