MA34887B1 - Utilisation de (5s,8s)-3-(4'-chloro-3'-fluoro-4-méthylbiphényl-3-yl)-4-hydroxy- 8-méthoxy-1-azaspiro[4.5]décane-3-en-2-one (composé a) à des fins thérapeutiques - Google Patents

Utilisation de (5s,8s)-3-(4'-chloro-3'-fluoro-4-méthylbiphényl-3-yl)-4-hydroxy- 8-méthoxy-1-azaspiro[4.5]décane-3-en-2-one (composé a) à des fins thérapeutiques

Info

Publication number
MA34887B1
MA34887B1 MA36152A MA36152A MA34887B1 MA 34887 B1 MA34887 B1 MA 34887B1 MA 36152 A MA36152 A MA 36152A MA 36152 A MA36152 A MA 36152A MA 34887 B1 MA34887 B1 MA 34887B1
Authority
MA
Morocco
Prior art keywords
methylbiphenyl
azaspiro
decane
fluoro
chloro
Prior art date
Application number
MA36152A
Other languages
English (en)
Inventor
Ningshu Liu
Kai Thede
Philip Lienau
Arne Scholz
Christoph-Stephan Hilger
Ulf Bömer
Maher Najjar
Knut Eis
Reiner Fischer
Wahed Ahmed Moradi
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102011011040A external-priority patent/DE102011011040A1/de
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MA34887B1 publication Critical patent/MA34887B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne l'utilisation de (5S,8S)-3-(4'-chloro-3'-fluoro-4-méthylbiphényl-3-yl)-4-hydroxy- 8-méthoxy-1-azaspiro[4.5]décane-3-en-2-one à des fins thérapeutiques, et des agents pharmaceutiques et leur utilisation en thérapie, en particulier pour la prophylaxie et la thérapie de maladies tumorales.
MA36152A 2011-02-06 2012-02-03 Utilisation de (5s,8s)-3-(4'-chloro-3'-fluoro-4-méthylbiphényl-3-yl)-4-hydroxy- 8-méthoxy-1-azaspiro[4.5]décane-3-en-2-one (composé a) à des fins thérapeutiques MA34887B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KW1411 2011-02-06
DE102011011040A DE102011011040A1 (de) 2011-02-08 2011-02-08 (5s,8s)-3-(4'-Chlor-3'-fluor-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-on (Verbindung A) zur Therapie
PCT/EP2012/051895 WO2012104428A1 (fr) 2011-02-06 2012-02-03 Utilisation de (5s,8s)-3-(4'-chloro-3'-fluoro-4-méthylbiphényl-3-yl)-4-hydroxy- 8-méthoxy-1-azaspiro[4.5]décane-3-en-2-one (composé a) à des fins thérapeutiques

Publications (1)

Publication Number Publication Date
MA34887B1 true MA34887B1 (fr) 2014-02-01

Family

ID=49485835

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36152A MA34887B1 (fr) 2011-02-06 2012-02-03 Utilisation de (5s,8s)-3-(4'-chloro-3'-fluoro-4-méthylbiphényl-3-yl)-4-hydroxy- 8-méthoxy-1-azaspiro[4.5]décane-3-en-2-one (composé a) à des fins thérapeutiques

Country Status (19)

Country Link
US (1) US9212140B2 (fr)
EP (1) EP2670408A1 (fr)
JP (1) JP2014504624A (fr)
KR (1) KR20140053844A (fr)
CN (1) CN103533932A (fr)
AP (1) AP2013007057A0 (fr)
AR (1) AR085146A1 (fr)
AU (1) AU2012213344A1 (fr)
BR (1) BR112013020015A2 (fr)
CA (1) CA2826515A1 (fr)
CL (1) CL2013002247A1 (fr)
EA (1) EA201391084A1 (fr)
IL (1) IL227804A0 (fr)
MA (1) MA34887B1 (fr)
MX (1) MX2013009065A (fr)
PH (1) PH12013501638A1 (fr)
TN (1) TN2013000336A1 (fr)
TW (1) TW201240659A (fr)
WO (1) WO2012104428A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1217448A1 (zh) 2013-09-12 2017-01-13 辉瑞大药厂 乙酰辅酶a羧化酶抑制剂用於治疗寻常痤疮的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2190786T3 (es) * 1994-04-05 2003-08-16 Bayer Cropscience Ag 1-h-3-aril-pirrolidin-2,4-dionas alcoxi-alquil-substituidas como herbicidas y pesticidas.
DE19813354A1 (de) * 1998-03-26 1999-09-30 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
DE10201239A1 (de) * 2002-01-15 2003-07-24 Bayer Cropscience Ag Fungizide biphenylsubstituierte cyclische Ketoenole
DE102006057037A1 (de) * 2006-12-04 2008-06-05 Bayer Cropscience Ag cis-Alkoxyspirocyclische biphenylsubstituierte Tetramsäure-Derivate
WO2010003624A2 (fr) * 2008-07-09 2010-01-14 Sanofi-Aventis Composés hétérocycliques, leurs procédés de préparation, médicaments comprenant lesdits composés et leur utilisation
DE102010008644A1 (de) * 2010-02-15 2011-08-18 Bayer Schering Pharma Aktiengesellschaft, 13353 Zyklische Ketoenole zur Therapie

Also Published As

Publication number Publication date
EP2670408A1 (fr) 2013-12-11
PH12013501638A1 (en) 2013-09-16
KR20140053844A (ko) 2014-05-08
AU2012213344A1 (en) 2013-08-22
IL227804A0 (en) 2013-09-30
AP2013007057A0 (en) 2013-08-31
JP2014504624A (ja) 2014-02-24
TN2013000336A1 (en) 2015-01-20
CA2826515A1 (fr) 2012-08-09
WO2012104428A1 (fr) 2012-08-09
US20140031407A1 (en) 2014-01-30
CL2013002247A1 (es) 2014-01-03
EA201391084A1 (ru) 2014-02-28
TW201240659A (en) 2012-10-16
CN103533932A (zh) 2014-01-22
BR112013020015A2 (pt) 2017-03-21
MX2013009065A (es) 2013-10-01
AR085146A1 (es) 2013-09-11
US9212140B2 (en) 2015-12-15

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