MA35151B1 - Microarn compounds and methods for modulating mir-21 activity - Google Patents
Microarn compounds and methods for modulating mir-21 activityInfo
- Publication number
- MA35151B1 MA35151B1 MA36437A MA36437A MA35151B1 MA 35151 B1 MA35151 B1 MA 35151B1 MA 36437 A MA36437 A MA 36437A MA 36437 A MA36437 A MA 36437A MA 35151 B1 MA35151 B1 MA 35151B1
- Authority
- MA
- Morocco
- Prior art keywords
- activity
- mir
- methods
- microarn
- compounds
- Prior art date
Links
- 108091062762 miR-21 stem-loop Proteins 0.000 title abstract 5
- 108091041631 miR-21-1 stem-loop Proteins 0.000 title abstract 5
- 108091044442 miR-21-2 stem-loop Proteins 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des compositions et des procédés pour l'inhibition de l'activité de mir-21. Les compositions ont certains motifs de modification de nucléoside qui fournissent des inhibiteurs puissants de l'activité de mir-21. Les compositions peuvent être utilisées pour inhiber mir-21 ainsi que pour traiter des maladies associées à une expression anormale de mir-21, telles qu'une fibrose et un cancer.The present invention provides compositions and methods for the inhibition of mir-21 activity. The compositions have certain nucleoside modification motifs that provide potent inhibitors of mir-21 activity. The compositions can be used to inhibit mir-21 as well as to treat diseases associated with abnormal expression of mir-21, such as fibrosis and cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478767P | 2011-04-25 | 2011-04-25 | |
| PCT/US2012/034880 WO2012148952A1 (en) | 2011-04-25 | 2012-04-25 | Microrna compounds and methods for modulating mir-21 activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA35151B1 true MA35151B1 (en) | 2014-06-02 |
Family
ID=51581886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA36437A MA35151B1 (en) | 2011-04-25 | 2013-11-15 | Microarn compounds and methods for modulating mir-21 activity |
Country Status (1)
| Country | Link |
|---|---|
| MA (1) | MA35151B1 (en) |
-
2013
- 2013-11-15 MA MA36437A patent/MA35151B1/en unknown
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