MA35430B1 - Procédés de réduction du taux de lipoprotéine(a) par l'administration d'un inhibiteur de proprotéine convertase subtilisine/kexine-9 (pcsk9) - Google Patents

Procédés de réduction du taux de lipoprotéine(a) par l'administration d'un inhibiteur de proprotéine convertase subtilisine/kexine-9 (pcsk9)

Info

Publication number
MA35430B1
MA35430B1 MA36809A MA36809A MA35430B1 MA 35430 B1 MA35430 B1 MA 35430B1 MA 36809 A MA36809 A MA 36809A MA 36809 A MA36809 A MA 36809A MA 35430 B1 MA35430 B1 MA 35430B1
Authority
MA
Morocco
Prior art keywords
inhibitor
level
methods
lipoprotein
administering
Prior art date
Application number
MA36809A
Other languages
English (en)
Inventor
Gary Swergold
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46881178&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35430(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA35430B1 publication Critical patent/MA35430B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des procédés permettant de réduire le taux de lipoprotéine(a) (lp(a)) chez un patient. Les procédés de la présente invention comprennent la sélection d'un patient présentant un taux sérique élevé de lp(a) et l'administration au patient d'une composition pharmaceutique contenant un inhibiteur de pcsk9. Dans certains modes de réalisation, l'inhibiteur de pcsk9 est un anticorps anti-pcsk9, tel que l'anticorps appelé mab316p dans le mémoire de l'invention.
MA36809A 2011-09-16 2014-03-06 Procédés de réduction du taux de lipoprotéine(a) par l'administration d'un inhibiteur de proprotéine convertase subtilisine/kexine-9 (pcsk9) MA35430B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161535392P 2011-09-16 2011-09-16
US201161559162P 2011-11-14 2011-11-14
US201261641321P 2012-05-02 2012-05-02
PCT/US2012/054756 WO2013039969A1 (fr) 2011-09-16 2012-09-12 Procédés de réduction du taux de lipoprotéine(a) par l'administration d'un inhibiteur de proprotéine convertase subtilisine/kexine-9 (pcsk9)

Publications (1)

Publication Number Publication Date
MA35430B1 true MA35430B1 (fr) 2014-09-01

Family

ID=46881178

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36809A MA35430B1 (fr) 2011-09-16 2014-03-06 Procédés de réduction du taux de lipoprotéine(a) par l'administration d'un inhibiteur de proprotéine convertase subtilisine/kexine-9 (pcsk9)

Country Status (26)

Country Link
US (2) US10076571B2 (fr)
EP (4) EP4461373A3 (fr)
JP (2) JP6158813B2 (fr)
KR (1) KR101964031B1 (fr)
CN (2) CN103930444B (fr)
AR (1) AR087881A1 (fr)
AU (1) AU2012308797B2 (fr)
BR (1) BR112014005522A2 (fr)
CA (1) CA2848201C (fr)
CL (1) CL2014000605A1 (fr)
CO (1) CO6910163A2 (fr)
EA (1) EA028278B1 (fr)
ES (3) ES2992345T3 (fr)
HR (1) HRP20241450T1 (fr)
HU (1) HUE069234T2 (fr)
IL (1) IL231011B (fr)
MA (1) MA35430B1 (fr)
MX (1) MX363642B (fr)
MY (1) MY170089A (fr)
PH (1) PH12014500342B1 (fr)
PL (1) PL4252857T3 (fr)
RS (1) RS66342B1 (fr)
SG (1) SG2014010524A (fr)
TW (1) TWI601740B (fr)
WO (1) WO2013039969A1 (fr)
ZA (1) ZA201401114B (fr)

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