MA36055B1 - Derivatives of pyridazin-3 (2h) -ones, preparation, pharmacological and biological activities - Google Patents

Derivatives of pyridazin-3 (2h) -ones, preparation, pharmacological and biological activities

Info

Publication number
MA36055B1
MA36055B1 MA36055A MA36055A MA36055B1 MA 36055 B1 MA36055 B1 MA 36055B1 MA 36055 A MA36055 A MA 36055A MA 36055 A MA36055 A MA 36055A MA 36055 B1 MA36055 B1 MA 36055B1
Authority
MA
Morocco
Prior art keywords
pharmacological
pyridazin
ones
biological activities
derivatives
Prior art date
Application number
MA36055A
Other languages
French (fr)
Other versions
MA20150035A1 (en
Inventor
M Hammed Ansar
Taoufik Jamal
Boukharssa Youness
Original Assignee
Univ Mohammed V Souissi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mohammed V Souissi filed Critical Univ Mohammed V Souissi
Priority to MA36055A priority Critical patent/MA36055B1/en
Priority to PCT/MA2013/000039 priority patent/WO2014209094A1/en
Publication of MA20150035A1 publication Critical patent/MA20150035A1/en
Publication of MA36055B1 publication Critical patent/MA36055B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Les dérivés oxygénés de la pyridazine sont connus en thérapeutique pour la richesse de leurs potentiels pharmacologique : antihypertenseur et cardiotonique. Des propriétés antibactériennes, anti-inflammatoires et psychotropes sont également mentionnées dans la littérature. De ces considérations, résulte l'idée de synthétiser et d'étudier de nouvelles séries dérivées des pyridazin-3(2h}-ones et des pyridazin3( 2h)-thiones sur le plan toxicologique, et d'explorer leurs activités pharmacologiques et biologiques. Une étude récente a démontrée que des produits déjà synthétisés ne sont pas toxiques aux doses thérapeutiques et qu'ils sont doués d'effets sédatifs, myorelaxant et anxiolytique, ils ont montré aussi une activité antiinflammatoire, analgésique, antifongique et antimicrobienne.The oxygenated derivatives of pyridazine are known therapeutically for the richness of their pharmacological potential: antihypertensive and cardiotonic. Antibacterial, anti-inflammatory and psychotropic properties are also mentioned in the literature. From these considerations, the idea is to synthesize and study new series derived from the toxicological pyridazin-3 (2h) -ones and pyridazin3 (2h) -thiones, and to explore their pharmacological and biological activities. A recent study has shown that products already synthesized are not toxic at therapeutic doses and that they are endowed sedative, muscle relaxant and anxiolytic, they have also shown anti-inflammatory, analgesic, antifungal and antimicrobial.

MA36055A 2013-06-27 2013-06-27 Derivatives of pyridazin-3 (2h) -ones, preparation, pharmacological and biological activities MA36055B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
MA36055A MA36055B1 (en) 2013-06-27 2013-06-27 Derivatives of pyridazin-3 (2h) -ones, preparation, pharmacological and biological activities
PCT/MA2013/000039 WO2014209094A1 (en) 2013-06-27 2013-12-05 Pyridazin-3(2h)-one derivatives, production, and pharmacological and biological activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MA36055A MA36055B1 (en) 2013-06-27 2013-06-27 Derivatives of pyridazin-3 (2h) -ones, preparation, pharmacological and biological activities

Publications (2)

Publication Number Publication Date
MA20150035A1 MA20150035A1 (en) 2015-02-27
MA36055B1 true MA36055B1 (en) 2015-12-31

Family

ID=49883182

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36055A MA36055B1 (en) 2013-06-27 2013-06-27 Derivatives of pyridazin-3 (2h) -ones, preparation, pharmacological and biological activities

Country Status (2)

Country Link
MA (1) MA36055B1 (en)
WO (1) WO2014209094A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220073471A1 (en) * 2019-01-04 2022-03-10 Jiangsu Hengrui Medicine Co., Ltd. 6-oxo-1,6-dihydropyridazine derivative, preparation method therefor and medical use thereof
WO2020169042A1 (en) * 2019-02-20 2020-08-27 江苏恒瑞医药股份有限公司 6-oxo-1,6-dihydropyridazine prodrug derivative, preparation method therefor, and application thereof in medicine
IL286481B2 (en) * 2019-03-20 2025-12-01 Goldfinch Bio Inc Pyridazinones and methods of using them
WO2022037647A1 (en) * 2020-08-19 2022-02-24 江苏恒瑞医药股份有限公司 Crystalline form of selective nav inhibitor and preparation method therefor

Also Published As

Publication number Publication date
WO2014209094A1 (en) 2014-12-31
MA20150035A1 (en) 2015-02-27

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