MA36330B1 - Kit de diagnostic de la leucemie myeloide chronique en reaction multiplex et ses applications dans le suivi du traitement et de la maladie residuelle - Google Patents

Kit de diagnostic de la leucemie myeloide chronique en reaction multiplex et ses applications dans le suivi du traitement et de la maladie residuelle

Info

Publication number
MA36330B1
MA36330B1 MA36330A MA36330A MA36330B1 MA 36330 B1 MA36330 B1 MA 36330B1 MA 36330 A MA36330 A MA 36330A MA 36330 A MA36330 A MA 36330A MA 36330 B1 MA36330 B1 MA 36330B1
Authority
MA
Morocco
Prior art keywords
kit
diagnosis
monitoring
treatment
residual disease
Prior art date
Application number
MA36330A
Other languages
English (en)
Other versions
MA20150144A1 (fr
Inventor
Moumen Abdeladim
Hassane Sefrioui El
Elamrani Manale
Elhadi Hichem
Bouchoutrouch Nadia
Original Assignee
Mascir Morrocan Foundation For Advanced Science Innovation & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mascir Morrocan Foundation For Advanced Science Innovation & Res filed Critical Mascir Morrocan Foundation For Advanced Science Innovation & Res
Priority to MA36330A priority Critical patent/MA36330B1/fr
Priority to PCT/MA2014/000031 priority patent/WO2015060703A2/fr
Publication of MA20150144A1 publication Critical patent/MA20150144A1/fr
Publication of MA36330B1 publication Critical patent/MA36330B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un kit de diagnostic in vitro pour l'identification et la quantification de la translocation génétique bcr-abl présent dans le cas de leucémie myéloïde chronique (lmc) et la leucémie iymphoblastique aigue (lla). Le présent kit est composée d'une combinaison innovante de nouveaux sets d'amorces et de sondes et d'une série de dilution plasmidique calibrant permettant la détection spécifique et la quantification du gène bcr-abl et du gène de référence abll en utilisant la méthode de pcr en temps réel (qpcr) en format multiplex ou simplex. Le présent kit est destiné pour le diagnostic, le suivi du traitement et l'établissement de la maladie résiduelle dans le cas de la lmcet lla.
MA36330A 2013-10-10 2013-10-10 Kit de diagnostic de la leucemie myeloide chronique en reaction multiplex et ses applications dans le suivi du traitement et de la maladie residuelle MA36330B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
MA36330A MA36330B1 (fr) 2013-10-10 2013-10-10 Kit de diagnostic de la leucemie myeloide chronique en reaction multiplex et ses applications dans le suivi du traitement et de la maladie residuelle
PCT/MA2014/000031 WO2015060703A2 (fr) 2013-10-10 2014-11-11 Kit de diagnostic de la leucemie myeloide chronique en reaction multiplex et ses applications dans le suivi du tratement et de la maladie residuelle

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MA36330A MA36330B1 (fr) 2013-10-10 2013-10-10 Kit de diagnostic de la leucemie myeloide chronique en reaction multiplex et ses applications dans le suivi du traitement et de la maladie residuelle

Publications (2)

Publication Number Publication Date
MA20150144A1 MA20150144A1 (fr) 2015-05-29
MA36330B1 true MA36330B1 (fr) 2016-04-29

Family

ID=52444609

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36330A MA36330B1 (fr) 2013-10-10 2013-10-10 Kit de diagnostic de la leucemie myeloide chronique en reaction multiplex et ses applications dans le suivi du traitement et de la maladie residuelle

Country Status (2)

Country Link
MA (1) MA36330B1 (fr)
WO (1) WO2015060703A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106701957A (zh) * 2017-01-12 2017-05-24 广州蓝吉生物技术有限公司 一种检测融合基因BCR‑ABL(P210）mRNA表达的试剂盒
CN109706147A (zh) * 2018-05-09 2019-05-03 深圳市第二人民医院 环状RNA circBA9.3及其在制备CML诊断试剂盒中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1454994A1 (fr) * 2003-03-07 2004-09-08 Université de la Méditerranée Procédé stamdardisé et optimisé d'amplification en chaine par transcription inversé et amplification quantitative en temps réel pour la détection d'une pathologie résiduelle minime de la leucémie
KR100652247B1 (ko) * 2004-06-29 2006-12-08 가톨릭대학교 산학협력단 Ｂｃｒ-ａｂｌ 정량키트
CN101624621B (zh) * 2008-07-11 2012-01-18 北京大学人民医院 一种定量检测BCR/ABL mRNA水平的试剂盒
CN101701253B (zh) * 2009-11-26 2012-05-30 南方医科大学 一种用于检测基因表达的双重荧光定量pcr试剂盒
WO2013036867A2 (fr) * 2011-09-08 2013-03-14 The Regents Of The University Of California Compositions et procédés destinés à la détection et à l'élimination du cancer et de cellules souches cancéreuses
CN102827937B (zh) * 2012-09-06 2014-03-19 上海源奇生物医药科技有限公司 一种检测白血病相关融合基因的引物和探针、及其试剂盒
MA35216B1 (fr) * 2012-09-13 2014-07-03 Mascir Sondes et amorces pour la detection du gene bcr-abl en reaction duplex

Also Published As

Publication number Publication date
WO2015060703A3 (fr) 2015-08-13
WO2015060703A4 (fr) 2015-10-01
MA20150144A1 (fr) 2015-05-29
WO2015060703A2 (fr) 2015-04-30

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