MA37472A1 - Composés hétérocycliques et leurs utilisations - Google Patents

Composés hétérocycliques et leurs utilisations

Info

Publication number
MA37472A1
MA37472A1 MA37472A MA37472A MA37472A1 MA 37472 A1 MA37472 A1 MA 37472A1 MA 37472 A MA37472 A MA 37472A MA 37472 A MA37472 A MA 37472A MA 37472 A1 MA37472 A1 MA 37472A1
Authority
MA
Morocco
Prior art keywords
inflammatory
acute
lla
diseases
disorders
Prior art date
Application number
MA37472A
Other languages
English (en)
Inventor
Minna Hue Thanh Bui
Timothy D Cushing
Lopez De Turiso Felix Gonzalez
Xiaolin Hao
Brian Lucas
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA37472A1 publication Critical patent/MA37472A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des hétéroaryles bicycliques substitués et des compositions les contenant, pour le traitement d'une inflammation générale, de l'arthrite, de maladies rhumatismales, de l'arthrose, de troubles inflammatoires intestinaux, de troubles oculaires inflammatoires, de troubles inflammatoires ou de vessie instable, du psoriasis, d'affections cutanées avec composantes inflammatoires, d'états inflammatoires chroniques, y compris mais de façon non limitative, les maladies auto-immunes telles que le lupus érythémateux disséminé (led), la myasthénie grave, l'arthrite rhumatoïde, l'encéphalomyélite aiguë disséminée, le purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de sjögren et l'anémie hémolytique auto-immune, les états allergiques comprenant toutes formes d'hypersensibilité. La présente invention concerne également des méthodes de traitement de cancers qui sont médiés par, dépendants de ou associés à l'activité p110, y compris mais de façon non limitative, des leucémies, telles que la leucémie myéloïde aiguë (lma), le syndrome myélodysplasique (smd), les maladies myélo-prolifératives (smp), la leucémie myéloïde chronique (lmc), la leucémie lymphoblastique aiguë à cellules t (lla-t), la leucémie lymphoblastique aiguë à cellules b (lla-b), le lymphome non hodgkinien (lnh), le lymphome à cellules b et les tumeurs solides, telles que le cancer du sein.
MA37472A 2012-04-04 2013-04-04 Composés hétérocycliques et leurs utilisations MA37472A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261620270P 2012-04-04 2012-04-04
PCT/US2013/035203 WO2013152150A1 (fr) 2012-04-04 2013-04-04 Composés hétérocycliques et leurs utilisations

Publications (1)

Publication Number Publication Date
MA37472A1 true MA37472A1 (fr) 2016-09-30

Family

ID=48142975

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37472A MA37472A1 (fr) 2012-04-04 2013-04-04 Composés hétérocycliques et leurs utilisations

Country Status (31)

Country Link
US (2) US8716290B2 (fr)
EP (1) EP2834231B1 (fr)
JP (1) JP2015512451A (fr)
KR (1) KR20140139547A (fr)
CN (1) CN104395305A (fr)
AP (1) AP3611A (fr)
AU (1) AU2013243506A1 (fr)
CA (1) CA2869413A1 (fr)
CL (1) CL2014002686A1 (fr)
CO (1) CO7091181A2 (fr)
CR (1) CR20140503A (fr)
CY (1) CY1117487T1 (fr)
DK (1) DK2834231T3 (fr)
EA (1) EA201491823A1 (fr)
ES (1) ES2577109T3 (fr)
HR (1) HRP20160352T1 (fr)
HU (1) HUE028762T2 (fr)
IL (1) IL234822A0 (fr)
MA (1) MA37472A1 (fr)
ME (1) ME02473B (fr)
MX (1) MX2014011970A (fr)
PE (1) PE20142457A1 (fr)
PH (1) PH12014502246A1 (fr)
PL (1) PL2834231T3 (fr)
RS (1) RS54716B1 (fr)
SG (1) SG11201406316VA (fr)
SI (1) SI2834231T1 (fr)
SM (1) SMT201600211B (fr)
TN (1) TN2014000412A1 (fr)
WO (1) WO2013152150A1 (fr)
ZA (1) ZA201407037B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013005567A (es) * 2010-11-17 2013-10-30 Amgen Inc Derivados de quinolina como inhibidores de pik3.
ME02473B (fr) * 2012-04-04 2017-02-20 Amgen Inc Composés hétérocycliques et leurs utilisations
WO2015171725A1 (fr) 2014-05-06 2015-11-12 Amgen Inc. Formes hydratées, cristallines hydratées et cristallines anhydres de la n-((1s)-1-(7-fluoro-2-(2-pyridinyl)-3-quinolinyl)éthyl)-9h-purine-6-amine, compositions pharmaceutiques en contenant et méthodes de traitement du cancer
HK1232227A1 (zh) 2014-07-04 2018-01-05 Lupin Limited 作为pi3k抑制剂的喹嗪酮衍生物
US9637488B2 (en) 2015-01-29 2017-05-02 Fuqiang Ruan Heterocyclic compounds as inhibitors of class I PI3KS
EP3400227B1 (fr) * 2016-03-05 2021-03-31 Hangzhou Zhengxiang Pharmaceuticals Co., Ltd. Analogues de quinoléine en tant qu'inhibiteurs de phosphatidylinositol 3-kinase
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TWI853009B (zh) * 2019-03-29 2024-08-21 瑞士商先正達農作物保護公司 殺有害生物活性之二-醯胺化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
US6043062A (en) 1995-02-17 2000-03-28 The Regents Of The University Of California Constitutively active phosphatidylinositol 3-kinase and uses thereof
GB9611460D0 (en) 1996-06-01 1996-08-07 Ludwig Inst Cancer Res Novel lipid kinase
US5858753A (en) 1996-11-25 1999-01-12 Icos Corporation Lipid kinase
US5822910A (en) 1997-10-02 1998-10-20 Shewmake; I. W. Fishing line tensioning device
EP1763526B1 (fr) * 2004-06-28 2009-06-24 Bayer Schering Pharma AG Pyrimidines 4,6-disubstituees et leur utilisation comme inhibiteurs des proteines kinases
EP2139882B1 (fr) * 2007-03-23 2013-12-25 Amgen Inc. Dérivés de quinoléine ou quinoxaline 3-substituée et leur utilisation en tant qu'inhibiteurs de phosphatidylinositol 3-kinase (pi3k)
EP2231641B1 (fr) * 2007-12-21 2016-06-01 UCB Biopharma SPRL Dérivés de quinoxaline et de quinoléine en tant qu'inhibiteurs de kinase
WO2010065923A2 (fr) * 2008-12-04 2010-06-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Médicaments à ciblage phosphatidylinositol-3-kinase p110 delta dans le traitement des troubles du snc
SG176986A1 (en) * 2009-06-25 2012-02-28 Amgen Inc Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases
MX2012006953A (es) * 2009-12-18 2012-10-09 Amgen Inc Compuestos heterociclicos y sus usos.
MX2012015134A (es) * 2010-07-02 2013-05-06 Amgen Inc Compuestos heterociclicos y su uso como inhibidores de actividad de pi3k.
ME02473B (fr) * 2012-04-04 2017-02-20 Amgen Inc Composés hétérocycliques et leurs utilisations

Also Published As

Publication number Publication date
CL2014002686A1 (es) 2015-05-08
US8835432B2 (en) 2014-09-16
AP2014007979A0 (en) 2014-09-30
CO7091181A2 (es) 2014-10-21
IL234822A0 (en) 2014-12-31
PL2834231T3 (pl) 2016-07-29
KR20140139547A (ko) 2014-12-05
EA201491823A1 (ru) 2015-01-30
US20130267524A1 (en) 2013-10-10
US20140206694A1 (en) 2014-07-24
SG11201406316VA (en) 2014-11-27
ZA201407037B (en) 2015-11-25
US8716290B2 (en) 2014-05-06
ME02473B (fr) 2017-02-20
PE20142457A1 (es) 2015-02-07
RS54716B1 (sr) 2016-08-31
HUE028762T2 (en) 2016-12-28
SMT201600211B (it) 2016-08-31
CR20140503A (es) 2015-03-06
AP3611A (en) 2016-02-29
CY1117487T1 (el) 2017-04-26
JP2015512451A (ja) 2015-04-27
CN104395305A (zh) 2015-03-04
SI2834231T1 (sl) 2016-09-30
DK2834231T3 (en) 2016-04-18
TN2014000412A1 (en) 2015-12-21
CA2869413A1 (fr) 2013-10-10
EP2834231B1 (fr) 2016-03-30
AU2013243506A1 (en) 2014-10-09
HRP20160352T1 (hr) 2016-05-06
MX2014011970A (es) 2015-05-12
PH12014502246A1 (en) 2014-12-15
EP2834231A1 (fr) 2015-02-11
WO2013152150A1 (fr) 2013-10-10
ES2577109T3 (es) 2016-07-13

Similar Documents

Publication Publication Date Title
MA37472A1 (fr) Composés hétérocycliques et leurs utilisations
MA34212B1 (fr) Composés hétérocycliques et leurs utilisations
EA201270013A1 (ru) Гетероциклические соединения и их применение
EA200901276A1 (ru) Гетероциклические соединения и их применение
PH12020500500A1 (en) Pyrazolopyrimidinone compounds and uses thereof
MX2012015134A (es) Compuestos heterociclicos y su uso como inhibidores de actividad de pi3k.
MX2013007261A (es) Compuestos heterociclicos y sus usos.
MX2012015135A (es) Compuestos heterociclicos y su uso como inhibidores de la actividad pi3k.
MX2009010050A (es) Derivados de quinolina o quinoxalina 3-sustituidos y su uso como inhibidores de fosfotidilinositol 3-cinasa (p13k).
MA41251B1 (fr) Dérivés de thiéno[2,3-c]pyrrol-4-one comme inhibiteurs erk
MX2011013901A (es) Derivados de 4h-pirido [1,2-a] pirimidin-4-ona como inhibidores de pi3k.
MX2011013666A (es) Compuestos heterociclicos y sus usos.
MX2009009913A (es) Derivados de quinolina o benzopirazina y sus usos para el tratamiento de enfermedades inflamatorias, enfermedades autoinmunitarias o varias clases de canceres.
MX2011013667A (es) Compuestos heterociclicos y sus usos.
PH12015500963A1 (en) Tricyclic fused thiophene derivatives as jak inhibitors
MX2012015143A (es) Compuestos heterociclicos que contienen nitrogeno como inhibidores de pi3k delta.
EA034135B9 (ru) Фармацевтические композиции на основе производных уридиновых нуклеозидов в качестве агонистов pyрецепторов
EA201891067A1 (ru) [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИН-7-ИЛЬНОЕ СОЕДИНЕНИЕ
MX2012015147A (es) Compuestos heterociclicos y su uso como inhibidores de la actividad pi3k.
EA201700042A1 (ru) Соединения имидазопиридазина
EP3432872A4 (fr) Compositions et méthodes pour l'utilisation d'éflornithine et de dérivés et analogues de cette dernière pour le traitement de cancers, dont les gliomes
MX2020009566A (es) Compuestos como moduladores de la se?alizacion de tlr2.
JOP20200272A1 (ar) مُعدّلات تفارغية سبيروبيريدين لمستقبلات أستيل كولين نيكوتينية
EA201991094A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
EA201990973A1 (ru) СОЕДИНЕНИЯ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2