MA37894B1 - Protéines de fusion d'interleukine-2 et leurs utilisations - Google Patents
Protéines de fusion d'interleukine-2 et leurs utilisationsInfo
- Publication number
- MA37894B1 MA37894B1 MA37894A MA37894A MA37894B1 MA 37894 B1 MA37894 B1 MA 37894B1 MA 37894 A MA37894 A MA 37894A MA 37894 A MA37894 A MA 37894A MA 37894 B1 MA37894 B1 MA 37894B1
- Authority
- MA
- Morocco
- Prior art keywords
- fusion proteins
- interleukin
- methods
- present
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne en général des protéines de fusion d'immunoglobulines et d'interleukine-2 (il-2). De plus, la présente invention concerne des polynucléotides codant pour de telles protéines de fusion, et des vecteurs et cellules hôtes comprenant de tels polynucléotides. L'invention concerne en outre des procédés de production des protéines de fusion de l'invention, et leurs procédés d'utilisation dans le traitement d'une maladie.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681676P | 2012-08-10 | 2012-08-10 | |
| PCT/EP2013/066516 WO2014023752A1 (fr) | 2012-08-10 | 2013-08-07 | Protéines de fusion d'interleukine-2 et leurs utilisations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA37894A1 MA37894A1 (fr) | 2018-07-31 |
| MA37894B1 true MA37894B1 (fr) | 2020-01-31 |
Family
ID=48948417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37894A MA37894B1 (fr) | 2012-08-10 | 2013-08-07 | Protéines de fusion d'interleukine-2 et leurs utilisations |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20140044675A1 (fr) |
| EP (1) | EP2882458B1 (fr) |
| JP (1) | JP6526561B2 (fr) |
| KR (1) | KR20150041628A (fr) |
| CN (2) | CN104507504A (fr) |
| AR (1) | AR092089A1 (fr) |
| AU (1) | AU2013301562B2 (fr) |
| BR (1) | BR112015002765A2 (fr) |
| CA (1) | CA2873291A1 (fr) |
| CL (1) | CL2014003322A1 (fr) |
| CO (1) | CO7121348A2 (fr) |
| CR (1) | CR20140532A (fr) |
| EA (1) | EA201500206A1 (fr) |
| HK (1) | HK1208827A1 (fr) |
| IL (1) | IL236933A0 (fr) |
| MA (1) | MA37894B1 (fr) |
| MX (1) | MX2015001749A (fr) |
| PE (1) | PE20150752A1 (fr) |
| PH (1) | PH12014502767A1 (fr) |
| SG (1) | SG11201407579QA (fr) |
| TW (1) | TW201420607A (fr) |
| WO (1) | WO2014023752A1 (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192673A1 (en) | 2011-02-10 | 2013-09-30 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| CA2894511C (fr) | 2012-12-11 | 2021-12-07 | Albert Einstein College Of Medicine Of Yeshiva University | Procedes pour identification de recepteur/ligand a rendement eleve |
| PT3102595T (pt) | 2014-02-06 | 2019-01-11 | Hoffmann La Roche | Proteínas de fusão de interleucina-2 e suas utilizações |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| MA40094B1 (fr) * | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| AU2015301936B2 (en) * | 2014-08-11 | 2019-03-07 | Delinia, Inc. | Modified IL-2 variants that selectively activate regulatory T cells for the treatment of autoimmune diseases |
| PT3328894T (pt) * | 2015-08-06 | 2019-02-13 | Agency Science Tech & Res | Anticorpos de cadeia comum gama/il2rbeta |
| RU2018124307A (ru) | 2015-12-04 | 2020-01-14 | Новартис Аг | Антительно-цитокиновые привитые композиции и способы применения для иммунорегуляции |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CN109689096A (zh) | 2016-05-18 | 2019-04-26 | 阿尔伯特爱因斯坦医学院公司 | 变体pd-l1多肽、t细胞调节性多聚体多肽及其使用方法 |
| WO2017201210A1 (fr) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | Polypeptides multimères modulateurs des lymphocytes t et leurs procédé d'utilisation |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| EP3534947A1 (fr) | 2016-11-03 | 2019-09-11 | Kymab Limited | Anticorps, combinaisons comprenant des anticorps, biomarqueurs, utilisations et procédés |
| EP3538548A4 (fr) | 2016-11-08 | 2020-08-19 | Delinia, Inc. | Variants d'il-2 pour le traitement de maladies auto-immunes |
| ES2973548T3 (es) | 2016-12-22 | 2024-06-20 | Cue Biopharma Inc | Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso |
| EP3565829A4 (fr) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | Polypeptides multimères modulateurs de lymphocytes t et leurs procédés d'utilisation |
| US20200010528A1 (en) | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| CN108623693B (zh) * | 2017-03-20 | 2022-03-25 | 徐寒梅 | 一种融合蛋白及其制备方法和其在制备治疗眼科疾病、抗炎、抗肿瘤药物中的应用 |
| MY206158A (en) | 2017-05-24 | 2024-12-02 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| IL275426B2 (en) | 2017-12-19 | 2025-03-01 | Xencor Inc | Engineered il-2 fc fusion proteins |
| CN111886241A (zh) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| WO2019147837A2 (fr) | 2018-01-24 | 2019-08-01 | Beijing Percans Oncology Co. Ltd. | Protéines de fusion de cytokines |
| EP3752178A1 (fr) | 2018-02-16 | 2020-12-23 | Iltoo Pharma | Utilisation de l'interleukine 2 pour traiter le syndrome de sjögren |
| EP3765517A1 (fr) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Molécules multifonctionnelles se liant à calréticuline et utilisations associees |
| PE20210313A1 (es) | 2018-03-28 | 2021-02-12 | Bristol Myers Squibb Co | Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso |
| WO2020007937A1 (fr) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Utilisation de l'interleukine-2 pour le traitement de la sclérose systémique |
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| WO2020127277A1 (fr) | 2018-12-18 | 2020-06-25 | Robert Koch-Institut | Cellule présentatrice du cmh-i chargée de peptides et il-2 présentant une demi-vie prolongée pour amplifier une réponse immunitaire cytotoxique cellulaire |
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| CN113912734B (zh) * | 2020-07-08 | 2025-02-28 | 南京师范大学 | 融合多肽及其用途 |
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| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| KR20230112632A (ko) | 2020-10-23 | 2023-07-27 | 애셔 바이오테라퓨틱스, 인크. | 면역 세포 기능을 조절하기 위한 cd8 항원 결합 분자와의 융합 |
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| JP2010534469A (ja) | 2007-07-25 | 2010-11-11 | アストラゼネカ アクチボラグ | Kdr指向性標的化結合物質およびその使用 |
| WO2009061853A2 (fr) | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Polypeptides d'interleukine-2 (il-2) mutants |
| AU2008343589A1 (en) | 2007-12-19 | 2009-07-09 | Centocor Ortho Biotech Inc. | Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods |
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| AU2010206840B2 (en) | 2009-01-21 | 2015-02-05 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| CA2806021C (fr) | 2010-08-13 | 2019-05-21 | Roche Glycart Ag | Anticorps anti-fap et procedes d'utilisation |
| CU23923B1 (es) | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| SG192673A1 (en) | 2011-02-10 | 2013-09-30 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| DK2683395T3 (en) | 2011-03-11 | 2018-11-19 | Hopitaux Paris Assist Publique | USE OF LOW DOSAGE IL-2 FOR TREATMENT OF TYPE 1 DIABETES |
| ES2692268T5 (en) | 2011-03-29 | 2025-02-26 | Roche Glycart Ag | Antibody fc variants |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| EP2723380B1 (fr) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Protéines hybrides d'immunoglobuline à chaîne légère et leurs procédés d'utilisation |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| PT3102595T (pt) | 2014-02-06 | 2019-01-11 | Hoffmann La Roche | Proteínas de fusão de interleucina-2 e suas utilizações |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
-
2013
- 2013-08-06 US US13/960,149 patent/US20140044675A1/en not_active Abandoned
- 2013-08-07 SG SG11201407579QA patent/SG11201407579QA/en unknown
- 2013-08-07 BR BR112015002765A patent/BR112015002765A2/pt active Search and Examination
- 2013-08-07 CN CN201380041053.1A patent/CN104507504A/zh active Pending
- 2013-08-07 MX MX2015001749A patent/MX2015001749A/es unknown
- 2013-08-07 CA CA2873291A patent/CA2873291A1/fr not_active Abandoned
- 2013-08-07 AU AU2013301562A patent/AU2013301562B2/en not_active Ceased
- 2013-08-07 MA MA37894A patent/MA37894B1/fr unknown
- 2013-08-07 HK HK15109669.4A patent/HK1208827A1/xx unknown
- 2013-08-07 CN CN202010331382.1A patent/CN111635460A/zh active Pending
- 2013-08-07 PE PE2014002251A patent/PE20150752A1/es not_active Application Discontinuation
- 2013-08-07 JP JP2015525869A patent/JP6526561B2/ja not_active Expired - Fee Related
- 2013-08-07 EA EA201500206A patent/EA201500206A1/ru unknown
- 2013-08-07 WO PCT/EP2013/066516 patent/WO2014023752A1/fr not_active Ceased
- 2013-08-07 EP EP13745844.4A patent/EP2882458B1/fr active Active
- 2013-08-07 KR KR20157003397A patent/KR20150041628A/ko not_active Withdrawn
- 2013-08-09 AR ARP130102839A patent/AR092089A1/es unknown
- 2013-08-09 TW TW102128732A patent/TW201420607A/zh unknown
-
2014
- 2014-10-31 CO CO14241630A patent/CO7121348A2/es unknown
- 2014-11-20 CR CR20140532A patent/CR20140532A/es unknown
- 2014-12-04 CL CL2014003322A patent/CL2014003322A1/es unknown
- 2014-12-10 PH PH12014502767A patent/PH12014502767A1/en unknown
-
2015
- 2015-01-26 IL IL236933A patent/IL236933A0/en unknown
- 2015-12-11 US US14/967,019 patent/US20160090407A1/en not_active Abandoned
-
2017
- 2017-09-05 US US15/695,899 patent/US10562949B2/en not_active Expired - Fee Related
-
2020
- 2020-02-05 US US16/783,141 patent/US11365232B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104507504A (zh) | 2015-04-08 |
| CN111635460A (zh) | 2020-09-08 |
| PH12014502767A1 (en) | 2015-02-09 |
| JP6526561B2 (ja) | 2019-06-05 |
| IL236933A0 (en) | 2015-03-31 |
| EA201500206A1 (ru) | 2016-04-29 |
| EP2882458A1 (fr) | 2015-06-17 |
| US20160090407A1 (en) | 2016-03-31 |
| US10562949B2 (en) | 2020-02-18 |
| AU2013301562A1 (en) | 2014-11-20 |
| JP2015530984A (ja) | 2015-10-29 |
| CL2014003322A1 (es) | 2015-02-13 |
| KR20150041628A (ko) | 2015-04-16 |
| SG11201407579QA (en) | 2014-12-30 |
| US20200172591A1 (en) | 2020-06-04 |
| US20180009868A1 (en) | 2018-01-11 |
| CR20140532A (es) | 2015-01-12 |
| US11365232B2 (en) | 2022-06-21 |
| PE20150752A1 (es) | 2015-05-15 |
| HK1208827A1 (en) | 2016-03-18 |
| CO7121348A2 (es) | 2014-11-20 |
| TW201420607A (zh) | 2014-06-01 |
| BR112015002765A2 (pt) | 2018-03-13 |
| EP2882458B1 (fr) | 2018-07-11 |
| MX2015001749A (es) | 2015-06-05 |
| AR092089A1 (es) | 2015-03-25 |
| WO2014023752A1 (fr) | 2014-02-13 |
| US20140044675A1 (en) | 2014-02-13 |
| AU2013301562B2 (en) | 2017-04-06 |
| CA2873291A1 (fr) | 2014-02-13 |
| MA37894A1 (fr) | 2018-07-31 |
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