MA38010B1 - Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5 - Google Patents
Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5Info
- Publication number
- MA38010B1 MA38010B1 MA38010A MA38010A MA38010B1 MA 38010 B1 MA38010 B1 MA 38010B1 MA 38010 A MA38010 A MA 38010A MA 38010 A MA38010 A MA 38010A MA 38010 B1 MA38010 B1 MA 38010B1
- Authority
- MA
- Morocco
- Prior art keywords
- modulators
- receptor activity
- derivatives used
- mglur5 receptor
- ethynyl derivatives
- Prior art date
Links
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des dérivés d'éthynyl de formule (i), dans laquelle y représente n ou ch, r
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12188943 | 2012-10-18 | ||
| PCT/EP2013/071476 WO2014060384A1 (fr) | 2012-10-18 | 2013-10-15 | Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38010A1 MA38010A1 (fr) | 2016-01-29 |
| MA38010B1 true MA38010B1 (fr) | 2016-10-31 |
Family
ID=47049068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38010A MA38010B1 (fr) | 2012-10-18 | 2015-04-17 | Dérivés d'éthynyl utilisés en tant que modulateurs de l'activité des récepteurs mglur5 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9359301B2 (fr) |
| EP (1) | EP2909178B1 (fr) |
| JP (1) | JP6263542B2 (fr) |
| KR (1) | KR20150070102A (fr) |
| CN (1) | CN104603110B (fr) |
| AR (1) | AR093029A1 (fr) |
| AU (1) | AU2013331782B2 (fr) |
| BR (1) | BR112015002320A2 (fr) |
| CA (1) | CA2879489A1 (fr) |
| CL (1) | CL2015000890A1 (fr) |
| CR (1) | CR20150158A (fr) |
| EA (1) | EA026941B1 (fr) |
| ES (1) | ES2599507T3 (fr) |
| IL (1) | IL237217A (fr) |
| MA (1) | MA38010B1 (fr) |
| MX (1) | MX2015002823A (fr) |
| MY (1) | MY171517A (fr) |
| NZ (1) | NZ703537A (fr) |
| PE (1) | PE20150733A1 (fr) |
| PH (1) | PH12015500346B1 (fr) |
| SG (1) | SG11201500729SA (fr) |
| TW (1) | TWI504593B (fr) |
| UA (1) | UA114008C2 (fr) |
| WO (1) | WO2014060384A1 (fr) |
| ZA (1) | ZA201500343B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016273751B2 (en) * | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| TR201909160T4 (tr) | 2015-07-15 | 2019-07-22 | Hoffmann La Roche | Metabotropik glutamat reseptörü modülatörleri olarak etinil türevleri. |
| ES2975136T3 (es) | 2016-03-30 | 2024-07-03 | Sinntaxis AB | Moduladores alost alostéricos negativos de MGLUR5 para uso en el tratamiento de daños cerebrales maduros |
| WO2018015235A1 (fr) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Dérivés d'éthynyle |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7531529B2 (en) * | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| US8853392B2 (en) * | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
| US20100273772A1 (en) * | 2009-04-23 | 2010-10-28 | Wyeth Llc | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) |
| US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| US8586581B2 (en) * | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| EA022019B1 (ru) * | 2011-04-26 | 2015-10-30 | Ф.Хоффманн-Ля Рош Аг | Этинильные производные в качестве положительных аллостерических модуляторов mglur5 |
| WO2013049255A1 (fr) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Analogues de 5-(prop-1-yn-1-yl)picolinamide substitué comme modulateurs allostériques des récepteurs de mglur5 |
| UA110995C2 (uk) * | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як модулятори метаботропного глутаматного рецептора |
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
| SI2875000T1 (sl) * | 2012-07-17 | 2017-01-31 | F.Hoffmann-La Roche Ag | Ariletinilni derivati |
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| ES2594031T3 (es) * | 2012-09-27 | 2016-12-15 | F. Hoffmann-La Roche Ag | Derivados de ariletinilo |
| PE20150628A1 (es) * | 2012-10-18 | 2015-05-11 | Hoffmann La Roche | Derivados de etinilo como moduladores de la actividad del receptor mglur5 |
| MY168937A (en) * | 2012-10-18 | 2019-01-10 | Hoffmann La Roche | Ethynyl derivatives as modulators of mglur5 receptor activity |
-
2013
- 2013-10-15 UA UAA201504679A patent/UA114008C2/uk unknown
- 2013-10-15 CN CN201380046124.7A patent/CN104603110B/zh not_active Expired - Fee Related
- 2013-10-15 ES ES13776507.9T patent/ES2599507T3/es active Active
- 2013-10-15 MY MYPI2015000250A patent/MY171517A/en unknown
- 2013-10-15 JP JP2015537217A patent/JP6263542B2/ja not_active Expired - Fee Related
- 2013-10-15 EP EP13776507.9A patent/EP2909178B1/fr active Active
- 2013-10-15 CA CA2879489A patent/CA2879489A1/fr not_active Abandoned
- 2013-10-15 BR BR112015002320A patent/BR112015002320A2/pt not_active Application Discontinuation
- 2013-10-15 NZ NZ703537A patent/NZ703537A/en not_active IP Right Cessation
- 2013-10-15 AU AU2013331782A patent/AU2013331782B2/en not_active Ceased
- 2013-10-15 EA EA201590676A patent/EA026941B1/ru not_active IP Right Cessation
- 2013-10-15 KR KR1020157006701A patent/KR20150070102A/ko not_active Abandoned
- 2013-10-15 PE PE2015000287A patent/PE20150733A1/es not_active Application Discontinuation
- 2013-10-15 WO PCT/EP2013/071476 patent/WO2014060384A1/fr not_active Ceased
- 2013-10-15 MX MX2015002823A patent/MX2015002823A/es unknown
- 2013-10-15 SG SG11201500729SA patent/SG11201500729SA/en unknown
- 2013-10-16 AR ARP130103749A patent/AR093029A1/es unknown
- 2013-10-17 TW TW102137559A patent/TWI504593B/zh not_active IP Right Cessation
-
2015
- 2015-01-16 ZA ZA2015/00343A patent/ZA201500343B/en unknown
- 2015-02-12 IL IL237217A patent/IL237217A/en not_active IP Right Cessation
- 2015-02-17 PH PH12015500346A patent/PH12015500346B1/en unknown
- 2015-03-20 CR CR20150158A patent/CR20150158A/es unknown
- 2015-04-09 CL CL2015000890A patent/CL2015000890A1/es unknown
- 2015-04-17 MA MA38010A patent/MA38010B1/fr unknown
- 2015-04-17 US US14/689,387 patent/US9359301B2/en active Active
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