MA38709A1 - Compositions et procédés pour une utilisation en diagnostic médical - Google Patents
Compositions et procédés pour une utilisation en diagnostic médicalInfo
- Publication number
- MA38709A1 MA38709A1 MA38709A MA38709A MA38709A1 MA 38709 A1 MA38709 A1 MA 38709A1 MA 38709 A MA38709 A MA 38709A MA 38709 A MA38709 A MA 38709A MA 38709 A1 MA38709 A1 MA 38709A1
- Authority
- MA
- Morocco
- Prior art keywords
- nanoparticles
- nanoparticle
- aggregates
- compositions
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 10
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 229910010272 inorganic material Inorganic materials 0.000 abstract 1
- 239000011147 inorganic material Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000012800 visualization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A61K49/0414—Particles, beads, capsules or spheres
- A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0457—Semi-solid forms, ointments, gels, hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
La présente invention concerne des compositions et des procédés pour une utilisation en diagnostic médical et en suivi de patient. Elle concerne plus particulièrement un gel biocompatible comprenant des nanoparticules et/ou des agrégats de nanoparticules, i) la nanoparticule et/ou l'agrégat de nanoparticules comprenant un matériau inorganique comprenant au moins un élément métallique présentant un nombre atomique z d'au moins 25, chacun parmi ladite nanoparticule et/ou ledit agrégat de nanoparticules étant recouvert d'un revêtement biocompatible ; ii) la concentration en nanoparticules et/ou en agrégats de nanoparticules étant d'environ ou inférieure à 0,5 % (p/p) ; et iii) la viscosité apparente à 2s-1 du gel comprenant des nanoparticules et/ou des agrégats de nanoparticules étant située entre environ 0,1 pa.S et environ 1000 pa.S lorsqu'elle est mesurée entre 20°c et 37°c. La composition de l'invention permet généralement la délimitation et la visualisation d'au moins 40 % du tissu biologique cible lorsque ledit tissu est observé à l'aide d'un équipement d'imagerie par rayons x.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305831 | 2013-06-20 | ||
| PCT/EP2014/062947 WO2014202723A1 (fr) | 2013-06-20 | 2014-06-19 | Compositions et procédés pour une utilisation en diagnostic médical |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA38709A1 true MA38709A1 (fr) | 2018-05-31 |
Family
ID=48745869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38709A MA38709A1 (fr) | 2013-06-20 | 2014-06-19 | Compositions et procédés pour une utilisation en diagnostic médical |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10588987B2 (fr) |
| EP (1) | EP3010495B1 (fr) |
| JP (1) | JP6560665B2 (fr) |
| KR (1) | KR20160027009A (fr) |
| CN (1) | CN105431141A (fr) |
| AU (1) | AU2014283217A1 (fr) |
| BR (1) | BR112015031977A2 (fr) |
| CA (1) | CA2915430A1 (fr) |
| EA (1) | EA201690050A1 (fr) |
| HK (1) | HK1222562A1 (fr) |
| MA (1) | MA38709A1 (fr) |
| MX (1) | MX2015017774A (fr) |
| SG (1) | SG11201510021TA (fr) |
| WO (1) | WO2014202723A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2790682T3 (pl) | 2011-12-16 | 2019-08-30 | Nanobiotix | Nanocząstki zawierające materiał metaliczny i materiał tlenku hafnu, ich wytwarzanie i zastosowanie |
| WO2016189125A1 (fr) | 2015-05-28 | 2016-12-01 | Nanobiotix | Nanoparticules à utiliser en tant que vaccin thérapeutique |
| CN105097174B (zh) * | 2015-08-12 | 2018-06-22 | 华南理工大学 | 一种木聚糖季铵盐纳米磁性颗粒及其制备方法 |
| CN115590955A (zh) | 2016-12-21 | 2023-01-13 | 纳米生物技术公司（Fr） | 用于治疗神经元障碍的纳米粒子 |
| KR20190107026A (ko) | 2016-12-21 | 2019-09-18 | 나노비오?스 | 뇌 성능을 향상시키거나 스트레스를 치료하는데 사용하기 위한 나노입자 |
| KR101949347B1 (ko) * | 2017-05-24 | 2019-02-18 | 이화여자대학교 산학협력단 | 유방암의 재발 예측을 위한 정보제공방법 |
| US11116793B2 (en) * | 2017-11-13 | 2021-09-14 | National University Corporation Hokkaido University | Modified metal nanoparticle comprising cyclic polyether and pharmaceutical composition |
| CN107998395A (zh) * | 2017-12-14 | 2018-05-08 | 天津市赛宁生物工程技术有限公司 | 一种双功能乳腺靶标及制备方法 |
| US20230270664A1 (en) * | 2020-08-13 | 2023-08-31 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Delivery device |
| EP4633676A1 (fr) | 2022-12-12 | 2025-10-22 | Nanobiotix | Nouvelles nanoparticules d'oxyde métallique et compositions de celles-ci destinées à être utilisées en tant que radioactivateurs ou pour visualiser un tissu biologique |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6161034A (en) | 1999-02-02 | 2000-12-12 | Senorx, Inc. | Methods and chemical preparations for time-limited marking of biopsy sites |
| US20050084869A1 (en) * | 2003-10-20 | 2005-04-21 | Sung Hyun Kim | Novel composition and methods for the diagnosis of lung cancer |
| FR2869803B1 (fr) * | 2004-05-10 | 2006-07-28 | Nanobiotix Sarl | Particules activables, preparation et utilisations |
| DE102006041495A1 (de) | 2006-08-29 | 2008-03-20 | Friedrich-Schiller-Universität Jena | Substanzgemisch zur lokalen Deposition von Magnetpartikeln in einem Medium, insbesondere in tumorbefallenem organischem Gewebe, sowie Applikationskit zur Verabreichung |
| DE102008008522A1 (de) * | 2008-02-11 | 2009-08-13 | Magforce Nanotechnologies Ag | Implantierbare Nanopartikel-enthaltende Produkte |
| EP2130553A1 (fr) | 2008-06-05 | 2009-12-09 | Nanobiotix | Nanoparticules inorganiques de haute densité pour détruire des cellules in-vivo |
| EP2275137A1 (fr) * | 2009-07-10 | 2011-01-19 | Nanobiotix | Nanoparticules métalliques, leur préparation et utilisations |
| CN102844054B (zh) | 2009-12-15 | 2016-04-20 | 因赛普特有限责任公司 | 植入物和能生物降解的基准标记物 |
| WO2013076305A1 (fr) | 2011-11-25 | 2013-05-30 | Danmarks Tekniske Universitet | Formulation de nanoparticules solides dans un système gélifiant |
| PL2790682T3 (pl) * | 2011-12-16 | 2019-08-30 | Nanobiotix | Nanocząstki zawierające materiał metaliczny i materiał tlenku hafnu, ich wytwarzanie i zastosowanie |
| US20140219926A1 (en) * | 2013-02-01 | 2014-08-07 | The Trustees Of Dartmouth College | Biodegradable Iron Oxide Nanoparticle Gel for Tumor Bed Therapy |
| KR102217217B1 (ko) * | 2013-06-20 | 2021-02-18 | 나노비오?笭? | 종양학에서의 사용을 위한 조성물 및 방법 |
-
2014
- 2014-06-19 MA MA38709A patent/MA38709A1/fr unknown
- 2014-06-19 AU AU2014283217A patent/AU2014283217A1/en not_active Abandoned
- 2014-06-19 US US14/898,763 patent/US10588987B2/en active Active
- 2014-06-19 HK HK16110780.5A patent/HK1222562A1/zh unknown
- 2014-06-19 MX MX2015017774A patent/MX2015017774A/es unknown
- 2014-06-19 CA CA2915430A patent/CA2915430A1/fr not_active Abandoned
- 2014-06-19 EA EA201690050A patent/EA201690050A1/ru unknown
- 2014-06-19 WO PCT/EP2014/062947 patent/WO2014202723A1/fr not_active Ceased
- 2014-06-19 EP EP14731285.4A patent/EP3010495B1/fr active Active
- 2014-06-19 CN CN201480034960.8A patent/CN105431141A/zh active Pending
- 2014-06-19 SG SG11201510021TA patent/SG11201510021TA/en unknown
- 2014-06-19 JP JP2016520491A patent/JP6560665B2/ja active Active
- 2014-06-19 KR KR1020167001660A patent/KR20160027009A/ko not_active Withdrawn
- 2014-06-19 BR BR112015031977A patent/BR112015031977A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014283217A1 (en) | 2015-12-24 |
| WO2014202723A1 (fr) | 2014-12-24 |
| EP3010495A1 (fr) | 2016-04-27 |
| EA201690050A1 (ru) | 2016-05-31 |
| EP3010495B1 (fr) | 2021-06-16 |
| JP2016527204A (ja) | 2016-09-08 |
| JP6560665B2 (ja) | 2019-08-14 |
| HK1222562A1 (zh) | 2017-07-07 |
| US20160136303A1 (en) | 2016-05-19 |
| KR20160027009A (ko) | 2016-03-09 |
| CN105431141A (zh) | 2016-03-23 |
| MX2015017774A (es) | 2016-03-31 |
| US10588987B2 (en) | 2020-03-17 |
| CA2915430A1 (fr) | 2014-12-24 |
| SG11201510021TA (en) | 2016-01-28 |
| BR112015031977A2 (pt) | 2017-07-25 |
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